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neo-adjuvant chemotherapy

Mohamed M Abdelfatah, Eric M Gochanour
A 53-year-old male was diagnosed with invasive adenocarcinoma of the pre-pyloric region. Imaging studies ruled out metastatic disease. The patient underwent neo-adjuvant chemotherapy followed by a partial gastrectomy. CT scan at 18 months' post-resection demonstrated right upper quadrant lesions suspicious for metastatic disease. EUS exam shows two round hypoechoic lesions. Fine needle aspiration with suction was performed with on-site cytology confirming malignant cells in the masses. Five gold fiducial markers were placed...
February 7, 2019: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad, Mohamed Al Bashir
BACKGROUND: Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5' promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen and progesterone receptor-DNA binding domains as direct response elements to estrogen and progesterone that are linked to breast functions or steroid regulation. The study was designed to determine the role of TFF3 in breast cancer chemoresistance with the aim of establishing TFF3 expression as a biomarker for drug resistance...
February 11, 2019: BMC Cancer
Yahya Ashraf, Hanane Mansouri, Valérie Laurent-Matha, Lindsay B Alcaraz, Pascal Roger, Séverine Guiu, Danielle Derocq, Gautier Robin, Henri-Alexandre Michaud, Helène Delpech, Marta Jarlier, Martine Pugnière, Bruno Robert, Anthony Puel, Lucie Martin, Flavie Landomiel, Thomas Bourquard, Oussama Achour, Ingrid Fruitier-Arnaudin, Alexandre Pichard, Emmanuel Deshayes, Andrei Turtoi, Anne Poupon, Joëlle Simony-Lafontaine, Florence Boissière-Michot, Nelly Pirot, Florence Bernex, William Jacot, Stanislas du Manoir, Charles Theillet, Jean-Pierre Pouget, Isabelle Navarro-Teulon, Nathalie Bonnefoy, André Pèlegrin, Thierry Chardès, Pierre Martineau, Emmanuelle Liaudet-Coopman
BACKGROUND: Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for TNBC are urgently needed. Immunotherapy is emerging as an exciting treatment option for TNBC patients. The aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer (BC), is overproduced and hypersecreted by human BC cells. This study explores whether cath-D is a tumor cell-associated extracellular biomarker and a potent target for antibody-based therapy in TNBC...
February 4, 2019: Journal for Immunotherapy of Cancer
Nari Jung, Hye Jung Kim, Jin Hyang Jung, Sang-Woo Lee, Yee Soo Chae, Hyejin Cheon, So Mi Lee, Won Hwa Kim
To evaluate predictive factors for residual metastatic axillary lymph node (ALN) disease in patients with negative imaging findings after neo-adjuvant chemotherapy (NAC) for breast cancer. From January 2011 to December 2015, 206 patients underwent imaging including ultrasonography, MRI, and PET/CT for restaging the axilla after NAC. Data collected included preoperative information regarding histologic grade, hormone receptor (HR) status, and human epidermal growth factor receptor 2 (HER2) status. Multivariate logistic regression analysis was performed to compare patients with and without residual metastatic ALN disease among patients who showed negative imaging findings after NAC...
February 3, 2019: Breast Journal
Alberto De Gobbi, Mario Salvatore Mangano, Giandavide Cova, Claudio Lamon, Luigino Maccatrozzo
Renal cell carcinoma has extremely heterogeneous presentation at the diagnosis: it may present as a confined organ disease, locally advanced, metastatic to locoregional lymph nodes or with single or multiple systemic metastases. Since chemotherapy and radiation therapy have not demonstrated efficacy either in primary therapy or in neo-adjuvant or adjuvant therapy for renal clear cell carcinoma, targeted agents like tirosine kinase inhibitors were developed and are largely used in locally advanced and metastatic renal cell carcinoma...
February 1, 2019: Urologia
Beat Roth, Marc Alain Furrer, Ioannis Giannakis, Mihai Dorin Vartolomei, Silvan Boxler, Patrick Y Wuetrich, Fiona C Burkhard, George N Thalmann, Bernhard Kiss
PURPOSE: To investigate the influence of positive pre-cystectomy biopsies of the prostatic urethra (in male) or bladder neck (in female) on urethral recurrence, CSS, OS and functional outcomes after orthotopic bladder substitution (OBS). MATERIALS AND METHODS: Retrospective analysis on 803 consecutive patients with OBS (703 male, 100 female) and pre-cystectomy biopsies of the prostatic urethra or bladder neck at our institution between 04/1986 and 12/2017. RESULTS: 94% (755/803) had negative (Group A), 6% (48/803) positive (Group B) pre-cystectomy biopsies: CIS: 73% (n=35/48); pTaG1/G2: 10% (n=5/48); pTaG3/pT1G3 17% (n=8/48)...
January 25, 2019: Journal of Urology
Makoto Aoki, Hiroyuki Fukunari, Yosuke Kawai, Akemi Watanabe, Yuya Umebayashi, Toshifumi Saito, Kenji Shitara, Tetsuji Hayashi, Annenkov Alexey, Yoichi Ajioka
Case 1: A 75-year-old man underwent distal gastrectomy with Billroth Ⅰ reconstruction and resection of the involved transverse mesocolon. Microscopic examination revealed adenocarcinoma(tub2, tub1), pT4b(SI)N3M0, pStageⅢc. Adjuvant chemotherapy with S-1 was performed for 6 months after the operation. One year later, CT revealed a localized dissemination in the transverse mesocolon; therefore, we performed transverse colectomy. Adjuvant chemotherapy with PTX was performed, and the patient remains free from recurrence 7 years after the initialoperation...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Lucas Provenzano, Silva Bortolussi, Sara J González, Ian Postuma, Nicoletta Protti, Agustina Portu, Maria Silvina Olivera, Luis Miguel Rodriguez, Daniel Fregenal, Saverio Altieri
Osteosarcoma is the most common primary malignant tumour of bone in young patients. The survival of these patients has largely been improved due to adjuvant and neo-adjuvant chemotherapy in addition to surgery. Boron neutron capture therapy (BNCT) is proposed as a complementary therapy, due to its ability to inactivate tumour cells that may survive the standard treatment and that may be responsible for recurrences and/or metastases. BNCT is based on neutron irradiation of a tumour enriched in 10 B with a boron-loaded drug...
January 28, 2019: Radiation and Environmental Biophysics
I Thomassin-Naggara, E Daraï, F Lécuru, L Fournier
Transvaginal ultrasound is the first-line examination allowing characterizing 80 to 90% of adnexal masses (LP1). If performed by an expert, a subjective analysis is optimal. If performed by a non-expert, combining the use of Simple Rules with subjective analysis can achieve the diagnostic performance of an expert (LP1). Whichever the chosen model (subjective analysis by an expert or combination of the Simple Rules with a subjective analysis by a non-expert), a second-line examination will have to be proposed in the complex or indeterminate cases (about 20% of the masses) (grade A)...
January 24, 2019: Gynecologie, Obstetrique, Fertilite & Senologie
Teresa Vaz, Susy Costa, Bárbara Peleteiro
INTRODUCTION: Sentinel lymph node biopsy is currently the standard surgical procedure for lymph node staging in patients with early stage breast cancer. It is performed using different techniques, such as the injection of vital dyes and / or radioisotopes and, more recently, guided by fluorescence using Indocyanine green. The aim of this study is to assess the detection rate of sentinel lymph node using Indocyanine green in breast cancer patients according to factors related to the patient and the tumor...
December 28, 2018: Acta Médica Portuguesa
Sara Alothman, Saqib Saeed, Khuram Khan, Alexius Ramcharan, Hector DePaz
We report a case of giant mucinous carcinoma of the breast in a 55-year-old female who presented with left breast lump for two years. The patient did not seek any medical attention for two years. On exam, the lump measured 12 x 14 cm. Core needle biopsy showed invasive mucinous adenocarcinoma without ductal component. The patient underwent neo-adjuvant chemotherapy without any response. She underwent left modified radical mastectomy. All lymph nodes were negative. This was followed by adjuvant chemotherapy...
November 17, 2018: Curēus
Asle Charles Hesla, Øyvind Sverre Bruland, Nina Jebsen, Emelie Styring, Sigvard Eriksson, Panagiotis Tsagozis
Object: Many patients with Ewing sarcoma (ES) of the mobile spine present with neurologic symptoms leading to emergency decompressive surgery. Only rarely is optimal treatment involving neo-adjuvant chemotherapy followed by en bloc excision possible. The purpose of this study was to study treatment, neurologic and oncologic outcome in patients with ES of the mobile spine. Methods: Twenty-four patients diagnosed between 1986 and 2012 were identified through the Scandinavian Sarcoma Group registry. Charts were reviewed in order to assess details in patient characteristics, neurologic status, treatment and outcome...
February 2019: Journal of Bone Oncology
Wenhua Ma, Fugang Zhao, Changpeng Zhou, Yongqian Zhang, Yingchun Zhao, Na Li, Peng Xie
Aim: To evaluate efficacy and safety of lapatinib or trastuzumab alone or both plus chemotherapy for the treatment of breast cancer patients with positive HER-2 expression. Methods: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, OVID, Embase, Chinese Biomedical Literature Database, and China Academic Journals Database were searched from 1994 through December 2017 using the keywords "breast cancer", "preoperative", "neo-adjuvant", "lapatinib", "pertuzumab", "Herceptin", and "trastuzumab"...
2019: OncoTargets and Therapy
Tom van den Ende, Emil Ter Veer, Mélanie Machiels, Rosa M A Mali, Frank A Abe Nijenhuis, Laura de Waal, Marety Laarman, Suzanne S Gisbertz, Maarten C C M Hulshof, Martijn G H van Oijen, Hanneke W M van Laarhoven
Background : Alternatives in treatment-strategies exist for resectable gastric cancer. Our aims were: (1) to assess the benefit of perioperative, neoadjuvant and adjuvant treatment-strategies and (2) to determine the optimal adjuvant regimen for gastric cancer treated with curative intent. Methods : PubMed, EMBASE, CENTRAL, and ASCO/ESMO conferences were searched up to August 2017 for randomized-controlled-trials on the curative treatment of resectable gastric cancer. We performed two network-meta-analyses (NMA)...
January 11, 2019: Cancers
Rekha Priyadarshini, Gerard Marshall Raj, Smita Kayal, Ananthakrishnan Ramesh, Deepak Gopal Shewade
WHAT IS KNOWN AND OBJECTIVE: Variable response to docetaxel-based neo-adjuvant chemotherapy (NACT) in breast cancer patients had been reported. Genetic polymorphisms in the ABCB1 gene coding for the efflux transporter MDR1 (P-glycoprotein, P-gp) could result in altered tumour response. Hence, this study was proposed to assess the effect of single nucleotide polymorphisms (SNPs) of ABCB1 gene on tumour response in locally advanced breast cancer patients (LABC) of South India who have a distinct genetic makeup...
January 13, 2019: Journal of Clinical Pharmacy and Therapeutics
Alex Friedlaender, Aurélie Vuilleumier, Valeria Viassolo, Aurélie Ayme, Solène De Talhouet, Jean-Damien Combes, Julien Peron, Alexandre Bodmer, Sophie Giraud, Adrien Buisson, Valerie Bonadona, Isabelle Gauchat-Bouchardy, Olivier Tredan, Pierre O Chappuis, S Intidhar Labidi-Galy
PURPOSE: BRCA1 and BRCA2 proteins are central to DNA repair process through homologous recombination. We hypothesize that BRCA1/BRCA2 mutation carriers may exhibit increased hematological toxicity when receiving genotoxic chemotherapy. METHODS: We included women with primary breast cancers screened for BRCA1/BRCA2 germline mutations and treated with (neo)adjuvant chemotherapy in Geneva (Swiss cohort). The primary endpoint was the incidence of febrile neutropenia following the first chemotherapy cycle (C1)...
January 11, 2019: Breast Cancer Research and Treatment
Xiaojing Zhang, Zunfu Lv, Hanmei Lou
BACKGROUND: Neuroendocrine cervical carcinoma (NECC) is a rare but aggressive form of cervical cancer representing less than 3% of all cervical cancer cases. The objective of this study is to evaluate the effects of the clinicopathologic features and treatment modalities on the survival of patients with NECC. METHODS: In all, 89 stage I-IV patients with NECC that were diagnosed and treated between 2006 and 2014 at the Zhejiang Cancer Hospital were retrospectively recruited in this study...
January 7, 2019: BMC Cancer
J Th C M de Kruif, M Visser, M M G A van den Berg, M J M Derks, M R de Boer, H W M van Laarhoven, J H M de Vries, Y C de Vries, E Kampman, R W Winkels, M J Westerman
BACKGROUND: More than 60% of women diagnosed with early stage breast cancer receive (neo)adjuvant chemotherapy. Breast cancer patients receiving chemotherapy often experience symptoms such as nausea, vomiting and loss of appetite that potentially affect body weight and body composition. Changes in body weight and body composition may detrimentally affect their quality of life, and could potentially increase the risk of disease recurrence, cardiovascular disease and diabetes. To date, from existing single method (quantitative or qualitative) studies is not clear whether changes in body weight and body composition in breast cancer patients are treatment related because previous studies have not included a control group of women without breast cancer...
January 5, 2019: BMC Cancer
Takayuki Ota, Takeshi Ishikawa, Yuki Endo, Shinya Matsumura, Juichirou Yoshida, Tomoyo Yasuda, Tetsuya Okayama, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Naoyuki Sakamoto, Kazuhiro Kamada, Kazuhiko Uchiyama, Tomohisa Takagi, Hideyuki Konishi, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Mitsuo Kishimoto, Yuji Naito, Yoshito Itoh
Undernutrition and sarcopenia are associated with a higher incidence of chemotherapy-related toxicity and a poor prognosis in several kinds of cancer, but the impact of sarcopenia on the outcomes of chemotherapy for esophageal cancer remains unclear. Thus, the purpose of this retrospective study was to investigate whether sarcopenia affects the efficacy and toxicities of chemotherapy for advanced esophageal cancer patients. Data were collected from 31 esophageal cancer patients who underwent neo-adjuvant chemotherapy followed by surgery...
January 2, 2019: Medical Oncology
Shin-Ae Kang, Jye Swei Guan, Hock Jin Tan, Tinghine Chu, Aye Aye Thike, Cristina Bernadó Morales, Joaquin Arribas, Chow Yin Wong, Puay Hoon Tan, Mihir Gudi, Thomas C Putti, Joohyuk Sohn, Swee Ho Lim, Soo-Chin Lee, Yoon Pin Lim
PURPOSE: Trastuzumab-based chemotherapy has shown remarkable clinical benefits for HER2-positive breast cancer patients. However, treatment regimens involving trastuzumab had little or no effect for a subset of patients. Preliminary studies revealed WW-binding protein 2 (WBP2), an oncogenic transcription co-activator, to be co-amplified with HER2 in 36% of HER2-positive breast cancers. We hypothesize that WBP2 regulates and correlates with the response of HER2-positive breast cancer to trastuzumab...
December 28, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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