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Neurosurgical oncology

E Emery
Bibliometrics are methods used to quantitatively analyze the scientific literature. The application of bibliometrics in neurosurgery is emerging and has not yet been studied in the French neurosurgical community. In France, the most used statistical method is named SIGAPS; the scores are based on the position of the author and the impact factor of the journal. The SIGAPS score, which can be calculated for a research team or an individual, impacts the public financial support of university hospitals in France...
February 6, 2019: Neuro-Chirurgie
Taylor A Wilson, Rebekah G Langston, Ka Hin Wong, Analiz Rodriguez
OBJECTIVEThe American Association of Neurological Surgeons (AANS) Neurosurgery Research and Education Foundation (NREF) provides ongoing competitive research fellowships for residents and young investigators. The authors sought to determine the characteristics and career tracks of award recipients.METHODSThe authors analyzed characteristics and academic productivity parameters of NREF resident and young investigator awardees in the United States and Canada from 1983 to 2017. Data were extracted from the NREF database and online resources (Web of Science, NIH reporter)...
February 8, 2019: Journal of Neurosurgery
Elly Chaskis, Niloufar Sadeghi, Olivier De Witte, Florence Lefranc
BACKGROUND: Neuro-oncological patients frequently require surgery, and neurosurgical devices are often implanted during neurosurgery. These devices could disturb oncological follow-up by magnetic resonance imaging. METHODS: The authors describe the use of neurosurgical devices such as bone substitutes, ventriculoperitoneal shunts and titanium skull fixations in neuro-oncological patients. RESULTS: Acrylic cement cranioplasty, valve of ventriculo-peritoneal shunt and titanium skull fixations produced magnetic artifacts disturbing postoperative magnetic resonance imaging...
January 23, 2019: World Neurosurgery
Jacob S Young, Fara Dayani, Ramin A Morshed, Hideho Okada, Manish K Aghi
The current standard of care for patients with high grade gliomas includes surgical resection, chemotherapy, and radiation; but even still the majority of patients experience disease progression and succumb to their illness within a few years of diagnosis. Immunotherapy, which stimulates an anti-tumor immune response, has been revolutionary in the treatment of some hematological and solid malignancies, generating substantial excitement for its potential for patients with glioblastoma. The most commonly used immunotherapies include dendritic cell and peptide vaccines, checkpoint inhibitors, and adoptive T cell therapy...
January 21, 2019: World Neurosurgery
Yair M Gozal, Erinç Aktüre, Vijay M Ravindra, Jonathan P Scoville, Randy L Jensen, William T Couldwell, Philipp Taussky
OBJECTIVEThe absence of a commonly accepted standardized classification system for complication reporting confounds the recognition, objective reporting, management, and avoidance of perioperative adverse events. In the past decade, several classification systems have been proposed for use in neurosurgery, but these generally focus on tallying specific complications and grading their effect on patient morbidity. Herein, the authors propose and prospectively validate a new neurosurgical complication classification based on understanding the underlying causes of the adverse events...
January 18, 2019: Journal of Neurosurgery
Massimiliano Del Bene, Alessandro Perin, Cecilia Casali, Federico Legnani, Andrea Saladino, Luca Mattei, Ignazio Gaspare Vetrano, Marco Saini, Francesco DiMeco, Francesco Prada
Introduction: Glioma surgery is aimed at obtaining maximal safe tumor resection while preserving or improving patient's neurological status. For this reason, there is growing interest for intra-operative imaging in neuro-oncological surgery. Intra-operative ultrasound (ioUS) provides the surgeon with real-time, anatomical and functional information. Despite this, in neurosurgery ioUS mainly relies only on gray-scale brightness mode (B-mode). Many other ultrasound imaging modalities, such as Fusion Imaging with pre-operative acquired magnetic resonance imaging (MRI), Doppler modes, Contrast Enhanced Ultrasound (CEUS), and elastosonography have been developed and have been extensively used in other organs...
2018: Frontiers in Oncology
Sandip S Panesar, Kumar Abhinav, Fang-Cheng Yeh, Timothée Jacquesson, Malie Collins, Juan Fernandez-Miranda
Magnetic resonance imaging tractography permits in vivo visualization of white matter structures. Aside from its academic value, tractography has been proven particularly useful to neurosurgeons for preoperative planning. Preoperative tractography permits both qualitative and quantitative analyses of tumor effects upon surrounding white matter, allowing the surgeon to specifically tailor their operative approach. Despite its benefits, there is controversy pertaining to methodology, implementation, and interpretation of results in this context...
December 12, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Nayan Lamba, Daniel N Cagney, Rachel H Brigell, Allison M Martin, Luke A Besse, Paul J Catalano, John G Phillips, Itai M Pashtan, Wenya Linda Bi, Elizabeth B Claus, Alexandra J Golby, Ian F Dunn, Timothy R Smith, Shyam K Tanguturi, Daphne A Haas-Kogan, Brian M Alexander, Ayal A Aizer
BACKGROUND: Brain metastases commonly manifest in cancer patients, with approximately 20-50% presenting with one intracranial lesion. Among patients with one, small brain metastasis and controlled or absent extracranial disease, it remains unclear if aggressive intracranial management utilizing neurosurgical resection and cavity stereotactic radiation (SRS/SRT) rather than SRS/SRT alone is beneficial. In patients with controlled or absent extracranial disease and one brain metastasis ≤2 cm in size, we evaluated the impact of surgery plus SRS/SRT compared to SRS/SRT on oncologic outcomes including overall survival...
November 21, 2018: World Neurosurgery
Nader Sanai
For the neurosurgical oncologist, a specialty practice in gliomas represents an intersection of tailored surgical approaches, emerging intraoperative technologies, expanding surgical trial portfolios, and new paradigms in glioma biology. Assembling these disparate pieces into a cohesive career trajectory is a difficult task but ultimately enables the subspecialist to navigate all domains relevant to improving glioma patient outcomes. Within the larger clinical and basic science community, thoughtful integration and intensive collaborations are essential mechanisms when building a multidisciplinary glioma program...
January 2019: Neurosurgery Clinics of North America
Jiri Bartek, Gerald Cooray, Mominul Islam, Margret Jensdottir
BACKGROUND AND IMPORTANCE: Stereotactic brain biopsy (SB) is an important part of the neurosurgical armamentarium, with the possibility of achieving histopathological diagnosis in otherwise inaccessible lesions of the brain. Nevertheless, the procedure is not without the risk of morbidity, which is especially true for lesions in eloquent parts of the brain, where even a minor adverse event can result in significant deficits. Navigated transcranial magnetic stimulation (nTMS) is widely used to chart lesions in eloquent areas, successfully guiding maximal safe resection, while its potential role in aiding with the planning of a stereotactic biopsy is so far unexplored...
October 26, 2018: Operative Neurosurgery (Hagerstown, Md.)
J Kim, S Radjadurai, Z Rahman, K Hitos, S Ghattas, L Gomes, C Wong, A Bleasel, M A Dexter
INTRODUCTION: Seizures are an important cause of morbidity in patients with low grade gliomas with approximately 40% of cases drug resistant. The pathogenesis is quite complex and poorly understood. The treatment aims vary between almost purely epilepsy considerations and those that are primarily oncologic. AIM: To determine whether patients who present with seizures and are found to have a low grade glioma have better outcomes when managed through a specialized epilepsy unit compared to the general neurosurgical service...
January 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Marion Rapp, Stephanie Schipmann, Kira Hoffmann, Rainer Wiewrodt, Hans-Jakob Steiger, Marcel Kamp, Walter Stummer, Dorothee Wiewrodt, Michael Sabel
Background: Cerebral tumors are associated with high rates of anxiety, depression and reduced health related quality of life. Nevertheless psychooncological screening instruments are neither implemented nor well defined in the daily routine of neurosurgical departments. Therefore, we tried (1) to identify a suitable screening algorithm for neurosurgical patients, (2) to define clinical risk factors for increased distress and (3) to analyze the optimal screening time point. Results: Between October 2013 and January 2015 472 elective neurosurgical in-patients (median age 55...
August 3, 2018: Oncotarget
Musa AlHarbi, Nahla Ali Mobark, Latifa AlMubarak, Rasha Aljelaify, Mariam AlSaeed, Amal Almutairi, Fatmah Alqubaishi, M Emarat Hussain, Ali Abdullah O Balbaid, Amal Said Marie, Lamia AlSubaie, Saeed AlShieban, Nada alTassan, Shakti H Ramkissoon, Malak Abedalthagafi
Primary brain tumors are a leading cause of cancer-related morbidity and mortality in children. Glioblastoma (GBM) is a high-grade astrocytoma that occurs in both children and adults and is associated with a poor prognosis. Despite extensive study in recent years, the clinical management of these tumors has remained largely unchanged, consisting of surgical resection, conventional chemotherapy, and radiotherapy. Although the etiology and genomic drivers in GBM are diverse, constitutional mismatch repair-deficiency (CMMRD) syndrome is a rare, recessively inherited disease with a predisposition to gliomagenesis...
August 13, 2018: Oncologist
Dieter Henrik Heiland, Gerrit Haaker, Ralf Watzlawick, Daniel Delev, Waseem Masalha, Pamela Franco, Marcia Machein, Ori Staszewski, Oliver Oelhke, Nils Henrik Nicolay, Oliver Schnell
INTRODUCTION: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults with peak incidence in patients older than 65 years. These patients are mostly underrepresented in clinical trials and often undertreated due to concomitant diseases. Recently, different therapeutic approaches for elderly patients with GBM were discussed. To date, there is no defined standard treatment. The aim of the present study is to evaluate the functional and oncological outcome in surgical treatment of elderly patients...
November 2018: Journal of Neuro-oncology
Piotr Kaźmierski, Mirosław Wąsiewicz, Jarosław Chrząstek, Michał Pająk
BACKGROUND: Iatrogenic vascular injuries, due to the particular nature of such pathology, are associated with high morbidity and mortality in the postoperative period. OBJECTIVES: The objective of this study was to present a case of non-classic approach to the therapy of iatrogenic arteriovenous fistula. MATERIAL AND METHODS: We present a case of a 17-year old female patient admitted to the Department of Vascular, General and Oncologic Surgery (Copernicus Memorial Hospital, Łódź, Poland) due to an iatrogenic injury to the common iliac vein and artery, following neurosurgical intervention on the spine...
July 30, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Ann Mansur, Selfy Oswari, Petra Octavian Perdana Wahjoepramono, Muhammad Kusdiansah, Mark Bernstein
OBJECTIVE: This study evaluated the sustainability of teaching awake craniotomy in Indonesia. We explored the factors affecting how awake craniotomy can be taught in a low- to middle-income (LMIC) country and the factors affecting the utilization of awake craniotomy in Indonesia. METHODS: This is a prospective mixed-methods study in Indonesia. A questionnaire was administered to 100 neurosurgeons at a conference on their experience with neuro-oncology, awake craniotomy, and teaching missions...
October 2018: World Neurosurgery
Francesco Acerbi, Francesco Restelli, Camilla De Laurentis, Jacopo Falco, Claudio Cavallo, Morgan Broggi, Julius Höhne, Karl-Michael Schebesch, Marco Schiariti, Paolo Ferroli
BACKGROUND: In recent years several techniques have been proposed with the aim of improving tumors visualization and extent of resection and, among them, the use of photosensitive dyes is gaining great interest. Regarding the application of the two most used dyes, 5-aminolevulinic acid (5-ALA) and sodium fluorescein (SF), there is still a lack of shared and established protocols among different centers. The main objective of the present study was to evaluate the current practice of fluorescence-guided techniques in neuro-oncological surgery in Europe...
July 17, 2018: Journal of Neurosurgical Sciences
Jang W Yoon, Wen Jiang, James T Rutka, Yuhui Huang, Betty Y S Kim
Significant advances in the design and understanding of the materials and systems of 1-100 nm have provided unprecedented tools to probe, diagnose, and treat diseases at the molecular level with greater efficiency and accuracy. In particular, optical and chemical properties of nanomaterials are being exploited to improve the effectiveness of neuro-oncological and neurosurgical interventions. Modern nanotechnology-driven clinical applications may have significant impact on management of brain tumors.
2018: Progress in Neurological Surgery
Francesco Acerbi, Ignazio G Vetrano, Tommaso Sattin, Jacopo Falco, Camilla de Laurentis, Costanza M Zattra, Lorenzo Bosio, Zefferino Rossini, Morgan Broggi, Marco Schiariti, Paolo Ferroli
OBJECTIVE The best management of veins encountered during the neurosurgical approach is still a matter of debate. Even if venous sacrifice were to lead to devastating consequences, under certain circumstances, it might prove to be desirable, enlarging the surgical field or increasing the extent of resection in tumor surgery. In this study, the authors present a large series of patients with vascular or oncological entities, in which they used indocyanine green videoangiography (ICG-VA) with FLOW 800 analysis to study the patient-specific venous flow characteristics and the management workflow in cases in which a venous sacrifice was necessary...
July 2018: Neurosurgical Focus
Yachun Li, Patra Charalampaki, Yong Liu, Guang-Zhong Yang, Stamatia Giannarou
PURPOSE: Probe-based confocal laser endomicroscopy (pCLE) enables in vivo, in situ tissue characterisation without changes in the surgical setting and simplifies the oncological surgical workflow. The potential of this technique in identifying residual cancer tissue and improving resection rates of brain tumours has been recently verified in pilot studies. The interpretation of endomicroscopic information is challenging, particularly for surgeons who do not themselves routinely review histopathology...
August 2018: International Journal of Computer Assisted Radiology and Surgery
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