A previously unreported malignancy of the thyroid

Bulent Cetin, Suleyman Buyukberber, Senem Senturk, Omer Uluoglu, Ugur Coskun, Mustafa Benekli
Medical Oncology 2012, 29 (3): 1418-20
Ameloblastic fibrosarcoma or ameloblastic sarcoma is an extremely rare odontogenic neoplasm. We report a case of an ameloblastic fibrosarcoma arising from thyroid gland in a 44 year-old woman. Following total thyroidectomy, a histopathologic, immunohistologic, and genotypic examination revealed ameloblastic fibrosarcoma. The tumor was composed of odontogenic epithelium, resembling that of ameloblastoma, and a mesenchymal part exhibiting features of fibrosarcoma. To our review, our case represents the first report of ameloblastic fibrosarcoma of the thyroid gland. Ameloblastic fibrosarcoma may arise from thyroid gland.

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