Riccardo Ferrero, Stefano Pantaleone, Cecilia Irene Gho, Gjylije Hoti, Francesco Trotta, Valentina Brunella, Marta Corno
Melatonin (MT) is a vital hormone controlling biorhythms, and optimizing its release in the human body is crucial. To address MT's unfavorable pharmacokinetics, we explored the inclusion complexes of MT with β-cyclodextrin (β-CD). Nano spray drying was applied to efficiently synthesize these complexes in three molar ratios (MT : β-CD = 1 : 1, 2 : 1, and 1 : 2), reducing reagent use and expediting inclusion. The complex powders were characterized through thermal analyses (TGA and DSC), Fourier transform infrared spectroscopy (FTIR), and in vitro MT release measurements via high-performance liquid chromatography (HPLC)...
April 3, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine