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Human T-lymphotropic virus 1

Diego Adrianzen Herrera, Noah Kornblum, Ana Acuna-Villaorduna, R Alejandro Sica, Urvi Shah, Moya Butler, Nivetha Vishnuvardhan, Nishi Shah, Lizamarie Bachier-Rodriguez, Olga Derman, Aditi Shastri, Ioannis Mantzaris, Amit K Verma, Ira Braunchweig, Murali Janakiram
In the United States (U.S.), Adult T-Cell Lymphoma-Leukemia (ATLL) carries a dismal prognosis and mainly affects immigrants from Human T-Cell Lymphotropic Virus 1 (HTLV-1) endemic areas. Allogeneic Hematopoietic Stem Cell Transplant (alloHSCT) can be effective and is recommended as an upfront treatment in the NCCN guidelines. We studied the barriers to alloHSCT in one of the largest ATLL populations in the U.S. Comprehensive chart and donor registry reviews were conducted for 88 ATLL patients treated at Montefiore Medical Center from 2003 to 2018...
February 12, 2019: Biology of Blood and Marrow Transplantation
Susan Darroudi, Samaneh Abolbashari, Najmeh Ahangari, Maryam Tayefi, Zahra Khashyarmanesh, Parvin Zamani, Hamideh Moalemzadeh Haghighi, Amir Hooshang Mohammadpour, Shima Tavalaei, Habibollah Esmaily, Gordon A Ferns, Zahra Meshkat, Batool Tayefi, Majid Ghayour-Mobarhan
Depression and Anxiety are two important public health problems that are known to be associated with viral infections. The association between the intake of nutrients such as zinc and copper with symptoms of depression has been studied previously. The aim of the current study was to investigate the association between depression with human T cell lymphotropic virus type 1 (HTLV-1) infection and serum content of zinc and copper in a large Iranian population cohort. The study population consisted of 279 HTLV-1-positive patients who were identified after recruitment as part of a large cohort study: the Mashhad Stroke and Heart Association Disorder (MASHAD) study...
February 4, 2019: Biological Trace Element Research
Sara Samadi, Samaneh Abolbashari, Zahra Meshkat, Amir Hooshang Mohammadpour, Theodoros Kelesidis, Aida Gholoobi, Mehrane Mehramiz, Mahla Tabadkani, Fatemeh Sadabadi, Razieh Dalirfardouei, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited...
January 29, 2019: BioFactors
Flávio Mileo Bacelar Guerreiro, Celso Tavares Sodré, Lorena Brandão Pavan, Paulo Feijó Barroso, Daniele Carvalho Quintella, Tullia Cuzzi, Marcia Ramos-E-Silva
Strongyloidiasis is a parasitic infestation caused by the helminth Strongyloides stercoralis. It is essentially gastrointestinal and in general asymptomatic but can sometimes present with skin signs. Immunocompromised patients can develop the disseminated form of the disease due to the parasite's opportunistic behavior, as in cases of coinfection by the human T-lymphotropic type 1 virus (HTLV-1). This article presents a case of a patient infected with HTLV-I and Strongyloides stercoralis who developed the disseminated form...
December 2018: Acta Dermatovenerologica Croatica: ADC
Lucy B Cook, Shigeo Fuji, Olivier Hermine, Ali Bazarbachi, Juan Carlos Ramos, Lee Ratner, Steve Horwitz, Paul Fields, Alina Tanase, Horia Bumbea, Kate Cwynarski, Graham Taylor, Thomas A Waldmann, Achilea Bittencourt, Ambroise Marcais, Felipe Suarez, David Sibon, Adrienne Phillips, Matthew Lunning, Reza Farid, Yoshitaka Imaizumi, Ilseung Choi, Takashi Ishida, Kenji Ishitsuka, Takuya Fukushima, Kaoru Uchimaru, Akifumi Takaori-Kondo, Yoshiki Tokura, Atae Utsunomiya, Masao Matsuoka, Kunihiro Tsukasaki, Toshiki Watanabe
PURPOSE: Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical features and prognosis. ATL remains a challenging disease as a result of its diverse clinical features, multidrug resistance of malignant cells, frequent large tumor burden, hypercalcemia, and/or frequent opportunistic infection. In 2009, we published a consensus report to define prognostic factors, clinical subclassifications, treatment strategies, and response criteria...
January 18, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Samaneh Abolbashari, Susan Darroudi, Maryam Tayefi, Zahra Khashyarmaneh, Parvin Zamani, Hamideh Moalemzadeh Haghighi, Amir Hooshang Mohammadpour, Shima Tavalaei, Mahsa Ahmadnezhad, Habibollah Esmaily, Gordon A Ferns, Zahra Meshkat, Majid Ghayour-Mobarhan
Introduction: Copper (Cu) and zinc (Zn) are important trace elements that are also structural ions of superoxide dismutase (SOD), which reduce oxidative stress. Zinc deficiency and excess copper have been reported to be associated with inflammation. The human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus, which is believed to cause systemic inflammation. The aim of this study is to measure levels of Zn, Cu, SOD, and prooxidant-antioxidant balance (PAB) in HTLV-1-positive patients and investigate the association between serum Zn and Cu concentrations and levels of oxidative stress in them...
2019: Journal of Blood Medicine
Mona Fani, Majid Rezayi, Zahra Meshkat, Seyed Abdolrahim Rezaee, Manoochehr Makvandi, Ebrahim Abouzari-Lotf, Gordon A Ferns
BACKGROUND: Human T-lymphotropic virus Type 1 (HTLV-1) is a retrovirus that is endemic in some regions of the world. It is known to cause several diseases like adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Serology and molecular methods have been used to detect this virus. Of these, enzyme-linked immunosorbent assay (ELISA) is used as a primary screening method and this is usually followed by western blotting (WB) and polymerase chain reaction (PCR) methods as confirmatory tests...
January 11, 2019: Journal of Cellular Physiology
Samaneh Abolbashari, Majid Ghayour-Mobarhan, Mahmoud Ebrahimi, Zahra Meshkat
Cardiovascular diseases are a major cause of morbidity and mortality. Chronic inflammation is an important risk factor for atherosclerosis, and viral infections can cause cardiovascular disease by developing inflammation. Infection with human T-lymphotropic virus (HTLV) is endemic in some parts of the world such as Japan, Africa, Caribbean islands, South America, and Iran. HTLV-1 is an oncogenic retrovirus, and can cause adult T-cell leukemia/lymphoma (ATL or ATLL). It also causes HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
July 2018: ARYA Atherosclerosis
Priyanka Namdev, Denzelle Lee Lyngdoh, Hamid Yousf Dar, Shivendra K Chaurasiya, Rupesh Srivastava, Timir Tripathi, Rajaneesh Anupam
Human T lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia and lymphoma (ATL) and other neuroinflammatory diseases. The pX region of HTLV-1 genome encodes an accessory protein p30 that is required for viral persistence and spread in the host. p30 regulates viral gene expression at the transcription level by competing with Tax for p300 binding and at post transcriptional level by nuclear retention of tax/rex mRNA. In addition, p30 modulates the host cellular environment by binding to various host proteins such as ATM, REGγ, PRMT5, etc...
January 8, 2019: AIDS Research and Human Retroviruses
Nicole Brenner, Alexander J Mentzer, Julia Butt, Kathrin L Braband, Angelika Michel, Katie Jeffery, Paul Klenerman, Barbara Gärtner, Paul Schnitzler, Adrian Hill, Graham Taylor, Maria A Demontis, Edward Guy, Stephen J Hadfield, Rachael Almond, Naomi Allen, Michael Pawlita, Tim Waterboer
Multiplex Serology is a high-throughput technology developed to simultaneously measure specific serum antibodies against multiple pathogens in one reaction vessel. Serological assays for hepatitis B (HBV) and C (HCV) viruses, human T-lymphotropic virus 1 (HTLV-1) and the protozoan parasite Toxoplasma gondii (T. gondii) were developed and validated against established reference assays. For each pathogen, between 3 and 5 specific antigens were recombinantly expressed as GST-tag fusion proteins in Escherichia coli and tested in Monoplex Serology, i...
2019: PloS One
S Nayar, B Pawar, L Einsiedel, D Fernandes, P George, S Thomas, C Sajiv
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) is endemic amongst the Aborigines of the Northern Territory of Australia. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) has been associated with this infection. In general population, isolated neurogenic bladder dysfunction in HTLV-1-infected individuals without HAM/TSP has been reported, and the HTLV-1 proviral load has been found to be higher in such patients compared with asymptomatic carriers. In solid organ transplantation, few cases of HAM/TSP have been reported worldwide, but not an isolated neurogenic bladder...
December 2018: Transplantation Proceedings
Arash Soltani, Seyed Isaac Hashemy, Farnaz Zahedi Avval, Anvar Soleimani, Houshang Rafatpanah, Seyed Abdorahim Rezaee, Renate Griffith, Baratali Mashkani
Human T-cell lymphotropic virus type 1 (HTLV-1) infection is linked to adult T-cell leukemia-lymphoma (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and several other disorders. ATLL occurs in approximately 5% of the 15-20 million people infected by HTLV-1 in the world. In general, ATLL is resistant to chemotherapy, which underlines the need for new and effective therapeutic strategies. Previous studies highlighted the role of viral enzymes, responsible for viral replication, and regulatory proteins such as Tax and HBZ in the progression of HTLV-1-associated diseases...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Vicente Soriano, Jorge Del Romero
Nearly 1 million people become infected every day with any of the four major curable sexually transmitted infections (STIs), namely trichomoniasis, chlamydia, gonorrhea, and syphilis. Despite huge global incidence, STIs remain as neglected diseases. The success of antiretrovirals for halting progression to AIDS in HIV-infected individuals and for stopping HIV transmission to uninfected contacts, either as pre- or post-exposure -prophylaxis, has to lead to increased risky sexual behaviors through risk compensation...
2018: AIDS Reviews
Mohadeseh Zarei Ghobadi, Sayed-Hamidreza Mozhgani, Fatemeh Hakimian, Mehdi Norouzi, Seyed Abdolrahim Rezaee, Hedayatollah Ghourchian
Detecting fluorescence changes due to energy transfer between a quencher and fluorophore is a common method used for the fluorescence-based biosensors. In the present report, a new biosensor for long segment detection of the human T cell-lymphotropic virus 1 genome was constructed based on the fluorescence quenching of graphene oxide by gold nanoparticles. The fluorescence signal of unmodified graphene oxide was measured before and after hybridization of target and probes functionalized with gold nanoparticles...
December 2018: Heliyon
Lisie Souza Castro, Grazielli Rocha de Rezende, Fernanda Rodas Pires Fernandes, Larissa Melo Bandeira, Marco Antonio Moreira Puga, Tayana Serpa Ortiz Tanaka, Sabrina Moreira Dos Santos Weis, Ana Carolina Paulo Vicente, Koko Otsuki, Ana Rita Coimbra Motta-Castro
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus discovered in humans and is endemic in several parts of the world. Because of risk behaviors, mainly sexual, men who have sex with men (MSM) are at high risk of acquiring HTLV-1 infection. A cross-sectional study was performed to estimate the prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) infection, to characterize genetically HTLV-1 sequences and to identify risk behaviors associated with this infection among MSM in Central Brazil...
December 5, 2018: Brazilian Journal of Infectious Diseases
Rakan Nasreddine, Roland de Wind, Stéphane De Wit, Charlotte Martin
No abstract text is available yet for this article.
January 27, 2019: AIDS
Simon Smith, Darren Russell, Peter Horne, Josh Hanson
Human T-lymphotropic virus type 1 (HTLV-1) is hyperendemic amongst Indigenous Australians living in Central Australia. The epidemiology of the disease is poorly defined in other parts of Australia, despite a high prevalence of classically associated conditions. All HTLV-1 serology tests requested through public health facilities in Far North Queensland (FNQ) from January 1999 to December 2016 were reviewed. The person's age, sex, ethnicity, location, rationale for testing and result were recorded. There were 444 tests performed in 409 people; 217 (53%) were male; 171 (42%) identified as Indigenous Australians...
November 28, 2018: Pathology
Christopher T Haley, Uyen Ngoc Mui, Ramya Vangipuram, Peter L Rady, Stephen K Tyring
In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Additionally, oncoviruses are associated with multiple benign mucocutaneous diseases...
November 28, 2018: Journal of the American Academy of Dermatology
Uyen Ngoc Mui, Christopher T Haley, Ramya Vangipuram, Stephen K Tyring
In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Additionally, oncoviruses are associated with many benign mucocutaneous diseases...
November 28, 2018: Journal of the American Academy of Dermatology
Jennifer Tam, Kevin Schwartz, Jay Keystone, Dimitri Dimitrakoudis, Mark Downing, Sigmund Krajden
Central nervous system (CNS) strongyloidiasis is a known but rare form of disseminated infection. The diagnosis is often made postmortem, with only five published cases of an antemortem diagnosis. We report two fatal cases of CNS strongyloidiasis diagnosed antemortem, with Strongyloides stercoralis larvae visualized in the CNS sample in one case. Risk factors for disseminated strongyloidiasis common to both cases included origination from the Caribbean, underlying human T-lymphotropic virus-1 infection, and recent prednisone use...
November 19, 2018: American Journal of Tropical Medicine and Hygiene
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