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JOURNAL ARTICLE
Tzu-Chun Chen, Yu-Tso Liao, John Huang, Ji-Shiang Hung, Jin-Tung Liang
BACKGROUND: The territory of D3-D4 lymphadenectomy for upper rectal and sigmoid colon cancer varies, and its oncological efficacy is unclear. This prospective study aimed to standardize the surgical technique of robotic D3-D4 lymphadenectomy and clarify its oncologic significance. METHODS: Patients with upper rectal or sigmoid colon cancer with clinically suspected more than N2 lymph node metastasis were prospectively recruited to undergo standardized robotic D3-D4 lymphadenectomy...
April 1, 2024: International Journal of Surgery
#2
JOURNAL ARTICLE
Valentina E Bounous, Carola Minella, Luca Fuso, Silvia Actis, Greta Petroni, Luca G Sgrò, Martina Borghese, Nicoletta Tomasi Cont, Riccardo Ponzone, Annamaria Ferrero
BACKGROUND: pregnancy-associated breast cancer (PABC) affects one in 3000 pregnancies, often presenting with aggressive features. METHODS: We retrospectively evaluated a cohort of 282 young BC patients (≤45 years old) treated between 1995 and 2019, dividing them into three groups: nulliparous women, women with PABC (diagnosed within 2 years since last pregnancy) and women with BC diagnosed > 2 years since last pregnancy. This last group was further stratified according to the time between pregnancy and BC...
April 19, 2024: Current Oncology
#3
JOURNAL ARTICLE
Veronica Siton Alcantara, Sut Mo Zachary Chan, Fuh Yong Wong, John Carson Allen, Geok Hoon Lim
Introduction: Bilateral breast cancers (BBC) diagnosed at an interval apart are uncommon. While metastatic staging guidelines are established in patients with unilateral breast cancer, its role in BBC diagnosed at an interval apart is unclear. We aim to identify the subgroup who would benefit from metastatic staging at contralateral cancer diagnosis. Methods: Eligible patients were divided into three categories: (A) ipsilateral invasive cancer and contralateral ductal carcinoma in situ (DCIS), (B) bilateral invasive cancers and (C) ipsilateral DCIS and contralateral invasive cancer and reviewed retrospectively...
April 2, 2024: Current Oncology
#4
JOURNAL ARTICLE
Suginthan Markandu, Arne Blickle, Caroline Burgard, Marc Remke, Katrin Altmeyer, Mathias Wagner, Samer Ezziddin, Florian Rosar
We report a [18 F]fluorodeoxyglucose positron emission tomography/computed tomography ([18 F]FDG PET/CT) scan of a 17-year-old male presenting increased focal glucose metabolism of a histologically proven solitary nodular fasciitis mimicking an extranodal manifestation of Hodgkin lymphoma. This interesting image should draw attention to considering nodular fasciitis as a possible pitfall in the staging of malignant diseases.
April 9, 2024: Diagnostics
#5
JOURNAL ARTICLE
Matheus Teles, Jose Omar Maximo, Adrienne Carol Lahti, Nina Vanessa Kraguljac
BACKGROUND: Heterogeneity in the etiology, pathophysiology, and clinical features of schizophrenia challenges clinicians and researchers. A helpful approach could be stratifying patients according to the presence or absence of clinical features of the deficit syndrome (DS). DS is characterized by enduring and primary negative symptoms, a clinically less heterogeneous subtype of the illness, and patients with features of DS are thought to present abnormal brain network characteristics, however, this idea has received limited attention...
April 26, 2024: Schizophrenia Bulletin
#6
Wai Kit Kung, Ka Man Chu, Kin Fen Kevin Fung, Tin Yan Elaine Cheung
This case report illustrates the presence of intranodal thyroid tissues in ipsilateral cervical lymph nodes after hemithyroidectomy for multinodular goiter in an adolescent patient. It highlights the rare radiological finding of thyroid tissues within cervical lymph nodes detected by ultrasonography and computed tomography, which is a great mimicker of nodal metastasis.
July 2024: Radiology Case Reports
#7
REVIEW
Giovanni Berlucchi, Carlo Alberto Marzi
This paper describes the scientific figure of Roger Sperry as a maverick researcher, an original thinker who arrived at definitive notions about the working of the brain mostly by distancing himself from the prevalent views of his peers. After solving the riddle of the functions of the corpus callosum, he won a Nobel prize in physiology or medicine for identifying the different cognitive abilities of the disconnected right and left hemispheres of the human brain. He could have won another Nobel prize for his work on the prenatal formation of behavioral neuronal networks and their growth and development after birth...
2024: Frontiers in Human Neuroscience
#8
JOURNAL ARTICLE
Valentin Loser, Katia Staedler, Eglé Sukockiené, Marjolaine Uginet, Renaud Du Pasquier, Patrice H Lalive, Marie Théaudin
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic autoimmune neuropathy. Its management has considerably evolved over the last decade. In 2021, the diagnostic guidelines for CIDP were updated and the diagnostic criteria simplified. They enable better characterization of the electro-clinical phenotype of the disease, and emphasize supportive criteria, in particular neuro-muscular imaging. In terms of pathophysiology, the discovery of antibodies directed against antigens in the nodal and paranodal regions has given rise to the concept of autoimmune nodopathy...
April 24, 2024: Revue Médicale Suisse
#9
JOURNAL ARTICLE
M Singh, P Maitre, R Mody, V Murthy
PURPOSE: To study prostate specific membrane antigen - positron emission tomography (Ga68 PSMA-PETCT) based patterns of relapse at biochemical failure (BCF) after prostate-only radiotherapy (PORT) in high-risk (HR) prostate cancer and its implications on pelvic contouring recommendations. METHODS AND MATERIALS: Patients with clinico-radiological high-risk node-negative prostate cancer treated with curative PORT and androgen deprivation therapy (ADT), either within the POP-RT randomised trial or off trial, who underwent a Ga68 PSMA-PETCT upon BCF were included...
April 4, 2024: Clinical Oncology: a Journal of the Royal College of Radiologists
#10
JOURNAL ARTICLE
Oliver S Chow, Nasser K Altorki
No abstract text is available yet for this article.
April 23, 2024: Annals of Thoracic Surgery
#11
JOURNAL ARTICLE
Brianna L Collie, Gianna Bello, Alexandra E Hernandez, Liz Quesada Sanchez, Matthew Meece, Nicole B Lyons, Alricka Jackson, Vanessa W Hui
INTRODUCTION: Colorectal cancer is the third most common cancer and the third leading cause of cancer deaths in the United States. As rectal squamous cell carcinoma (SCC) is an uncommon colorectal cancer, there is limited data on this clinical entity. We aimed to evaluate the tumor characteristics, treatment, and clinical outcomes of this rare deadly disease. METHODS: Pathological specimens from 2017 to 2022 at a single National Cancer Institute-designated cancer center were screened for all rectal cases with a diagnosis of SCC...
April 24, 2024: Journal of Surgical Research
#12
JOURNAL ARTICLE
Arianna Polverino, Emahnuel Troisi Lopez, Marianna Liparoti, Roberta Minino, Antonella Romano, Lorenzo Cipriano, Francesca Trojsi, Viktor Jirsa, Giuseppe Sorrentino, Pierpaolo Sorrentino
OBJECTIVE: To test the hypothesis that patients affected by Amyotrophic Lateral Sclerosis (ALS) show an altered spatio-temporal spreading of neuronal avalanches in the brain, and that this may related to the clinical picture. METHODS: We obtained the source-reconstructed magnetoencephalography (MEG) signals from thirty-six ALS patients and forty-two healthy controls. Then, we used the construct of the avalanche transition matrix (ATM) and the corresponding network parameter nodal strength to quantify the changes in each region, since this parameter provides key information about which brain regions are mostly involved in the spreading avalanches...
April 16, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
#13
JOURNAL ARTICLE
Giacomo Montagna, Mary M Mrdutt, Susie X Sun, Callie Hlavin, Emilia J Diego, Stephanie M Wong, Andrea V Barrio, Astrid Botty van den Bruele, Neslihan Cabioglu, Varadan Sevilimedu, Laura H Rosenberger, E Shelley Hwang, Abigail Ingham, Bärbel Papassotiropoulos, Bich Doan Nguyen-Sträuli, Christian Kurzeder, Danilo Díaz Aybar, Denise Vorburger, Dieter Michael Matlac, Edvin Ostapenko, Fabian Riedel, Florian Fitzal, Francesco Meani, Franziska Fick, Jacqueline Sagasser, Jörg Heil, Hasan Karanlik, Konstantin J Dedes, Laszlo Romics, Maggie Banys-Paluchowski, Mahmut Muslumanoglu, Maria Del Rosario Cueva Perez, Marcelo Chávez Díaz, Martin Heidinger, Mathias K Fehr, Mattea Reinisch, Mustafa Tukenmez, Nadia Maggi, Nicola Rocco, Nina Ditsch, Oreste Davide Gentilini, Regis R Paulinelli, Sebastián Solé Zarhi, Sherko Kuemmel, Simona Bruzas, Simona di Lascio, Tamara K Parissenti, Tanya L Hoskin, Uwe Güth, Valentina Ovalle, Christoph Tausch, Henry M Kuerer, Abigail S Caudle, Jean-Francois Boileau, Judy C Boughey, Thorsten Kühn, Monica Morrow, Walter P Weber
IMPORTANCE: Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from node positive to negative with neoadjuvant chemotherapy are sparse. Additionally, the best axillary surgical staging technique in this scenario is unknown. OBJECTIVE: To investigate oncological outcomes after sentinel lymph node biopsy (SLNB) with dual-tracer mapping or targeted axillary dissection (TAD), which combines SLNB with localization and retrieval of the clipped lymph node...
April 25, 2024: JAMA Oncology
#14
JOURNAL ARTICLE
Jiayu Jiang, Weizhen Meng, Lei Jin, Hongli Gao, Xiaoming Zhang
Electrides have attracted significant attention in the fields of physics, materials science, and chemistry due to their distinctive electron properties characterized by weak nuclear binding. In this study, based on first-principles calculations and symmetry analysis, we report that the pure zirconium with alpha-phase ( α -Zr) is expected to be the electrically neutral electride with topological nodal loop. Furthermore, the nodal loop located at the kz = 0 plane exhibits a clear drumhead-like surface state...
April 25, 2024: Journal of Physics. Condensed Matter: An Institute of Physics Journal
#15
Di Lang, Haibo Ni, Roman Y Medvedev, Fang Liu, Claudia P Alvarez-Baron, Leonid Tyan, Daniel G P Turner, Aleah Warden, Stefano Morotti, Thomas A Schrauth, Christian Rickert, Catherine Proenza, Baron Chanda, Timothy J Kamp, Gail A Robertson, Eleonora Grandi, Alexey V Glukhov
BACKGROUND: Heart rhythm relies on complex interactions between the electrogenic membrane proteins and intracellular Ca 2+ signaling in sinoatrial node (SAN) myocytes; however, the mechanisms underlying the functional organization of the proteins involved in SAN pacemaking and its structural foundation remain elusive. Caveolae are nanoscale, plasma membrane pits that compartmentalize various ion channels and transporters, including those involved in SAN pacemaking, via binding with the caveolin-3 scaffolding protein, however the precise role of caveolae in cardiac pacemaker function is unknown...
April 17, 2024: bioRxiv
#16
Alberto Preda, Alessio Testoni, Matteo Baroni, Patrizio Mazzone, Lorenzo Gigli
A 46-year-old woman with congenitally corrected transposition of the great arteries (ccTGA) associated with dextrocardia, situs viscerus inversus, and left superior vena cava persistence presented with an incessant supraventricular tachycardia. Electrophysiological study was not conclusive in differential diagnosis of atrial tachycardia versus atypical atrioventricular (AV) nodal reentrant tachycardia, also due to the unconventional anatomy of the coronary sinus. By a comprehensive mapping of cardiac chambers, a double side slow-pathway was localized in both atrial chambers and subsequently ablated by radiofrequency delivery without tachycardia changes...
April 2024: Clinical Case Reports
#17
JOURNAL ARTICLE
Hideshige Seki, Ken Morita, Megumi Yasunaga, Masanori Toho, Hiroaki Maki, Mineo Kurokawa
Approximately 30-40% of malignant lymphomas are classified as diffuse large B-cell lymphoma (DLBCL), with 30% of DLBCL cases manifesting as extranodal lymphomas. Among these extranodal DLBCLs, primary DLBCL in oral lesions, particularly in the lips, is rare. While the treatment methods, chemotherapy assessment, and prognosis for nodal and extranodal DLBCLs are generally similar, diagnostic challenges can lead to delayed therapeutic intervention. We herein present a recent case of primary extranodal DLBCL in the lips that was swiftly diagnosed and managed using rituximab-containing chemotherapies...
April 23, 2024: Internal Medicine
#18
JOURNAL ARTICLE
Giorgio Bogani, Luca Lalli, Jvan Casarin, Fabio Ghezzi, Valentina Chiappa, Francesco Fanfani, Giovanni Scambia, Francesco Raspagliesi
OBJECTIVE: To assess the role of histopathological and molecular features in predicting the risk of nodal metastases in apparent early-stage endometrial cancer patients undergoing sentinel node mapping. METHODS: This is a prospective trial. Consecutive patients with apparent early-stage endometrial cancer, undergoing laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and sentinel node mapping, were enrolled. Histological and molecular features were used to predict the node positivity...
April 23, 2024: International Journal of Gynecological Cancer
#19
JOURNAL ARTICLE
Vishnu Prathapan, Peter Eipert, Nicole Wigger, Markus Kipp, Revathi Appali, Oliver Schmitt
In light of extensive work that has created a wide range of techniques for predicting the course of multiple sclerosis (MS) disease, this paper attempts to provide an overview of these approaches and put forth an alternative way to predict the disease progression. For this purpose, the existing methods for estimating and predicting the course of the disease have been categorized into clinical, radiological, biological, and computational or artificial intelligence-based markers. Weighing the weaknesses and strengths of these prognostic groups is a profound method that is yet in need and works directly at the level of diseased connectivity...
April 17, 2024: Computers in Biology and Medicine
#20
JOURNAL ARTICLE
A L Peters, P S Hall, L B Jordan, F Y Soh, L Hannington, S Makaranka, G Urquhart, M Vallet, D Cartwright, H Marashi, B Elsberger
INTRODUCTION: The Oncotype DX Breast RS test has been adopted in Scotland and has been the subject of a large population-based study by a Scottish Consensus Group to assess the uptake of the recurrence score (RS), evaluate co-variates associated with the RS and to analyse the effect it may have had on clinical practice. MATERIALS & METHODS: Pan-Scotland study between August 2018-August 2021 evaluating 833 patients who had a RS test performed as part of their diagnostic pathway...
April 13, 2024: Breast: Official Journal of the European Society of Mastology
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