Franciéle Romero Machado, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Mustafa Munir Mustafa Dahleh, Eliana Jardim Fernandes, Elize Aparecida Santos Musachio, Ana Cláudia Funguetto-Ribeiro, Sandra Elisa Haas, Gustavo Petri Guerra, Marina Prigol, Silvana Peterini Boeira
Nanotechnology involves the utilization of nanomaterials, including polymeric nanocapsules (NCs) that are drug carriers. For modify drug release and stability, nanoformulations can feature different types of polymers as surface coatings: Polysorbate 80 (P80), Polyethylene glycol (PEG), Chitosan (CS) and Eudragit (EUD). Although nanoencapsulation aims to reduce side effects, these polymers can interact with living organisms, inducing events in the antioxidant system. Thus far, little has been described about the impacts of chronic exposure, with Drosophila melanogaster being an in vivo model for characterizing the toxicology of these polymers...
May 7, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP