Francesca Nonne, Mariagrazia Molfetta, Rebecca Nappini, Chiara La Guidara, Roberta Di Benedetto, Siwaphiwe Mfana, Barbara Bellich, Maria Michelina Raso, Gianmarco Gasperini, Renzo Alfini, Paola Cescutti, Francesco Berlanda Scorza, Neil Ravenscroft, Francesca Micoli, Carlo Giannelli
Klebsiella pneumoniae (Kp) is a Gram-negative bacterium, and a leading cause of neonatal sepsis in low- and middle-income countries, often associated with anti-microbial resistance. Two types of polysaccharides are expressed on the Kp cell surface and have been proposed as key antigens for vaccine design: capsular polysaccharides (known as K-antigens, K-Ags) and O-antigens (O-Ags). Historically, Kp has been classified using capsule serotyping and although 186 distinct genotypes have been predicted so far based on sequence analysis, many structures are still unknown...
April 12, 2024: Biology