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JOURNAL ARTICLE
Rainer Kaiser, Konstantin Stark
No abstract text is available yet for this article.
April 25, 2024: Blood
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JOURNAL ARTICLE
Fahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
Platelets play an essential role in thrombotic processes. Recent studies suggest a direct link between increased plasma glucose, lipids, and inflammatory cytokines with platelet activation and aggregation, resulting in an increased risk of atherothrombotic events in cardiovascular patients. Antiplatelet therapies are commonly used for the primary prevention of atherosclerosis. Transitioning from a population-based strategy to patient-specific care requires a better understanding of the risks and advantages of antiplatelet therapy for individuals...
April 9, 2024: Lab on a Chip
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JOURNAL ARTICLE
Caelan Taggart, Andreas Roos, Erik Kadesjö, Atul Anand, Ziwen Li, Dimitrios Doudesis, Kuan Ken Lee, Anda Bularga, Ryan Wereski, Matthew T H Lowry, Andrew R Chapman, Amy V Ferry, Anoop S V Shah, Anton Gard, Bertil Lindahl, Gustaf Edgren, Nicholas L Mills, Dorien M Kimenai
IMPORTANCE: Whether the diagnostic classifications proposed by the universal definition of myocardial infarction (MI) to identify type 1 MI due to atherothrombosis and type 2 MI due to myocardial oxygen supply-demand imbalance have been applied consistently in clinical practice is unknown. OBJECTIVE: To evaluate the application of the universal definition of MI in consecutive patients with possible MI across 2 health care systems. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from 2 prospective cohorts enrolling consecutive patients with possible MI in Scotland (2013-2016) and Sweden (2011-2014) to assess accuracy of clinical diagnosis of MI recorded in hospital records for patients with an adjudicated diagnosis of type 1 or type 2 MI...
April 1, 2024: JAMA Network Open
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REVIEW
John W Hirshfeld
Chronic coronary heart disease encompasses a broad spectrum of disorders that range in severity from trivial to imminently life-threatening. The primary care physician encounters coronary disease at all stages. The number of available diagnostic and therapeutic options for evaluating and treating coronary disease is vast, presenting a complex selection strategy challenge when making choices for the individual patient. The primary care physician is responsible to tailor evaluation and management strategies to each individual patient based on his/her particular disease characteristics...
May 2024: Medical Clinics of North America
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JOURNAL ARTICLE
Wolfgang C Winkelmayer, Anthonie W A Lensing, Ravi I Thadhani, Kenneth W Mahaffey, Michael Walsh, Ákos F Pap, Stefan Willmann, Kirstin Thelen, Sophie Hodge, Alexander Solms, Sheila J M Ingham, John Eikelboom
Patients with kidney failure on hemodialysis (KF-HD) are at high risk for both atherothrombotic events and bleeding. This Phase IIb study evaluated the dose-response of fesomersen, an inhibitor of hepatic Factor XI expression, versus placebo, for bleeding and atherothrombosis in patients with KF-HD. Patients were randomized to receive fesomersen 40, 80, or 120 mg once-monthly, or matching placebo, for up to 12 months. The primary safety endpoint was a composite of major bleeding and clinically relevant non-major bleeding (MB/CRNMB)...
March 25, 2024: Kidney International
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JOURNAL ARTICLE
Bin Zhang, Hongbing Xu, Xinghou He, Tong Wang, Mengyao Li, Xuyang Shan, Yutong Zhu, Changjie Liu, Qian Zhao, Xiaoming Song, Yele Sun, Lemin Zheng, Wei Huang
Evidence of the precise biological pathway responsible for acute cardiovascular events triggered by particulate matter (PM) exposure from anthropogenic emissions is sparse. We investigated the associations of biomarkers relevant to the pathophysiology of atherothrombosis (ceramide metabolism, pro-inflammatory response, and blood coagulation) with primary and secondary components in particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5 ). A total of 152 healthy participants were followed with four repeated clinical visits between September 2019 and January 2020 in Beijing...
March 19, 2024: Toxics
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JOURNAL ARTICLE
Alexandre Slater, Sophia Khattak, Mark R Thomas
Glycoprotein (GP) VI plays a major role in thrombosis but not haemostasis, making it a promising antithrombotic target. The primary role of GPVI on the surface of platelets is a signalling receptor for collagen, which is one of the most potent thrombotic sub-endothelial components that is exposed by atherosclerotic plaque rupture. Inhibition of GPVI has therefore been investigated as a strategy for treatment and prevention of atherothrombosis, such as during stroke and acute coronary syndromes. A range of specific GPVI inhibitors have been characterised and 2 of these inhibitors, glenzocimab and revacept, have completed phase II clinical trials in ischemic stroke...
March 7, 2024: European Heart Journal. Cardiovascular Pharmacotherapy
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JOURNAL ARTICLE
Meishan Yan, Zelong Wang, Yao An, Zhanni Li, Yun Li, Hongyu Zhang, Caixia Li, Lifeng Wang, Li Chen, Chao Gao, Dongsheng Wang, Chunyan Gao
Oxidized low-density lipoprotein (oxLDL), a key component in atherosclerosis and hyperlipidemia, is a risk factor for atherothrombosis in dyslipidemia, yet its mechanism is poorly understood. In this study, we used oxLDL-induced human aortic endothelial cells (HAECs) and high-fat diet (HFD)-fed mice as a hyperlipidemia model. Phosphatidylserine (PS) exposure, cytosolic Ca2+ , reactive oxygen species (ROS), and lipid peroxidation were measured by flow cytometer. TMEM16F expression was detected by immunofluorescence, western blot, and reverse transcription polymerase chain reaction...
March 5, 2024: Cell Biology International
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JOURNAL ARTICLE
Giovanna Petrucci, Georgina A Buck, Bianca Rocca, Sarah Parish, Colin Baigent, Duaa Hatem, Marion Mafham, Aida Habib, Louise Bowman, Jane Armitage, Carlo Patrono
BACKGROUND AND AIMS: Thromboxane (TX) A2, released by activated platelets, plays an important role in atherothrombosis. Urinary 11-dehydro-TXB2 (U-TXM), a stable metabolite reflecting the whole-body TXA2 biosynthesis, is reduced by ∼70% by daily low-dose aspirin. The U-TXM represents a non-invasive biomarker of in vivo platelet activation and is enhanced in patients with diabetes. This study assessed whether U-TXM is associated with the risk of future serious vascular events or revascularizations (SVE-R), major bleeding, or cancer in patients with diabetes...
February 22, 2024: European Heart Journal
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JOURNAL ARTICLE
Pedro G M de Barros E Silva, Charlene Troiani do Nascimento, Rodrigo Pinto Pedrosa, Marcelo Arruda Nakazone, Michel Ulloffo do Nascimento, Leiliandry de Araújo Melo, Osvaldo Lourenço Silva Júnior, Sérgio Luiz Zimmermann, Rodrigo Morel Vieira de Melo, Ricardo Reinaldo Bergo, Dalton Bertolim Precoma, Lucas Tramujas, Eduardo Gomes Lima, João Miguel Malta Dantas, Antônio Cláudio do Amaral Baruzzi, Ronald Luiz Gomes Flumignan, Maria Sanali Moura de Oliveira Paiva, Luís Henrique Wolff Gowdak, Priscila Nasser de Carvalho, José Albuquerque de Figueiredo Neto, Odilson Marcos Silvestre, Alexandre Fioranelli, Ricardo D 'Oliveira Vieira, Ana Clara Peneluppi Horak, Debora Harumi Kodama Miyada, Flávia Cristina Soares Kojima, Júlia Souza de Oliveira, Leila de Oliveira Silva, Ricardo Pavanello, Eduardo Ramacciotti, Renato D Lopes
There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease...
February 20, 2024: Scientific Reports
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JOURNAL ARTICLE
James Nadel, Xiaoying Wang, Prakash Saha, André Bongers, Sergey Tumanov, Nicola Giannotti, Weiyu Chen, Niv Vigder, Mohammed M Chowdhury, Gastao Lima da Cruz, Carlos Velasco, Claudia Prieto, Andrew Jabbour, René M Botnar, Roland Stocker, Alkystis Phinikaridou
AIMS: Unstable atherosclerotic plaques have increased activity of myeloperoxidase (MPO). We examined whether molecular magnetic resonance imaging (MRI) of intraplaque MPO activity predicts future atherothrombosis in rabbits and correlates with ruptured human atheroma. METHODS AND RESULTS: Plaque MPO activity was assessed in vivo in rabbits ( n = 12) using the MPO-gadolinium (Gd) probe at 8 and 12 weeks after induction of atherosclerosis and before pharmacological triggering of atherothrombosis...
January 2024: Eur Heart J Imaging Methods Pract
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MULTICENTER STUDY
Copeptin for the differentiation of type 1 versus type 2 myocardial infarction or myocardial injury.
Mona Kassem, Pedro Lopez Ayala, Tijana Andric-Cancarevic, Milos Tajsic, Kris G Vargas, Dimitri Bendik, Christoph Kaufmann, Johann Wojta, Christian Mueller, Kurt Huber
BACKGROUND: The rapid and reliable differentiation of myocardial infarction (MI) due to atherothrombosis (T1MI) from MI due to supply-demand mismatch (T2MI) or acute myocardial injury is of major clinical relevance due to very different treatments, but still a major unmet clinical need. This study aimed to investigate whether copeptin, a stress hormone produced in the hypothalamus, helps to differentiate between T1MI versus T2MI or injury. METHODS: In a retrospective analysis, 1271 unselected consecutive patients presenting with symptoms suggestive of MI to the emergency department were evaluated...
May 15, 2024: International Journal of Cardiology
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JOURNAL ARTICLE
Ariel Roguin, Ofer Kobo, Simha-Ron Meisel, Ziad Darawsha, Mahmood Odeh, Aharon Frimerman, Naama Amsalem, Rami Abu Fanne
(1) Introduction : A significant proportion of patients undergoing coronary angiography (CAG) have normal (NCA) or non-obstructive coronary artery disease (NOCAD). This study retrospectively tested the incidence of re-catheterization, and long-term outcomes of this population in patients aged over 50 years. (2) Methods : We identified all patients above 50 years of age with NOCAD who underwent their first CAG at our center between January 2008 and December 2019. Patients were evaluated for their baseline characteristics, risk factors profile, and indication for CAG...
February 2, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Priscila de Souza Furtado, Gil Mendes Viana, Alana Agnes Silva Camargo de Oliveira, Vitor Won-Held Rabelo, Ingryd Wenderroschy Cerqueira, Caroline Reis Santiago Paschoal, Thiago da Silva Honório, Alice Simon, Carlos Rangel Rodrigues, Paula Alvarez Abreu, Lucio Mendes Cabral, Plínio Cunha Sathler
INTRODUCTION: Thrombotic disorders are among the leading causes of morbidity and mortality worldwide. Drugs used in the prevention and treatment of atherothrombosis have pharmacokinetic limitations and adverse effects such as hemorrhagic conditions, highlighting the importance of developing more effective antiplatelet agents. ethod: In this work, we synthesized N,N'-disubstituted ureas 3a-3j and evaluated their antiplatelet profiles through in vitro, ex vivo, and in silico studies. The synthesized derivatives exhibited a selective inhibitory profile against platelet aggregation induced by arachidonic acid (AA) in vitro, without significantly affecting other aspects of primary hemostasis and blood coagulation...
January 17, 2024: Current Medicinal Chemistry
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REVIEW
Caroline Dix, Gerry Dolan, Beverley J Hunt
Revolutionary advances in the treatment of haemophilia has led to a significant improvement in life expectancy. Associated with this has been an increase in age-related diseases especially atherosclerotic cardiovascular disease (CVD). While people with haemophilia (PWH) develop atherosclerosis at rates similar to the general population, rates of atherothrombosis and mortality related to CVD have been much lower, due to their hypocoagulable state. Changing treatment paradigms, aimed at reducing the risk of bleeding by improving haemostasis to levels approaching normality, has meant the protection they are thought to have had may be lost...
February 1, 2024: Journal of Thrombosis and Haemostasis: JTH
#16
REVIEW
Daniel Elieh-Ali-Komi, Ilze Bot, Mónica Rodríguez-González, Marcus Maurer
Mast cells (MCs) are commonly recognized for their crucial involvement in the pathogenesis of allergic diseases, but over time, it has come to light that they also play a role in the pathophysiology of non-allergic disorders including atherosclerosis. The involvement of MCs in the pathology of atherosclerosis is supported by their accumulation in atherosclerotic plaques upon their progression and the association of intraplaque MC numbers with acute cardiovascular events. MCs that accumulate within the atherosclerotic plaque release a cocktail of mediators through which they contribute to neovascularization, plaque progression, instability, erosion, rupture, and thrombosis...
January 30, 2024: Clinical Reviews in Allergy & Immunology
#17
JOURNAL ARTICLE
Irma Isordia-Salas, David Santiago-Germán, Rosa María Jiménez-Alvarado, Reyes Ismael Carrillo-Juárez, Alfredo Leaños-Miranda
BACKGROUND: Previous studies had identified genetic variants associated with Myocardial Infarction, but results are inconclusive. We examined the association between FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016), ATR1 A1166C (rs5186) and MTHFR A1298C (rs1801131) polymorphisms and ST elevation Myocardial Infarction in young Mexican individuals. METHODS: We included a total of 350 patients with Myocardial Infarction <45 years old and 350 controls matched by age and gender...
January 25, 2024: Molecular Biology Reports
#18
RANDOMIZED CONTROLLED TRIAL
Daniel Košuta, Marko Novaković, Mojca Božič Mijovski, Borut Jug
Exercise training is associated with an acute net increase in coagulation, which may increase the risk of atherothrombosis in coronary artery disease (CAD) patients. We sought to compare the acute haemostatic effects of a bout of moderate-intensity continuous (MICT) and high-intensity interval training (HIIT) in patients with CAD. Patients after a recent myocardial infarction were randomized into a HIIT or MICT session of exercise training on a stationary bike. Blood was sampled at baseline, after the exercise bout and after a one-hour resting period...
January 23, 2024: Scientific Reports
#19
JOURNAL ARTICLE
Karita Claudia Freitas Lidani, Patrick James Trainor, Harpreet S Bhatia, Khurram Nasir, Michael J Blaha, Michael Y Tsai, Rebecca F Gottesman, Wendy S Post, George Thanassoulis, Sotirios Tsimikas, Susan R Heckbert, Andrew Paul DeFilippis
BACKGROUND AND AIMS: Although several biomarkers have been studied in thromboembolic stroke, measuring the balance between thrombus formation and thrombolysis and data on its role in predicting stroke and atrial fibrillation (AF)-related stroke is limited. We sought to assess atherothrombotic biomarkers grouped into composite factors that reflect thrombotic and thrombolytic potential, and the balance between these factors as it relates to incident stroke or transient ischemic attack (TIA) and stroke/TIA in AF...
January 10, 2024: Atherosclerosis
#20
JOURNAL ARTICLE
Dr Ajay Yadav, Dr Vivek Sawant, Dr Varinder Singh Bedi, Dr Kanupriya Yadav
Peripheral arterial disease (PAD) affects 12 % of adult population and is increasing globally and in India. Peripheral arterial disease when associated with atherosclerosis in two or more other arterial beds such as coronary artery disease (CAD), mesenteric/renal artery and cerebrovascular disease (CVD), is known as polyvascular disease. The Reduction of Atherothrombosis for Continued Health (REACH) registry reported that 1 out of 6 patients had multi-vascular bed involvement. Progression of PAD to critical limb ischaemia (CLI) is seen in 1 % of affected patients per year, but patients who progress to CLI may have a 10- to 15-fold increased risk of cardiovascular death...
January 13, 2024: Indian Heart Journal
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