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JOURNAL ARTICLE
Fausto Petrelli, Maria Antista, Francesca Marra, Fulvia Milena Cribiu', Valentina Rampulla, Filippo Pietrantonio, Lorenzo Dottorini, Michele Ghidini, Andrea Luciani, Alberto Zaniboni, Gianluca Tomasello
BACKGROUND: Perioperative chemotherapy (CT) is an established therapeutic approach for patients diagnosed with stage IB-III gastric cancer (GC). OBJECTIVES: This study aimed to investigate the efficacy of this approach in individuals with GC exhibiting high microsatellite instability (MSI-H). DESIGN: A systematic review was conducted, including studies that provided data on (neo)adjuvant CT outcomes in patients with MSI-H GC. METHODS: Systematic searches were conducted in PubMed, Cochrane Central of Controlled Trials, and Embase databases...
2024: Therapeutic Advances in Medical Oncology
#22
REVIEW
Mengyuan Liu, Alice C Wei
A multimodality approach, which usually includes chemotherapy, surgery, and/or radiotherapy, is optimal for patients with localized pancreatic cancer. The timing and sequence of these interventions depend on anatomic resectability and the biological suitability of the tumor and the patient. Tumors with vascular involvement (ie, borderline resectable/locally advanced) require surgical reassessments after therapy and participation of surgeons familiar with advanced techniques. When indicated, venous reconstruction should be offered as standard of care because it has acceptable morbidity...
February 29, 2024: Hematology/oncology Clinics of North America
#23
REVIEW
Swagata Dilip Tavhare
Millets, the nutria-cereals, are one of the oldest utilized grain. Millets are reported to possess nutraceuticals health benefits which include improvement in functioning of digestive system, reduction in cholesterol, prevention of heart disease, protection against diabetes, lowering risks of cancer etc. With the widespread commemoration of the International Year of Millets in 2023, the Indian government is moving towards the global recognition of millets in light of its medicinal value in correction of lifestyles diseases...
February 28, 2024: Journal of Ayurveda and Integrative Medicine
#24
JOURNAL ARTICLE
Yong Ho You, Min Kyoon Kim, Joo Yun Lee
PURPOSE: Proper breast cancer screening and treatment should be considered in the elderly population; however, some tend to be less proactive. Our study aimed to investigate the impact of old age on treatment and prognosis in triple-negative breast cancer (TNBC). METHOD: The study included patients with primary TNBC stage I-III diagnosed from 2002 to 2019 in single institution and retrospectively analyzed. We defined young (< 40 years), middle and old (> 70 years) groups...
January 30, 2024: Clinical Breast Cancer
#25
JOURNAL ARTICLE
Meng-Qi Jiang, Li-Qiang Qian, Yu-Jia Shen, Yuan-Yuan Fu, Wen Feng, Zheng-Ping Ding, Yu-Chen Han, Xiao-Long Fu
BACKGROUND: Despite promising overall survival of stage I lung adenocarcinoma (LUAD) patients, 10-25 % of them still went through recurrence after surgery. [1] While it is still disputable whether adjuvant chemotherapy is necessary for stage I patients. [2] IASLC grading system for non-mucinous LUAD shows that minor high-grade patterns are significant indicator of poor prognosis. [3] Other risk factors, such as, pleura invasion, lympho-vascular invasion, STAS, etc. are also related to poor prognosis...
February 21, 2024: Neoplasia: An International Journal for Oncology Research
#26
JOURNAL ARTICLE
Rehena Sulthana, Akshita Singh
Background Sentinel lymph node biopsy (SLNB) is based on the hypothesis that lymph from a primary solid neoplasm drains into one or more sentinel nodes, which are the first nodes at risk for harbouring occult metastatic disease. Sentinel lymph node biopsy has replaced axillary lymph node dissection (ALND) as the standard method for axillary staging in clinically node-negative patients. It avoids the complications associated with ALND and allows assessment of nodal status in patients with clinically node-negative breast cancer...
January 2024: Curēus
#27
JOURNAL ARTICLE
Jonathan Servayge, Ester P Olthof, Constantijne H Mom, Maaike A van der Aa, Hans H B Wenzel, Jacobus van der Velden, Remi A Nout, Ingrid A Boere, Helena C van Doorn, Heleen J van Beekhuizen
AIM: To investigate and compare overall survival (OS), disease-free survival (DFS) and toxicity of women who underwent either chemoradiotherapy with or without prior lymph node debulking or upfront chemotherapy followed by radiotherapy and hyperthermia (triple therapy) for locally advanced cervical cancer (LACC) to identify a potential role for triple therapy. METHODS: Women with histologically proven LACC and with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB2 and IIA2 to IVA were included...
February 1, 2024: Cancers
#28
JOURNAL ARTICLE
Takayuki Iwamoto, Hiraku Kumamaru, Naoki Niikura, Yasuaki Sagara, Minoru Miyashita, Takaaki Konishi, Naoko Sanuki, Kenta Tanakura, Masayuki Nagahashi, Naoki Hayashi, Masayuki Yoshida, Chie Watanabe, Naoko Kinukawa, Masakazu Toi, Shigehira Saji
This is a prognostic report by the Japanese Breast Cancer Society on breast cancer extracted from the National Clinical Database-Breast Cancer Registry of Japan. Here, we present a summary of 457,878 breast cancer cases registered between 2004 and 2016. The median follow-up duration was 5.6 years. The median age at the start of treatment was 59 years (5-95%: 38-82 years) and increased from 57 years between 2004 and 2008 to 60 years between 2013 and 2016. The proportion of patients with Stage 0-II disease increased from 74...
March 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
#29
REVIEW
Sarah M Dry
Dedifferentiation traditionally is defined by descriptive criteria as a tumor showing an abrupt change in histology from a conventional, classic, low-grade appearing neoplasm to a tumor that is more cellular, pleomorphic and "high grade", with grading typically being performed by subjective criteria. The dedifferentiated areas range from areas with recognizable histologic differentiation which differs from the primary tumor (such as an osteosarcoma arising from a low-grade chondrosarcoma) to areas containing sarcomas without specific histologic differentiation (such as pleomorphic or spindle cell sarcoma)...
February 2, 2024: Human Pathology
#30
JOURNAL ARTICLE
Vanessa Petry, Renata Colombo Bonadio, Karina Moutinho, Luiz Senna Leite, Laura Testa, Daniela J B Heinemann Cohn, Allyne Carneiro Cagnacci, Veronica E H Kim, Maria Del Pilar Estevez-Diz, Maria Candida Barrisson Villares Fragoso
PURPOSE: Breast cancer (BC) is the most common malignancy in female patients with Li-Fraumeni syndrome (LFS), a condition associated with an increased risk of various malignancies, including radiation therapy (RT)-induced malignancies (RIM) within previously irradiated areas. Our study aimed to assess the incidence of RIM in patients with LFS and early-stage BC treated with adjuvant RT, including the effect of RT dose and technique. METHODS AND MATERIALS: We examined patients with a germline pathogenic/likely pathogenic TP53 variant diagnosed with early-stage BC and monitored by a hereditary cancer team at a single cancer center...
February 1, 2024: International Journal of Radiation Oncology, Biology, Physics
#31
JOURNAL ARTICLE
Kingsley Bosompem, Joseph Yorke, Tonnies Abeku Buckman, Samuel Gyasi Brenu, Michael Nyantakyi, Francis Somiah-Kwaw Aitpillah, Ishmael Kyei, Michael Ofoe Adinku, Dennis Afful Yorke, Christian Obirikorang, Emmanuel Acheampong
Breast cancer is increasingly common among young women in Ghana. BCa is heterogeneous with unique traits that impact causes, prognostic, and predictive outcomes of patients before and after menopause. However, limited evidence exists on differences between young premenopausal (YPM) and postmenopausal cases in Ghana. This study compared breast tumour characteristics between YPM women (under 35 years) and postmenopausal women. We conducted a prospective cross-sectional study involving 140 BCa-diagnosed women at the Breast Care Clinic of Komfo Anokye Teaching Hospital (KATH), Kumasi from November 2019 to June 2021...
February 1, 2024: Scientific Reports
#32
JOURNAL ARTICLE
Patricia A Ganz, Hanna Bandos, Tanja Španić, Sue Friedman, Volkmar Müller, Sherko Kuemmel, Suzette Delaloge, Etienne Brain, Masakazu Toi, Hideko Yamauchi, Eduardo-M de Dueñas, Anne Armstrong, Seock-Ah Im, Chuan-Gui Song, Hong Zheng, Tomasz Sarosiek, Priyanka Sharma, Cuizhi Geng, Peifen Fu, Kerstin Rhiem, Heike Frauchiger-Heuer, Pauline Wimberger, Daphné t'Kint de Roodenbeke, Ning Liao, Annabel Goodwin, Camille Chakiba-Brugère, Michael Friedlander, Keun Seok Lee, Sylvie Giacchetti, Toshimi Takano, Fernando Henao-Carrasco, Shamsuddin Virani, Frances Valdes-Albini, Susan M Domchek, Charles Bane, Edward C McCarron, Monica Mita, Giovanna Rossi, Priya Rastogi, Anitra Fielding, Richard D Gelber, Elsemieke D Scheepers, David Cameron, Judy Garber, Charles E Geyer, Andrew N J Tutt
PURPOSE: The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline BRCA1/2 , high-risk human epidermal growth factor receptor 2-negative early breast cancer after completing (neo)adjuvant chemotherapy ([N]ACT), surgery, and radiotherapy. The patient-reported outcome primary hypothesis was that OL-treated patients may experience greater fatigue during treatment. METHODS: Data were collected before random assignment, and at 6, 12, 18, and 24 months...
February 1, 2024: Journal of Clinical Oncology
#33
JOURNAL ARTICLE
Ramachandra Mohan Rao Pandhari, Tarikere Chandrashekharappa Taranath
OBJECTIVE: Ethnomedicinally Simarouba glauca DC is an important plant containing major class of phenols and terpenoids as bioactive compounds. The present study focuses on the evaluation of the anticancer effects of S. glauca bark UAE-EA (Ultrasonicator Assisted Extraction - Ethyl Acetate) fraction (SG-Fraction) against MDA-MB-231 triple negative breast cancer cell lines. METHODS: UAE-EA technique was used for the extraction of phytochemicals from S. glauca bark...
January 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
#34
REVIEW
Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka
Surgical resection is the most effective therapeutic option for the cure in early stage resectable non-small-cell lung cancer (NSCLC). However, despite complete resection, up to 70% of patients die within 5 years mainly due to tumor recurrence in extra-thoracic organs. Adjuvant or neoadjuvant platinum-based chemotherapy may improve postoperative survival, but the absolute survival benefit is modest with an around 5% improvement at 5 years. Recent advance in systemic therapy has changed treatment strategy for advanced unresectable NSCLC, and also has provided a paradigm shift in treatment strategy for resectable NSCLC...
January 28, 2024: International Journal of Clinical Oncology
#35
JOURNAL ARTICLE
Petros Grivas, Damien Pouessel, Chandler H Park, Philippe Barthelemy, Manojkumar Bupathi, Daniel P Petrylak, Neeraj Agarwal, Sumati Gupta, Aude Fléchon, Chethan Ramamurthy, Nancy B Davis, Alejandro Recio-Boiles, Cora N Sternberg, Astha Bhatia, Cabilia Pichardo, Mitch Sierecki, Julia Tonelli, Huafeng Zhou, Scott T Tagawa, Yohann Loriot
PURPOSE: Pembrolizumab is standard therapy for patients with metastatic urothelial cancer (mUC) who progress after first-line platinum-based chemotherapy; however, only approximately 21% of patients respond. Sacituzumab govitecan (SG) is a trophoblast cell surface antigen-2-directed antibody-drug conjugate with US Food and Drug Administration-accelerated approval to treat patients with locally advanced or mUC who previously received platinum-based chemotherapy and a checkpoint inhibitor (CPI)...
January 23, 2024: Journal of Clinical Oncology
#36
JOURNAL ARTICLE
Corrado Tinterri, Bethania Fernandes, Alberto Zambelli, Andrea Sagona, Erika Barbieri, Simone Di Maria Grimaldi, Shadya Sara Darwish, Flavia Jacobs, Camilla De Carlo, Martina Iuzzolino, Damiano Gentile
BACKGROUNDS: The majority of breast cancer (BC) patients treated with neo-adjuvant chemotherapy (NAC) achieves a pathologic partial response with different patterns of residual disease. No clear correlation between these patterns and oncological results was described. Our aims were to define the predictive factors for different patterns of residual disease and compare the outcomes between the scattered versus the circumscribed pattern. METHODS: We reviewed 219 postoperative surgical specimens...
January 16, 2024: Cancers
#37
REVIEW
Jacek Wilczyński, Edyta Paradowska, Miłosz Wilczyński
High-grade serous tubo-ovarian cancer (HGSTOC) is the most lethal tumor of the female genital tract. The foregoing therapy consists of cytoreduction followed by standard platinum/taxane chemotherapy; alternatively, for primary unresectable tumors, neo-adjuvant platinum/taxane chemotherapy followed by delayed interval cytoreduction. In patients with suboptimal surgery or advanced disease, different forms of targeted therapy have been accepted or tested in clinical trials. Studies on HGSTOC discovered its genetic and proteomic heterogeneity, epigenetic regulation, and the role of the tumor microenvironment...
December 29, 2023: Journal of Personalized Medicine
#38
JOURNAL ARTICLE
Yair Peled, Dror Levin, Michal Manisterski, Netania Kollander, Rachel Shukrun, Ronit Elhasid
BACKGROUND: Weight loss and malnutrition are common findings in pediatric oncology patients, but their prognostic significance is controversial. We sought to evaluate the correlation between weight loss and response to neo-adjuvant chemotherapy in pediatric patients with osteosarcoma. PROCEDURE: All medical files of patients treated for osteosarcoma in a single pediatric haemato-oncology center between January 2011 and October 2022 were retrospectively reviewed...
January 18, 2024: European Journal of Clinical Nutrition
#39
REVIEW
Alessandra Elvevi, Alice Laffusa, Federica Elisei, Sabrina Morzenti, Luca Guerra, Antonio Rovere, Pietro Invernizzi, Sara Massironi
Intrahepatic cholangiocarcinoma (iCCA) is recognized as the second most frequently diagnosed liver malignancy, following closely after hepatocellular carcinoma. Its incidence has seen a global upsurge in the past several years. Unfortunately, due to the lack of well-defined risk factors and limited diagnostic tools, iCCA is often diagnosed at an advanced stage, resulting in a poor prognosis. While surgery is the only potentially curative option, it is rarely feasible. Currently, there are ongoing investigations into various treatment approaches for unresectable iCCA, including conventional chemotherapies, targeted therapies, immunotherapies, and locoregional treatments...
December 27, 2023: World Journal of Hepatology
#40
JOURNAL ARTICLE
Deying Zhao, Shaoxing Sun, Zhiyong Yang, Ping Wang, Hui Qiu
Small-cell neuroendocrine carcinoma of the cervix (SCNCC) is a rare and aggressive tumor with a poor prognosis. Surgical resection followed by adjuvant therapy is the standard treatment for early-stage disease, but the influence of different neo/adjuvant treatment approaches remains unclear. Retrospectively, we collected patients' characteristics and treatments in two medical centers. Disease status and survival outcomes were renewed through follow-up. Statistics analysis mainly included Kaplan-Meier methods for survival curve estimation, log-rank test for survival curve comparison, and Cox proportional hazards models for independent prognostic factors prediction...
January 12, 2024: Neoplasma
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