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https://read.qxmd.com/read/31000429/hemorrhagic-cholecystitis-a-case-of-expedited-diagnosis-by-point-of-care-ultrasound-in-the-emergency-department
#1
David Reens, Beata Podgorski
BACKGROUND: Hemorrhagic cholecystitis is a rare complication of acute cholecystitis and is a potentially fatal diagnosis. It may be difficult to detect because the symptoms are similar to more common diagnoses. Point-of-care ultrasound is a useful imaging technique in the emergency setting and is readily available to allow for immediate interpretation and application of the results to guide medical decision making. CASE REPORT: We report a 76-year-old man with a history of hypertension, hyperlipidemia, diabetes, atrial fibrillation on warfarin, and coronary artery disease presenting with epigastric pain radiating to the back, nausea, and vomiting who was found to have hemorrhagic cholecystitis with gallbladder perforation...
April 15, 2019: Journal of Emergency Medicine
https://read.qxmd.com/read/30951031/ocular-point-of-care-ultrasound-in-the-pediatric-emergency-department
#2
Jade Seguin, Cathie-Kim Le, Jason W Fischer, Mark Oliver Tessaro, Ron Berant
OBJECTIVE: Point-of-care ultrasound has become an important adjunct for diagnostic assessment in pediatric emergency medicine. In this case series, we demonstrate how ocular point-of-care ultrasound is used to correctly diagnose ocular pathologies and to expedite care. METHODS/RESULTS: We present a series of cases in which the point-of-care ultrasound ocular examination proved valuable in the timely diagnosis of pathologies involving the lens, vitreous, retina, and retrobulbar segment of the eye...
February 14, 2019: Pediatric Emergency Care
https://read.qxmd.com/read/30946655/time-of-transfer-of-admitted-patients-from-the-ed-a-contributor-to-ed-boarding-in-high-volume-community-hospitals
#3
Leila Salehi, Prashant Phalpher, Rahim Valani, Andrew Wan, Jaclyn Herman, Mathew Mercuri
The twin challenges of bed boarding and "hallway medicine" have emerged in recent years as key healthcare issues. Many hospitals, challenged with increasing demand and limited resources, have tried to find efficiencies within their operations. One such strategy is that of early morning discharges and expedited bed turnaround times. We conducted a retrospective study within three high-volume hospitals in the Greater Toronto Area looking at discharge times of in-patients and transfer times of admitted, Emergency Department (ED)-boarded patients...
January 2019: Healthcare Quarterly
https://read.qxmd.com/read/30930079/the-implementation-of-a-pulmonary-embolism-response-team-in-the-management-of-intermediate-or-high-risk-pulmonary-embolism
#4
Eleftherios S Xenos, George Davis, Qiang He, Amanda Green, Susan Smyth
BACKGROUND: Massive and submassive pulmonary embolism (PE) can be life-threatening. Treatment options include anticoagulation, fibrinolysis, catheter-directed or open surgical thrombus removal, and extracorporeal membrane oxygenation. With increasing patient complexity and advanced therapeutic options, the approach to optimal care for patients with intermediate- to high-risk PE is not clearly established. Multidisciplinary, rapid response teams can optimize risk stratification and expedite management...
March 28, 2019: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://read.qxmd.com/read/30925593/discovering-small-molecules-as-wnt-inhibitors-that-promote-heart-regeneration-and-injury-repair
#5
Shuying Xie, Wenbin Fu, Guangju Yu, Xueli Hu, Kaa Seng Lai, Xiangwen Peng, Yating Zhou, Xuejiao Zhu, Plamen Christov, Leah Sawyer, Terri T Ni, Gary A Sulikowski, Zhongzhou Yang, Ethan Lee, Chunyu Zeng, Wei E Wang, Tao P Zhong
There are intense interests in discovering proregenerative medicine leads that can promote cardiac differentiation and regeneration, as well as repair damaged heart tissues. We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects. Two related compounds with novel structures, named as Cardiomogen1 and 2 (CDMG1 and CDMG2), were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population...
March 29, 2019: Journal of Molecular Cell Biology
https://read.qxmd.com/read/30921265/ocular-point-of-care-ultrasound-in-the-pediatric-emergency-department
#6
Jade Seguin, Cathie-Kim Le, Jason W Fischer, Mark Oliver Tessaro, Ron Berant
OBJECTIVE: Point-of-care ultrasound has become an important adjunct for diagnostic assessment in pediatric emergency medicine. In this case series, we demonstrate how ocular point-of-care ultrasound is used to correctly diagnose ocular pathologies and to expedite care. METHODS/RESULTS: We present a series of cases in which the point-of-care ultrasound ocular examination proved valuable in the timely diagnosis of pathologies involving the lens, vitreous, retina, and retrobulbar segment of the eye...
February 14, 2019: Pediatric Emergency Care
https://read.qxmd.com/read/30920313/how-can-we-develop-better-antispasmodics-for-irritable-bowel-syndrome
#7
Sheyda Ranjbar, Seyed Afshin Seyednejad, Shekoufeh Nikfar, Roja Rahimi, Mohammad Abdollahi
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal (GI) disease. Antispasmodics are a heterogeneous group of drugs that tackle IBS-associated altered bowel habit and abdominal pain. However, some studies have shown their failure to exhibit benefit over placebo. Considering the place of antispasmodics in managing key symptoms of IBS, there is a growing need for developing more efficacious and safe antispasmodics. Areas covered: The authors discuss the role of rational drug design (RDD) in developing new antispasmodics with desired features...
March 28, 2019: Expert Opinion on Drug Discovery
https://read.qxmd.com/read/30908433/ocular-point-of-care-ultrasound-in-the-pediatric-emergency-department
#8
Jade Seguin, Cathie-Kim Le, Jason W Fischer, Mark Oliver Tessaro, Ron Berant
OBJECTIVE: Point-of-care ultrasound has become an important adjunct for diagnostic assessment in pediatric emergency medicine. In this case series, we demonstrate how ocular point-of-care ultrasound is used to correctly diagnose ocular pathologies and to expedite care. METHODS/RESULTS: We present a series of cases in which the point-of-care ultrasound ocular examination proved valuable in the timely diagnosis of pathologies involving the lens, vitreous, retina, and retrobulbar segment of the eye...
February 14, 2019: Pediatric Emergency Care
https://read.qxmd.com/read/30900994/community-based-point-of-care-sexually-transmitted-infection-screening-among-high-risk-adolescents-in-los-angeles-and-new-orleans-protocol-for-a-mixed-methods-study
#9
Chelsea Lee Shannon, Maryann Koussa, Sung-Jae Lee, Jasmine Fournier, Sue Ellen Abdalian, Mary Jane Rotheram, Jeffrey D Klausner
BACKGROUND: Sexually transmitted infection (STI) rates are increasing in the United States, with approximately half of new infections occurring among adolescents aged 15-24 years. Gay, bisexual, and transgender youth (GBTY), homeless youth, and youth with histories of drug use, mental health disorders, and incarceration are all at uniquely high risk for STIs. However, these adolescents often lack access to sexual health services. OBJECTIVE: This study aims to use point-of-care STI tests in community-based settings to screen for and treat STIs in adolescents...
March 22, 2019: JMIR Research Protocols
https://read.qxmd.com/read/30888814/deciphering-the-rules-of-in-silico-autophagy-methods-for-expediting-medicinal-research
#10
Yi Chen, Guan Wang, Haoyang Cai, Yang Sun, Liang Ouyang, Bo Liu
Autophagy is a highly evolutionarily conserved cellular catabolic process responsible for degradation of damaged organelles and long-lived proteins. It is not surprising that scientific interest in the connection of autophagy and diseases has been growing. Over the past two decades, many new experimental approaches have been emerging in the field of targeting autophagy for medicinal research. Interestingly, in addition to experimental methods, a number of databases, webservers, mathematics models, omics approaches and systems biology network approaches related to autophagy have become available online, which may be collectively considered to be "in silico autophagy methods" for expediting current medicinal research...
March 19, 2019: Journal of Medicinal Chemistry
https://read.qxmd.com/read/30885881/medicinal-plants-of-the-caatinga-northeastern-brazil-ethnopharmacopeia-1980-1990-of-the-late-professor-francisco-jos%C3%A3-de-abreu-matos
#11
Karla do Nascimento Magalhães, William Antonio Sagástegui Guarniz, Kellen Miranda Sá, Amélia Branches Freire, Mirian Parente Monteiro, Ronald Targino Nojosa, Isanete Geraldini Costa Bieski, Jéssica Bezerra Custódio, Sikiru Olaitan Balogun, Mary Anne Medeiros Bandeira
ETHNOPHARMACOLOGICAL IMPORTANCE: The Caatinga (semi-arid region), is an exclusively Brazilian biome. Considering the scarcity of ethnobotanical and ethnopharmacological studies in this region before the year 2000, this study presents data from ethnobotanical expeditions carried out between 1980 and 1990, by the late professor Francisco José de Abreu Matos (1924-2008). The information revealed in this present work are valuable and remained unpublished until now. MATERIALS AND METHODS: The objective was to organize, systematize and analyze ethnobotanical and ethnopharmacological data using ethnobotanical analytical techniques...
March 15, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30868281/enhanced-recovery-pathways-for-cardiac-surgery
#12
REVIEW
Scott R Coleman, Ming Chen, Srikant Patel, Hong Yan, Alan D Kaye, Marcus Zebrower, Julie A Gayle, Henry Liu, Richard D Urman
PURPOSE OF REVIEW: Enhanced recovery after surgery (ERAS) has become a widespread topic in perioperative medicine over the past 20 years. The goals of ERAS are to improve patient outcomes and perioperative experience, reduce length of hospital stay, minimize complications, and reduce cost. Interventions and factors before, during, and after surgery all potentially play a role with the cumulative effect being superior quality of patient care. RECENT FINDINGS: Preoperatively, patient and family education, optimization of nutritional status, and antibiotic prophylaxis all improve outcomes...
March 14, 2019: Current Pain and Headache Reports
https://read.qxmd.com/read/30855425/ocular-point-of-care-ultrasound-in-the-pediatric-emergency-department
#13
Jade Seguin, Cathie-Kim Le, Jason W Fischer, Mark Oliver Tessaro, Ron Berant
OBJECTIVE: Point-of-care ultrasound has become an important adjunct for diagnostic assessment in pediatric emergency medicine. In this case series, we demonstrate how ocular point-of-care ultrasound is used to correctly diagnose ocular pathologies and to expedite care. METHODS/RESULTS: We present a series of cases in which the point-of-care ultrasound ocular examination proved valuable in the timely diagnosis of pathologies involving the lens, vitreous, retina, and retrobulbar segment of the eye...
February 14, 2019: Pediatric Emergency Care
https://read.qxmd.com/read/30850482/proceedings-pathways-for-successful-translation-of-new-imaging-agents-and-modalities-phase-iii-studies
#14
Sanjiv S Gambhir, Lalitha K Shankar, Eben Rosenthal, Jason M Warram, Munir V Ghesani, Thomas A Hope, Paula M Jacobs, Gunilla B Jacobson, Terri Wilson, Barry A Siegel
Significant advances continue in the development of cancer-specific molecular imaging agents and modalities for diagnosing, staging, and treating various cancer types. For these advances to successfully translate to widespread clinical use, both regulatory approval by the U.S. Food and Drug Administration (FDA), and completion of the reimbursement approval process with the Centers for Medicare & Medicaid Services (CMS), must be achieved. To this end, methods for expediting these processes are being addressed by both agencies...
March 8, 2019: Journal of Nuclear Medicine
https://read.qxmd.com/read/30822281/ocular-point-of-care-ultrasound-in-the-pediatric-emergency-department
#15
Jade Seguin, Cathie-Kim Le, Jason W Fischer, Mark Oliver Tessaro, Ron Berant
OBJECTIVE: Point-of-care ultrasound has become an important adjunct for diagnostic assessment in pediatric emergency medicine. In this case series, we demonstrate how ocular point-of-care ultrasound is used to correctly diagnose ocular pathologies and to expedite care. METHODS/RESULTS: We present a series of cases in which the point-of-care ultrasound ocular examination proved valuable in the timely diagnosis of pathologies involving the lens, vitreous, retina, and retrobulbar segment of the eye...
March 2019: Pediatric Emergency Care
https://read.qxmd.com/read/30820522/the-changing-profile-of-patients-in-a-geriatric-medicine-led-memory-clinic-over-12-years
#16
X Y Chua, N H L Ha, C Y Cheong, S L Wee, P L K Yap
OBJECTIVES: Memory clinics play an important role in enabling early dementia diagnosis and intervention. Few studies have investigated the changing patient profiles at memory clinics over time. We studied the trend of patient characteristics in a geriatric medicine-led memory clinic over 12 years to improve services and care to meet their needs. SETTING AND PARTICIPANTS: Data from 2340 first-visit patients seen at a memory clinic from 2005-2017 were extracted from a registered database and analysed...
2019: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/30815512/eu-regulatory-pathways-for-atmps-standard-accelerated-and-adaptive-pathways-to-marketing-authorisation
#17
REVIEW
Giulia Detela, Anthony Lodge
Advanced therapy medicinal products (ATMPs) require evaluation by the European Medicines Agency's Committee for Advanced Therapies prior to being placed on the European market, subject to a Marketing Authorisation granted by the European Commission. In common with other medicinal products, various regulatory pathways are available for taking ATMPs through clinical trials to market authorisation, and the regulatory pathway taken will depend on a product's characteristics and the target patient population. With the industry poised to deliver more late-stage clinical and commercial ATMPs for serious diseases with high unmet medical need (e...
June 14, 2019: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/30783568/the-origin-of-oxalis-corniculata-l
#18
Quentin J Groom, Jan Van der Straeten, Ivan Hoste
Background: Oxalis corniculata L. is a weed with a world-wide distribution and unknown origin. Though it belongs to a section of the genus from South America, the evidence that this species came from there is weak. Methods: We reviewed the evidence for the origin of O. corniculata using herbarium specimens, historic literature and archaeobotanical research. We also summarized ethnobotanical literature to understand where this species is most used by humans as a medicine...
2019: PeerJ
https://read.qxmd.com/read/30774136/production-of-extracellular-matrix-fibers-via-sacrificial-hollow-fiber-membrane-cell-culture
#19
Kevin Roberts, John Taehwan Kim, Shelby White, Jamie Hestekin, Jeffrey C Wolchok
Engineered scaffolds derived from extracellular matrix (ECM) have driven significant interest in medicine for their potential in expediting wound closure and healing. Extraction of extracellular matrix from fibrogenic cell cultures in vitro has potential for generation of ECM from human- and potentially patient-specific cell lines, minimizing the presence of xenogeneic epitopes which has hindered the clinical success of some existing ECM products. A significant challenge in in vitro production of ECM suitable for implantation is that ECM production by cell culture is typically of relatively low yield...
February 2, 2019: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/30766574/ethnobotanical-study-of-curative-plants-used-by-traditional-healers-to-treat-rhinitis-in-the-limpopo-province-south-africa
#20
Sebua Silas Semenya, Alfred Maroyi
Background: Studies focusing on plants used medicinally to heal and manage rhinitis are very scarce in Africa and elsewhere. Objectives: To document plants used by traditional healers (THs) in the treatment and management of rhinitis and related symptoms in the Limpopo Province of South Africa. Methods: Data was gathered using a semi structured interviews with 105 THs in the Limpopo Province, supplemented by field expeditions for plant specimen collection and observation...
December 2018: African Health Sciences
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