Olga A Sukocheva, Junqi Liu, Margarita E Neganova, Narasimha M Beeraka, Yulia R Aleksandrova, Prasath Manogaran, Ekaterina M Grigorevskikh, Vladimir N Chubarev, Ruitai Fan
Epigenetic regulation by microRNAs (miRs) demonstrated a promising therapeutic potential of these molecules to regulate genetic activity in different cancers, including colorectal cancers (CRCs). The RNA-based therapy does not change genetic codes in tumor cells but can silence oncogenes and/or reactivate inhibited tumor suppressor genes. In many cancers, specific miRs were shown to promote or stop tumor progression. Among confirmed and powerful epigenetic regulators of colon carcinogenesis and development of resistance are onco-miRs, which include let-7, miR-21, miR-22, miR-23a, miR-27a, miR-34, miR-92, miR-96, miR-125b, miR-135b, miR-182, miR-200c, miR-203, miR-221, miR-421, miR-451, and others...
May 24, 2022: Seminars in Cancer Biology