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REVIEW
Mayur Brahmania, Shari Rogal, Marina Serper, Arpan Patel, David Goldberg, Amit Mathur, Julius Wilder, Jennifer Vittorio, Andrew Yeoman, Nicole E Rich, Mariana Lazo, Ani Kardashian, Sumeet Asrani, Ashley Spann, Nneka Ufere, Manisha Verma, Elizabeth Verna, Dinee Simpson, Jesse D Schold, Russell Rosenblatt, Lisa McElroy, Sharad I Wadwhani, Tzu-Hao Lee, Alexandra T Strauss, Raymond T Chung, Ignacio Aiza, Rotonya Carr, Jin Mo Yang, Carla Brady, Brett E Fortune
Racial, ethnic, and socioeconomic disparities exist in the prevalence and natural history of chronic liver disease, access to care, and clinical outcomes. Solutions to improve health equity range widely, from digital health tools to policy changes. The current review outlines the disparities along the chronic liver disease health care continuum from screening and diagnosis to the management of cirrhosis and considerations of pre-liver and post-liver transplantation. Using a health equity research and implementation science framework, we offer pragmatic strategies to address barriers to implementing high-quality equitable care for patients with chronic liver disease...
May 1, 2024: Hepatology Communications
#2
EDITORIAL
L Ignacio Cortinez, Brian J Anderson
No abstract text is available yet for this article.
May 2, 2024: Paediatric Anaesthesia
#3
JOURNAL ARTICLE
Wen Feng, Thomas Gemming, Lars Giebeler, Jiang Qu, Kristina Weinel, Leonardo Agudo Jácome, Bernd Büchner, Ignacio Gonzalez-Martinez
In this work we instigated the fragmentation of Au microparticles supported on a thin amorphous carbon film by irradiating them with a gradually convergent electron beam inside the Transmission Electron Microscope. This phenomenon has been generically labeled as "electron beam-induced fragmentation" or EBIF and its physical origin remains contested. On the one hand, EBIF has been primarily characterized as a consequence of beam-induced heating. On the other, EBIF has been attributed to beam-induced charging eventually leading to Coulomb explosion...
April 22, 2024: Ultramicroscopy
#4
JOURNAL ARTICLE
Karen K Zhu, Ignacio Gispert Contamina, Oscar Ces, Laura M C Barter, James W Hindley, Yuval Elani
Synthetic cells can be constructed from diverse molecular components, without the design constraints associated with modifying 'living' biological systems. This can be exploited to generate cells with abiotic components, creating functionalities absent in biology. One example is magnetic responsiveness, the activation and modulation of encapsulated biochemical processes using a magnetic field, which is absent from existing synthetic cell designs. This is a critical oversight, as magnetic fields are uniquely bio-orthogonal, noninvasive, and highly penetrative...
May 1, 2024: Journal of the American Chemical Society
#5
JOURNAL ARTICLE
Elena Álvarez-Ruiz, Ignacio Sancho, Marta Navarro, Israel Fernández, Cristina Santamaría, Alberto Hernán-Gómez
The synthesis, structure, and catalytic activity of a Ti(II)/Ti(III) inverted sandwich compound are presented in this study. Synthesis of the arene-bridged dititanium compound begins with the preparation of the titanium(IV) precursor [TiCl2 (Mes PDA)(thf)2 ] (Mes PDA = N , N '-bis(2,4,6-trimethylphenyl)- o -phenylenediamide) ( 2 ). The reduction of 2 with sodium metal results in species [{Ti(Mes PDA)(thf)}2 (μ-Cl)3 {Na}] ( 3 ) in oxidation state III. To achieve the lower oxidation state II, 2 undergoes reduction through alkylation with lithium cyclopentyl...
May 1, 2024: Inorganic Chemistry
#6
JOURNAL ARTICLE
Ana Carrillo de Albornoz, Eduardo Montero, Andrea Alonso-Español, Mariano Sanz, Ignacio Sanz-Sánchez
AIM: To evaluate the effectiveness of a flapless surgical approach in the treatment of peri-implantitis and to explore the factors influencing its outcome. MATERIALS AND METHODS: The present retrospective study evaluated patients with at least one implant diagnosed with peri-implantitis and treated with a flapless surgical access, with or without systemic antimicrobials, curettage and, when needed, prostheses modification. Clinical and radiographic parameters were assessed at baseline and at 3 months and at least 12 months...
May 1, 2024: Journal of Clinical Periodontology
#7
JOURNAL ARTICLE
Abel Gómez Cáceres, Iskandar Tamimi Mariño, Francisco Javier Martínez Malo, Ignacio Vieitez Riestra, Raphael Pierre Idiart
Medial meniscal ramp injury has gained the attention of orthopaedic surgeons in recent years. It consists of a tear of the peripheral insertion of the posterior horn of the medial meniscus. Its prevalence in anterior cruciate ligament reconstruction varies between 9% and 40% according to different studies. Ramp lesions cannot always be diagnosed using magnetic resonance imaging scans. To identify ramp lesions, the arthroscope should be introduced into the posteromedial compartment of the knee during the routine examination of the knee (Gillquist maneuver)...
April 2024: Arthroscopy Techniques
#8
JOURNAL ARTICLE
Roberto de la Plaza Llamas, Lorena Ortega Azor, Marina Hernández Yuste, Ludovica Gorini, Raquel Aránzazu Latorre-Fragua, Daniel Alejandro Díaz Candelas, Farah Al Shwely Abduljabar, Ignacio Antonio Gemio Del Rey
BACKGROUND: The quality-adjusted life year (QALY) is a metric that is increasingly used today in the field of health economics to evaluate the value of different medical treatments and procedures. Surgical waiting lists (SWLs) represent a pressing problem in public healthcare. The QALY measure has rarely been used in the context of surgery. It would be interesting to know how many QALYs are lost by patients on SWLs. AIM: To investigate the relationship between QALYs and SWLs in a systematic review of the scientific literature...
April 27, 2024: World Journal of Gastrointestinal Surgery
#9
JOURNAL ARTICLE
Tim R E Harris, Zain A Bhutta, Isma Qureshi, Nadir Kharma, Tasleem Raza, Ali Ait Hssain, Ankush Suresh Pathare, Ashwin D'Silva, Mohamad Yahya Khatib, Mohamed Gafar Hussein Mohamedali, Ignacio Miguel Gomez Macineira, Victor Ramon Garcia Hernandez, Jorge Rosales Garcia, Stephen H Thomas, Sameer A Pathan
BACKGROUND: Awake prone position (APP) has been reported to improve oxygenation in patients with COVID-19 disease and to reduce the requirement for invasive mechanical ventilation for patients requiring support with high flow nasal cannula. There is conflicting data for patients requiring lower-level oxygen support. RESEARCH QUESTION: Does APP reduce escalation of oxygen support in COVID-19 patients requiring supplementary oxygen?The primary outcome was defined as an escalation of oxygen support from simple supplementary oxygen (NP, HM, NRB) to NIV (CPAP or BiPAP), HFNC or IMV; OR from NIV (CPAP or BiPAP) or HFNC to IMV by day30...
June 2024: Contemporary Clinical Trials Communications
#10
David J Eldridge, Jingyi Ding, Josh Dorrough, Manuel Delgado-Baquerizo, Osvaldo Sala, Nicolas Gross, Yoann Le Bagousse-Pinguet, Max Mallen-Cooper, Hugo Saiz, Sergio Asensio, Victoria Ochoa, Beatriz Gozalo, Emilio Guirado, Miguel García-Gómez, Enrique Valencia, Jaime Martínez-Valderrama, César Plaza, Mehdi Abedi, Negar Ahmadian, Rodrigo J Ahumada, Julio M Alcántara, Fateh Amghar, Luísa Azevedo, Farah Ben Salem, Miguel Berdugo, Niels Blaum, Bazartseren Boldgiv, Matthew Bowker, Donaldo Bran, Chongfeng Bu, Rafaella Canessa, Andrea P Castillo-Monroy, Ignacio Castro, Patricio Castro-Quezada, Simone Cesarz, Roukaya Chibani, Abel Augusto Conceição, Anthony Darrouzet-Nardi, Yvonne C Davila, Balázs Deák, Paloma Díaz-Martínez, David A Donoso, Andrew David Dougill, Jorge Durán, Nico Eisenhauer, Hamid Ejtehadi, Carlos Ivan Espinosa, Alex Fajardo, Mohammad Farzam, Ana Foronda, Jorgelina Franzese, Lauchlan H Fraser, Juan Gaitán, Katja Geissler, Sofía Laura Gonzalez, Elizabeth Gusman-Montalvan, Rosa Mary Hernández, Norbert Hölzel, Frederic Mendes Hughes, Oswaldo Jadan, Anke Jentsch, Mengchen Ju, Kudzai F Kaseke, Melanie Köbel, Anika Lehmann, Pierre Liancourt, Anja Linstädter, Michelle A Louw, Quanhui Ma, Mancha Mabaso, Gillian Maggs-Kölling, Thulani P Makhalanyane, Oumarou Malam Issa, Eugene Marais, Mitchel McClaran, Betty Mendoza, Vincent Mokoka, Juan P Mora, Gerardo Moreno, Seth Munson, Alice Nunes, Gabriel Oliva, Gastón R Oñatibia, Brooke Osborne, Guadalupe Peter, Margerie Pierre, Yolanda Pueyo, R Emiliano Quiroga, Sasha Reed, Ana Rey, Pedro Rey, Víctor Manuel Reyes Gómez, Víctor Rolo, Matthias C Rillig, Peter C le Roux, Jan Christian Ruppert, Ayman Salah, Phokgedi Julius Sebei, Anarmaa Sharkhuu, Ilan Stavi, Colton Stephens, Alberto L Teixido, Andrew David Thomas, Katja Tielbörger, Silvia Torres Robles, Samantha Travers, Orsolya Valkó, Liesbeth van den Brink, Frederike Velbert, Andreas von Heßberg, Wanyoike Wamiti, Deli Wang, Lixin Wang, Glenda M Wardle, Laura Yahdjian, Eli Zaady, Yuanming Zhang, Xiaobing Zhou, Fernando T Maestre
No abstract text is available yet for this article.
April 30, 2024: Nature Plants
#11
JOURNAL ARTICLE
Esteban Portilla-Rojas, Pablo Pineda-Sanabria, Lina Ramírez, Maria Isabel Cuevas, Juliana Lores, Karen Sarmiento, Ignacio Zarante
Clubfoot is a common musculoskeletal congenital abnormality, with a prevalence of 5-20 cases per 10 000 live births in low to middle-income countries. If left untreated, clubfoot causes severe consequences for the child: gait disturbances, reduced quality of life, and limited work opportunities. Our objective was to characterize clubfoot and determine its prevalence and associated risk factors in Bogotá and Cali, Colombia, from 2002 to 2020. A retrospective case-control study design was employed, analyzing data from birth defect reports provided by the Program for the Prevention and Follow-up of Congenital Defects and Orphan Diseases surveillance system...
April 25, 2024: Journal of Pediatric Orthopedics. Part B
#12
RANDOMIZED CONTROLLED TRIAL
Federico Martinón-Torres, Ignacio Salamanca de la Cueva, Michael Horn, Soeren Westerholt, Samantha Bosis, Nadia Meyer, Brigitte Cheuvart, Navpreet Virk, Rupert W Jakes, Maurine Duchenne, Peter Van den Steen
Since the introduction of Haemophilus Influenzae type b (Hib) conjugate vaccines, invasive Hib disease has strongly declined worldwide, yet continued control of Hib disease remains important. In Europe, currently three different hexavalent combination vaccines containing Hib conjugates are marketed. In this phase IV, single-blind, randomized, controlled, multi-country study (NCT04535037), we aimed to compare, in a 2 + 1 vaccination schedule, the immunogenicity and safety and show non-inferiority, as well as superiority, of DTPa-HBV-IPV/Hib (Ih group) versus DTaP5-HB-IPV-Hib (Va group) in terms of anti-polyribosylribitol phosphate (PRP) antibody geometric mean concentrations (GMCs) and proportion of participants reaching anti-PRP antibody concentrations greater than or equal to a threshold of 5 µg/mL...
December 31, 2024: Human Vaccines & Immunotherapeutics
#13
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Mariana Villarroel-Dorrego, Clara Herrera Freire, Ignacio Molina-Ávila, Juan Martin Pimentel-Solá, Gerardo Gilligan, Eduardo Piemonte, René Panico, Juan Cruz Romero Panico, Saray Aranda-Romo, Francisco Javier Tejeda-Nava, Mônica Simões Israel, John Lennon Silva Cunha, Vanessa Alves de Medeiros, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Israel Leal Cavalcante, José Victor Lemos Ventura, Fernanda Silva de Lima, Victor Zanetti Drumond, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Felipe Paiva Fonseca, Ricardo Alves Mesquita, René Martínez-Flores, Karina Cordero-Torres, Richard Ahumada-Ossandón, Jorge Guzmán, Raiza Toro, José Cândido Caldeira Xavier-Júnior, Sebastião Silvério Sousa-Neto, Diego Antônio Costa Arantes, Elismauro Francisco Mendonça, Victor de Mello Palma, Márcia Gaiger de Oliveira, Fernanda Visioli, Karem L Ortega, Jefferson R Tenório, Bruno Augusto Benevenuto de Andrade
BACKGROUND: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that may affect the oral mucosa. The variable spectrum of oral lesions observed in SLE can pose challenges in diagnosis, particularly when the lesions occur in isolation. The aim of this study was to describe the oral lesions occurring in patients with SLE from Latin America. METHODS: This collaborative record-based study involving 11 oral and maxillofacial pathology and medicine services across Venezuela, Argentina, Chile, Brazil, and Mexico describes the clinicopathological profile of SLE-related oral lesions...
April 30, 2024: Lupus
#14
COMPARATIVE STUDY
Cristina Delgado-Alonso, Alfonso Delgado-Alvarez, María Díez-Cirarda, Silvia Oliver-Mas, Constanza Cuevas, Paloma Montero-Escribano, Ana Maria Ramos-Leví, María José Gil-Moreno, Juan Ignacio López-Carbonero, Bruce P Hermann, Jorge Matias-Guiu, Jordi A Matias-Guiu
Post-COVID condition (PCC) and multiple sclerosis (MS) share some clinical and demographic features, including cognitive symptoms and fatigue. Some pathophysiological mechanisms well-known in MS, such as autoimmunity, neuroinflammation and myelin damage, have also been implicated in PCC. In this study, we aimed to compare the cognitive phenotypes of two large cohorts of patients with PCC and MS, and to evaluate the relationship between fatigue and cognitive performance. Cross-sectional study including 218 patients with PCC and 218 with MS matched by age, sex, and years of education...
April 29, 2024: Scientific Reports
#15
COMPARATIVE STUDY
Samuel P Forry, Stephanie L Servetas, Jason G Kralj, Keng Soh, Michalis Hadjithomas, Raul Cano, Martha Carlin, Maria G de Amorim, Benjamin Auch, Matthew G Bakker, Thais F Bartelli, Juan P Bustamante, Ignacio Cassol, Mauricio Chalita, Emmanuel Dias-Neto, Aaron Del Duca, Daryl M Gohl, Jekaterina Kazantseva, Muyideen T Haruna, Peter Menzel, Bruno S Moda, Lorieza Neuberger-Castillo, Diana N Nunes, Isha R Patel, Rodrigo D Peralta, Adrien Saliou, Rolf Schwarzer, Samantha Sevilla, Isabella K T M Takenaka, Jeremy R Wang, Rob Knight, Dirk Gevers, Scott A Jackson
Several studies have documented the significant impact of methodological choices in microbiome analyses. The myriad of methodological options available complicate the replication of results and generally limit the comparability of findings between independent studies that use differing techniques and measurement pipelines. Here we describe the Mosaic Standards Challenge (MSC), an international interlaboratory study designed to assess the impact of methodological variables on the results. The MSC did not prescribe methods but rather asked participating labs to analyze 7 shared reference samples (5 × human stool samples and 2 × mock communities) using their standard laboratory methods...
April 29, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Philipp M Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Beckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa Ten Hacken, Martin Schneider, Dominic Helm, Deyan Yordanov Yosifov, Joseph Kauer, Alexey V Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A Burger, Dimitar G Efremov, Peter Lichter, Sascha Dietrich, José Ignacio Martín-Subero, Karsten Rippe, Martina Seiffert
The T-box transcription factor T-bet is known as a master regulator of T-cell response but its role in malignant B cells is not sufficiently explored. Here, we conducted single-cell resolved multi-omics analyses of malignant B cells from patients with chronic lymphocytic leukemia (CLL) and studied a CLL mouse model with genetic knockout of TBX21. We found that T-bet acts as a tumor suppressor in malignant B cells by decreasing their proliferation rate. NF-κB activity induced by inflammatory signals provided by the microenvironment, triggered T-bet expression which impacted on promoter proximal and distal chromatin co-accessibility and controlled a specific gene signature by mainly suppressing transcription...
April 29, 2024: Blood
#17
JOURNAL ARTICLE
Juliana Díaz, Gonzalo Puentes Garrido, Ignacio Saguier Padilla, Silvia S Folgar, Flavio C B Mercado
No abstract text is available yet for this article.
2024: Medicina
#18
JOURNAL ARTICLE
Indalecio Carboni Bisso, Leiniker Navarro Rey, Julieta González Anaya, Ignacio Fernández Ceballos, Marcos Las Heras
No abstract text is available yet for this article.
2024: Medicina
#19
COMPARATIVE STUDY
Ignacio Fernández Ceballos, Joaquín Ems, Emilio Steinberg, Juan M Nuñez Silveira, Micaela B Hornos, Melany Berdiñas Anfuso, Carlos Videla, Nicolás M Ciarrocchi, Indalecio Carboni Bisso, Marcos Las Heras
The apnea test, employed for brain death assessment, aims to demonstrate the absence of respiratory drive due to hypercapnia. The tracheal oxygen insufflation apnea test mode (I-AT) involves disconnecting the patient from invasive mechanical ventilation (iMV) for approximately 8 minutes while maintaining oxygenation. This test supports the diagnosis of brain death based on a specified increase in PaCO2. Common complications include hypoxemia and hemodynamic instability, and lung collapse-induced reduction in end-expiratory lung volume (EELV)...
2024: Medicina
#20
JOURNAL ARTICLE
Darío Vezzani, Ignacio Diribarne, Juan José Palacios, Jesica Lopez, Sofía Martinez, María Del Carmen Weis, Luciano Gentile, Andrea Castex, Mirna Damiani, Natacha Del Blanco, Juan Agustín Castiglia Sole, Gabriela Rozas Dennis
OBJECTIVES: To monitor the oviposition activity of the mosquito Aedes aegypti and of dengue and chikungunya cases in four localities of temperate Argentina, during the 2023 epidemic. METHODS: During the summer and autumn of 2023, the oviposition activity of the mosquito vector was monitored weekly using ovitraps, and the arrival of cases with dengue or chikungunya in Tandil, Olavarría, Bahía Blanca and Laprida were registered. RESULTS: Monthly variations of the percentage of positive traps were similar in the first three locations; in Laprida the mosquito was not detected...
2024: Medicina
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