Hélder Antônio Rebelo Pontes, Flávia Sirotheau Corrêa Pontes, Brunno Santos de Freitas Silva, Sérgio Elias Vieira Cury, Felipe Paiva Fonseca, Rodrigo Alves Salim, Décio dos Santos Pinto Júnior
Ameloblastic fibrosarcoma (AFS), regarded as the malignant counterpart of the benign ameloblastic fibroma, is an extremely rare odontogenic neoplasm with only 68 cases reported in the English literature up to 2009. It is composed of a benign odontogenic epithelium, resembling that of ameloblastoma, and a malignant mesenchymal part exhibiting features of fibrosarcoma. Due to the rarity of the lesion, little is known about its molecular pathogenesis; therefore, in the current study, we sought to evaluate the immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in AFS, comparing the results obtained with its benign counterpart, as well as to report a new case of this rare entity affecting a 19-year-old female patient...
December 2010: Annals of Diagnostic Pathology