Agilė Tunaitytė, Silvijus Abramavičius, Augusta Volkevičiūtė, Mantas Venslauskas, Algimantas Bubulis, Vytis Bajoriūnas, Ulf Simonsen, Vytautas Ostaševičius, Vytautas Jūrėnas, Kasparas Briedis, Edgaras Stankevičius
The present study aimed to investigate the effect of a H2 S donor, GYY 4137, on human pulmonary arteries and whether low-frequency ultrasound (20 kHz, 4 W/cm2 ) inhibits GYY 4137 contractions. Functional studies were conducted on human and rat pulmonary arteries mounted on microvascular myographs. We placed an ultrasonic gadget in the tissue organ bath to insonate the arteries with low-frequency ultrasound. To measure the effect of the low-frequency ultrasound on the entrance of extracellular Ca2+ , the preparations were placed in a Ca2+ -free solution, and the thromboxane agonist, U46619, and extracellular calcium were added in the presence of insonation...
February 21, 2024: Biomolecules