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(Concurrent) AND (training or Exercise or activity or sport)

Himanshu Yadav, Bechan Lal
Despite important actions of BMP15 (a TGFβ superfamily member) in follicular development in vertebrates, studies are mostly limited to mammals. The folliculogenic processes in lower vertebrates, particularly, fishes are quite different from mammals. It was, therefore, decided to detect the presence of BMP15 in ovarian follicles and what are its role in folliculogenesis and steroidogenesis in catfish? BMP15 protein was detected in different cellular compartments of ovarian follicles of the catfish collected during different reproductive phases, using immunohistochemical and Western blotting methods, with concurrent measurement of ovarian steroids through ELISA...
February 14, 2019: Theriogenology
Ammar Sukari, Misako Nagasaka, Maria Diab, Khaled Al Sibai, Bassel Atassi, Jailan A Elayoubi, Seongho Kim, Ömer Küçük
Cetuximab (CTX) and methotrexate (MTX) have both shown single-agent activity in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) but data on CTX/MTX combination is limited. We report safety and efficacy data of 54 R/M HNSCC patients treated with concurrent CTX/MTX. Median progression-free survival and overall survival were 2.98 months (95% CI, 2.16-4.85 months) and 8.66 months (95% CI, 7.02-12.26 months), respectively. Grade 3 rash and hypomagnesemia were observed in four (7%) and two (4%) of patients...
February 19, 2019: Clinical Otolaryngology
S Pose, M J Zuluaga, M Ferreño, D Agrati, G Bedó, N Uriarte
The maternal behavior of a rat dynamically changes during the postpartum period, adjusting to the characteristics and physiological needs of the pups. This adaptation has been attributed to functional modifications in the maternal circuitry. Maternal behavior can also flexibly adapt according to different litter compositions. Thus, mothers with two overlapping litters can concurrently take care of neonate and juvenile pups; mostly directing their attention to the newborns. We hypothesized that the maternal circuitry of these mothers would show a differential activation pattern after interacting with pups depending on their offspring's developmental stage...
February 19, 2019: Journal of Neuroendocrinology
Khine Myint, Riya Biswas, Yan Li, Nancy Jong, Stephen Jamieson, Johnson Liu, Catherine Han, Christopher Squire, Fabrice Merien, Jun Lu, Takeo Nakanishi, Ikumi Tamai, Mark McKeage
Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin transporters were previously identified but their relative contributions to determining oxaliplatin tumour responses and gastrointestinal tumour cell sensitivity to oxaliplatin remains unclear. We studied clinical associations between tumour expression of oxaliplatin transporter candidate genes and patient response to oxaliplatin, then experimentally verified associations found with MRP2 in models of human gastrointestinal cancer...
February 19, 2019: Scientific Reports
Vasti Aguayo, Bianca N Valdés Fernandez, Madeline Rodríguez-Valentín, Caleb Ruiz-Jiménez, Marcos J Ramos-Benítez, Loyda B Méndez, Ana M Espino
Parasitic helminths and helminth-derived molecules have demonstrated to possess powerful anti-inflammatory properties and confirmed therapeutic effects on inflammatory diseases. The helminth Fasciola hepatica has been reported to suppress specific Th1 specific immune responses induced by concurrent bacterial infections, thus demonstrating its anti-inflammatory ability in vivo. In this study, we demonstrate that native F. hepatica glutathione S-transferase (nFhGST), a major parasite excretory-secretory antigen, majorly comprised of Mu-class GST isoforms, significantly suppresses the LPS-induced TNFα and IL1β of mouse bone-marrow derived macrophages in vitro and the pro-inflammatory cytokine/chemokine storm within C57BL/6 mice exposed to lethal doses of LPS increasing their survival rate by more than 85%...
February 19, 2019: Scientific Reports
Jumpei Terakawa, Vanida Ann Serna, Makoto Mark Taketo, Takiko Daikoku, Adrian A Suarez, Takeshi Kurita
Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in PTEN , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and CTNNB1 exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. While epithelial cells with a monoallelic mutation in any one of three genes failed to propagate in the endometrium, any combination of two or more mutant alleles promoted the growth of epithelium, causing simple hyperplasia, in a dose-dependent manner...
February 19, 2019: Proceedings of the National Academy of Sciences of the United States of America
Nora Wiium, Reidar Säfvenbom
Engagement in organized sports is associated with developmental factors, such as, healthy growth, cognitive abilities, psychological well-being and lower substance use. Research also suggest that the spontaneous free play that characterises self-organized physical activity (PA) provides young people with opportunities to learn social skills, such as self-regulation and conflict-resolution skills. We assessed associations between participation in the two activity types and several demographics along with developmental factors (e...
February 18, 2019: International Journal of Environmental Research and Public Health
Kathryn A Johnson, Lisa J Mauer
Water plays a significant role in the gelatinization and retrogradation (crystallization) of starch. Amylopectin crystalline regions can adopt several hydrated polymorphic forms; however, reports differ on the migration of water during retrogradation. The objectives of this study were to determine the moisture sorption patterns of gelatinized starch lyophiles during retrogradation in controlled relative humidity (RH) environments and document the amylopectin polymorph(s) formed. Starches from different botanical sources containing A-type and B-type amylopectin polymorphs were studied...
February 19, 2019: Journal of Food Science
Alvin Kuowei Tay, Mohammed Mohsin, Susan Rees, Natalino Tam, Moses Kareth, Derrick Silove
PURPOSE: Refugees may be at risk of experiencing a complicated form of bereavement. As yet, however, the nosological status of this putative category across cultures remains in question. We apply qualitative and quantitative methods to investigate the manifestations, prevalence, factorial structure and psychosocial correlates of complicated bereavement amongst refugees from West Papua, a population with no past exposure to western concepts of grief or to formal mental health services...
February 18, 2019: Social Psychiatry and Psychiatric Epidemiology
Yoonseok Choi, Seung Keun Cha, Hyunwoo Ha, Siwon Lee, Hyeon Kook Seo, Jeong Yong Lee, Hyun You Kim, Sang Ouk Kim, WooChul Jung
Highly active metal nanoparticles are desired to serve in high-temperature electrocatalysis, for example, in solid oxide electrochemical cells. Unfortunately, the low thermal stability of nanosized particles and the sophisticated interface requirement for electrode structures to support concurrent ionic and electronic transport make it hard to identify the exact catalytic role of nanoparticles embedded within complex electrode architectures. Here we present an accurate analysis of the reactivity of oxide electrodes boosted by metal nanoparticles, where all particles participate in the reaction...
February 18, 2019: Nature Nanotechnology
Zutao Yu, Zhuo Chen, Qiongli Su, Shiqi Ye, Hongbo Yuan, Mengni Kuai, Meng Lv, Zhijun Tu, Xiaoping Yang, RangRu Liu, Gaoyun Hu, Qianbin Li
The dysfunction and mutual compensatory activation of RAF-MEK-ERK and PI3K-PDK1-AKT pathways have been demonstrated as the hallmarks in several primary and recurrent cancers. The strategy of concurrent blocking of these two pathways shows clinical merits on effective cancer therapy, such as combinatory treatments and dual-pathway inhibitors. Herein, we report a novel prototype of dual-pathway inhibitors by means of merging the core structural scaffolds of a MEK1 inhibitor and a PDK1 inhibitor. A library of 43 compounds that categorized into three series (Series I-III) was synthesized and tested for antitumor activity in lung cancer cells...
January 26, 2019: Bioorganic & Medicinal Chemistry
I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai, Yi-Ching Wang
BACKGROUND: Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biomarkers for predicting CCRT response is immensely important. In this study, we evaluated the predicting value of SRY (sex determining region Y)-box 17 (SOX17) protein during CCRT and its dysregulation of transcriptional targets in CCRT resistance in ESCC. METHODS: Pyrosequencing methylation, RT-qPCR and immunohistochemistry assays were performed to examine the DNA methylation, mRNA expression and protein expression levels of SOX17 in endoscopic biopsy from a total of 70 ESCC patients received CCRT...
February 18, 2019: Journal of Biomedical Science
Melissa Martyn, Anaita Kanga-Parabia, Elly Lynch, Paul A James, Ivan Macciocca, Alison H Trainer, Jane Halliday, Louise Keogh, Janney Wale, Ingrid Winship, Michael Bogwitz, Giulia Valente, Maie Walsh, Lilian Downie, David Amor, Mathew Wallis, Fiona Cunningham, Matthew Burgess, Natasha J Brown, Anna Jarmolowicz, Sebastian Lunke, Ilias Goranitis, Clara L Gaff
Internationally, the practice of offering additional findings (AFs) when undertaking a clinically indicated genomic test differs. In the USA, the recommendation is to include analysis for AFs alongside diagnostic analysis, unless a patient opts-out, whereas European and Canadian guidelines recommend opt-in models. These guidelines all consider the offer of AFs as an activity concurrent with the offer of diagnostic testing. This paper describes a novel two-step model for managing AFs within the healthcare system in Victoria, Australia and presents the study protocol for its evaluation...
February 18, 2019: Journal of Genetic Counseling
Lidan Hou, Jie Zhao, Shaobing Gao, Tong Ji, Tianyu Song, Yining Li, Jingjie Wang, Chenlu Geng, Min Long, Jiang Chen, Hui Lin, Xiujun Cai, Yong Cang
About 257 million people with chronic infection of hepatitis B virus (HBV) worldwide are at high risk of developing terminal liver diseases. Reactivation of virus replication has been frequently reported in those patient populations receiving imatinib (an Abl kinase inhibitor) or bortezomib (a proteasome inhibitor) to treat concurrent diseases, but the underlying mechanism for this reactivation is unknown. We report that the HBV polymerase protein is recruited by Cdt2 to the cullin-RING ligase 4 (CRL4) for ubiquitination and proteasome degradation and that this process is stimulated by the c-Abl nonreceptor tyrosine kinase...
February 2019: Science Advances
D Paniagua, I Vergara, R Román, C Romero, M Benard-Valle, A Calderón, L Jiménez, M J Bernas, M H Witte, L V Boyer, A Alagón
CONTEXT: Historically, administration and dosing of antivenom (AV) have been guided primarily by physician judgment because of incomplete understanding of the envenomation process. As demonstrated previously, lymphatic absorption plays a major role in the availability and pharmacokinetics (PK) of coral snake venom injected subcutaneously, which suggests that absorption from subcutaneous tissue is the limiting step for venom bioavailability, supporting the notion that the bite site is an ongoing venom depot...
February 18, 2019: Clinical Toxicology
Maria Vogel, Anett Georgi, Frank-Dieter Kopinke, Katrin Mackenzie
Nanoscale zero-valent iron (nZVI) is a powerful reductant for many water pollutants. The lifetime of nZVI in aqueous environments is one of its limitations. Sulfidation of the nZVI surface by reduced sulfur species is known to significantly modify the particle properties. In the present study we examined various post-synthesis sulfidation methods applied on Carbo-Iron, a composite material where iron nanostructures are embedded in colloidal activated carbon (AC) particles. In such cases, where ZVI is surrounded by carbon, sulfidation largely inhibits the anaerobic corrosion of ZVI in water whereas its dechlorination activity was slightly increased...
February 10, 2019: Science of the Total Environment
Jacek Kwiecinski, Damini Dey, Sebastien Cadet, Sang-Eun Lee, Yuka Otaki, Phi T Huynh, Mhairi K Doris, Evann Eisenberg, Mijin Yun, Maurits A Jansen, Michelle C Williams, Balaji K Tamarappoo, John D Friedman, Marc R Dweck, David E Newby, Hyuk-Jae Chang, Piotr J Slomka, Daniel S Berman
OBJECTIVES: This study aimed to assess the association between increased lesion peri-coronary adipose tissue (PCAT) density and coronary 18 F-sodium fluoride (18 F-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA). BACKGROUND: Coronary 18 F-NaF uptake reflects the rate of calcification of coronary atherosclerotic plaque. Increased PCAT density is associated with vascular inflammation...
February 11, 2019: JACC. Cardiovascular Imaging
Lumin Wang, Fawei Zhu, Sen Liao, Miao Chen, Yu Qiu Zhu, Qi Liu, Xiaoqing Chen
Facile and cost-effective detection of multiple targets is essential for a variety of applications ranging from life sciences to environmental monitoring. Here, we report a versatile ratiometric fluorescence platform for multiple detection of various targets based on the conjugation of single-stranded DNA (ssDNA) with protonated graphitic carbon nitride nanosheets (Pg-C3 N4 NSs). We demonstrate that intrinsic peroxidase-like activity of Pg-C3 N4 NSs is enhanced by conjugating with ssDNA, and thus the oxidation of substrate o-phenylenediamine (OPD) is promoted in the presence of H2 O2 ...
May 15, 2019: Talanta
Shanna Hamilton, Iuliia Polina, Radmila Terentyeva, Peter Bronk, Tae Yun Kim, Karim Roder, Richard T Clements, Gideon Koren, Bum-Rak Choi, Dmitry Terentyev
KEY POINTS SUMMARY: Small-conductance Ca2+ -activated K+ (SK) channels expressed in ventricular myocytes are dormant in health yet become functional in cardiac disease. SK channels are voltage independent and their gating is controlled by intracellular [Ca2+ ] in a biphasic manner. Submicromolar [Ca2+ ] activates the channel via constitutively-bound calmodulin, while higher [Ca2+ ] exerts inhibitory effect during depolarization. Using a rat model of cardiac hypertrophy induced by thoracic aortic banding, we found that functional upregulation of SK2 channels in hypertrophic rat ventricular cardiomyocytes is driven by PKA phosphorylation...
February 16, 2019: Journal of Physiology
Jiayi Huang, Rekha Chaudhary, Adam L Cohen, Karen Fink, Samuel Goldlust, John Boockvar, Prakash Chinnaiyan, Leping Wan, Stephen Marcus, Jian L Campian
PURPOSE: Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II study aimed to estimate the potential effectiveness of DSF/Cu to re-sensitize recurrent GBM to TMZ. METHODS: This open-label, single-arm phase II study treated recurrent TMZ-resistant GBM patients with standard monthly TMZ plus concurrent daily DSF 80 mg PO TID and Cu 1...
February 15, 2019: Journal of Neuro-oncology
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