Rendy Hosea, Wei Duan, Ian Timothy Sembiring Meliala, Wenfang Li, Mankun Wei, Sharon Hillary, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Spindle assembly checkpoint (SAC) is a crucial safeguard mechanism of mitosis fidelity that ensures equal division of duplicated chromosomes to the two progeny cells. Impaired SAC can lead to chromosomal instability (CIN), a well-recognized hallmark of cancer that facilitates tumor progression; paradoxically, high CIN levels are associated with better therapeutic response and prognosis. However, the mechanism by which CIN determines tumor cell survival and therapeutic response remains poorly understood. Here, using a cross-omics approach, YY2 is identified as a mitotic regulator that promotes SAC activity by activating the transcription of budding uninhibited by benzimidazole 3 (BUB3), a component of SAC...
April 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)