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Joaquin Reyna, Kyra Fetter, Romeo Ignacio, Cemil Can Ali Marandi, Nikhil Rao, Zichen Jiang, Daniela Salgado Figueroa, Sourya Bhattacharyya, Ferhat Ay
HiChIP enables cost-effective and high-resolution profiling of regulatory and structural loops. To leverage the increasing number of publicly available HiChIP datasets from diverse cell lines and primary cells, we developed the Loop Catalog ( https://loopcatalog.lji.org ), a web-based database featuring HiChIP loop calls for 1319 samples across 133 studies and 44 high-resolution Hi-C loop calls. We demonstrate its utility in interpreting fine-mapped GWAS variants (SNP-to-gene linking), in identifying enriched sequence motifs and motif pairs at loop anchors, and in network-level analysis of loops connecting regulatory elements (community detection)...
April 29, 2024: bioRxiv
#22
JOURNAL ARTICLE
Pablo Expósito-Campos, José Ignacio Pérez-Fernández, Karmele Salaberria
OBJECTIVE: The main goal of this article is to identify areas of psychotherapeutic work with detransitioners, that is, individuals who stop or reverse a gender transition, given the scarcity of information and resources. METHODS: We conducted a systematic review and metasummary of qualitative data published until April 2023. Data were extracted, grouped, and refined to conform meta-findings. RESULTS: The database search yielded 845 records, of which 15 comprising 2689 people who detransitioned were included in the review...
2024: International Journal of Clinical and Health Psychology: IJCHP
#23
REVIEW
Pompeo Costantino Kouroupis, Niall O'Rourke, Sinead Kelly, Myles McKittrick, Elne Noppe, Luis F Reyes, Alejandro Rodriguez, Ignacio Martin-Loeches
INTRODUCTION: Hospital-acquired pneumonia (HAP) represents a significant cause of mortality among critically ill patients admitted to Intensive Care Units (ICUs). Timely and precise diagnosis is imperative to enhance therapeutic efficacy and patient outcomes. However, the diagnostic process is challenged by test limitations and a wide-ranging list of differential diagnoses, particularly in patients exhibiting escalating oxygen requirements, leukocytosis, and increased secretions. AREAS COVERED: This narrative review aims to update diagnostic modalities, facilitating the prompt identification of nosocomial pneumonia while guiding, developing, and assessing therapeutic interventions...
May 14, 2024: Expert Review of Anti-infective Therapy
#24
JOURNAL ARTICLE
Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes.
Minsoo Kim, Alexander N Gorelick, Ignacio Vàzquez-García, Marc J Williams, Sohrab Salehi, Hongyu Shi, Adam C Weiner, Nick Ceglia, Tyler Funnell, Tricia Park, Sonia Boscenco, Ciara H O'Flanagan, Hui Jiang, Diljot Grewal, Cerise Tang, Nicole Rusk, Payam A Gammage, Andrew McPherson, Sam Aparicio, Sohrab P Shah, Ed Reznik
The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and genotype, and the phenotypic and evolutionary consequences of such variation, are poorly characterized. Here we use amplification-free single-cell whole-genome sequencing (Direct Library Prep (DLP+)) to simultaneously assay mtDNA copy number and nuclear DNA (nuDNA) in 72,275 single cells derived from immortalized cell lines, patient-derived xenografts and primary human tumors. Cells typically contained thousands of mtDNA copies, but variation in mtDNA copy number was extensive and strongly associated with cell size...
May 13, 2024: Nature Genetics
#25
JOURNAL ARTICLE
Maria J Garcia-Leon, Cristina Liboni, Vincent Mittelheisser, Louis Bochler, Gautier Follain, Clarisse Mouriaux, Ignacio Busnelli, Annabel Larnicol, Florent Colin, Marina Peralta, Naël Osmani, Valentin Gensbittel, Catherine Bourdon, Rafael Samaniego, Angélique Pichot, Nicodème Paul, Anne Molitor, Raphaël Carapito, Martine Jandrot-Perrus, Olivier Lefebvre, Pierre H Mangin, Jacky G Goetz
Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression...
May 13, 2024: Nature Communications
#26
JOURNAL ARTICLE
Nahuel Ezequiel Wanionok, María Silvina Molinuevo, Juan Manuel Fernandez, Lucas Nahuel Besada, Ana M Cortizo, Evelyn Castillo, Jessica Jirón, Claudia Sedlinsky, León Schurman, José Ignacio Aguirre, Antonio Desmond McCarthy
INTRODUCTION: We previously showed that a 3-week oral Metformin (MET) treatment enhances the osteogenic potential of bone marrow stromal cells (BMSCs) and improves several bone histomorphometric parameters in Wistar rats with metabolic syndrome (MetS). However, the skeletal effects of extended periods of MET are still not completely elucidated. Hence, we investigated the impact of a prolonged (3-month) MET treatment on bone architecture, histomorphometric and biomechanics variables and osteogenic potential of BMSCs in Wistar rats with or without MetS...
May 13, 2024: Experimental and Clinical Endocrinology & Diabetes
#27
JOURNAL ARTICLE
Armando Pérez De Prado, Almudena Castro Conde, Ignacio Ferreira-González
No abstract text is available yet for this article.
May 11, 2024: Revista Española de Cardiología
#28
JOURNAL ARTICLE
Precious C Oyem, Oluwapeyibomi I Runsewe, Nickelas Huffman, Ignacio Pasqualini, Pedro J Rullán, Alison K Klika, Matthew E Deren, Robert M Molloy, Nicolas S Piuzzi
INTRODUCTION: A pronounced gender imbalance is evident among orthopaedic surgeons. In the field of arthroplasty, there exists a dearth of comprehensive data regarding gender representation. This study aimed to analyze the gender diversity, or lack thereof, within the field of total hip arthroplasty (THA). In addition, this study used literature review to identify possible reasons for the gender disparity among THA surgeons and identify the best next steps to promote gender equity within orthopaedics...
May 10, 2024: Journal of the American Academy of Orthopaedic Surgeons
#29
JOURNAL ARTICLE
Ignacio E Sánchez, Ezequiel A Galpern, Diego U Ferreiro
We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to the chemical composition of biopolymers and crucially depend on the solvent in which they are embedded. We show that molecular information theory and energy landscape theory allow us to explore the limits that solvents impose on biopolymer existence. We consider 54 solvents, including water, alcohols, hydrocarbons, halogenated solvents, aromatic solvents, and low molecular weight substances made up of elements abundant in the universe, which may potentially take part in alternative biochemistries...
May 21, 2024: Proceedings of the National Academy of Sciences of the United States of America
#30
JOURNAL ARTICLE
Raúl Martínez-Fernández, Elena Natera-Villalba, Rafael Rodríguez-Rojas, Marta Del Álamo, Jose A Pineda-Pardo, Ignacio Obeso, Pasqualina Guida, Tamara Jiménez-Castellanos, Diana Pérez-Bueno, Alicia Duque, Jorge U Mañez-Miró, Carmen Gasca-Salas, Michele Matarazzo, Fernando Alonso-Frech, Jose A Obeso
IMPORTANCE: Unilateral magnetic resonance imaging (MRI)-guided focused ultrasound subthalamotomy (FUS-STN) improves cardinal motor features among patients with asymmetrical Parkinson disease (PD). The feasibility of bilateral FUS-STN is as yet unexplored. OBJECTIVE: To assess the safety and effectiveness of staged bilateral FUS-STN to treat PD. DESIGN, SETTING, AND PARTICIPANTS: This prospective, open-label, case series study was conducted between June 18, 2019, and November 7, 2023, at HM-CINAC, Puerta del Sur University Hospital, Madrid, Spain, and included 6 patients with PD who had been treated with unilateral FUS-STN contralateral to their most affected body side and whose parkinsonism on the untreated side had progressed and was not optimally controlled with medication...
May 13, 2024: JAMA Neurology
#31
JOURNAL ARTICLE
Ignacio Pasqualini, Luciano Andrés Rossi, Eoghan T Hurley, Oguz Turan, Ignacio Tanoira, Maximiliano Ranalletta
PURPOSE: This study aimed to evaluate the predictive ability of psychological readiness to return to sports on clinical outcomes and recurrences in athletes who return to sports following shoulder instability surgery. METHODS: A retrospective analysis was performed of patients who underwent shoulder instability surgery between September 2020 and October 2021 (arthroscopic Bankart repair or Latarjet procedure) with a minimum follow-up of 2 years. Patients were grouped according to the achievement of psychological readiness to return to play using the SIRSI scale (≥ 55 points) measured at 6 months following surgery...
May 10, 2024: Arthroscopy
#32
JOURNAL ARTICLE
Joan Fernando, Ignacio Revuelta, Eva Palou, Rosario Scandurra, Beatriu Bayés, Joan Escarrabill
BACKGROUND: Patient perspectives on their post-operative health are acknowledged as valuable healthcare outcomes and should be scrupulously considered when designing interventions for patient-centered healthcare. Yet, following the COVID-19 lockdown and in the absence of standardized guidelines on how to best provide virtual chronic care to kidney transplant recipients, little is known about how this unique population coped and managed to comply with public health indications during confinement...
May 12, 2024: Journal of Nephrology
#33
JOURNAL ARTICLE
Isabel Morales Benito, Juan José Guardia Hernández, Ignacio Macpherson Mayol
The consumption of pornography over the Internet by minors has been increasing exponentially in recent years. The use of digital technologies and the ease of access to these contents are causes that explain this event. Simultaneously, there is concern about the increase in sexual violence, associated with discriminatory behavior, despite the efforts of laws and programs that promote sexual reproductive health (SRH) and the principle of equality. From a bioethical point of view, it is urgent to address this issue, which affects the physical and psychological health of minors and their affective-sexual education...
2024: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
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JOURNAL ARTICLE
Viviana Parra Izquierdo, Albis Cecilia Hani, Consuelo Romero-Sánchez, Ana Isabel Sánchez, Yuly Laguado, Ana María Leguizamó, Juan Sebastián Frías-Ordoñez, Gerardo Andrés Puentes, Ignacio Zarante
INTRODUCTION: Attempts have been made to identify the genetic factors related to susceptibility to inflammatory bowel disease (IBD), and the current conclusions are in favor of a complex pathology model, without a clear hereditary pattern. OBJECTIVE: To perform phenotypic and genotypic characterization of patients with IBD in Colombian population and to describe its possible association with predisposition. MATERIALS AND METHODS: case series, 16 patients with IBD according to clinical and pathological criteria, onset of gastrointestinal symptoms after 18 years of age...
2024: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
#35
JOURNAL ARTICLE
Felipe Silva, Gonzalo Latorre, Patricio Medel, Miguel Bustamante, Isabella Montero, Camila Robles, Eitan Dukes, Francisca Martinez, María Victoria Binder, Javier Uribe, Diego Reyes, Marcela Bittner, Marisol Sirhan, Manuel Espinoza, Eduardo Fuentes-López, Roberto Candia, Carlos Agüero, José Ignacio Vargas, Alberto Espino, Arnoldo Riquelme
UNLABELLED: Latin America presents a high prevalence of Helicobacter pylori(Hp) infection. Between1996-2003, the prevalence in Santiago, Chile, was 70%; recent studies indicate a decreasein this infection. Updating the frequency of Hp is crucial due to its associated health impact. OBJECTIVE: Our objective was to describe the trend in Hp infection in patients undergoingambulatory esophagogastroduodenoscopy (EGD) in a Chilean population. MATERIALS AND METHODS: A retrospective observational study was conducted on patients over 18 years old who attended a first EGD with a rapid urease test between 2010-2020...
2024: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
#36
JOURNAL ARTICLE
Felipe Aluja-Jaramillo, Fernando R Gutiérrez, Carlos Previgliano, Francisco Faican, Antonio Luna-Alcalá, Ignacio Rossi, Sanjeev Bhalla
INTRODUCTION: Medical imaging has undergone significant technical advancements in recent years, posing a considerable challenge for radiologists to stay up-to-date with emerging modalities and their applications in daily practice. This challenge is even more daunting in developing countries with limited resources compared to the US and other developed nations with greater economic assets. The collaboration between the United States and other advanced nations with radiological institutions in Latin America has been a significant achievement in the pursuit of new opportunities for continuous medical education...
May 7, 2024: Current Problems in Diagnostic Radiology
#37
JOURNAL ARTICLE
Ivan Cherrez-Ojeda, Jean Bousquet, Ana Giménez-Arnau, Kiran Godse, Dorota Krasowska, Joanna Bartosińska, Paulina Szczepanik-Kułak, Bartłomiej Wawrzycki, Pavel Kolkhir, Anastasiia Allenova, Andrey Allenov, Sergey Tkachenko, Natasa Teovska Mitrevska, Dragan Mijakoski, Sasho Stoleski, Marta Kolacinska-Flont, Izabela Kuprys-Lipinska, Joanna Molinska, Alicja Kasperska-Zając, Magdalena Zajac, Mateusz Zamlynski, Florin Mihaltan, Ruxandra Ulmeanu, Anna Zalewska-Janowska, Katarzyna Tomaszewska, Mona Al-Ahmad, Maryam Ali Al-Nesf, Tayseer Ibrahim, Sami Aqel, David Pesqué, Mónica Rodríguez-González, Guillermo Hideo Wakida-Kuzunoki, German D Ramon, Gonzalo N Ramon, Sophia Neisinger, Hanna Bonnekoh, Maia Rukhadze, Maryam Khoshkhui, Daria Fomina, Désirée Larenas-Linnemann, Mitja Košnik, Rabia Oztas Kara, Chrystopherson Gengyny Caballero López, Qiang Liu, Juan Carlos Ivancevich, Luis Felipe Ensina, Nelson Rosario, Violeta Kvedariene, Moshe Ben-Shoshan, Roberta Fachini Jardim Criado, Andrea Bauer, Annia Cherrez, Sofia Cherrez, Herberto Chong-Neto, Maria Isabel Rojo-Gutierrez, Michael Rudenko, José Ignacio Larco Sousa, Aleksandra Lesiak, Edgar Matos, Ivan Tinoco, Carolina Crespo Shijin, Romina Hinostroza Logroño, Juan C Sagñay, Marco Faytong-Haro, Karla Robles-Velasco, Torsten Zuberbier, Marcus Maurer
No abstract text is available yet for this article.
May 9, 2024: Journal of Allergy and Clinical Immunology in Practice
#38
JOURNAL ARTICLE
Javier Trujillo-Santos, Pablo Demelo-Rodríguez, Alexis Bravo de Laguna-Taboada, Santiago Zubicoa-Ezpeleta, Alejandro Rodríguez-Morata, Ignacio Lojo-Rocamonde, Antoni Riera-Mestre
INTRODUCTION: Deep vein thrombosis (DVT) poses a complex challenge and often leads to postthrombotic syndrome (PTS), a debilitating complication. The emergence of venous stents offers a potential preventive avenue against this complication. This study aimed to provide consensus recommendations on the use of venous stent for DVT. MATERIALS AND METHODS: From June to July 2023, 20 internal medicine, angiology and vascular surgery, and vascular and interventional radiology experts were involved in the Delphi process...
May 11, 2024: Seminars in Thrombosis and Hemostasis
#39
JOURNAL ARTICLE
Carlos Abril-Pérez, Miguel Mansilla-Polo, Begoña Escutia-Muñoz, Onofre Sanmartín, Joan R Garcés, Manuel A Rodríguez-Prieto, Verónica Ruiz-Salas, Esther de Eusebio-Murillo, Román Miñano-Medrano, Beatriz González-Sixto, Juan L Artola-Igarza, Alberto Alfaro-Rubio, Pedro Redondo, Yolanda Delgado-Jiménez, Julia M Sánchez-Schmidt, Irati Allende-Markixana, María L Alonso-Pacheco, Beatriz García-Bracamonte, Pablo de la Cueva-Dobao, Raquel Navarro-Tejedor, Cristina Ciudad-Blanco, Lucía Carnero-González, Hugo Vázquez-Veiga, Natividad Cano-Martínez, Carlos Serra-Guillén, Eva Vilarrasa, Pedro Sánchez-Sambucety, José L López-Estebaranz, Ángeles Flórez-Menéndez, Antonio Martorell-Calatayud, Pilar Gil, Victoriano Morales-Gordillo, Agustí Toll, Izascun Ocerin-Guerra, Matías Mayor-Arenal, Ricardo Suárez-Fernández, Laura Sainz-Gaspar, Miguel A Descalzo, Ignacio Garcia-Doval, Rafael Botella-Estrada
BACKGROUND: Immunosuppressed (IS) patients, particularly solid organ transplant recipients and those on immunosuppressive therapy, face a higher incidence and recurrence of nonmelanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Mohs micrographic surgery (MMS) is the preferred treatment for high-risk NMSC due to its high cure rate and margin examination capabilities. However, IS patients may experience more complications, such as surgical site infections, and a greater risk of recurrence, making their outcomes a subject of interest...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#40
JOURNAL ARTICLE
Lucía Penalba-Sánchez, Gabriel Silva, Mark Crook-Rumsey, Alexander Sumich, Pedro Miguel Rodrigues, Patrícia Oliveira-Silva, Ignacio Cifre
Understanding and classifying brain states as a function of sleep quality and age has important implications for developing lifestyle-based interventions involving sleep hygiene. Current studies use an algorithm that captures non-linear features of brain complexity to differentiate awake electroencephalography (EEG) states, as a function of age and sleep quality. Fifty-eight participants were assessed using the Pittsburgh Sleep Quality Inventory (PSQI) and awake resting state EEG. Groups were formed based on age and sleep quality (younger adults n = 24, mean age = 24...
April 28, 2024: Sensors
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