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https://read.qxmd.com/read/38522544/molybdenum-mediated-nitrogen-accumulation-and-assimilation-in-legumes-stepwise-boosted-by-the-coexistence-of-arbuscular-mycorrhizal-fungi-and-earthworms
#21
JOURNAL ARTICLE
Dongguang Yang, Li Wang
Molybdenum (Mo) is a critical micronutrient for nitrogen (N) metabolism in legumes, yet the impact of Mo on legume N metabolism in the context of natural coexistence with soil microorganisms remains poorly understood. This study investigated the dose-dependent effects of Mo on soil N biogeochemical cycling, N accumulation, and assimilation in alfalfa under conditions simulating the coexistence of arbuscular mycorrhizal fungi (AMF) and earthworms. The findings indicated that Mo exerted a hormetic effect on alfalfa N accumulation, facilitating it at low concentrations (below 29...
March 22, 2024: Science of the Total Environment
https://read.qxmd.com/read/38522315/polyphenols-from-hickory-nut-reduce-the-occurrence-of-atherosclerosis-in-mice-by-improving-intestinal-microbiota-and-inhibiting-trimethylamine-n-oxide-production
#22
JOURNAL ARTICLE
Chenyu Jiang, Song Wang, Yihan Wang, Ketao Wang, Chunying Huang, Fei Gao, Huang Peng Hu, Yangyong Deng, Wen Zhang, Jian Zheng, Jianqin Huang, Yan Li
BACKGROUND: Trimethylamine N-oxide (TMAO), a metabolite produced by intestinal microbiota through metabolizing phosphatidylcholine, choline, l-carnitine and betaine in the diet, has been implicated in the pathogenesis of atherosclerosis (AS). Concurrently, dietary polyphenols have garnered attention for their potential to ameliorate obesity, diabetes and atherosclerosis primarily by modulating the intestinal microbial structure. Hickory (Carya cathayensis) nut, a polyphenol-rich food product favored for its palatability, emerges as a candidate for exploration...
January 9, 2024: Phytomedicine
https://read.qxmd.com/read/38521958/promoting-healthy-diet-and-active-lifestyle-pedal-a-protocol-for-the-development-and-feasibility-study-of-a-multicomponent-intervention-among-primary-school-children-in-singapore
#23
JOURNAL ARTICLE
Cindy Mei Jun Chan, Falk Müller-Riemenschneider, Michael Yong Hwa Chia, Zoe Jane-Lara Hildon, Mary Foong-Fong Chong
BACKGROUND: Setting healthy lifestyle habits during the formative years of childhood is critical as habits can track to adulthood and help prevent obesity and chronic disease risks in later life. While multicomponent interventions have been shown to be effective in changing the lifestyle behaviours of children, there is a limited understanding of the feasibility of such interventions in primary schools in Singapore. A multiphase mixed method study was conducted to develop and examine the feasibility of a theory-based multicomponent school-based intervention-Promoting hEatlthy Eating and Active Lifestyle (PEDAL)...
March 23, 2024: Pilot and Feasibility Studies
https://read.qxmd.com/read/38521521/prostate-cancer-survivorship-essentials-for-men-with-prostate-cancer-on-androgen-deprivation-therapy-protocol-for-a-randomised-controlled-trial-of-a-tele-based-nurse-led-survivorship-care-intervention-pcessentials-hormone-therapy-study
#24
JOURNAL ARTICLE
Anna Green, Robert U Newton, David P Smith, Haitham Tuffaha, Daniel A Galvão, Peter Heathcote, Manish I Patel, David Christie, Sam Egger, Sally Am Sara, Nicole Heneka, Suzanne K Chambers, Jeff Dunn
INTRODUCTION: Androgen deprivation therapy (ADT) is commonly used to treat men with locally advanced or metastatic prostate cancer. Men receiving ADT experience numerous side effects and frequently report unmet supportive care needs. An essential part of quality cancer care is survivorship care. To date, an optimal effective approach to survivorship care for men with prostate cancer on ADT has not been described. This protocol describes a randomised trial of tele-based nurse-led survivorship that addresses this knowledge gap: (1) determine the effectiveness of a nurse-led survivorship care intervention (PCEssentials), relative to usual care, for improving health-related quality of life (HR-QoL) in men with prostate cancer undergoing ADT and (2) evaluate PCEssentials implementation strategies and outcomes, including cost-effectiveness, compared with usual care...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521474/suppression-of-nsclc-progression-via-the-co-administration-of-danusertib-an-aurk-inhibitor-and-kribb11-an-hsf1-inhibitor
#25
JOURNAL ARTICLE
Xiang Zhang, Ying Lei, Xiang Chen, Jiahuang He, Zitian Liu, Wentao Zhu, Yi Xu, Xuru Jin
Aurora kinase (AURK) and heat shock factor 1 (HSF1) are commonly overexpressed in non-small cell lung cancer (NSCLC), correlating with poor prognosis. This study aims to assess the therapeutic potential of combining the Danusertib (Danu, AURK inhibitor) and KRIBB11 (HSF1 inhibitor) for NSCLC treatment. The effects of this combination were investigated in A549 cells and a tumor xenograft mouse model. The findings demonstrate that concurrent administration of Danu and KRIBB11 effectively impedes cell proliferation, induces apoptosis, and triggers G2/M cell cycle arrest...
March 21, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38521369/l-methionine-accentuates-anti-tumor-action-of-gefitinib-in-gefitinib-resistant-lung-adenocarcinoma-role-of-egfr-erk-akt-signaling-and-histone-h3k36me2-alteration
#26
JOURNAL ARTICLE
Swagata Pal, Shaheen Wasil Kabeer, Kulbhushan Tikoo
Adenocarcinoma, the predominant subtype of non-small cell lung cancer (NSCLC), poses a significant clinical challenge due to its prevalence and aggressive nature. Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor is often susceptible to development of resistance despite being the preferred treatment option for NSCLC. In this study, we investigated the potential of L-Methionine in enhancing the cytotoxicity of Gefitinib and preventing resistance development. In vitro experiment employing the H1975 cell line demonstrated a notable enhancement in cytotoxic efficacy when L-Methionine (10 mM) was combined with Gefitinib, as indicated by a substantial reduction in IC50 values (155...
March 21, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38521107/the-spatiotemporal-heterogeneity-of-fertosphere-hotspots-impacted-by-biochar-addition-and-the-implications-for-nh-3-and-n-2-o-emissions
#27
JOURNAL ARTICLE
Mingyue Chen, Hongyu Ran, Sven G Sommer, Ying Liu, Gang Wang, Kun Zhu
The fertosphere, as the interfaces between fertilizer granular and soil particles, represents a key hotspot for nitrogen transformation processes, particularly for ammonia (NH3 ) and nitrous oxide (N2 O) emissions. Understanding the heterogeneity of the fertosphere, especially when incorporating organic amendments like biochars, is crucial for predicting NH3 and N2 O emissions after soil fertilization. In this study, we investigated the effects of three types of biochar (pristine, aged, and acid-washed biochar) on heterogeneity of fertosphere induced by localized urea application...
March 21, 2024: Chemosphere
https://read.qxmd.com/read/38521003/concurrent-inhibition-of-alk-and-src-kinases-disrupts-the-alk-lung-tumor-cell-proteome
#28
JOURNAL ARTICLE
Alberto Diaz-Jimenez, Maria Ramos, Barbara Helm, Sara Chocarro, Dario Lucas Frey, Shubham Agrawal, Kalman Somogyi, Ursula Klingmüller, Junyan Lu, Rocio Sotillo
Precision oncology has revolutionized the treatment of ALK-positive lung cancer with targeted therapies. However, an unmet clinical need still to address is the treatment of refractory tumors that contain drug-induced resistant mutations in the driver oncogene or exhibit resistance through the activation of diverse mechanisms. In this study, we established mouse tumor-derived cell models representing the two most prevalent EML4-ALK variants in human lung adenocarcinomas and characterized their proteomic profiles to gain insights into the underlying resistance mechanisms...
March 19, 2024: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://read.qxmd.com/read/38520956/impact-of-hypoxia-on-glucose-metabolism-and-hypoxia-signaling-pathways-in-juvenile-horseshoe-crabs-tachypleus-tridentatus
#29
JOURNAL ARTICLE
Lingfeng Jiang, Yueyong Shang, Yuntian Shi, Xiaowan Ma, Malik ShahZaib Khalid, Meilian Huang, James Kar-Hei Fang, Youji Wang, Kianann Tan, Menghong Hu
Marine hypoxia poses a significant challenge in the contemporary marine environment. The horseshoe crab, an ancient benthic marine organism, is confronted with the potential threat of species extinction due to hypoxia, making it an ideal candidate for studying hypoxia tolerance mechanisms. In this experiment, juvenile Tachypleus tridentatus were subjected to a 21-day trial at DO:2 mg/L (hypoxia) and DO:6 mg/L conditions. The experimental timeline included a 14-day exposure phase followed by a 7-day recovery period...
March 19, 2024: Marine Environmental Research
https://read.qxmd.com/read/38520329/transition-metal-ru-ii-catalysts-immobilized-nanoreactors-for-conditional-bioorthogonal-catalysis-in-cells
#30
JOURNAL ARTICLE
Zhiguo Gao, Yaojia Li, Jiaqi Xing, Yougong Lu, Quanlin Shao, Jinzhong Hu, Shan Zhao, Wei He, Baiwang Sun
Employing transition metal catalysts (TMCs) to perform bioorthogonal activation of prodrugs and pro-fluorophores in biological systems, particularly in a conditional fashion, remains a challenge. Here, we used a mesoporous organosilica nanoscaffold (RuMSN), which localizes Ru(II) conjugates on the pore wall, enabling the biorthogonal photoreduction reactions of azide groups. Due to easily adjustable surface charges and pore diameter, this efficiently engineering RuMSN catalyst, with abundant active sites on the inner pore well, could spontaneously repel or attract substrates with different molecular sizes and charges and thus ensure selective bioorthogonal catalysis...
March 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38518599/utilizing-machine-learning-to-identify-nifuroxazide-as-an-inhibitor-of-ubiquitin-specific-protease-21-in-a-drug-repositioning-strategy
#31
JOURNAL ARTICLE
Jihoon Tak, Tan Khanh Nguyen, Kyeong Lee, Sang Geon Kim, Hee-Chul Ahn
Ubiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is involved in biological processes related to metabolic disorders and cancer proliferation. We focused on constructing predictive models tailored to unveil compounds boasting USP21 inhibitory attributes. Six models, Extra Trees Classifier, Random Forest Classifier, LightGBM Classifier, XGBoost Classifier, Bagging Classifier, and a convolutional neural network harnessed from empirical data were selected for the screening process...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518107/anticancer-drugs-related-hypogonadism-in-male-patients-with-advanced-cancers-on-active-treatment-a-systematic-review
#32
JOURNAL ARTICLE
Giacomo Massa, Luca Zambelli, Ernesto Zecca, Morena Shkodra, Gabriele Tinè, Augusto Caraceni
BACKGROUND: In male patients with cancer treated with antineoplastic drug, hypogonadism is a neglected cause of diminished quality of life. This condition may be cancer related as well as toxicity related. The role of antineoplastic drug in causing hypogonadism is poorly understood. The aim of this systematic review was to establish the prevalence, nature (primary/secondary), and impact of hypogonadism on quality of life in male patients with cancer on antineoplastic therapy. METHODS: The search strategy used PubMed, Embase, and Cochrane databases to select articles in English language that described hypogonadism in male patients with cancer...
March 22, 2024: Oncologist
https://read.qxmd.com/read/38518094/neuropsychiatric-symptoms-in-systemic-lupus-erythematosus-mixed-methods-analysis-of-patient-derived-attributional-evidence-in-the-international-inspire-project
#33
JOURNAL ARTICLE
Melanie Sloan, Thomas A Pollak, Efthalia Massou, Guy Leschziner, Laura Andreoli, Rupert Harwood, Michael Bosley, Mervi Pitkanen, Wendy Diment, Alessandra Bortoluzzi, Michael S Zandi, Mandeep Ubhi, Caroline Gordon, David Jayne, Felix Naughton, Colette Barrere, Chris Wincup, James Brimicombe, James A Bourgeois, David D'Cruz
OBJECTIVE: Attribution of neuropsychiatric symptoms in systemic lupus erythematosus (SLE) relies heavily on clinician assessment. Limited clinic time, variable knowledge, and symptom under-reporting contributes to discordance between clinician assessments and patient symptoms. We obtained attributional data directly from patients and clinicians in order to estimate and compare potential levels of direct attribution to SLE of multiple neuropsychiatric symptoms using different patient-derived measures...
March 22, 2024: Rheumatology
https://read.qxmd.com/read/38517995/comprehensive-assessment-of-the-effects-of-concurrent-strength-and-endurance-training-on-lipid-profile-glycemic-control-and-insulin-resistance-in-type-2-diabetes-a-meta-analysis
#34
JOURNAL ARTICLE
Yaowei Sun, Bin Lu, Wenbo Su, Xu Song, Xueyan Shang, Jing Zheng, Jing Wang, Hezhang Yun
BACKGROUND: To investigate the effect of concurrent strength combined with endurance training on the lipid and glucose profile of type 2 diabetes mellitus (T2DM) using Meta-analysis. METHODS: The literature was searched from PubMed, Web of Science, EBSCO, and China National Knowledge Infrastructure(CNKI) databases for relevant randomized controlled trials with dates from the date of establishment to June 2023, and the included studies were individually assessed according to the Cochrane Risk of Bias tool in the Cochrane Systematic Assessor's Handbook, and the data were analyzed using RevMan 5...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517817/prognostic-modeling-for-nasopharyngeal-carcinoma-nc-undergoing-concurrent-chemoradiotherapy-using-clinical-and-enhanced-mri-delta-radiomics-data-a-preliminary-study
#35
JOURNAL ARTICLE
Qiuyang Wang, Peng An, Lina Song, Junjie Liu, Jisheng Liu
BACKGROUND: Nasopharyngeal carcinoma (NC) is one of the prevalent malignancies of the head and neck region with poor prognosis. OBJECTIVE: The aim of this study is to establish a predictive model for assessing NC prognosis based on clinical and MR radiomics data, subsequently to develop a nomogram for practical application. METHODS: Retrospective analysis was conducted on clinical and imaging data collected between May 2010 and August 2018, involving 211 patients diagnosed with histologically confirmed NC who received concurrent chemoradiotherapy or radical surgery in Xiangyang No...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38516872/er-3-activated-ba-2-v-2-o-7-upconversion-nanosheets-for-dual-mode-temperature-sensing
#36
JOURNAL ARTICLE
Satish Kumar Samal, Sahana Kulkarni, Jyoti Yadav, Boddu S Naidu
So far, there has been substantial research on non-contact luminescence thermometry approaches that rely on luminescence intensity ratio (LIR) technology. However, there is limited availability of phosphors doped with Er3+ ions that exhibit on-par luminescence and high sensitivity. In this work, samples of Ba2 V2 O7 :Er3+ were synthesized using a sol-gel method aided by citric acid. The luminescence properties of these samples, including upconversion and down-shifting, were investigated using both ultraviolet and 980 nm laser stimulation...
March 22, 2024: Nanoscale
https://read.qxmd.com/read/38516172/mn-phenolic-networks-as-synergistic-carrier-for-sting-agonists-in-tumor-immunotherapy
#37
JOURNAL ARTICLE
Yingcai Meng, Jiaxin Huang, Jinsong Ding, Haiyan Zhou, Yong Li, Wenhu Zhou
The cGAS-STING pathway holds tremendous potential as a regulator of immune responses, offering a means to reshape the tumor microenvironment and enhance tumor immunotherapy. Despite the emergence of STING agonists, their clinical viability is hampered by stability and delivery challenges, as well as variations in STING expression within tumors. In this study, we present Mn-phenolic networks as a novel carrier for ADU-S100, a hydrophilic STING agonist, aimed at bolstering immunotherapy. These nanoparticles, termed TMA NMs, are synthesized through the coordination of tannic acid and manganese ions, with surface modification involving bovine serum albumin to enhance their colloidal stability...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38515463/katz-index-of-activities-of-daily-living-in-assessing-functional-status-of-older-people-reliability-and-validity-of-sinhala-version
#38
JOURNAL ARTICLE
Nirmala Rathnayake, Ruvini Karunadasa, Thilina Abeygunasekara, Warsha De Zoysa, Dhammika Palangasinghe, Sarath Lekamwasam
PURPOSE: This study evaluated the reliability and validity of the Sinhala version of Katz index of activities of daily living (ADL) in assessing the functional status of older people aged >65 years. MATERIALS AND METHODS: The Katz index was translated to Sinhala, cross-culturally adapted and administered in two stages. In stage 01, 200 patients aged ≥65 years, selected randomly from out-patient medical clinics, were asked to fill the Sinhala version of Katz index along with the Sinhala version of the 10-item Barthel index (BI)...
December 2023: Dialogues Health
https://read.qxmd.com/read/38515396/determination-of-in-vitro-and-in-vivo-effects-of-taxifolin-and-epirubicin-on-epithelial-mesenchymal-transition-in-mouse-breast-cancer-cells
#39
JOURNAL ARTICLE
Muhammet Ocak, Duygu Deniz Usta, Gokce Nur Arik Erol, Gulnur Take Kaplanoglu, Ece Konac, Atiye Seda Yar Saglam
Background: One of the most significant characteristics of cancer is epithelial-mesenchymal transition and research on the relationship between phenolic compounds and anticancer medications and epithelial-mesenchymal transition is widespread. Methods: In order to investigate the potential effects of Taxifolin on enhancing the effectiveness of Epirubicin in treating breast cancer, specifically in 4T1 cells and an allograft BALB/c model, the effects of Taxifolin and Epirubicin, both individually and in combination, were examined...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38515320/from-couplepause-to-doublepause-the-impact-of-midlife-physical-psychological-and-social-changes-on-the-sexual-life-of-aging-couples
#40
JOURNAL ARTICLE
Annamaria Giraldi, Rossella E Nappi, Santiago Palacios, Yacov Reisman, Emmanuele A Jannini
INTRODUCTION: Midlife men and women are facing frequent sexual problems that affect not only individuals' sexual health but also the sexual health of aging couples. OBJECTIVES: To review the main sexual life challenges faced by midlife couples, to present the concepts of couplepause and doublepause as 2 new paradigms to address the sexual health needs of aging couples, and to discuss key aspects in couple-focused care. METHODS: An online meeting attended by 5 European experts in sexual health was carried out in June 2023 to discuss the topic...
March 21, 2024: Sexual Medicine Reviews
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