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In-Soo Kim, Hyun-Jung Kim, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
BACKGROUND: Amiodarone, which inhibits CYP2C9 and P-glycoprotein, is commonly prescribed with non-vitamin K antagonist oral anticoagulants (NOACs) and polypharmacy in high-risk atrial fibrillation (AF) patients. We studied efficacy and safety of NOACs in AF patients receiving amiodarone, P-glycoprotein inhibitor, or polypharmacy. METHODS: After a systematic database search (Medline, EMBASE, CENTRAL, SCOPUS, and Web of Science), four phase-III randomized trials comparing NOACs and warfarin in "with/without amiodarone," "with/without P-glycoprotein inhibitors," or "with/without multiple (≥5, polypharmacy) concomitant drugs" subgroups were included...
February 12, 2019: Journal of Cardiology
Ye Ji Shim, Yun Jung Bae, Gwang Seok An, Kyogu Lee, Yoonjoong Kim, Sang-Youp Lee, Byung Yoon Choi, Byung Se Choi, Jae Hyoung Kim, Ja-Won Koo, Jae-Jin Song
OBJECTIVE: To investigate the effects of cavitating lesions involving the internal auditory canal (IAC) in subjects with cochlear otosclerosis with regard to poststapedotomy hearing outcome. STUDY DESIGN: Retrospective study. SETTING: Tertiary referral center. PATIENTS: A retrospective chart review of 134 subjects with otosclerosis treated from January 2011 to June 2017 at Seoul National University Bundang Hospital was conducted...
March 2019: Otology & Neurotology
Peter Nai Yuh Yek, Rock Keey Liew, Mohammad Shahril Osman, Chern Leing Lee, Joon Huang Chuah, Young-Kwon Park, Su Shiung Lam
Microwave-steam activation (MSA), an innovative pyrolysis approach combining the use of microwave heating and steam activation, was investigated for its potential production of high grade activated carbon (AC) from waste palm shell (WPS) for methylene blue removal. MSA was performed via pyrolytic carbonization of WPS to produce biochar as the first step followed by steam activation of the biochar using microwave heating to form AC. Optimum yield and adsorption efficiency of methylene blue were obtained using response surface methodology involving several key process parameters...
February 5, 2019: Journal of Environmental Management
Soon-Jung Park, Ji-Heon Lee, Seul-Gi Lee, Jeoung Eun Lee, Joseph Seo, Jong Jin Choi, Taek-Hee Jung, Eun-Bin Chung, Ha Na Kim, Jongil Ju, Yun-Ho Song, Hyung-Min Chung, Dong Ryul Lee, Sung-Hwan Moon
The derivation of human embryonic stem cells (hESCs) by somatic cell nuclear transfer (SCNT) has prompted a re-emerging interest in utilizing such cells for therapeutic cloning. Despite recent advancements in derivation protocols, the functional potential of CHA-NT4 derived cells is yet to be elucidated. For this reason, this study sought to differentiate CHA-NT4 cells toward an endothelial lineage in order to evaluate in vitro and in vivo functionality. To initial differentiation, embryoid body formation of CHA-NT4 was mediated by concave microwell system which was optimized for hESC-endothelial cell (EC) differentiation...
February 5, 2019: Stem Cells
Keon Ho, Seunghyun Moon, Hyung Chae Lee, Young Kyu Hwang, Chang-Ha Lee
Removal of gaseous radioactive iodine (131 I and 129 I) compounds from nuclear facilities is an important issue. Herein we assessed the adsorptive capacity of gaseous non-radioactive methyl iodide (CH3 127 I) as a simulant on two commercial TEDA-metal impregnated activated carbon(AC)s. The characterizations of the ACs were determined ICP-MS, XPS, and 77 K N2 isotherms. As a result, it was found that one AC has a small amount of TEDA but a well-developed porosity, and the other one was abundant with TEDA, but the porosity was relatively less developed...
January 24, 2019: Journal of Hazardous Materials
Magdalena Sanz Cortes, Ivan Davila, Paola Torres, Mayel Yepez, Wesley Lee, Carolina V Guimaraes, Haleh Sangi-Haghpeykar, William Whitehead, Jonathan Castillo, Ahmed A Nassr, Jimmy Espinoza, Alireza Shamshirsaz, Michael Belfort
BACKGROUND: Fetoscopic myelomeningocele (MMC) repair has unknown effects on fetal growth. Fetal surgery itself and/or exposure to a CO2 environment during spina bifida repair may affect placental function and impair fetal growth. OBJECTIVE: To assess growth in fetuses and infants with MMC who underwent a prenatal fetoscopic or open repair. STUDY DESIGN: Fetal biometrics were serially measured using ultrasound after fetoscopic (N=32) or open hysterotomy (N=34) in-utero MMC repair...
January 23, 2019: Ultrasound in Obstetrics & Gynecology
Byunghun Lee, Maysam Ghovanloo
An adaptive averaging low noise analog front-end (AFE) is presented for central and peripheral nerve recording applications. The proposed topology allows users to trade off, on the fly, between input referred noise and the number of channels via averaging. The new low noise amplifier (LNA) utilizes a complementary doubled input transconductance ( g m ) topology to effectively increase the noise efficiency factor (NEF) without chopping or use of a costly BiCMOS process. It addresses a disadvantage of the doubled- g m technique by a high input impedance DC-coupled LNA and saves on-chip space for higher density by eliminating AC-coupling capacitors...
July 2018: IEEE Transactions on Circuits and Systems. II, Express Briefs: a Publication of the IEEE Circuits and Systems Society
In Young Yoo, Hee Jae Huh, On-Kyun Kang, Byung Woo Jhun, Won-Jung Koh, Nam Yong Lee
BACKGROUND: The AdvanSure MDR-TB GenoBlot Assay detects isoniazid- and rifampin-resistant tuberculosis using mutation-specific probes, including probes to disputed rpoB mutations. The aim of this study was to evaluate the clinical usefulness of molecular drug susceptibility testing (DST) using the AdvanSure assay with weekly batch testing in routine clinical laboratory settings in a country with an intermediate tuberculosis burden. METHODS: The AdvanSure assay was evaluated against an absolute concentration (AC) method and the Mycobacterial Growth Indicator Tube (MGIT) 960 System, which are phenotypic DST methods, using 496 Mycobacterium tuberculosis (MTB) isolates...
January 2019: Respiratory Medicine
Linde van Lee, Sarah R Crozier, Izzuddin M Aris, Mya T Tint, Suresh Anand Sadananthan, Navin Michael, Phaik Ling Quah, Sian M Robinson, Hazel M Inskip, Nicholas C Harvey, Mary Barker, Cyrus Cooper, Sendhil S Velan, Yung Seng Lee, Marielle V Fortier, Fabian Yap, Peter D Gluckman, Kok Hian Tan, Lynette P Shek, Yap-Seng Chong, Keith M Godfrey, Mary F F Chong
Background: Choline status has been positively associated with weight and fat mass in animal and human studies. As evidence examining maternal circulating choline concentrations and offspring body composition in human infants/children is lacking, we investigated this in two cohorts. Methods: Maternal choline concentrations were measured in the UK Southampton Women's Survey (SWS; serum, n = 985, 11 weeks' gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n = 955, 26-28 weeks' gestation) mother-offspring cohorts...
January 11, 2019: International Journal of Epidemiology
Te-An Kung, Shu-Hui Lee, Wei-Hsien Wang
A precise and reliable analytical method to measure trace levels of sulfamonomethoxine (SMM) and N4 -acetyl metabolite in tilapia samples using liquid chromatography-tandem mass spectrometry was developed. Optimized chromatographic separation was performed on C18 reversed-phase columns using gradient elution with methanol and 5 mmol/L of an ammonium acetate aqueous solution (adjusted to pH 3.5 using formic acid). This study investigated the pharmacokinetic properties and tissue distribution of SMM and its major metabolite N4 -acetyl sulfamonomethoxine (AC-SMM) in tilapia after a single dose of 100 mg kg-1 body weight of orally administered SMM...
January 2019: Journal of Food and Drug Analysis
In-Yu Lin, Yi-Shiou Chiou, Li-Ching Wu, Chen-Yu Tsai, Chiung-Tong Chen, Wu-Chang Chuang, Ming-Chung Lee, Ching-Che Lin, Ting-Ting Lin, Ssu-Ching Chen, Min-Hsiung Pan, Nianhan Ma
CCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transaminase (GOT) and glutamic pyruvic transaminase (GPT), prevented liver damage and collagen deposition, and downregulated TGF-β/Smad signaling in a dose-dependent manner compared with CCl4 treatment alone...
January 2019: Journal of Food and Drug Analysis
Bombi Lee, Riwon Hong, Pooreum Lim, Daeun Cho, Mijung Yeom, Sanghyun Lee, Ki Sung Kang, Sang Cheon Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm
BACKGROUND: Post-traumatic stress disorder (PTSD) is a disease associated with that the experience of traumatic stress. The traumatic experience results in the development of a prolonged stress response that causes impaired memory function and increased inflammation in the hippocampus. Currently, antidepressants are the only approved therapy for PTSD. However, the efficacy of antidepressants in the treatment of PTSD is marginal. The ethanol extract of Aralia continentalis (AC) is traditionally used in oriental medicine, and has been showed to possess pharmacological properties, including anti-inflammatory, anti-cancer, anti-atherosclerotic, and anti-diabetic effects...
January 8, 2019: BMC Complementary and Alternative Medicine
Younghyun Cho, Chung-Yul Yoo, Seung Woo Lee, Hana Yoon, Ki Sook Lee, SeungCheol Yang, Dong Kook Kim
Flow-electrode-based capacitive deionization (FCDI) has attracted much attention owing to its continuous and scalable desalination process without the need for a discharging step, which is required in conventional fixed-electrode capacitive deionization. However, flow electrode slurry is poorly conductive, which restricts desalination performance, but higher carbon mass loading in the slurry could improve salt removal capacity due to enhanced connectivity. However, increased viscosity restricts higher loading of active materials...
December 7, 2018: Water Research
Jaeyeon Lee, Se-Hwan Lee, Byung Soo Kim, Young-Sam Cho, Yongdoo Park
Background: Bioprinting has recently appeared as a powerful tool for building complex tissue and organ structures. However, the application of bioprinting to regenerative medicine has limitations, due to the restricted choices of bio-ink for cytocompatible cell encapsulation and the integrity of the fabricated structures. Methods: In this study, we developed hybrid bio-inks based on acrylated hyaluronic acid (HA) for immobilizing bio-active peptides and tyramine-conjugated hyaluronic acids for fast gelation...
December 2018: Tissue Engineering and Regenerative Medicine
Chou-Jui Lin, Shih-Wei Lee, Chi-Wei Liu, Chih-Pin Chuu, Yung-Hsi Kao, Lawrence Shih-Hsin Wu
BACKGROUND: Suppressors of cytokine signaling (SOCS), particularly SOCS-3, allow discrimination of patients with active tuberculosis (TB) from healthy subjects in a gender- and age-dependent manner. However, no information is available on whether single nucleotide polymorphisms (SNPs) in the SOCS-3 gene occur in patients with TB. This study was designed to investigate SOCS-3 SNPs in association with susceptibility to TB in the Taiwanese population. METHODS: Four SNPs in the SOCS-3 gene located at rs8064821, rs4969168, rs2280148, and rs35037722 were studied by the TaqMan SNP Genotyping assay in 200 healthy and 210 TB patients enrolled in 2015-2018...
December 20, 2018: Cytokine
Yeondong Cho, Yoonki Heo, Hanul Choi, Ki Hoon Park, Sehyun Kim, Yuyeon Jang, Hee-Jung Lee, Minji Kim, Young Bong Kim
PERV is a major virus concerning xenotransplantation study. However, the interesting part is that PERV is present in all kinds of pigs without pathogenicity and immune response. Furthermore, since pig cells have receptors for PERV, the gene delivery system using PERV envelope is highly likely to develop into an excellent viral vector in pigs. We developed a recombinant baculovirus with a modified surface for expressing the porcine endogenous retrovirus (PERV) envelope. Porcine reproductive and respiratory syndrome virus (PRRSV) infection is a severe concern in the porcine industry due to reproduction failure and respiratory symptoms...
December 20, 2018: Animal Biotechnology
Sungkyoung Choi, Sungyoung Lee, Yongkang Kim, Heungsun Hwang, Taesung Park
Although genome-wide association studies (GWAS) have successfully identified thousands of single nucleotide polymorphisms (SNPs) associated with common diseases, these observations are limited for fully explaining "missing heritability". Determining gene-gene interactions (GGI) are one possible avenue for addressing the missing heritability problem. While many statistical approaches have been proposed to detect GGI, most of these focus primarily on SNP-to-SNP interactions. While there are many advantages of gene-based GGI analyses, such as reducing the burden of multiple-testing correction, and increasing power by aggregating multiple causal signals across SNPs in specific genes, only a few methods are available...
October 30, 2018: Journal of Bioinformatics and Computational Biology
Jun Woo Park, Soo Jung Lee
PURPOSE: To compare the characteristics and surgical outcomes in patients with tenacious proximal fusion (TPF) and high accommodative convergence/accommodation ratio (AC/A) types of intermittent exotropia. METHODS: This study retrospectively enrolled 40 patients with intermittent exotropia, 23 with TPF and 17 with high AC/A. Binocular function was evaluated by Worth's 4-dot test. Patients underwent lateral rectus recession, and surgical outcomes were compared. Surgical success was defined as less than ±10 prism diopters (PD) at 12 months postoperatively...
December 2018: Korean Journal of Ophthalmology: KJO
Yu-Ping Lee, Hsin-Yu Liu, Po-Chun Lin, Yi-Huan Lee, Leng-Rong Yu, Chih-Chen Hsieh, Po-Jen Shih, Wen-Pin Shih, I-Jong Wang, Jia-Yush Yen, Chi-An Dai
Biocompatible and highly porous network hydrogel scaffolds were fabricated for the development of artificial cornea (AC) periphery/skirt that could be used to enhance the long-term retention of the implants. In this study, a series of hydrogel scaffolds for this application was fabricated from the photo-polymerization of a mixture of poly(ethylene glycol) (PEG)- and poloxamer (P407)-based macromer solutions in dichloromethane in which solvent-induced phase separation (SIPS) arose to form scaffolds with macroporous structure and high water content...
November 8, 2018: Colloids and Surfaces. B, Biointerfaces
Yang Woo Kwon, Seung Jun Lee, Soon Chul Heo, Tae Wook Lee, Gyu Tae Park, Jung Won Yoon, Seung-Chul Kim, Ho Jin Shin, Sang Chul Lee, Jae Ho Kim
Circulating angiogenic cells (CACs) have been implicated in the repair of ischemic tissues, and their mobilization from bone marrow is known to be regulated by the activations of chemokine receptors, including CXCR2 and CXCR4. This study was conducted to investigate the role of N-acetylated proline-glycine-proline (Ac-PGP; a collagen-derived chemotactic tripeptide) on CAC mobilization and its therapeutic potential for the treatment of peripheral artery diseases. Ac-PGP was administered daily to a murine hind limb ischemia model, and the effects of Ac-PGP on blood perfusion and CAC mobilization (Sca1+ Flk1+ cells) into peripheral blood were assessed...
November 26, 2018: Stem Cells Translational Medicine
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