Elham Assary, Jonathan Coleman, Gibran Hemani, Margot van Der Veijer, Laurence Howe, Teemu Palviainen, Katrina Grasby, Rafael Ahlskog, Marianne Nygaard, Rosa Cheesman, Kai Lim, Chandra Reynolds, Juan Ordoñana, Lucia Colodro-Conde, Scott Gordon, Juan Madrid-Valero, Anbupalam Thalamuthu, Jouke-Jan Hottenga, Jonas Mengel-From, Nicola J Armstrong, Perminder Sachdev, Teresa Lee, Henry Brodaty, Julian Trollor, Margaret Wright, David Ames, Vibeke Catts, Antti Latvala, Eero Vuoksimaa, Travis Mallard, K Harden, Elliot Tucker-Drob, Sven Oskarsson, Christopher Hammond, Kaare Christensen, Mark Taylor, Sebastian Lundström, Henrik Larsson, Robert Karlsson, Nancy Pedersen, Karen Mather, Sarah Medland, D Boomsma, Nicholas Martin, Robert Plomin, Meike Bartels, Paul Lichtenstein, Jaakko Kaprio, Thalia Eley, Neil Davies, Patricia Munroe, Robert Keers
Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes. However, environmental sensitivity genetic variants have proven challenging to detect. GWAS of monozygotic twin differences is a family-based variance analysis method, which is more robust to systemic biases that impact population-based methods. We combined data from up to 21,792 monozygotic twins (10,896 pairs) from 11 studies to conduct the largest GWAS meta-analysis of monozygotic phenotypic differences in children and adolescents/adults for seven psychiatric and neurodevelopmental phenotypes: attention deficit hyperactivity disorder (ADHD) symptoms, autistic traits, anxiety and depression symptoms, psychotic-like experiences, neuroticism, and wellbeing...
May 2, 2024: Research Square