Charlotte Vetter, Jakob Schieb, Nora Vedder, Tim Lange, Tobias Brunn, Chiel van Geffen, Philipp Gercke, Saeed Kolahian
Myeloid-derived suppressor cells (MDSCs) hold promise for clinical applications due to their immunosuppressive properties, particularly in the context of inflammation. In the present study, the number and immunosuppressive activity of MDSCs isolated from naïve Il10-/- , Il17-/- , and WT mice as control, as well as from house dust mite extract (HDM)-induced asthmatic Il10-/- and Il17-/- mice, were investigated. IL-10 deficiency increased the number of polymorphonuclear (PMN)-MDSCs in the lung, spleen, and bone marrow, without concurrent impairment of their suppressive activity in vitro...
April 23, 2024: European Journal of Immunology