Tomokazu Kimura, Yukari Okita, Yoshiyuki Nagumo, Jas Min Chin, Muhammad Ali Fikry, Masanobu Shiga, Shuya Kandori, Takashi Kawahara, Hiroyuki Suzuki, Hiroyuki Nishiyama, Mitsuyasu Kato
Bladder cancer is one of the most common cancers among men worldwide. Although multiple genomic mutations and epigenetic alterations have been identified, an efficacious molecularly targeted therapy has yet to be established. Therefore, a novel approach is anticipated. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein that is highly expressed in various cancers. In this study, we evaluated bladder cancer patient samples and found that GPNMB protein abundance is associated with high-grade tumors, and both univariate and multivariate analyses showed that GPNMB is a prognostic factor...
March 19, 2024: Pathology International