Carlo Bergamini, Giovanni Alemanno, Alessio Giordano, Desiré Pantalone, Giovanni Fontani, Anna Maria Di Bella, Veronica Iacopini, Paolo Prosperi, Jacopo Martellucci
PURPOSE: Acute mesenteric ischemia with non-occlusive mechanism (NOMI) is a possible complication after cardiac surgery in patients admitted to Intensive Care Unit (ICU). Since the diagnosis is often difficult with CT-scan, some authors have evaluated the role of bed-side diagnostic laparoscopy (DL). We aimed to contribute to this topic with a personal series. METHODS: We retrospectively evaluated patients admitted to ICU after cardiac surgery since 2009 up to 2019, successively operated on for a suspected NOMI of recent onset with non-conclusive CT...
September 19, 2020: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Wanqiong Yuan, Bao Hai, Xiaoqing Ren, Junxiong Zhu, Chenggui Zhang, Zhiyuan Guan, Jialin Jia, Hong Wang, Baoshan Cao, Chunli Song
Tumor vessels play important roles in cancer development and angiogenesis has been characterized as an essential process for tumor cell tumor growth. Our previous studies found that a single-dose local intraosseous simvastatin injection rapidly and long-termly mobilized bone marrow-derived endothelial progenitor cells to peripheral blood, promoting angiogenesis and ameliorating ischemia injury. However, whether intraosseous injection of simvastatin participates in cancer progression and the role of angiogenesis enhancement in this process remain unknown...
September 17, 2020: Translational Oncology
Kimmo Koivula, Kaari K Konttila, Markku J Eskola, Mika Martiskainen, Heini Huhtala, Vesa K Virtanen, Jussi Mikkelsson, Kati Järvelä, Kari O Niemelä, Pekka J Karhunen, Kjell C Nikus
BACKGROUND: Long-term outcome of real-life acute coronary syndrome (ACS) patients with selected ECG patterns is not well known. PURPOSE: To survey the 10-year outcome of pre-specified ECG patterns in ACS patients admitted to a university hospital. METHODS: A total of 1184 consecutive acute coronary syndrome patients in 2002-2003 were included and followed up for 10 years. The patients were classified into nine pre-specified ECG categories: 1) ST elevation; 2) pathological Q waves without ST elevation; 3) left bundle branch block (LBBB); 4) right bundle branch block (RBBB) 5) left ventricular hypertrophy (LVH) without ST elevation except in leads aVR and/or V1 ; 6) global ischemia ECG (ST depression ≥0...
August 8, 2020: Journal of Electrocardiology
Rachel Jensen, John S Lane, Erik Owens, Dennis Bandyk, Mahmoud Malas, Antonio Covarrubias, Michael Levine, Andrew Barleben
BACKGROUND: Common iliac artery aneurysms (CIAAs) are seen in 20-40% of patients with abdominal aortic aneurysms. Historically treated with sacrifice of the hypogastric artery, which can result in significant morbidity related to pelvic ischemia, new devices have made hypogastric artery preservation more feasible, but are only applicable to a small subset of aneurysm anatomy. We sought to assess the safety and efficacy or a novel technique for hypogastric artery preservation applicable to a wider variety of CIAA patients...
September 17, 2020: Annals of Vascular Surgery
Anjali Ghimire, Susan E Howlett
BACKGROUND: The G-protein coupled estrogen receptor (GPER) mediates rapid responses to estrogen. GPER activation may contribute to cardioprotective effects of estrogen in ischemia and reperfusion, although whether it is beneficial in aging myocardium is unclear. We determined whether a GPER agonist (G1) added to standard cardioplegic solution (used to protect hearts from ischemia-reperfusion injury during cardiac surgery) would improve outcomes in isolated hearts from adult and aged mice of both sexes...
September 17, 2020: Experimental Gerontology
Francesco Liistro, Paolo Angioli, Giorgio Ventoruzzo, Kenneth Ducci, Matteo Rocco Reccia, Lucia Ricci, Giovanni Falsini, Alessia Scatena, Maurizio Pieroni, Leonardo Bolognese
OBJECTIVES: The aim of this study was to investigate the efficacy and safety of the Litos drug-coated balloon (DCB) versus plain old balloon angioplasty (POBA) for reduction of late lumen loss (LLL) in patients with critical limb ischemia undergoing below-the-knee (BTK) intervention. BACKGROUND: Restenosis after balloon angioplasty of BTK arteries approximates 70%. Previous studies of DCBs in BTK arteries produced conflicting results. METHODS: ACOART-BTK (Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos® in Below-the-Knee Arteries to Treat Critical Limb Ischemia) is a randomized controlled single-center study...
September 11, 2020: JACC. Cardiovascular Interventions
Marianne Brodmann, Matej Moscovic, John Chaw Chian Wang, Giovanni Nano, Johannes Dahm, Thomas Zeller, Johnny Kent Christensen, Koen Keirse, Reza Ghotbi, Jean-Marc Corpataux, Gunnar Tepe
OBJECTIVES: The aim of the BIOLUX P-III (A Prospective, International, Multi-Centre, Post-Market All-Comers Registry to Assess the Clinical Performance of the Passeo-18 Lux Paclitaxel Releasing Balloon Catheter in Infrainguinal Arteries - III) registry was to collect real-world data on the Passeo-18 Lux paclitaxel-coated balloon. BACKGROUND: Critical limb ischemia (CLI) is a severe condition associated with high morbidity and mortality. Prospective data are needed to provide further insights on drug-eluting devices...
September 11, 2020: JACC. Cardiovascular Interventions
Beau M Hawkins, Isaac C Meier
No abstract text is available yet for this article.
September 11, 2020: JACC. Cardiovascular Interventions
Marjan Akbari-Kamrani, Bita Akbari-Kamrani, Mehdi Tavakoli
Orbital compartment syndrome is a critical ophthalmic emergency that needs urgent diagnosis and treatment to prevent permanent vision loss caused by optic nerve compression or retinal ischemia. In this article, we present a child with orbital compartment syndrome caused by orbital emphysema as a result of a rare type of ocular trauma and introduce a simple technique to decompress the pressure. The patient was a 4-year-old boy who experienced a compressed air blast to his left eye. He presented to the emergency department with a frozen globe, tight orbit, and chemosis, without any evidence of globe rupture, conjunctival laceration, and orbital bone fracture...
September 16, 2020: Annals of Emergency Medicine
Gabriela Warpsinski, Matthew J Smith, Salil Srivastava, Thomas P Keeley, Richard C M Siow, Paul A Fraser, Giovanni E Mann
Ischemic stroke is associated with a surge in reactive oxygen species generation during reperfusion. The narrow therapeutic window for the delivery of intravenous thrombolysis and endovascular thrombectomy limits therapeutic options for patients. Thus, understanding the mechanisms regulating neurovascular redox defenses are key for improved clinical translation. Our previous studies in a rodent model of ischemic stroke established that activation of Nrf2 defense enzymes by pretreatment with sulforaphane (SFN) affords protection against neurovascular and neurological deficits...
September 8, 2020: Redox Biology
Shannon Hextrum, Jatinder S Minhas, Eric M Liotta, Farzaneh A Sorond, Andrew M Naidech, Matthew B Maas
BACKGROUND: An association between spontaneous hyperventilation, delayed cerebral ischemia, and poor clinical outcomes has been reported in subarachnoid hemorrhage. We evaluated the relationship between early pCO2 changes, ischemic lesions and outcomes in patients with intracerebral hemorrhage (ICH). METHODS: Consecutive patients with spontaneous ICH were enrolled in an observational cohort study conducted between 2006 and 2019. Patient characteristics and discharge outcome were prospectively recorded...
September 12, 2020: Journal of the Neurological Sciences
Y Charifi, Y Lamrani, L Chbani, M Maaroufi, B Alami
INTRODUCTION: Epiploic appendagitis is a torsion of fatty appendages of ligamentum trees (1), it's a rare cause of abdominal pain that usually manifests by right or left iliac fossa pain, reminding of appendicitis, diverticulitis or ischemia of the omentum. CASE PRESENTATION: We report the case of a 56 years old male patient admitted for an epigastric pain and a right-upper quadrant abdominal pain, for whom he underwent an abdominal ultrasound and a CT-scan who shown an abscessed mass under colic transverse to the unusual seat...
September 11, 2020: International Journal of Surgery Case Reports
Shinichiro Yoshikawa, Tomoya Kamide, Yuichiro Kikkawa, Kaima Suzuki, Toshiki Ikeda, Shinya Kohyama, Hiroki Kurita
OBJECTIVE: Long-term outcomes after surgical treatment and intensive care have not been investigated in elderly patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to analyze 12-month outcomes and prognostic factors of patients with poor-grade aSAH who were at least 70 years of age. METHODS: We performed a single-center, retrospective study including poor-grade (World Federation of Neurological societies [WFNS] grades IV and V) aSAH patients who were at least 70 years of age, were admitted to our stroke center, and received aneurysmal treatment between April 2012 and September 2018...
September 16, 2020: World Neurosurgery
Heng Wen, Hu Zhang, Weina Wang, Yuebing Li
BACKGROUND: Limb ischemia/reperfusion (I/R) is a common clinical process that frequently induces acute lung injury (ALI). Tetrahydropalmatine (THP) is a major bioactive constituent of various traditional Chinese medicine with protective effects on inflammation and oxidation. In this study, we aimed to investigate the possible protective effect of THP on ALI induced by limb I/R. METHODS: Rats were used to establish ALI through limb I/R. After administration of three doses of THP, the lung injury was evaluated by hematoxylin-eosin staining, tissue wet/dry weight ratio and ELISA examination of myeloperoxidase (MPO), malondialdehyde (MDA) and Super Oxide Dismutase (SOD)...
September 16, 2020: Pulmonary Pharmacology & Therapeutics
Yan Wang, Xiaoqing Wang, Yingbo Li, Di Chen, Zhao Liu, Yu Zhao, Liu Tu, Shali Wang
Progranulin is a secreted glycoprotein expressed in neurons and microglial cells that is involved in maintaining physiological functions. Many studies have found that progranulin may play a protective role against ischemic brain injury, but little is known about how the expression level and cellular localization status of progranulin is regulated after hypoxia-ischemia. Research has confirmed that sortilin, encoded by SORT1, can bind with progranulin and deliver a mature secretory isoform of progranulin to lysosomes, and progranulin is then cleaved...
September 16, 2020: Neuroscience Letters
Jing Huang, Yunhan Liu, Liusiyuan Cheng, Jihong Li, Tangrui Zhang, Gang Zhao, Huinan Zhang
Glucagon-like peptide-1 (GLP-1) is an endogenous gut hormone and a key regulator in maintaining glucose homeostasis by stimulating insulin secretion. Its natural cleavage product GLP-1 (9-36), which was formerly considered a "bio-inactive" metabolite mainly due to its low affinity for GLP-1 receptor, possesses unique properties such as cardiovascular protection. Little is known about the effects and mechanisms of GLP-1 (9-36) in cerebral ischemia and reperfusion injury. Here, we report that systemic application of GLP-1 (9-36) in adult mice facilitated functional recovery and reduced infarct volume, astrogliosis, and neuronal apoptosis following middle cerebral artery occlusion and reperfusion...
September 16, 2020: European Journal of Pharmacology
Marius R Bigler, Michael Stoller, Christine Tschannen, Raphael Grossenbacher, Christian Seiler
BACKGROUND: Natural, non-surgical internal mammary artery (IMA) bypasses to the coronary circulation have been shown to function as extracardiac sources of myocardial blood supply. The goal of this randomized, placebo-controlled, double blind trial was to test the efficacy of permanent right IMA (RIMA) device occlusion on right coronary artery (RCA) occlusive blood supply, and on clinical and ECG signs of myocardial ischemia. METHODS: This was a prospective superiority trial in 100 patients with chronic coronary artery disease (CAD) randomly allocated (1:1) to RIMA vascular device occlusion (verum group) or to RIMA sham procedure (placebo group)...
September 16, 2020: American Heart Journal
Gerald A Dienel
Metabolomic technologies including imaging mass spectrometry (IMS; also called mass spectrometry imaging, MSI, or matrix-assisted laser desorption/ionization-mass spectrometry imaging, MALDI MSI) are important methods to evaluate levels of many compounds in brain with high spatial resolution, characterize metabolic phenotypes of brain disorders, and identify disease biomarkers. ATP is central to brain energetics, and reports of its heterogeneous distribution in brain and regional differences in ATP/ADP ratios reported in IMS studies conflict with earlier studies...
September 19, 2020: Neurochemical Research
Davide Ghinolfi, Daniele Dondossola, Erion Rreka, Caterina Lonati, Daniele Pezzati, Andrea Cacciatoinsilla, Alessia Kersik, Chiara Lazzeri, Alberto Zanella, Adriano Peris, Marco Maggioni, Giandomenico Biancofiore, Paolo Reggiani, Riccardo Morganti, Paolo De Simone, Giorgio Rossi
In Italy, 20 minutes of continuous, flat-line electrocardiogram are required for declaration of death. In the setting of organ donation after cardiocirculatory death (DCD), prolonged warm ischemia time prompted introduction of abdominal normothermic regional perfusion (NRP) followed by post-procurement, ex-situ machine perfusion. This was a retrospective review of DCD liver transplantations performed at two centers using sequential NRP and ex-situ machine perfusion. From January 2018 to April 2019, 34 DCD donors were evaluated...
September 18, 2020: Liver Transplantation
Erin Iannacone, Bryce Robinson, Mohamed Rahouma, Leonard Girardi
BACKGROUND AND AIM: Aortic branch malperfusion complicates up to one-third of acute type A aortic dissection (ATAAD), and it is a strong predictor of poor outcomes. We analyzed our results for the surgical management of this high-risk cohort. METHODS: We queried our aortic database for consecutive patients undergoing ATAAD repair. Those presenting with malperfusion were compared with those without. Outcomes were compared using univariate and multivariate analysis...
September 19, 2020: Journal of Cardiac Surgery
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