Benjamin Sebastian Summers, Sarah Thomas Broome, Tsz Wai Rosita Pang, Hamish D Mundell, Naomi Koh Belic, Nicole C Tom, Mei Li Ng, Maylin Yap, Monokesh K Sen, Sara Sedaghat, Michael W Weible, Alessandro Castorina, Chai K Lim, Michael D Lovelace, Bruce J Brew
Stem cells are ubiquitously found in various tissues and organs in the body, and underpin the body's ability to repair itself following injury or disease initiation, though repair can sometimes be compromised. Understanding how stem cells are produced, and functional signaling systems between different niches is critical to understanding the potential use of stem cells in regenerative medicine. In this context, this review considers kynurenine pathway (KP) metabolism in multipotent adult progenitor cells, embryonic, haematopoietic, neural, cancer, cardiac and induced pluripotent stem cells, endothelial progenitor cells, and mesenchymal stromal cells...
2024: International Journal of Tryptophan Research: IJTR