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Testosterone AND Supplement

Eduarda Escobar, Sabrina Lopes, Cristiano Malavolta, Juliana Bernera Ramalho, Daniele Missio, Hirya Fernandes Pinto, Melina Bucco Soares, Fábio Gallas Leivas, Daniela Dos Santos Brum, Francielli Weber Santos Cibin
The present study assessed the effects of daily supplementation with 33 mg/metabolic weight (MW) of γ-oryzanol on testicular degeneration induced by scrotal insulation in rams. Eight animals were divided into two groups: Control (subjected to scrotal insulation without treatment) and Gamma (subjected to scrotal insulation and γ-oryzanol treatment). The rams were subjected to scrotal insulation by covering the scrotum with a thermal bag for 72 h. Animals in the Gamma group received 33 mg/MW oral γ-oryzanol once-daily, beginning 7 days before insulation and continuing during insulation and for 20 days afterward, for a total treatment period of 30 days...
February 7, 2019: Theriogenology
Rahil Jannatifar, Kazem Parivar, Nasim Hayati Roodbari, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supplementation with N-acetyl-cysteine (NAC) on the sperm quality, chromatin integrity and levels of oxidative stress in infertile men. METHODS: The study was carried out in the unit of ACECR Infertility Research Center, Qom, Iran...
February 16, 2019: Reproductive Biology and Endocrinology: RB&E
Adithya Balasubramanian, Nannan Thirumavalavan, Ashwin Srivatsav, Justin Yu, Larry I Lipshultz, Alexander W Pastuszak
INTRODUCTION: Testosterone-boosting supplements (T-Boosters) are prominently featured on, with numerous dedicated pages and claims that they "naturally" increase testosterone levels. AIM: To evaluate the highest rated and frequently reviewed T-Boosters on to facilitate patient counseling regarding marketing myths, T-Booster formulations, and evidence for efficacy and safety. METHODS: The Amazon marketplace was queried using the key words "testosterone" + "booster," with default search settings and ranking items based on relevance...
February 2019: Journal of Sexual Medicine
Heitor O Santos, Filipe J Teixeira
Hypogonadism affects an extensive part of the male population, especially among the elderly. The quest for treatment regarding low levels of serum testosterone and male infertility has, therefore, worldwide relevance. Zinc has important biological actions insofar as the male reproductive physiology and endocrine system. In general, a common and safe recommendation for zinc in the treatment of male hypogonadism is 220 mg of zinc sulfate (equivalent to 50 mg of elemental zinc) twice a day, over one to four months...
February 15, 2019: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Behnam Abbaspour, Seyed Davood Sharifi, Shekofeh Ghazanfari, Abdollah Mohammadi-Sangcheshmeh, Shirin Honarbakhsh
The objective of this study was to investigate the effect of dietary supplementation of l-arginine and flaxseed on testosterone and lipid parameters of serum and semen quality, as well as histological and morphometric parameters of testes in old broiler breeder rooster. Fifty four 52-week-old Ross 308 broiler breeder roosters with similar weights (4900 g ± 210) were used for a 6-week trial period in a 3 × 3 factorial arrangement of dietary treatments that three levels of l-arginine (0.52, 0.68 and 0...
February 1, 2019: Theriogenology
Katarzyna Nierwińska, Marta Nowacka-Chmielewska, Jacek Bernacki, Sławomir Jagsz, Małgorzata Chalimoniuk, Józef Langfort, Andrzej Małecki
The present study aimed to estimate the effect of endurance training, two doses of testosterone, and the combination of these stimuli on the level of the endothelial proteins claudin, occludin, JAM-1, VE-cadherin, ZO-1, ZO-2, and P-glycoprotein in rat spinal cords. Adult male Wistar rats were trained using a motor-driven treadmill for 6 weeks (40-60 min, 5 times per week) and/or were treated for 6 weeks with two doses of testosterone (i.m.; 8 mg/kg or 80 mg/kg body weight). Spinal cords were collected 48 hours after the last training cycle and stored at -80°C...
2019: PloS One
Maliha Naseer, Erica P Turse, Ali Syed, Francis E Dailey, Mallak Zatreh, Veysel Tahan
BACKGROUND: Sarcopenia, i.e ., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis. AIM: To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt (TIPS) to improve muscle mass in cirrhosis...
January 26, 2019: World Journal of Clinical Cases
Gehan M Badr, Hany Elsawy, Azza Sedky, Rania Eid, Awatef Ali, Basem M Abdallah, Abdullah M Alzahrani, Ashraf M Abdel-Moneim
The aim of this study was to evaluate the probable protective effect of quercetin (QUE) against cadmium (Cd)-induced sub-chronic toxicity in rats. Adult male rats were given either Cd (as cadmium chloride; 5 mg/kg) alone or in combination with QUE (50 mg/kg) daily for 4 weeks by oral gavage. At the end of the experimental period, Cd accumulation, and selected hematological, thyroid, and reproductive markers were assessed. Results revealed that Cd treatment significantly increased Cd concentrations in blood, thyroid gland, and testicular tissue of rats...
January 29, 2019: Environmental Science and Pollution Research International
Vahidreza Ostadmohammadi, Mehri Jamilian, Fereshteh Bahmani, Zatollah Asemi
OBJECTIVE: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS). METHODS: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 109  CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks...
January 21, 2019: Journal of Ovarian Research
Polly Zhang, Adam Schatz, Babatunde Adeyemi, David Kozminski, JoEllen Welsh, Martin Tenniswood, Wei-Lin Winnie Wang
Vitamin D3 and its receptor are responsible for controlling energy expenditure in adipocytes and have direct roles in the transcriptional regulation of energy metabolic pathways. This phenomenon also has a significant impact on the etiology of prostate cancer (PCa). Using several in vitro models, the roles of vitamin D3 on energy metabolism and its implication in primary, early and late invasive PCa was investigated. BODIPY staining and qPCR analyses show that 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) up-regulates de novo lipogenesis in PCa cells by orchestrating transcriptional regulation that affects cholesterol and lipid metabolic pathways...
January 18, 2019: Journal of Steroid Biochemistry and Molecular Biology
Zeeshan Javed, Maria Papageorgiou, Harshal Deshmukh, Eric S Kilpatrick, Vincent Mann, Lynsey Corless, George Abouda, Alan S Rigby, Stephen L Atkin, Thozhukat Sathyapalan
Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemistry in patients with NAFLD; however, its effects on PCOS are unknown. This randomized, double-blind, placebo-controlled study explored the effect of vitamin D supplementation on cardiovascular risk factors (high-sensitivity C-reactive protein ( hs -CRP), weight, body mass index (BMI), lipid profile, glucose levels, insulin levels, the homeostatic model assessment-insulin resistance (HOMA-IR), hormones (free androgen index (FAI), testosterone, sex hormone binding globulin (SHBG), and liver markers (alanine aminotransferase (ALT), hyaluronic acid (HA), N-terminal pro-peptide of type III procollagen (PIIINP), tissue inhibitor of metallo-proteinases-1 (TIMP-1), and the enhanced liver fibrosis (ELF) score)...
January 17, 2019: Nutrients
S A Masudul Hoque, Tomoko Kawai, Zhendong Zhu, Masayuki Shimada
Granulosa cell (GC) proliferation is essential for follicular development. FSH is a key factor in GC proliferation, and a continuous supply of high levels of ATP is necessary for cell proliferation. However, genes encoding proteins of the glycolytic pathways are poorly expressed in GCs. Therefore, we hypothesized that mitochondrial gene expression and protein synthesis play a primary role in ATP production during GC proliferation. To test this hypothesis, we performed an in vivo study of GCs collected from 23-day-old mice ovaries with or without equine chorionic gonadotropin (eCG) priming...
February 1, 2019: Journal of the Endocrine Society
Sanasam Sanjeev, Meesala Krishna Murthy, Maibam Sunita Devi, Maurya Khushboo, Zothanmawii Renthlei, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian
Bergenin is one of the phytochemical constituents in marlberry (Ardisia colorata Roxb.) having antioxidant, anti-diabetic, and anti-inflammatory properties. A. colorata has been used as an herbal medicine in Southeast Asia particularly in Northeast India to treat diabetes. Bergenin was isolated from methanol extract of A. colorata leaf (MEACL) by column chromatography and TLC profiling. Characterization and structural validation of bergenin were performed by spectroscopic analyses. A LC-ESI-MS/MS method was developed for the quantitation of bergenin and validated as per the guidelines of FDA and EMA...
January 15, 2019: Environmental Science and Pollution Research International
Leila Hadjadj, Éva Pál, Anna Monori-Kiss, Réka Eszter Sziva, Ágnes Korsós-Novák, Eszter Mária Horváth, Rita Benkő, Attila Magyar, Péter Magyar, Zoltán Benyó, György L Nádasy, Szabolcs Várbíró
Vitamin D (vitD) insufficiency affects 1 billion people worldwide. Androgen excess (AE) occurs in 8% of fertile females. There are few data about the combined effect of vitD deficiency and AE on the early biomechanical changes of cerebral arterioles in fertile-aged female. Forty-six adolescent female Wistar rats (21-28 day-old, weighing 90-110 g) were grouped randomly in four groups: vitD supplemented groups with and without transdermal testosterone (T) treatment, as well as vitD deficient groups also with and without transdermal T (n = 11 or 12, in all cases)...
January 9, 2019: Gynecological Endocrinology
Dong Sup Lee, Jin Bong Choi, Dong Wan Sohn
INTRODUCTION: It is unclear how sleep deprivation (SD) exerts a negative effect on men's health in terms of hypogonadism. AIM: To evaluate the hypothalamic-pituitary-gonadal (HPG) axis in subjects with SD and ultimately to evaluate the erectile tissue in response to the hormonal changes. METHODS: 56 male Wistar rats were used. First, 16 rats (16 weeks old) were subjected to 72 hours of SD, and the following were compared with 16 control rats: (i) levels of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and cortisol; (ii) the expression of the kisspeptin mRNA in the brain; and (iii) assessment of immunohistochemistry (IHC) of brain and testis...
January 2019: Journal of Sexual Medicine
Fabio Facchinetti, Beatrice Orrù, Giovanni Grandi, Vittorio Unfer
Metformin (MET), the most commonly used insulin sensitizer, is the reference off-label drug for the treatment of polycystic ovary syndrome (PCOS), worldwide. However, its use may be limited mainly by gastrointestinal adverse effects. Myo-inositol (MI), a well-recognized food supplement, also represents an evidence-based treatment for PCOS women, popular in many countries. Our aim is to provide a systematic review of the literature and a meta-analysis which compares these two treatments, for their short-term efficacy and safety in PCOS patients...
January 7, 2019: Gynecological Endocrinology
Jyotsna Pundir, David Charles, Luca Sabatini, Danielle Hiam, Sonia Jitpiriyaroj, Helena Teede, Arri Coomarasamy, Lisa Moran, Shakila Thangaratinam
BACKGROUND: Polycystic ovary syndrome (PCOS) is a major contributor to subfertility, diabetes and cardiovascular disease in women. The role of non-pharmacological interventions to prevent these outcomes has been reported in many systematic reviews, but robust conclusions have not been made due to variations in the scope, quality and findings of these reviews. OBJECTIVE AND RATIONALE: Our aim was to provide an overview of existing evidence on the effects of non-pharmacological interventions in women with PCOS on fertility and non-fertility outcomes by a review of existing systematic reviews...
January 4, 2019: Human Reproduction Update
Yin-Wei Chen, Yong-Hua Niu, Hao Xu, Dao-Qi Wang, Hong-Yang Jiang, Gaurab Pokhrel, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Gonadotropin therapy is commonly used to induce virilization and spermatogenesis in male isolated hypogonadotropic hypogonadism (IHH) patients. In clinical practice, 5.6%-15.0% of male IHH patients show poor responses to gonadotropin treatment; therefore, testosterone (T) supplementation can serve as an alternative therapy to normalize serum T levels and promote virilization. However, treatment with exogenous T impairs spermatogenesis and suppresses intratesticular T levels. This retrospective study aimed to determine whether oral testosterone undecanoate (TU) supplementation together with human chorionic gonadotropin (hCG) would negatively affect spermatogenesis in IHH patients compared with hCG alone...
December 25, 2018: Asian Journal of Andrology
Chih-Ling Wang, Hsiu-Ni Kung, Ching-Ho Wu, Ching-Jang Huang
Loss of skeletal muscle mass and strength is often associated with disability and poor quality of life. Selective Androgen Receptor Modulators (SARMs) are under development as potential treatment. This study aims at examining the potential of wild bitter gourd (BG) as a SARM and its effects on the muscle decline induced by orchiectomy. In the cell-based androgen receptor (AR) transactivation assay, the BGP extract showed weak agonistic and antagonistic activities, resembling those of some SARMs. Male C57BL/6J mice were sham-operated (Sham group) or castrated (Cast groups) and fed a modified AIN-93G high sucrose diet supplemented without (Cast group) or with 5% lyophilized BG powder (Cast + BGP) or with testosterone propionate (7 mg TP per kg diet, Cast + TP) for 23 weeks...
January 2, 2019: Food & Function
Peter Kelechi Ajuogu, Osaro O Mgbere, Disere S Bila, James R McFarlane
ETHNOPHARMACOLOGICAL RELEVANCE: Moringa oleifera Lam. (Moringaceae) is an important plant based staple food, known for its nutritional and medicinal value and is usually prescribed by herbal practitioners in Nigeria and in other tropical countries for the treatment of male infertility problems and reproductive diseases in females. Although the aphrodisiac properties and fertility enhancement potential in males have been reported, the underlying mechanisms for the activity remain unclear...
December 26, 2018: Journal of Ethnopharmacology
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