Juan Suárez, Marialuisa de Ceglia, Miguel Rodríguez-Pozo, Antonio Vargas, Ignacio Santos, Sonia Melgar-Locatelli, Adriana Castro-Zavala, Estela Castilla-Ortega, Fernando Rodríguez de Fonseca, Juan Decara, Patricia Rivera
Paracetamol, or acetaminophen (N-acetyl-para-aminophenol, APAP), is an analgesic and antipyretic drug that is commonly used worldwide, implicated in numerous intoxications due to overdose, and causes serious liver damage. APAP can cross the blood-brain barrier and affects brain function in numerous ways, including pain signals, temperature regulation, neuroimmune response, and emotional behavior; however, its effect on adult neurogenesis has not been thoroughly investigated. We analyze, in a mouse model of hepatotoxicity, the effect of APAP overdose (750 mg/kg/day) for 3 and 4 consecutive days and after the cessation of APAP administration for 6 and 15 days on cell proliferation and survival in two relevant neurogenic zones: the subgranular zone of the dentate gyrus and the hypothalamus...
February 6, 2024: International Journal of Molecular Sciences