Yongzhen Wei, Huan Jiang, Fengjuan Li, Chao Chai, Yaping Xu, Mengmeng Xing, Weiliang Deng, He Wang, Yuexin Zhu, Sen Yang, Yongquan Yu, Wenming Wang, Yan Wei, Yu Guo, Jinwei Tian, Jie Du, Zhikun Guo, Yuan Wang, Qiang Zhao
An abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. We identified plasma insulin-like growth factor 1 (IGF1) as an independent risk factor in patients with AAA by correlating plasma IGF1 with risk. Smooth muscle cell- or fibroblast-specific knockout of Igf1r , the gene encoding the IGF1 receptor (IGF1R), attenuated AAA formation in two mouse models of AAA induced by angiotensin II infusion or CaCl2 treatment. IGF1R was activated in aortic aneurysm samples from human patients and mice with AAA...
May 2024: Science Translational Medicine