Moyinoluwa T Taiwo, Emily Huang, Vai Pathak, Annette Bellar, Nicole Welch, Jaividhya Dasarathy, David Streem, Craig J McClain, Mack C Mitchell, Bruce A Barton, Gyongyi Szabo, Srinivasan Dasarathy, Esperance A Schaefer, Jay Luther, Le Z Day, Xinshou Ouyang, Suyavaran Arumugam, Wajahat Z Mehal, Jon M Jacobs, Russell P Goodman, Daniel M Rotroff, Laura E Nagy
Diagnostic challenges continue to impede development of effective therapies for successful management of alcohol-associated hepatitis (AH), thus creating an unmet need to identify and develop non-invasive biomarkers for AH. In murine models of ethanol-induced liver injury, complement activation contributes to hepatic inflammation and injury. Therefore, we hypothesized that complement proteins could be rational diagnostic/prognostic biomarkers in AH. Here, we performed a comparative analysis of data derived from the human hepatic and serum proteome to identify and characterize complement protein signatures in severe AH (sAH)...
April 4, 2024: JCI Insight