Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Amirmahdi Mostofinejad, David A Romero, Dana Brinson, Alba E Marin-Araujo, Aimy Bazylak, Thomas K Waddell, Siba Haykal, Golnaz Karoubi, Cristina H Amon
Tissue engineering predominantly relies on trial and error in vitro and ex vivo experiments to develop protocols and bioreactors to generate functional tissues. As an alternative, in silico methods have the potential to significantly reduce the timelines and costs of experimental programs for tissue engineering. In this paper, we propose a methodology to formulate, select, calibrate, and test mathematical models to predict cell population growth as a function of the biochemical environment and to design optimal experimental protocols for model inference of in silico model parameters...
2024: PloS One
#2
JOURNAL ARTICLE
Felipe Kauai, Quinten Bafort, Frederik Mortier, Marc Van Montagu, Dries Bonte, Yves Van de Peer
Hybridization blurs species boundaries and leads to intertwined lineages resulting in reticulate evolution. Polyploidy, the outcome of whole genome duplication (WGD), has more recently been implicated in promoting and facilitating hybridization between polyploid species, potentially leading to adaptive introgression. However, because polyploid lineages are usually ephemeral states in the evolutionary history of life it is unclear whether WGD-potentiated hybridization has any appreciable effect on their diploid counterparts...
May 21, 2024: Proceedings of the National Academy of Sciences of the United States of America
#3
JOURNAL ARTICLE
Zehua Si, Zhixue He, Chen Shen, Jun Tanimoto
Evolutionary game theory, encompassing discrete, continuous, and mixed strategies, is pivotal for understanding cooperation dynamics. Discrete strategies involve deterministic actions with a fixed probability of one, whereas continuous strategies employ intermediate probabilities to convey the extent of cooperation and emphasize expected payoffs. Mixed strategies, though akin to continuous ones, calculate immediate payoffs based on the action chosen at a given moment within intermediate probabilities. Although previous research has highlighted the distinct impacts of these strategic approaches on fostering cooperation, the reasons behind the differing levels of cooperation among these approaches have remained somewhat unclear...
May 1, 2024: Chaos
#4
JOURNAL ARTICLE
Rostislav Arkhipov, Anton Pakhomov, Olga Diachkova, Mikhail Arkhipov, Nikolay Rosanov
The coherent interaction of extremely short light pulses with a resonant medium can result in the formation of population difference gratings. Such gratings have been created by pulses that are π/2 or smaller. This paper demonstrates that a microcavity with Bragg-like mirrors can be formed by colliding two single-cycle attosecond self-induced transparency pulses in the center of a two-level medium. The parameters of this structure can be quickly adjusted by increasing the number of collisions, which showcases the ability to control the dynamic properties of the medium on a sub-cycle time scale by using attosecond pulses...
May 15, 2024: Optics Letters
#5
JOURNAL ARTICLE
Olivia Bennett, Antonia Freibert, K Eryn Spinlove, Graham A Worth
Quantum dynamics simulations are becoming a standard tool for simulating photo-excited molecular systems involving a manifold of coupled states, known as non-adiabatic dynamics. While these simulations have had many successes in explaining experiments and giving details of non-adiabatic transitions, the question remains as to their predictive power. In this work, we present a set of quantum dynamics simulations on cyclobutanone using both grid-based multi-configuration time-dependent Hartree and direct dynamics variational multi-configuration Gaussian methods...
May 7, 2024: Journal of Chemical Physics
#6
JOURNAL ARTICLE
Xin He, Xiangsong Cheng, Baihua Wu, Jian Liu
Recent progress on the constraint coordinate-momentum phase space (CPS) formulation of finite-state quantum systems has revealed that the triangle window function approach is an isomorphic representation of the exact population-population correlation function of the two-state system. We use the triangle window (TW) function and the CPS mapping kernel element to formulate a novel useful representation of discrete electronic degrees of freedom (DOFs). When it is employed with nonadiabatic field (NaF) dynamics, a new variant of the NaF approach (i...
May 15, 2024: Journal of Physical Chemistry Letters
#7
JOURNAL ARTICLE
Lewis G Spurgin, Mirte Bosse, Frank Adriaensen, Tamer Albayrak, Christos Barboutis, Eduardo Belda, Andrey Bushuev, Jacopo G Cecere, Anne Charmantier, Mariusz Cichon, Niels J Dingemanse, Blandine Doligez, Tapio Eeva, Kjell Einar Erikstad, Vyacheslav Fedorov, Matteo Griggio, Dieter Heylen, Sabine Hille, Camilla A Hinde, Elena Ivankina, Bart Kempenaers, Anvar Kerimov, Milos Krist, Laura Kvist, Veronika N Laine, Raivo Mänd, Erik Matthysen, Ruedi Nager, Boris P Nikolov, Ana Claudia Norte, Markku Orell, Jenny Ouyang, Gergana Petrova-Dinkova, Heinz Richner, Diego Rubolini, Tore Slagsvold, Vallo Tilgar, János Török, Barbara Tschirren, Csongor I Vágási, Teru Yuta, Martien A M Groenen, Marcel E Visser, Kees van Oers, Ben C Sheldon, Jon Slate
A major aim of evolutionary biology is to understand why patterns of genomic diversity vary within taxa and space. Large-scale genomic studies of widespread species are useful for studying how environment and demography shape patterns of genomic divergence. Here, we describe one of the most geographically comprehensive surveys of genomic variation in a wild vertebrate to date; the great tit (Parus major) HapMap project. We screened ca 500,000 SNP markers across 647 individuals from 29 populations, spanning ~30 degrees of latitude and 40 degrees of longitude - almost the entire geographical range of the European subspecies...
May 15, 2024: Molecular Ecology Resources
#8
JOURNAL ARTICLE
Sara Gomez, Chiara Cappelli
The UV-Vis spectrum of the solvated purine derivative Hypoxanthine (HYX) is investigated using the Quantum Mechanics/Fluctuating Charges (QM/FQ) multiscale approach combined with a sampling of configurations through atomistic Molecular Dynamics (MD) simulations. Keto 1H7H and 1H9H tautomeric forms of HYX are the most stable in aqueous solution and form different stable complexes with the surrounding water molecules, ultimately affecting the electronic absorption spectra. The final simulated spectrum resulting from the combination of the individual spectra of tautomers agrees very well with most of the characteristics in the measured spectrum...
May 15, 2024: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
#9
JOURNAL ARTICLE
Cristiano Trevisin, Lorenzo Mari, Marino Gatto, Andrea Rinaldo
We focus on distinctive data-driven measures of the fate of ongoing epidemics. The relevance of our pursuit is suggested by recent results proving that the short-term temporal evolution of infection spread is described by an epidemicity index related to the maximum instantaneous growth rate of new infections, echoing concepts and tools developed to study the reactivity of ecosystems. Suitable epidemicity indices can showcase the dynamics of infections, together with commonly employed effective reproduction numbers, especially when the latter assume values less than 1...
September 2024: Infectious Disease Modelling
#10
JOURNAL ARTICLE
Kursat Altay, Ufuk Erol, Omer Faruk Sahin, Mehmet Can Ulucesme, Ayperi Aytmirzakizi, Munir Aktas
INTRODUCTION: Tick-borne pathogens (TBP) are an important group of organisms that can affect animals and humans all over the world. Equine piroplasmosis (EP), caused by Theileria equi and Babesia caballi , is considered one of the most important tick-borne diseases and can cause significant clinical symptoms and mortality in horses. Moreover, EP plays a restrictive role in international horse traditions and transportation. Although these species can cause similar symptoms, there are different 18S rRNA genotypes of T...
2024: Frontiers in Veterinary Science
#11
Jordann Lewis, Basil Yaseen, Anita Saraf
Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) allow for high-throughput evaluation of cardiomyocyte (CM) physiology in health and disease. While multimodality testing provides a large breadth of information related to electrophysiology, contractility, and intracellular signaling in small populations of iPSC-CMs, current technologies for analyzing these parameters are expensive and resource-intensive. We sought to design a 2D/3D hybrid organoid system and harness optical imaging techniques to assess electromechanical properties, calcium dynamics, and signal propagation across CMs in a high-throughput manner...
April 30, 2024: bioRxiv
#12
Changyi Ji, Xiaofeng Yang, Mohamed Eleish, Yixiang Jiang, Amber Tetlow, Soomin Song, Alejandro Martín-Ávila, Qian Wu, Yanmei Zhou, Wenbiao Gan, Yan Lin, Einar M Sigurdsson
UNLABELLED: We previously reported altered neuronal Ca 2+ dynamics in the motor cortex of 12-month-old JNPL3 tauopathy mice during quiet wakefulness or forced running, with a tau antibody treatment significantly restoring the neuronal Ca 2+ activity profile and decreasing pathological tau in these mice 1 . Whether neuronal functional deficits occur at an early stage of tauopathy and if tau antibody treatment is effective in younger tauopathy mice needed further investigation. In addition, neuronal network activity and neuronal firing patterns have not been well studied in behaving tauopathy models...
May 1, 2024: bioRxiv
#13
Leonor García-Bayona, Nathania Said, Michael J Coyne, Katia Flores, Nazik M Elmekki, Madeline L Sheahan, Adriana Gutierrez Camacho, Kathryn Hutt, Fitnat H Yildiz, Ákos T Kovács, Matthew K Waldor, Laurie E Comstock
Although horizontal gene transfer is pervasive in the intestinal microbiota, we understand only superficially the roles of most exchanged genes and how the mobile repertoire affects community dynamics. Similarly, little is known about the mechanisms underlying the ability of a community to recover after a perturbation. Here, we identified and functionally characterized a large conjugative plasmid that is one of the most frequently transferred elements among Bacteroidales species and is ubiquitous in diverse human populations...
April 29, 2024: bioRxiv
#14
Elizabeth Abraham, Mikel Zubillaga, Thomas Roule, Eleonora Stronati, Naiara Akizu, Conchi Estaras
UNLABELLED: Over the last decade, single-cell approaches have become the gold standard for studying gene expression dynamics, cell heterogeneity, and cell states within samples. Before single-cell advances, the feasibility of capturing the dynamic cellular landscape and rapid cell transitions during early development was limited. In this paper, we designed a robust pipeline to perform single-cell and nuclei analysis on mouse embryos from E6.5 to E8, corresponding to the onset and completion of gastrulation...
May 1, 2024: bioRxiv
#15
Hannah Van Wyk, Gwenyth O Lee, Robert J Schillinger, Christine A Edwards, Douglas J Morrison, Andrew F Brouwer
BACKGROUND: Environmental enteric dysfunction (EED) is a syndrome characterized by epithelial damage including blunting of the small intestinal villi and altered digestive and absorptive capacity which may negatively impact linear growth in children. The 13 C-sucrose breath test ( 13 C-SBT) has been proposed to estimate sucrase-isomaltase (SIM) activity, which is thought to be reduced in EED. We previously showed how various summary measures of the 13 C-SBT breath curve reflect SIM inhibition...
May 3, 2024: medRxiv
#16
JOURNAL ARTICLE
Daniel Mertten, Catherine M McKenzie, Edwige J F Souleyre, Rodrigo R Amadeu, Michael Lenhard, Samantha Baldwin, Paul M Datson
UNLABELLED: Flowering plants exhibit a wide range of sexual reproduction systems, with the majority being hermaphroditic. However, some plants, such as Actinidia arguta (kiwiberry), have evolved into dioecious species with distinct female and male vines. In this study, we investigated the flower load and growth habits of female kiwiberry genotypes to identify the genetic basis of high yield with low maintenance requirements. Owing to the different selection approaches between female and male genotypes, we further extended our study to male kiwiberry genotypes...
May 2024: Molecular Breeding
#17
JOURNAL ARTICLE
Vineetha Karuveettil, Chandrashekar Janakiram, Denny John, Manu Mathur, Balagopal Varma, Heidi Green
OBJECTIVE: The objective of this scoping review is to identify and map the literature on concepts, definitions, frameworks, outcomes, and applications of political economic analysis of health. INTRODUCTION: The political economy of health approach seeks to understand how political and economic domains interact and shape individual and population health outcomes. A political economic analysis can provide insights into health problems and inequalities; however, there needs to be more clarity on how the political economy framework is defined and the methods adopted for conducting political economy analysis concerning health...
May 15, 2024: JBI evidence synthesis
#18
JOURNAL ARTICLE
Jorge Arroyo-Esquivel, Christopher A Klausmeier, Elena Litchman
Simple models have been used to describe ecological processes for over a century. However, the complexity of ecological systems makes simple models subject to modelling bias due to simplifying assumptions or unaccounted factors, limiting their predictive power. Neural ordinary differential equations (NODEs) have surged as a machine-learning algorithm that preserves the dynamic nature of the data (Chen et al. 2018 Adv. Neural Inf. Process. Syst. ). Although preserving the dynamics in the data is an advantage, the question of how NODEs perform as a forecasting tool of ecological communities is unanswered...
May 2024: Journal of the Royal Society, Interface
#19
JOURNAL ARTICLE
Hugo Pereira, Nayden Chakarov, Joseph I Hoffman, Tony Rinaud, Meinolf Ottensmann, Kai-Philipp Gladow, Busche Tobias, Barbara A Caspers, Öncü Maraci, Oliver Krüger
BACKGROUND: Exploring the dynamics of gut microbiome colonisation during early-life stages is important for understanding the potential impact of microbes on host development and fitness. Evidence from model organisms suggests a crucial early-life phase when shifts in gut microbiota can lead to immune dysregulation and reduced host condition. However, our understanding of gut microbiota colonisation in long-lived vertebrates, especially during early development, remains limited. We therefore used a wild population of common buzzard nestlings (Buteo buteo) to investigate connections between the early-life gut microbiota colonisation, environmental and host factors...
May 14, 2024: Animal microbiome
#20
JOURNAL ARTICLE
Rong Ye, Yingsi Lai, Jing Gu
BACKGROUND: In Guangdong Province, China, there is lack of information on the HIV epidemic among high-risk groups and the general population, particularly in relation to sexual transmission, which is a predominant route. The new HIV infections each year is also uncertain owing to HIV transmission from men who have sex with men (MSM) to women, as a substantial proportion of MSM also have female sexual partnerships to comply with social demands in China. METHODS: A deterministic compartmental model was developed to predict new HIV infections in four risk groups, including heterosexual men and women and low- and high-risk MSM, in Guangdong Province from 2016 to 2050, considering HIV transmission from MSM to women...
May 14, 2024: BMC Public Health
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
