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alcoholic liver cirrhosis

Asdrúbal Aguilera-Méndez
Alteration of hepatic lipid metabolism can originate an excessive accumulation of lipids and lead to hepatic steatosis emergence and when not related to chronic alcohol consumption, it is known as non-alcoholic fatty liver disease. Being a disease with a complex pathophysiology and with several phases, which encompass different degrees of complexity and severity: simple steatosis, steatohepatitis, fibrosis, cirrhosis and in some cases even liver cancer. Besides, this disease is difficult to diagnose and asymptomatic until it presents complications...
March 15, 2019: Revista Médica del Instituto Mexicano del Seguro Social
Kris Barnekow, Paige Shyken, Joy Ito, Jie Deng, Saeed Mohammad, Mark Fishbein
OBJECTIVES: To assess information retention by parents/caretakers regarding nonalcoholic fatty liver disease (NAFLD) utilizing the actual image of their child's affected liver. METHODS: In this pilot study, parents/caretakers of children with newly-diagnosed NAFLD were presented with an MR image of their child's fatty liver. An adjacent image of a normal-appearing liver was used to highlight the degree of fat accumulation present in their child's liver. The appearance of the fatty liver was used as an adjunct to patient education as provided by a nurse clinician...
March 5, 2019: Journal of Pediatric Gastroenterology and Nutrition
Paul J Thuluvath, Avesh J Thuluvath, Yulia Savva, Talan Zhang
BACKGROUND & AIMS: Little is known about outcomes of patients who underwent liver transplantation for acute on chronic liver failure (ACLF) and multiple organ failures. We compared Karnofsky Performance Status (KPS) before and after liver transplantation among patients with different numbers of organ failures and probable ACLF. METHODS: We performed a retrospective cohort study, of adults who underwent liver transplantation within 30-days of listing with the United Network for Organ Sharing (UNOS) network from January 1, 2006 through September 30, 2016...
March 15, 2019: Clinical Gastroenterology and Hepatology
Cristiano Silva Cruz, Valentina Tosatto, Paula Oliveira Nascimento, Rita Barata Moura
Hepatic hydrothorax, a rare and debilitating complication of cirrhosis, carries high morbidity and mortality. First-line treatment consists of dietary sodium restriction and diuretic therapy. Some patients, mainly those who are refractory to medical management, will require invasive pleural drainage. The authors report the case of a 76-year-old man in a late cirrhotic stage of alcoholic chronic liver disease, presenting with recurrent right-sided hepatic hydrothorax, portal hypertension, hepatosplenomegaly and thrombocytopaenia...
March 15, 2019: BMJ Case Reports
Viktorija Basyte-Bacevice, Jurgita Skieceviciene, Irena Valantiene, Jolanta Sumskiene, Vitalija Petrenkiene, Jurate Kondrackiene, Dalius Petrauskas, Frank Lammert, Juozas Kupcinskas
Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the TM6SF2 and MBOAT7 genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between TM6SF2 variant rs58542926 and MBOAT7 variant rs641738 and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the PNPLA3 rs738409 risk variant for the development of hepatic fibrosis and liver cirrhosis...
March 14, 2019: International Journal of Molecular Sciences
Fabio Nascimbeni, Elisa Pellegrini, Simonetta Lugari, Alberto Mondelli, Serena Bursi, Giovanna Onfiani, Francesca Carubbi, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of alcohol-like hepatic histological changes, which occur in the absence of any competing causes of chronic liver disease, notably including significant alcohol consumption. A close and bi-directional relationship links NAFLD with the metabolic syndrome (MetS), and concurrent MetS will hasten the progression to more severe forms of NAFLD, including cirrhosis and hepatocellular carcinoma (HCC). Patients with NAFLD will typically exhibit atherogenic dyslipidemia and increased cardiovascular risk (CVR)...
March 3, 2019: Atherosclerosis
Reema Fayez Tayyem, Hanaa Mahmoud Al-Dayyat, Yaser Mohammed Rayyan
BACKGROUND AND STUDY AIMS: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD may progress from simple steatosis to nonalcoholic steatohepatitis, cirrhosis and finally decompensated liver failure. This study aims at assessing the relationship between lifestyle factors and nutrients intake and the development of non-alcoholic fatty liver disease (NAFLD) in a group of Jordanian adults 30-60 years of age. PATIENTS AND METHODS: In this case-control study, a total of 120 Jordanian adults 30-60 years of age were recruited...
March 11, 2019: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Jia Xiao, Fei Wang, Nai-Kei Wong, Jinhan He, Rui Zhang, Ruijuan Sun, Yanying Xu, Yingxia Liu, Wei Li, Kazuo Koike, Weiling He, Hong You, Yinglei Miao, Xiaowei Liu, Mingming Meng, Bin Gao, Hua Wang, Cui Li
Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programs for systematic immunization against hepatitis B virus (HBV) have also significantly brought down the number of new cases in many countries, including China. In contrast, with the improvement of living standards, prevalence of metabolic liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) is set to rise, which ultimately leads to more cases of end-stage liver diseases (liver failure, cirrhosis, and liver cancer)...
March 11, 2019: Journal of Hepatology
Sébastien Dharancy
When to transplant a patient with alcoholic liver disease? Alcoholic liver disease is the leading cause of cirrhosis in France, but there is only a minority of patients who have access to liver transplantation. Although still controversial, this disease is a validated indication of liver transplantation with survival similar to that of other indications. The survival benefit of transplantation is limited to patients with severe decompensation. A period of abstinence is essential before accessing to the waiting list, but the 6-month abstinence rule is not a strong criterion for predicting the recurrent alcohol consumption after transplantation...
September 2018: La Revue du Praticien
Oyuntugs Byambasukh, Dorien Zelle, Eva Corpeleijn
OBJECTIVES: We examined the dose-dependent association of habitual moderate-to-vigorous physical activity (MVPA) with the biochemical markers for nonalcoholic fatty liver disease (NAFLD) and whether this association changes with age and degree of impaired glucose metabolism. We also investigated whether the associations depend on the domain of MVPA. METHODS: In this study, using data from the population-based Lifelines cohort (N = 42,661), MVPA was self-reported on the short questionnaire to assess health-enhancing physical activity...
March 8, 2019: American Journal of Gastroenterology
Page Axley, Zunirah Ahmed, Sumant Arora, Allen Haas, Yong-Fang Kuo, Patrick S Kamath, Ashwani K Singal
BACKGROUND & AIMS: Acute on chronic liver failure (ACLF) among patients with cirrhosis is characterized by multiple organ failure (OF) with high short-term mortality. There is lack of population based data on trends on ACLF related morbidity and disease burden based on liver disease etiology. METHODS: National Inpatient Sample (2006-2014) was queried using the ICD-09 codes for admissions with cirrhosis and ACLF (defined with ≥2 extrahepatic organ failures)...
March 12, 2019: Liver Transplantation
C Martín-González, E González-Reimers, G Quintero-Platt, A Martínez-Riera, F Santolaria-Fernández
AIMS AND BACKGROUND: Alpha Klotho is a transmembrane protein that serves as co-receptor for FGF23. Ectodomain of membrane bound α Klotho may be shed by membrane bound proteases (activated, among other factors, by tumor necrosis factor (TNF)-α) generating the soluble form of the protein (sKl) that functions as a hormone by itself. It modulates calcium influx into cells, blunts IGF-1/Insulin signaling, promotes synthesis of antioxidants, generally slows down tumor progression, delays cell senescence, is neuroprotective and promotes oligodendrocyte maturation and myelin synthesis, and muscle rejuvenation...
March 12, 2019: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
Camila Maestas, Mohamad Lazkani, Michael Sultan, Geetha Kolli, Maheen Sheikh, Madhavgopal Cherukuri
INTRODUCTION: Acute decompensated heart failure is a known complication following orthotopic liver transplant. Among those, there are some cases of takostubo type cardiomyopathy (TC), commonly referred to as "broken heart syndrome". While the exact mechanism of TC is unknown, it frequently proceeds a physical or emotional stressor. Here we present a series of seven cases of TC following orthotopic liver transplant. METHODS: A retrospective chart review was conducted on 454 patients were identified as having post-operative cardiac dysfunction in the setting of orthotopic liver transplantation...
March 7, 2019: Clinics and Research in Hepatology and Gastroenterology
Rongrong Zhou, Xuegong Fan, Bernd Schnabl
Liver cirrhosis is a major cause of morbidity and mortality worldwide. The most common chronic liver diseases in western countries are alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Although these diseases have different causes, liver fibrosis develops via shared mechanisms. The liver and intestinal microbiome are linked by the portal vein and have bidirectional interactions. Changes in the intestinal microbiota are believed to contribute to the pathogenesis and progression of liver diseases including ALD, NAFLD, viral hepatitis, and cholestatic disorders, based on studies in patients and animal models...
February 16, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Philipp Konstantin Haber, Simon Wabitsch, Felix Krenzien, Christian Benzing, Andreas Andreou, Wenzel Schöning, Robert Öllinger, Johann Pratschke, Moritz Schmelzle
BACKGROUND: Minimal-invasive liver resection has gained considerable attention in recent years, assuming a weighty position in the field of HPB surgery. Even lesions in posterosuperior segments, the technically most challenging localization, have been resected while achieving comparable outcomes to laparotomy. The objective of this study is to evaluate whether the similar beneficial results can be conveyed through minimal-invasive techniques for patients with liver cirrhosis. MATERIALS AND METHODS: We retrospectively analyzed all consecutive patients undergoing laparoscopic liver resection with at least one lesion in the posterosuperior liver segments (IVa, VII, VIII) at our center between January 2012 and July 2018...
March 2019: Surgical Oncology
Yoshihiro Fujiya, Kayoko Hayakawa, Yoshiaki Gu, Kei Yamamoto, Momoko Mawatari, Satoshi Kutsuna, Nozomi Takeshita, Yasuyuki Kato, Shuzo Kanagawa, Norio Ohmagari
PURPOSE: Invasive Group G streptococcal infection (iGGS) has increasingly been recognized as a cause of severe disease, mainly among elderly people with chronic illnesses. This study aimed to examine age-related differences in clinical characteristics of iGGS and describe its characteristics among very elderly individuals (≥80 years). METHODS: Fifty-four iGGS patients for whom detailed clinical information was available were identified from 2002 to 2014 in a tertiary care hospital in Japan...
2019: PloS One
V V Pavan Kedar Mukthinuthalapati, Samuel Akinyeye, Zachary P Fricker, Moinuddin Syed, Eric S Orman, Lauren Nephew, Eduardo Vilar-Gomez, James Slaven, Naga Chalasani, Maya Balakrishnan, Michelle T Long, Bashar M Attar, Marwan Ghabril
BACKGROUND: Safety-net hospitals provide care for racially/ethnically diverse and disadvantaged urban populations. Their hospitalized patients with cirrhosis are relatively understudied and may be vulnerable to poor outcomes and racial/ethnic disparities. AIMS: To examine the outcomes of patients with cirrhosis hospitalized at regionally diverse safety-net hospitals and the impact of race/ethnicity. METHODS: A study of patients with cirrhosis hospitalized at 4 safety-net hospitals in 2012 was conducted...
2019: PloS One
Efrat Kessler, Eyal Hassoun
Fibrosis is characterized by excessive deposition of collagen and additional extracellular matrix (ECM) components in response to chronic injuries. Liver fibrosis often results from chronic hepatitis C virus infection and alcohol abuse that can deteriorate to cirrhosis and liver failure. Current noninvasive diagnostic methods of liver fibrosis are limited in their ability to detect and differentiate between early and intermediate stages of fibrosis. New biomarkers of fibrosis that reflect ECM turnover are therefore badly needed...
2019: Methods in Molecular Biology
Francesco Francini-Pesenti, Giorgia Querin, Cristina Martini, Sara Mareso, David Sacerdoti
Spinal-bulbar muscular atrophy (SBMA), is an X-linked motor neuron disease caused by a CAG-repeat expansion in the first exon of the androgen receptor gene (AR) on chromosome X. In SBMA, non-neural clinical phenotype includes disorders of glucose and lipid metabolism. We investigated the prevalence of metabolic syndrome (MS), insulin resistance (IR) and non alcoholic fatty liver disease (NAFLD) in a group of SBMA patients. Forty-seven consecutive patients genetically diagnosed with SBMA underwent biochemical analyses...
September 2018: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
Alba J Kihn-Alarcón, María F Toledo-Ponce, Angel Velarde, Ximing Xu
PURPOSE: Guatemala has the highest mortality and incidence of liver cancer in Central and South America. The aim of this study is to describe the extent of liver cancer in the country from 2012 to 2016 and the associated risk factors. METHODS: A secondary analysis was performed using liver cancer mortality and morbidity data and data on risk factors, such as hepatitis B virus infection, cirrhosis, and alcoholism. RESULTS: Analysis revealed that liver cancer causes approximately 20% of cancer deaths in the country, is more frequent in the population older than age 65 years old, and is increasing in those age 30 to 44 years...
February 2019: Journal of Global Oncology
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