Dawn Bannerman, Simon Pascual Gil de Gomez, Qinghua Wu, Ian Fernandes, Yimu Zhao, Karl T Wagner, Sargol Okhovatian, Shira Landau, Naimeh Raftian, David F Bodenstein, Ying Wang, Trevor R Nash, Gordana Vunjak-Novakovic, Gordon Keller, Slava Epelman, Milica Radisic
Epicardial cells (EPIs) form the outer layer of the heart and play an important role in development and disease. Current heart-on-a-chip platforms still do not fully mimic the native cardiac environment due to the absence of relevant cell types, such as EPIs. Here, using the Biowire II platform, we constructed engineered cardiac tissues with a defined epicardial outer layer and inner myocardial structure, and developed an image analysis approach to track the EPI cell migration in a beating myocardial environment...
April 29, 2024: Advanced Healthcare Materials