Greta Doden, Michael M Garner, Lisa M Mangus, Samantha Sander
Giraffes ( Giraffa camelopardalis ) are commonly managed in zoos and conservation programs worldwide, but the current understanding of the occurrence and progression of neoplastic disease in this species is limited by the scarcity of published reports. This study collated documented cases of neoplasia on the basis of gross and histologic evaluation of ante- and postmortem samples. In total, 30 giraffes from 22 institutions across the United States were included. Subspecies was not reported in all cases, but those identified included Masai ( Giraffa camelopardalis tippelskirchi ), Rothschild ( Giraffa camelopardalis rothschildi ), and reticulated subspecies ( Giraffe camelopardalis reticulata )...
April 2021: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Wenrui Xu, Cheng Shen, Xiaojie Luo, Lei He, Min Chen
No abstract text is available yet for this article.
May 2021: Radiology Case Reports
Takeshi Onda, Azusa Yamazaki, Kamichika Hayashi, Takahiro Iwasaki, Kazuhiko Hashimoto, Masayuki Takano
An ameloblastic fibroma (AF) is a proliferative mixed tumor which includes components of both odontogenic epithelium and mesenchymal tissue. It is a relatively rare neoplasm, accounting for approximately only 1.5-4.5% of odontogenic tumors. This case report describes an AF that occurred in the mandibular anterior tooth region in a 9-year-old girl who presented with the chief complaint of swelling in the left mandibular anterior tooth region. Intraoral examination revealed a swelling along the labial gingiva, extending from the left mandibular lateral incisor region to the left mandibular canine...
February 15, 2021: Bulletin of Tokyo Dental College
Bruna Pizziolo Coura, Vanessa Fátima Bernardes, Sílvia Ferreira de Sousa, Marina Gonçalves Diniz, Rennan Garcias Moreira, Bruno Augusto Benevenuto de Andrade, Mario José Romañach, Helder Antônio Rebelo Pontes, Ricardo Santiago Gomez, Edward William Odell, Carolina Cavalieri Gomes
The molecular pathogenesis of mixed odontogenic tumors has not been established and understanding their genetic basis could refine their classification and help define molecular markers for diagnostic purposes. We assessed potentially pathogenic mutations in the component tissues of 28 cases of mixed odontogenic tumors. Laser capture microdissected tissue from ten ameloblastic fibromas (AF), four ameloblastic fibrodentinomas (AFD), six ameloblastic fibro-odontomas (AFO), three ameloblastic fibrosarcomas (AFS), and five odontomas (OD) were screened by next-generation sequencing for a panel of 50 oncogenes and tumour suppressor genes and results confirmed by TaqMan allele-specific qPCR...
September 20, 2020: Journal of Molecular Diagnostics: JMD
Amjad Soltany, Ghazal Asaad, Rami Daher, Mouhannad Dayoub, Ali Khalil, Zuheir Alshehabi
Ameloblastic fibrosarcoma (AFS) is a rare, aggressive malignant odontogenic tumor. AFS is seen most frequently in second and third decades of life. We are reporting a case of a low grade AFS in a 21-year-old male complaining of a painless swelling in the right side of the maxilla. The patient was treated with surgical excision followed by radiotherapy, which is considered the most effective approach for most of soft tissue sarcomas. AFS has a high-reported recurrence rate (up to 37%); therefore, long-term surveillance for recurrence is crucial...
August 2020: Journal of Surgical Case Reports
M S Munisekhar, Sanjeevareddigari Shylaja, R Vijay Kumar, Krishna A Rao, Santosh R Patil, Mohammad Khursheed Alam
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour classified by the WHO (1992) as an odontogenic sarcoma and defined as "a neoplasm with a similar structure to ameloblastic fibroma (AF) but in which the ectomesenchymal component shows the features of a sarcoma." The first report of AFS was published by Heath in 1887. AFS and related lesions are less frequently diagnosed than odontogenic carcinomas. Approximately two-thirds of AFSs seem to arise de novo, but others have developed in recurrent AF, in which the ectomesenchymal cells retain their embryonic appearance and develop malignant characteristics...
September 2019: JPRAS Open
Abbas Agaimy, Alena Skalova, Alessandro Franchi, Rana Alshagroud, Anthony J Gill, Robert Stoehr, Daniel Baumhoer, Sebastian Bauer
AIMS: Ameloblastic fibrosarcoma (AFS) is an aggressive odontogenic neoplasm featuring malignant mesenchymal stroma in addition to an ameloblastic epithelial component, and is hence considered to be the malignant counterpart of ameloblastic fibroma (AF). AFS is exceedingly rare, with <110 cases having been reported so far. Although BRAF mutations are recognised driver mutations in ameloblastoma, the molecular pathogenesis of AFS remains elusive. METHODS AND RESULTS: We herein describe seven AFSs that were analysed, for the first time, for mutations in the BRAF-NRAS pathway...
January 3, 2020: Histopathology
Ciro Dantas Soares, Wilson Delgado-Azañero, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Hugo Ghersi Miranda
This study reports 2 odontogenic carcinosarcomas, including the clinicopathologic and immunoprofile characteristics of these rare tumors. The first case occurred in a 22-year-old male presenting a bilobular mass involving the gingiva and bone of the premolar region of the left mandible, with paresthesia of the lower lip. Microscopic examination revealed a tumor similar to ameloblastic fibrosarcoma, with atypical mesenchymal cells; however, the odontogenic epithelium also showed atypia. In the second case, a 16-year-old female had a painless, asymptomatic, large intraosseous mandibular lesion...
June 2020: International Journal of Surgical Pathology
Suvendu Maji, Indranil Ghosh
AFS is a rare tumor of odontogenic origin. Less than 100 cases have been reported so far in the literature. Due to its extreme rarity, we do not have clear management guidelines at present. The entire clinical spectrum and natural history of this uncommon malignancy is unknown. Most of the cases present with facial swelling along with varying degrees of oral signs and symptoms. AFS has higher incidence in male and common in third decade of life. However, presentation in female can be unique and may have a different course and outcome then what is known to us...
March 2019: Indian Journal of Surgical Oncology
Manisha S Ahire, Jagdish V Tupkari, Tabita J Chettiankandy, Arush Thakur, Ruchika R Agrawal
CONTEXT: This retrospective study was planned to ascertain the relative frequency of odontogenic tumors (OTs) in an Indian population in the light of the latest World Health Organization (WHO) classification. AIM: To compare data with various reports from other parts of the world. STUDY DESIGN: Retrospective study. MATERIALS AND METHODS: The histopathology records and archived slides of all lesions diagnosed as "OT" in the Department of Oral Pathology and Microbiology of Government Dental teaching institute, Mumbai, Maharashtra, India, were recovered from the period January 1981-December 2016...
July 2018: Indian Journal of Cancer
Celeste Sánchez-Romero, Adalberto Mosqueda-Taylor, Wilson Delgado-Azañero, Oslei Paes de Almedia, Ronell Bologna-Molina
OBJECTIVES: The aim of this study was to analyze the immunohistochemical expression of fatty acid synthase (FASN) and cyclooxygenase-2 (COX-2) in tooth germ (TG), ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF), and ameloblastic fibrosarcoma (AFS). STUDY DESIGN: Immunohistochemistry for FASN and COX-2 was performed in 10 TG, 44 AM, 10 AC, 9 AF, and 5 AFS specimens. The results were analyzed by using the immunoreactive score (IRS) and Kruskal-Wallis test followed by Dunn's post-test...
December 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Scott M Peters, Michele S Bergen, Elizabeth M Philipone, Angela J Yoon
Ameloblastic fibro-odontoma (AFO) is a rare benign odontogenic tumor with the histologic features of ameloblastic fibroma (AF) but also contains enamel and dentin. It is most commonly observed in the pediatric population. Distinction between AFO and AF becomes important as ameloblastic fibromas are associated with higher recurrence rates of up to 18%, and 35% of these recurrent lesions can undergo malignant transformation to ameloblastic fibrosarcoma. Hence, for amelobastic fibroma, conservative curettage is recommended for the initial lesion and marginal resection is considered for recurrent cases...
2018: Journal of Clinical Pediatric Dentistry
Ipsita Sharma, Deepa Venkatesh, Geetanjali Bawa, Syed Vaseemuddin, Amit Joseph, Jimmy K Sangtani
INTRODUCTION: Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/ or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. MATERIALS AND METHODS: This study was conducted in Department of Oral Pathology and Microbiology...
November 1, 2017: Journal of Contemporary Dental Practice
Bruno Ramos Chrcanovic, Peter A Brennan, Siavash Rahimi, Ricardo Santiago Gomez
PURPOSE: To integrate the available data published to date on ameloblastic fibromas (AF) and ameloblastic fibrosarcomas (AFS) into a comprehensive analysis of their clinical/radiological features. METHODS: An electronic search was undertaken in July 2017. Eligibility criteria included publications having enough clinical, radiological and histological information to confirm a definite diagnosis. RESULTS: A total of 244 publications (279 central AF tumours, 10 peripheral AF, 103 AFS) were included...
April 2018: Journal of Oral Pathology & Medicine
Nkhensani Yvonne Chauke, Chrysis Sofianos, Dimitri Liakos, Elias Ndobe
A 24-year-old womanpresented with ameloblastic fibrosarcoma arising from ameloblastic fibroma. The delayed presentation accounted for the extensive destruction of the mandible and complete occlusion of her oral cavity. This resulted in an inability to eat and maintain oral hygiene. A multidisciplinary team management approach involved nutritional optimisation, segmental mandibulectomy, reconstruction with a reconstructive plate and a free anterolateral thigh flap to line the the floor of mouth. Functional and aesthetic outcome was acceptable, and the patient is planned for secondary free fibular flap bony reconstruction...
August 1, 2017: BMJ Case Reports
João Paulo Silva Servato, Paulo Rogério de Faria, Cássio Vinhadelli Ribeiro, Sergio Vitorino Cardoso, Paulo Rogério de Faria, Fernando Luiz Dias, Ana Lúcia Amaral Eisenberg, Adriano Mota Loyola
Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS's clinical-demographic features and prognostic factors...
March 2017: Brazilian Dental Journal
Michael Oertel, Gabriele Reinartz, Sergiu Scobioala, Hans Theodor Eich
Sarcomas are rare diseases of the head and neck region, representing around 1% of all malignancies. Amongst them, ameloblastic fibrosarcoma (AFS) is of even greater rarity, with less than 100 cases reported in the literature. Consequently, no standard treatment or guidelines have been made available. Surgery is often performed as primary therapy, but may be limited due to anatomical or functional reasons. We present a case of AFS successfully treated by postoperative radiation therapy. A detailed case study is provided, followed by a review of the English-language literature focusing on the role of radiation therapy...
August 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Nitin Verma, Neha
Ameloblastic fibroma (AF) is an uncommon true mixed odontogenic tumor, with a relative frequency between 1.5% and 4.5% of all odontogenic tumors. It may behave either as a true neoplasm or as a hamartomatous proliferation of odontogenic epithelium of the enamel organ and odontogenic mesenchyme of the primitive dental pulp. Frequently diagnosed between the first and second decades of life with 75% of cases was diagnosed before the age of 20 and present with a well-defined unilocular or multilocular radiolucencies...
July 2016: National Journal of Maxillofacial Surgery
Elizabeth Ann Bilodeau, Bobby M Collins
This article reviews a myriad of common and uncommon odontogenic cysts and tumors. The clinical presentation, gross and microscopic features, differential diagnosis, prognosis, and diagnostic pitfalls are addressed for inflammatory cysts (periapical cyst, mandibular infected buccal cyst/paradental cyst), developmental cysts (dentigerous, lateral periodontal, glandular odontogenic, orthokeratinized odontogenic cyst), benign tumors (keratocystic odontogenic tumor, ameloblastoma, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, ameloblastic fibroma and fibroodontoma, odontoma, squamous odontogenic tumor, calcifying cystic odontogenic tumor, primordial odontogenic tumor, central odontogenic fibroma, and odontogenic myxomas), and malignant tumors (clear cell odontogenic carcinoma, ameloblastic carcinoma, ameloblastic fibrosarcoma)...
March 2017: Surgical Pathology Clinics
Rachael R Pillay, Arthur Bilski, Martin Batstone
BACKGROUND: Ameloblastic fibrosarcoma (AFS) is a rare odontogenic neoplasm of the jaw that usually arises de novo or through a malignant change in the mesenchymal component of a preexisting or recurrent benign fibroma. The majority of AFS cases reported in the literature arise in the mandible. CASE REPORT: A 35-year-old male presented with an asymptomatic left maxillary mass that on imaging was found to be effacing most of his maxillary sinus. He underwent a left maxillectomy with free-flap reconstruction and adjuvant radiotherapy to the tumor bed...
2016: Ochsner Journal
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