keyword
https://read.qxmd.com/read/37232350/ginsenoside-rg1-regulates-autophagy-and-endoplasmic-reticulum-stress-via-the-ampk-mtor-and-perk-atf4-chop-pathways-to-alleviate-alcohol%C3%A2-induced-myocardial-injury
#21
JOURNAL ARTICLE
Ge Tian, Jing Li, Lina Zhou
It has been reported that ginsenoside Rg1 (G‑Rg1) can alleviate alcoholic liver injury, cardiac hypertrophy and myocardial ischemia, as well as reperfusion injury. Therefore, the present study aimed to investigate the role of G‑Rg1 in alcohol‑induced myocardial injury, as well as to elucidate its underlying mechanisms of action. For this purpose, H9c2 cells were stimulated with ethanol. Subsequently, H9c2 cell viability and apoptosis were determined using a Cell Counting Kit‑8 assay and flow cytometric analysis, respectively...
July 2023: International Journal of Molecular Medicine
https://read.qxmd.com/read/37172886/liraglutide-alleviates-myocardial-ischemia%C3%A2-reperfusion-injury-in-diabetic-mice
#22
JOURNAL ARTICLE
Binbin Fang, Fen Liu, Xiaolin Yu, Junyi Luo, Xuehe Zhang, Tong Zhang, Jixin Zhang, Yining Yang, Xiaomei Li
Diabetic patients are prone to acute myocardial infarction. Although reperfusion therapy can preserve the viability of the myocardium, it also causes fatal ischemia‒reperfusion injury. Diabetes can exacerbate myocardial ischemia‒reperfusion injury, but the mechanism is unclear. We aimed to characterize the effects of liraglutide on the prevention of ischemia‒reperfusion injury and inadequate autophagy. Liraglutide reduced the myocardial infarction area and improved cardiac function in diabetic mice...
May 10, 2023: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/37123908/fir-preconditioning-promotes-akt-mtor-exosome-manufacture-in-cooperation-with-mitf-to-boost-resilience-of-rat-bone-marrow-derived-stem-cells
#23
JOURNAL ARTICLE
Yun-Mi Jeong, Weon Kim
A previous study from our laboratory observed the protective effects of far-infrared irradiation (FIR) on bone marrow-derived stem cells (BMSCs) against oxidative stress. However, it remains unknown precisely how FIR influences BMSC survival. We identify an unexpected route among the expression of MITF, BCL2, mTOR, and exosome in FIR-preconditioned BMSCs. MITF siRNA demonstrated that loss of MITF expression not only inhibited cell proliferation but also reduced the FIR-mediated expression of mTOR, BCL2, and exosome...
April 2023: Heliyon
https://read.qxmd.com/read/36988259/bone-marrow-stromal-cell-derived-exosomes-improve-oxidative-stress-and-pyroptosis-in-doxorubicin-induced-myocardial-injury-in-vitro-by-regulating-the-transcription-of-gsdmd-through-the-pi3k-akt-foxo1-pathway
#24
JOURNAL ARTICLE
Hong Zeng, Yong Yang, Fangfang Tou, Yuliang Zhan, Songtao Liu, Pengtao Zou, Yanmei Chen, Liang Shao
OBJECTIVES: Doxorubicin (DOX) can contribute to severe myocardial injury, and bone marrow stromal cells (BMSC)-exosomes (Exos) improves acute myocardial infarction. Hence, this research investigated whether BMSC-Exos alleviated DOX-induced myocardial injury. METHODS: BMSC-derived Exos were isolated and identified, and the optimal concentration of DOX was confirmed. H9C2 cells were treated with DOX and BMSC-Exos or in combination with the protein kinase B (AKT) inhibitor...
March 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/36959603/suxiao-jiuxin-pill-alleviates-myocardial-ischemia-reperfusion-injury-through-the-alkbh5-gsk3%C3%AE-mtor-pathway
#25
JOURNAL ARTICLE
Yiping Li, Ruixia Lu, Zhenchao Niu, Dan Wang, Xiaolong Wang
BACKGROUND: Many studies have shown effective protection from myocardial ischemia-reperfusion injury (MIRI) in animal models, but few, if any, treatments have yielded a substantial reduction in clinical. Several studies showed significant therapeutic effects for the Chinese patent medicine Suxiao Jiuxin Pill (SJP) in MIRI, although the specific molecular mechanisms remain undefined. Recently, increasing evidence indicates an important role for m6A modification in autophagy regulation in MIRI, and SJP has not been investigated in this regard...
March 23, 2023: Chinese Medicine
https://read.qxmd.com/read/36934412/microrna-17-3p-protects-against-excessive-posthypoxic-autophagy-in-h9c2-cardiomyocytes-via-pten-akt-mtor-signaling-pathway
#26
JOURNAL ARTICLE
Yi He, Dengwen Zhang, Qingqing Zhang, Yin Cai, Chongfeng Huang, Zhengyuan Xia, Sheng Wang
The activity of phosphatase and tensin homolog (PTEN) can be inhibited by miR-17-3p, which results in attenuating myocardial ischemia/reperfusion injury (IRI), however, the mechanism behind this phenomenon is still elusive. Suppression of PTEN leads to augmented protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling strength and constrained autophagy activation, which might be the one mechanism for the ameliorated myocardial IRI. Thus, we tested the hypothesis that miR-17-3p attenuated hypoxia/reoxygenation (H/R)-mediated damage in cardiomyocytes by downregulating excessive autophagy via the PTEN-Akt-mTOR axis...
May 2023: Cell Biology International
https://read.qxmd.com/read/36788223/stomatin-like-protein-2-deficiency-exacerbates-adverse-cardiac-remodeling
#27
JOURNAL ARTICLE
Yuntao Hu, Hongwei Jiang, Yueyue Xu, Ganyi Chen, Rui Fan, Yifei Zhou, Yafeng Liu, Yiwei Yao, Renjie Liu, Wen Chen, Ke Zhang, Xin Chen, Rui Wang, Zhibing Qiu
Myocardial fibrosis, oxidative stress, and autophagy both play key roles in the progression of adverse cardiac remodeling. Stomatin-like protein 2 (SLP-2) is closely related to mitochondrial function, but little is known about its role and mechanism in cardiac remodeling. We developed doxorubicin (Dox), angiotensin (Ang) II, and myocardial ischemia-reperfusion (I/R) injury induced cardiac remodeling model and Dox treated H9C2 cell injury model using SLP-2 knockout (SLP-2-/- ) mice and H9C2 cells with low SLP-2 expression...
February 14, 2023: Cell Death Discovery
https://read.qxmd.com/read/36772911/microrna-494-regulates-high-glucose-induced-cardiomyocyte-apoptosis-and-autophagy-by-pi3k-akt-mtor-signalling-pathway
#28
JOURNAL ARTICLE
Shuwei Ning, Siqi Zhang, Zhikun Guo
AIMS: Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of diabetes. However, the mechanism of DCM is not fully understood. Studies have confirmed that certain microRNAs (miRNAs/miRs) are key regulators of DCM. The aim of this study was to investigate the role and mechanism of microRNA (miR)-494 in cardiomyocyte apoptosis and autophagy induced by high glucose (HG). METHODS AND RESULTS: By establishing a rat DCM model and an HG-treated H9c2 cells injury model, cardiac function was detected by echocardiography, myocardial tissue was stained by immunohistochemistry, and Cell Counting Kit-8 assay and lactate dehydrogenase assay were used to detect the cardiomyocyte injury...
February 11, 2023: ESC Heart Failure
https://read.qxmd.com/read/36751963/ginkgo-biloba-extract-protects-against-diabetic-cardiomyopathy-by-restoring-autophagy-via-adenosine-monophosphate-activated-protein-kinase-mammalian-target-of-the-rapamycin-pathway-modulation
#29
JOURNAL ARTICLE
Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song
Studies demonstrated that Ginkgo biloba extract (GBE) played a cardioprotective role in diabetic conditions. Impaired autophagy is one of the mechanisms underlying diabetic cardiomyopathy (DCM). The effect of GBE on autophagy has been observed in several diseases; however, whether GBE can ameliorate DCM by regulating autophagy remains unclear. Here, we investigated the effect of GBE on DCM and the potential mechanisms regarding autophagy using a streptozotocin (STZ)-induced diabetic rat model and a high-glucose (HG)-stimulated H9C2 cell model...
February 8, 2023: Phytotherapy Research: PTR
https://read.qxmd.com/read/36742144/the-protective-effect-of-apelin-13-against-cardiac-hypertrophy-through-activating-the-pi3k-akt-mtor-signaling-pathway
#30
JOURNAL ARTICLE
Yu Peng, Ruan Jingming, Chen Shaowen, Huang Feng, Zhu Pengli
OBJECTIVES: To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway. MATERIALS AND METHODS: The phenylephrine-induced cardiomyocyte hypertrophy model was established in H9C2 cells in vitro . Electroporation transfection technology was utilized to prepare and screen the H9C2 cells inducing low expression of the angiotensin type one receptor-related protein (Si-APJ). H9C2 and Si-APJ cells were divided independently into five groups: the control group, the PE group, the PE+Apelin group, the PE+Rapa group, and the PE+Apelin+Rapa group...
February 2023: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/36701072/klotho-improves-cardiac-fibrosis-inflammatory-cytokines-ferroptosis-and-oxidative-stress-in-mice-with-myocardial-infarction
#31
JOURNAL ARTICLE
Kai Wang, Zhongming Li, Yinzhang Ding, Zheng Liu, Yansong Li, Xianling Liu, Yan Sun, Jian Hong, Wei Zheng, Lijun Qian, Di Xu
The anti-aging protein Klotho has been associated with cardiovascular health protection. Nevertheless, the protective mechanism remains unknown. The present study is aimed at exploring the effect of Klotho on cardiac remodeling and its potential mechanism in mice with myocardial infarction (MI). We used left anterior coronary artery descending ligation to develop an MI model for in vivo analyses. In contrast, H9C2 cells and cardiac fibroblasts were used to establish the oxygen-glucose deprivation (OGD) model in in vitro analyses...
January 26, 2023: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/36682136/myocardial-ischemia-reperfusion-injury-is-probably-due-to-the-excessive-production-of-mitochondrial-ros-caused-by-the-activation-of-5-ht-degradation-system-mediated-by-paf-receptor
#32
JOURNAL ARTICLE
Jiaqi Jin, Fan Xu, Yuxin Zhang, Jing Guan, Jihua Fu
AIM: Previously, we revealed a crucial role of 5-HT degradation system (5DS), consisting of 5-HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase A (MAO-A), in ischemia-reperfusion (IR)-caused organ injury. Whereas, platelet activating factor receptor (PAFR) also mediates myocardial ischemia-reperfusion injury (MIRI). Here, we try to clarify the relationship between 5DS and PAFR in mediating MIRI. METHODS: H9c2 cell injury and rat MIRI were caused by hypoxia/reoxygenation (H/R) or PAF, and by ligating the left anterior descending coronary artery then untying, respectively...
January 20, 2023: Molecular Immunology
https://read.qxmd.com/read/36674423/gpr30-alleviates-pressure-overload-induced-myocardial-hypertrophy-in-ovariectomized-mice-by-regulating-autophagy
#33
JOURNAL ARTICLE
Shuaishuai Zhang, Jipeng Ma, Xiaowu Wang, Diancai Zhao, Jinglong Zhang, Liqing Jiang, Weixun Duan, Xiaoya Wang, Ziwei Hong, Zilin Li, Jincheng Liu
The incidence of heart failure mainly resulting from cardiac hypertrophy and fibrosis increases sharply in post-menopausal women compared with men at the same age, which indicates a cardioprotective role of estrogen. Previous studies in our group have shown that the novel estrogen receptor G Protein Coupled Receptor 30 (GPR30) could attenuate myocardial fibrosis caused by ischemic heart disease. However, the role of GPR30 in myocardial hypertrophy in ovariectomized mice has not been investigated yet. In this study, female mice with bilateral ovariectomy or sham surgery underwent transverse aortic constriction (TAC) surgery...
January 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36627546/chronic-intermittent-hypoxia-induced-bnip3-expression-mitigates-contractile-dysfunction-and-myocardial-injury-in-animal-and-cell-model-via-modulating-autophagy
#34
JOURNAL ARTICLE
Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang
Obstructive sleep apnea syndrome is generally associated with multiple cardiovascular disorders, such as myocardial hypertrophy. Autophagy is strictly modulated to maintain cardiac homeostasis. Post-injury autophagy is closely associated with pathological cardiac hypertrophy. BCL2 interacting protein 3 (BNIP3) and BNIP3-like protein (BNIP3L) can cause cell death and are important for hypoxia-elicited autophagy. Here, we evaluated whether BNIP3 could mitigate functional remodeling and cardiac hypertrophy through regulation of autophagy...
January 10, 2023: Human Cell
https://read.qxmd.com/read/36587924/aldh2-attenuates-ischemia-and-reperfusion-injury-through-regulation-of-mitochondrial-fusion-and-fission-by-pi3k-akt-mtor-pathway-in-diabetic-cardiomyopathy
#35
JOURNAL ARTICLE
Xin Tan, Yong-Feng Chen, Shi-Ying Zou, Wei-Jie Wang, Ning-Ning Zhang, Zheng-Yu Sun, Wei Xian, Xiao-Rong Li, Bi Tang, Hong-Ju Wang, Qin Gao, Pin-Fang Kang
The function of mitochondrial fusion and fission is one of the important factors causing ischemia-reperfusion (I/R) injury in diabetic myocardium. Aldehyde dehydrogenase 2 (ALDH2) is abundantly expressed in heart, which involved in the regulation of cellular energy metabolism and stress response. However, the mechanism of ALDH2 regulating mitochondrial fusion and fission in diabetic myocardial I/R injury has not been elucidated. In the present study, we found that the expression of ALDH2 was downregulated in rat diabetic myocardial I/R model...
February 1, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/36550401/vitamin-c-alleviates-lps-induced-myocardial-injury-by-inhibiting-pyroptosis-via-the-ros-akt-mtor-signalling-pathway
#36
JOURNAL ARTICLE
Pu Zhang, Meirong Zang, Zhenzhen Sang, Yunxia Wei, Yan Yan, Xiaohua Bian, Shimin Dong
BACKGROUND: The efficacy of vitamin C in sepsis remains controversial. Whether vitamin C can alleviate lipopolysaccharide (LPS)-induced myocardial injury by inhibiting pyroptosis has not been studied. This study aimed to evaluate the effects of vitamin C on LPS-induced myocardial injury in vitro. METHODS: H9C2 cells were treated with indicated concentrations of LPS, and the cell viability was then assessed by CCK-8 assay. The levels of lactate dehydrogenase (LDH), CK-MB, IL-18 and IL-1β were examined by enzyme-linked immunosorbent assay (ELISA)...
December 22, 2022: BMC Cardiovascular Disorders
https://read.qxmd.com/read/36474083/dihydromyricetin-alleviates-h9c2-cell-apoptosis-and-autophagy-by-regulating-circhipk3-expression-and-pi3k-akt-mtor-pathway
#37
JOURNAL ARTICLE
Zhi-Ying Zhang, Chao Liu, Peng-Xiang Wang, Yi-Wei Han, Yi-Wen Zhang, Mei-Li Hao, Zi-Xu Song, Xiao-Ying Zhang
OBJECTIVE: To investigate the effect and potential mechanism of dihydromyricetin (Dmy) on H9C2 cell proliferation, apoptosis, and autophagy. METHODS: H9C2 cells were randomly divided into 7 groups, namely control, model, EV (empty pCDH-CMV-MCS-EF1-CopGFP-T2A-Puro vector), IV (circHIPK3 interference), Dmy (50 µ mol/L), Dmy+IV, and Dmy+EV groups. Cell proliferation and apoptosis were detected by cell counting kit-8 assay and flow cytometry, respectivley. Western blot was used to evaluate the levels of light chain 3 II/I (LC3II/I), phospho-phosphoinositide 3-kinase (p-PI3K), protein kinase B (p-AKT), and phospho-mammalian target of rapamycin (p-mTOR)...
December 7, 2022: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/36448058/srpx2-attenuated-oxygen-glucose-deprivation-and-reperfusion-induced-injury-in-cardiomyocytes-via-alleviating-endoplasmic-reticulum-stress-induced-apoptosis-through-targeting-pi3k-akt-mtor-axis
#38
JOURNAL ARTICLE
Zhiyuan Sun, Xin Gao
Myocardial infraction (MI) is the leading cause of high morbidity and mortality worldwide. It was still urgently needed to find new and effective drugs for MI treatment by the use of myocardial ischemia/reperfusion (I/R) model. Sushi repeats contain the protein X-Linked 2 (SRPX2), which regulates a variety of important cell functions. However, its possible role in myocardial I/R and the progression of MI is still unclear. In this study, we investigated the role of SRPX2 in myocardial I/R. SRPX2 showed low expression in IR rats and H9C2 cells induced by oxygen-glucose deprivation/reperfusion (OGD/R)...
2022: Open Life Sciences
https://read.qxmd.com/read/36430296/high-glucose-induced-cardiomyocyte-damage-involves-interplay-between-endothelin-et-1-et-a-et-b-receptor-and-mtor-pathway
#39
JOURNAL ARTICLE
Sudhir Pandey, Corina T Madreiter-Sokolowski, Supachoke Mangmool, Warisara Parichatikanond
Patients with type two diabetes mellitus (T2DM) are at increased risk for cardiovascular diseases. Impairments of endothelin-1 (ET-1) signaling and mTOR pathway have been implicated in diabetic cardiomyopathies. However, the molecular interplay between the ET-1 and mTOR pathway under high glucose (HG) conditions in H9c2 cardiomyoblasts has not been investigated. We employed MTT assay, qPCR, western blotting, fluorescence assays, and confocal microscopy to assess the oxidative stress and mitochondrial damage under hyperglycemic conditions in H9c2 cells...
November 10, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36410277/dj-1-activates-the-ampk-mtor-pathway-by-binding-rack1-to-induce-autophagy-and-protect-the-myocardium-from-ischemia-hypoxia-injury
#40
JOURNAL ARTICLE
Xiao-Yan Zhao, Jian-Min Ren, Hui-Ru Liu, Ting-Ting Zhou, Xue-Ying Wang, Song Liu, He-Ping Chen
Myocardial Ischemic Injury is a serious threat to human health, and DJ-1 is involved in cardioprotection. The research intended to explore the effects and mechanism of DJ-1 to protect myocardium against ischemia injury. DJ-1 overexpression lentivirus vectors were transduced into the myocardium of SD rats and H9c2 cells, and an AMI model in vivo and a hypoxia model in vitro were established, respectively. Results showed that DJ-1 overexpression alleviated myocardial ischemia injury, as demonstrated by reduced the extent of myocardial infarction, improved cell survival, decreased LDH activity and CK-MB release...
November 14, 2022: Biochemical and Biophysical Research Communications
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