Gustavo Chagoya, Arsalaan Salehani, B Ethan Tabibian, Nicholas M B Laskay, Brandon M Fox, Nidal B Omar, Bart Thaci, Joshua D Bernstock, Galal A Elsayed, Mark R Harrigan
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality. Amongst the most common sequelae of aSAH is delayed cerebral ischemia. Hyperdynamic therapy (fluid supplementation and hypertension), is used to increase cerebral perfusion. However, the safety of hyperdynamic therapy in patients with separate unruptured, unsecured intracranial aneurysms is not well-established. Herein, a rare case demonstrating the rapid evolution and rupture of an incidental unsecured aneurysm in the setting of hyperdynamic therapy is presented...
September 18, 2020: World Neurosurgery
Patrick J Geraghty, George Adams, Andrej Schmidt
OBJECTIVE: There is no vascular implant commercially available in the U.S. to treat post-angioplasty dissections in below-the-knee (BTK) arteries. The Tack Endovascular System® is purpose-built to repair post-percutaneous transluminal angioplasty (PTA) BTK dissections. A trial was conducted to investigate the safety and efficacy of the first-of-a-kind implantable BTK device to treat post-PTA dissections in the setting of critical limb ischemia. METHODS: This prospective, single arm, multi-center study evaluated the Tack Endovascular System for treating post-PTA dissections in the mid/distal popliteal, tibial, and peroneal arteries...
September 18, 2020: Journal of Vascular Surgery
Peixian Gao, Gang Li, Jianfeng Chen, Renfeng Qiu, Changyu Qiao, Kun Luo, Shuxiao Chen, Xuejun Wu, Dianning Dong
OBJECTIVE: To evaluate the efficacy and clinical outcomes of endovascular treatment for superior mesenteric artery dissection (SMAD) and its effect on superior mesenteric artery (SMA) remodeling compared with medical management alone after successful initial medical management. METHODS: In this retrospective analysis, all patients with spontaneous SMAD at a single institution were identified from March 2007 to August 2019. The primary outcomes were freedom from major adverse events (MAEs, a composite of dissection-related death, the recurrence of mesenteric ischemia symptoms, and a requirement for intervention)...
September 18, 2020: Journal of Vascular Surgery
Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Nipon Chattipakorn, Siriporn C Chattipakorn
Cardiac ischemia/reperfusion (I/R) injury induces brain pathology. Donepezil, a well-known acetylcholine esterase (AChE) inhibitor, has been proven to exert neuroprotective effects against several neurodegenerative diseases. However, the comprehensive mechanism regarding the therapeutic potential of donepezil on the brain under cardiac I/R injury remains obscure. Here, we hypothesized that treatment with donepezil ameliorates brain pathology following cardiac I/R injury by decreasing blood brain barrier (BBB) breakdown, oxidative stress, neuroinflammation, mitochondrial dysfunction, mitochondrial dynamics imbalance, microglial activation, amyloid-beta (Aβ) accumulation, neuronal apoptosis, and dendritic spine loss...
September 18, 2020: Biochimica et Biophysica Acta. Molecular Basis of Disease
Christina Stathopoulos, Bruno Bartolini, Guillaume Marie, Maja Beck-Popovic, Guillaume Saliou, Francis L Munier
PURPOSE: To identify risk factors for acute choroidal ischemia (ACI) after intra-arterial chemotherapy (IAC) for retinoblastoma. DESIGN: Retrospective cohort study PARTICIPANTS: 220 patients (248 eyes) treated with IAC in Lausanne between November 2008 and September 2019 (665 procedures). All cases were evaluated on a monthly basis with fundus photography and fluorescein angiography before and after each IAC. METHODS: ACI, defined as any new choroidal ischemia clinically diagnosed within 35 days after an IAC, were noted...
September 18, 2020: Ophthalmology
Nir Polak, Gregory Fishelev, Erez Lang, Zemer Wang, Amos Neheman, Ben Haim Yacov, Amir Hadanny, Efrati Shai
Ischemic complications of glans penis following circumcision are rare, and if occurs can culminate in irreversible necrosis with severe long-term consequences. Here we present two challenging cases of neonates suffering from acute severe glans penis ischemia after circumcision that were treated by hyperbaric oxygen treatment (HBOT). In addition to case presentations, the literature related to complications of circumcision and the physiological effects of HBOT are being reviewed. Based on the review and the case presented, we conclude that HBOT can be used as salvage treatment for circumcision induced glans ischemia as early as possible before full necrosis develops...
September 18, 2020: Urology
Yue Wu, Yulian Pang, Wei Wei, An Shao, Cong Deng, Xiongfeng Li, Haoyu Chang, Piaopiao Hu, Xuequn Liu, Xu Zhang
It is reported that Ischemia and reperfusion damage (I/R damage) can lead to retinal ganglion cell (RGC) death and neurodegeneration, which in turn can lead to irreversible vision loss. In this study, we sought to understand the neuroprotective effect of resveratrol, the important activator of sirtuin1 (SIRT1), on RGC survival in I/R damage model and the molecular mechanism that mediate this effect. Our results show that resveratrol could reverse axonal swelling, holes, and the chaos of the nucleus in axons of RGCs caused by I/R...
September 18, 2020: Experimental Eye Research
Kristopher P Croome, Mani A Daneshmand
Donation after circulatory death (DCD) heart transplantation is currently being performed in the United States as part of a clinical trial. As with all donor procurements, effective coordination between all involved teams is vital for successful organ recovery and maximal utilization of donor organs. The current discussion relays a viewpoint on combined DCD liver and heart donor procurement. Key issues highlighted include the vital importance of donor warm ischemia time (DWIT) on outcome for both recipients as well as issues pertaining to DWIT that may arise when performing combined DCD liver and heart donor procurement...
September 21, 2020: American Journal of Transplantation
Katherine A Leyba, Sandhya Vasudevan, Thomas D O'Sullivan, Craig J Goergen
BACKGROUND AND OBJECTIVES: Spatial frequency domain imaging (SFDI), an optical imaging technique capable of quantitatively measuring tissue hemodynamics over a large field-of-view, has captured the interest of scientists and clinicians due to its ability to image rapidly and noninvasively. The goal of this study was to apply SFDI in a preclinical murine model to assess its ability to measure hemodynamic changes due to hindlimb ischemia in vivo longitudinally. STUDY DESIGN/MATERIALS AND METHODS: Complete unilateral femoral artery ligation was performed on a total of nine C57BL/6J mice to induce ischemia in the left hindlimb...
September 21, 2020: Lasers in Surgery and Medicine
Brittany L Rodriguez, Emmanuel E Vega-Soto, Christopher S Kennedy, Matthew H Nguyen, Paul S Cederna, Lisa M Larkin
Volumetric muscle loss (VML) is the loss of skeletal muscle that results in significant and persistent impairment of function. The unique characteristics of craniofacial muscle compared trunk and limb skeletal muscle, including differences in gene expression, satellite cell phenotype, and regenerative capacity, suggest that VML injuries may affect craniofacial muscle more severely. However, despite these notable differences, there are currently no animal models of craniofacial VML. In a previous sheep hindlimb VML study, we showed that our lab's tissue engineered skeletal muscle units (SMUs) were able to restore muscle force production to a level that was statistically indistinguishable from the uninjured contralateral muscle...
2020: PloS One
Stine Lohmann, Marco Eijken, Ulla Møldrup, Bjarne K Møller, James Hunter, Cyril Moers, Henri Leuvenink, Rutger J Ploeg, Marian C Clahsen-van Groningen, Martin Hoogduijn, Carla C Baan, Anna Krarup Keller, Bente Jespersen
BACKGROUND: Mesenchymal stromal cell (MSC) therapy may improve renal function after ischemia-reperfusion injury in transplantation. Ex vivo renal intraarterial administration is a targeted delivery method, avoiding the lung vasculature, a known barrier for cellular therapies. In a randomized and blinded study, we tested the feasibility and effectiveness of MSC therapy in a donation after circulatory death autotransplantation model to improve posttransplant kidney function, using an ex vivo MSC delivery method similar to the clinical standard procedure of pretransplant cold graft flush...
September 18, 2020: Transplantation
Chun Chien, Chun-Jen Lin, Feng-Chi Chang, Chih-Ping Chung, Chung-Jung Lin, Hung-Yu Liu, Nai-Fang Chi, Li-Chi Hsu, Chih-Wei Tang, Wan-Yuo Guo, Chao-Bao Luo, Yen-Jun Lai, I-Hui Lee
BACKGROUND: Clinical and radiological outcomes of endovascular thrombectomy (EVT) are related to etiologies of large vessel occlusion (LVO) in acute stroke. However, preprocedural computed tomography angiography (CTA) or CT perfusion imaging can hardly distinguish embolic occlusion from atherosclerotic occlusion. We hypothesized that quantitative multiphase CTA (mCTA) of LVO may predict occlusion types and thrombectomy outcome. METHODS: We retrospectively evaluated the consecutive stroke patients who had undergone mCTA and EVT <6 hours of onset at two independent medical centers...
September 18, 2020: Journal of the Chinese Medical Association: JCMA
Qianyi Liang, Xiaoling Huang, Chaokun Zeng, Dewei Li, Yongyong Shi, Gaofeng Zhao, Min Zhong
The purpose of this study was to explore the protective effect of BW373U86 (a δ-opioid receptor (DOR) agonist) on ischemia-reperfusion (I/R) injury in rat cardiomyocytes and its underlying mechanism. Primary rat cardiomyocytes were cultured and pretreated with BW373U86 for intervention. The cardiomyocytes were cultured under the condition of 94% N2 and 5% CO2 for 24 h to perform hypoxia culture and conventionally cultured for 12 h to perform reoxygenation culture. The cell viability of cardiomyocytes was detected by an MTT assay (Sigma-Aldrich)...
September 21, 2020: Canadian Journal of Physiology and Pharmacology
Jordan Nolan, Peter L Mclennan, Gregory E Peoples
BACKGROUND: Rock climbers are characterized by enhanced forearm fatigue resistance. This study compared the forearm isometric force of rock climbers (RC), strength-matched power lifters (PL) and aerobically trained (AT) athletes to determine the contribution of muscle oxygen desaturation during ischemia. METHODS: Aerobically trained athletes (N.=6, 23±1 years, 77±1 kg), power lifters (N.=7, 24±1 years, 80±3 kg) and rock climbers (N.=8, 25±2 years, 74±2 kg) took part in a controlled forearm ischemic occlusion (5 min) assessment using near infrared spectroscopy...
August 2020: Journal of Sports Medicine and Physical Fitness
Aleksandra Leligdowicz, James T Ross, Nicolas Nesseler, Michael A Matthay
BACKGROUND: The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to experimental conditions. However, there is a lack of studies evaluating biomarker kinetics during perfusion and after exposure to stimuli. In this study, we analyzed the ex vivo-perfused lung response to three key perturbations: exposure to the perfusion circuit, exogenous fresh whole blood, and bacteria...
September 21, 2020: Intensive Care Medicine Experimental
Ali O Malik, John A Spertus, Manesh R Patel, Gregory J Dehmer, Kevin Kennedy, Paul S Chan
No abstract text is available yet for this article.
September 21, 2020: JAMA Internal Medicine
Michaela Olthoff, Federico Franchi, Karen M Peterson, Ramasamy Paulmurugan, Martin Rodriguez-Porcel
There is significant interest in the use of stem cells (SCs) for the recovery of cardiac function in individuals with myocardial injuries. Most commonly, cardiac stem cell therapy is studied by delivering SCs concurrently with the induction of myocardial injury. However, this approach presents two significant limitations: the early hostile pro-inflammatory ischemic environment may affect the survival of transplanted SCs, and it does not represent the subacute infarction scenario where SCs will likely be used...
September 3, 2020: Journal of Visualized Experiments: JoVE
Kristoffer B Hansen, Christian Staehr, Palle D Rohde, Casper Homilius, Sukhan Kim, Mette Nyegaard, Vladimir V Matchkov, Ebbe Boedtkjer
Acid-base conditions modify artery tone and tissue perfusion but the involved vascular sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort. We show that endothelial cells express the putative HCO3 - -sensor receptor-type tyrosine-protein phosphatase RPTPg, which enhances endothelial intracellular Ca2+ -responses in resistance arteries and facilitates endothelium-dependent vasorelaxation only when CO2 /HCO3 - is present...
September 21, 2020: ELife
Luke G Terlouw, Mandy Verbeten, Desirée van Noord, Marjolein Brusse-Keizer, Ruth R Beumer, Robert H Geelkerken, Marco J Bruno, Jeroen J Kolkman
INTRODUCTION: This study aimed to determine the incidence of chronic mesenteric ischemia (CMI) and to examine the influence of the etiological cause, location, and severity of a mesenteric artery stenosis on the probability of having CMI. METHODS: A prospective database, containing the details of all patients with suspected CMI referred to a renowned CMI expert center, was used. Patients residing within the expert centers' well-defined region, between January 2014 and October 2019, were included...
August 2020: Clinical and Translational Gastroenterology
Mustafa Yolcu, Ali Dogan, Nuri Kurtoglu, Veysel Sabri Hancer, Mehmet Gürbüzel
OBJECTIVE: Coronary slow-flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to the distal vascular bed in at least 1 major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in the blood once released from nucleated cells. The aim of this study was to determine if the level of cfDNA, which is an indicator of ischemia at the cellular level, was increased in CSFP. METHODS: The study included 46 patients in total: 23 patients with CSFP and 23 with a normal coronary angiogram (NCA)...
September 2020: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
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