Jinque Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A Steiner, Xiaoqian Wu, Shuyi Si, Zheng Gen Jin
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-induced ALF, acetaminophen (APAP) overdose is the most common cause. However, the molecular mechanisms underlying APAP hepatoxicity remain incompletely understood. Sirtuin 6 (Sirt6) is a stress responsive protein deacetylase and plays an important role in regulation of DNA repair, genomic stability, oxidative stress, and inflammation...
April 22, 2024: Cell Death & Disease