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JOURNAL ARTICLE
Adam C Farsheed, Christian Zevallos-Delgado, Le Tracy Yu, Sajede Saeidifard, Joseph W R Swain, Jonathan T Makhoul, Adam J Thomas, Carson C Cole, Eric Garcia Huitron, Kathryn Jane Grande-Allen, Manmohan Singh, Kirill V Larin, Jeffrey D Hartgerink
Progress in the design and synthesis of nanostructured self-assembling systems has facilitated the realization of numerous nanoscale geometries, including fibers, ribbons, and sheets. A key challenge has been achieving control across multiple length scales and creating macroscopic structures with nanoscale organization. Here, we present a facile extrusion-based fabrication method to produce anisotropic, nanofibrous hydrogels using self-assembling peptides. The application of shear force coinciding with ion-triggered gelation is used to kinetically trap supramolecular nanofibers into aligned, hierarchical macrostructures...
May 3, 2024: ACS Nano
#2
JOURNAL ARTICLE
Aravdeep S Jhand, Waiel Abusnina, Hyo Jung Tak, Arslan Ahmed, Mahmoud Ismayl, S Elissa Altin, Matthew W Sherwood, John H Alexander, Sunil V Rao, J Dawn Abbott, Jeffrey L Carson, Andrew M Goldsweig
BACKGROUND: Although anemia is common in patients with myocardial infarction (MI), management remains controversial. We quantified the association of anemia with in-hospital outcomes and resource utilization in patients admitted with MI using a large national database. METHODS: All hospitalizations with a primary diagnosis code for acute MI in the National Inpatient Sample (NIS) between 2014 and 2018 were identified. Among these hospitalizations, patients with anemia were identified using a secondary diagnosis code...
April 30, 2024: International Journal of Cardiology
#3
JOURNAL ARTICLE
Andrew S Perry, Kai Zhang, Venkatesh L Murthy, Bina Choi, Shilin Zhao, Priya Gajjar, Laura A Colangelo, Lifang Hou, Mary Rice, John Jeffrey Carr, April P Carson, Anne E Nigra, Ramachandran S Vasan, Robert E Gerszten, Sadiya S Khan, Ravi Kalhan, Matthew Nayor, Ravi V Shah
Rationale: The biological mechanisms linking environmental exposures with cardiovascular disease (CVD) pathobiology are incompletely understood. We sought to identify circulating proteomic signatures of environmental exposures, and examine their associations with cardiometabolic and respiratory disease (CMD) in observational cohort studies. Methods: We tested the relations of >6500 circulating proteins with 29 environmental exposures across the built environment, green space, air pollution, temperature, and social vulnerability indicators in nearly 3000 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study across 4 centers using penalized and ordinary linear regression...
April 25, 2024: Circulation Research
#4
JOURNAL ARTICLE
Michael G Brandel, Jillian H Plonsker, Robert C Rennert, Gautam Produturi, Megana Saripella, Arvin R Wali, Carson McCann, Vijay M Ravindra, David R Santiago-Dieppa, J Scott Pannell, Jeffrey A Steinberg, Alexander A Khalessi, Michael L Levy
INTRODUCTION: Pediatric intracranial aneurysms (IAs) are rare and have distinct clinical profiles compared to adult IAs. They differ in location, size, morphology, presentation, and treatment strategies. We present our experience with pediatric IAs over an 18-year period using surgical and endovascular treatments and review the literature to identify commonalities in epidemiology, treatment, and outcomes. METHODS: We identified all patients < 20 years old who underwent treatment for IAs at our institution between 2005 and 2020...
April 18, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#5
JOURNAL ARTICLE
Carson A Wills, Xiaoming Liu, Longgui Chen, Yuanjun Zhao, Zhenqiu Liu, Vladimir S Spiegelman, Jeffrey Sundstrom, Hong-Gang Wang
No abstract text is available yet for this article.
July 2024: Genes & Diseases
#6
JOURNAL ARTICLE
Melissa J Mann, Chris Melendez-Suchi, Hannah E Vorndran, Maria Sukhoplyasova, Ashley R Flory, Mary Carson Irvine, Anuradha R Iyer, Christopher J Guerriero, Jeffrey L Brodsky, Linda M Hendershot, Teresa M Buck
GRP170 ( Hyou1 ) is required for mouse embryonic development, and its ablation in kidney nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its chaperone family in the ER lumen. However, the cellular requirement for GRP170, which both binds non-native proteins and acts as nucleotide exchange factor for BiP, is poorly understood. Here, we report on the isolation of mouse embryonic fibroblasts obtained from mice in which LoxP sites were engineered in the Hyou1 loci ( Hyou1LoxP/ LoxP )...
March 6, 2024: Molecular Biology of the Cell
#7
Sanjay Jain, Liming Pei, Jeffrey M Spraggins, Michael Angelo, James P Carson, Nils Gehlenborg, Fiona Ginty, Joana P Gonçalves, James S Hagood, John W Hickey, Neil L Kelleher, Louise C Laurent, Shin Lin, Yiing Lin, Huiping Liu, Alexandra Naba, Ernesto S Nakayasu, Wei-Jun Qian, Andrea Radtke, Paul Robson, Brent R Stockwell, Raf Van de Plas, Ioannis S Vlachos, Mowei Zhou, Katy Börner, Michael P Snyder
No abstract text is available yet for this article.
March 1, 2024: Nature Cell Biology
#8
REVIEW
Carson Welker, Jeffrey Huang, Omar Elmadhoun, Sarvie Esmaeilzadeh, Farouk Mookadam, Harish Ramakrishna
No abstract text is available yet for this article.
February 7, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#9
JOURNAL ARTICLE
Monica B Pagano, Simon J Stanworth, Stacey Valentine, Ryan Metcalf, Erica M Wood, Katerina Pavenski, Jill Cholette, Cynthia So-Osman, Jeffrey L Carson
No abstract text is available yet for this article.
April 2024: Transfusion
#10
Adam C Farsheed, Christian Zevallos-Delgado, Le Tracy Yu, Sajede Saeidifard, Joseph W R Swain, Jonathan T Makhoul, Adam J Thomas, Carson C Cole, Eric Garcia Huitron, K Jane Grande-Allen, Manmohan Singh, Kirill V Larin, Jeffrey D Hartgerink
Fibrous proteins that comprise the extracellular matrix (ECM) guide cellular growth and tissue organization. A lack of synthetic strategies able to generate aligned, ECM-mimetic biomaterials has hampered bottom-up tissue engineering of anisotropic tissues and led to a limited understanding of cell-matrix interactions. Here, we present a facile extrusion-based fabrication method to produce anisotropic, nanofibrous hydrogels using self-assembling peptides. The application of shear force coinciding with ion-triggered gelation is used to kinetically trap supramolecular nanofibers into aligned, hierarchical structures...
February 4, 2024: bioRxiv
#11
JOURNAL ARTICLE
Scott A Koepsell, Moritz Stolla, Rebecca L Sedjo, Jeffrey Carson, Michael Knudson, Richard Cook, Ross Fasano, Samantha G Ngamsuntikul, Claudia Cohn, Jed Gorlin, Meghan Delaney, Sherrill Slichter, Paul Ness, Jeffrey McCullough
BACKGROUND: The Mirasol® Pathogen Reduction Technology System was developed to reduce transfusion-transmitted diseases in platelet (PLT) products. STUDY DESIGN AND METHODS: MiPLATE trial was a prospective, multicenter, controlled, randomized, non-inferiority (NI) study of the clinical effectiveness of conventional versus Mirasol-treated Apheresis PLTs in participants with hypoproliferative thrombocytopenia. The novel primary endpoint was days of ≥Grade 2 bleeding with an NI margin of 1...
February 5, 2024: Transfusion
#12
JOURNAL ARTICLE
David L Perez, Timothy R Nicholson, Ali A Asadi-Pooya, Matthew Butler, Alan J Carson, Anthony S David, Quinton Deeley, Ibai Diez, Mark J Edwards, Alberto J Espay, Jeannette M Gelauff, Johannes Jungilligens, Mark Hallett, Richard A A Kanaan, Marina A J Tijssen, Kasia Kozlowska, W Curt LaFrance, Ramesh S Marapin, Carine W Maurer, Antje A T S Reinders, Petr Sojka, Jeffrey P Staab, Jon Stone, Jerzy P Szaflarski, Selma Aybek
No abstract text is available yet for this article.
January 30, 2024: NeuroImage: Clinical
#13
JOURNAL ARTICLE
Peter D Hibbert, Charlotte J Molloy, Ian D Cameron, Leonard C Gray, Richard L Reed, Louise K Wiles, Johanna Westbrook, Gaston Arnolda, Rebecca Bilton, Ruby Ash, Andrew Georgiou, Alison Kitson, Clifford F Hughes, Susan J Gordon, Rebecca J Mitchell, Frances Rapport, Carole Estabrooks, Gregory L Alexander, Charles Vincent, Adrian Edwards, Andrew Carson-Stevens, Cordula Wagner, Brendan McCormack, Jeffrey Braithwaite
BACKGROUND: This study estimated the prevalence of evidence-based care received by a population-based sample of Australian residents in long-term care (LTC) aged ≥ 65 years in 2021, measured by adherence to clinical practice guideline (CPG) recommendations. METHODS: Sixteen conditions/processes of care amendable to estimating evidence-based care at a population level were identified from prevalence data and CPGs. Candidate recommendations (n = 5609) were extracted from 139 CPGs which were converted to indicators...
January 23, 2024: BMC Medicine
#14
JOURNAL ARTICLE
Isabel Song, Elizabeth W Thompson, Anurag Verma, Matthew T MacLean, Jeffrey Duda, Ameena Elahi, Richard Tran, Pavan Raghupathy, Sophia Swago, Mohamad Hazim, Abhijit Bhattaru, Carolin Schneider, Marijana Vujkovic, Drew A Torigian, Charles E Kahn, James C Gee, Arijitt Borthakur, Colleen M Kripke, Christopher C Carson, Rotonya Carr, Qasim Jehangir, Yi-An Ko, Harold Litt, Mark Rosen, David A Mankoff, Mitchell D Schnall, Haochang Shou, Julio Chirinos, Scott M Damrauer, Marina Serper, Jinbo Chen, Daniel J Rader, Walter R T Witschey, Hersh Sagreiya
The objective of this study is to define CT imaging derived phenotypes for patients with hepatic steatosis, a common metabolic liver condition, and determine its association with patient data from a medical biobank. There is a need to further characterize hepatic steatosis in lean patients, as its epidemiology may differ from that in overweight patients. A deep learning method determined the spleen-hepatic attenuation difference (SHAD) in Hounsfield Units (HU) on abdominal CT scans as a quantitative measure of hepatic steatosis...
January 2, 2024: Scientific Reports
#15
JOURNAL ARTICLE
Mehdi Chaib, Jeremiah R Holt, Emilie L Fisher, Laura M Sipe, Margaret S Bohm, Sydney C Joseph, Boston W Simmons, Samson Eugin Simon, Johnathan R Yarbro, Ubaid Tanveer, Jessica L Halle, James A Carson, T J Hollingsworth, QingQing Wei, Jeffrey C Rathmell, Paul G Thomas, D Neil Hayes, Liza Makowski
Mononuclear phagocytes (MPs) play a crucial role in tissue homeostasis; however, MPs also contribute to tumor progression and resistance to immune checkpoint blockade (ICB). Targeting MPs could be an effective strategy to enhance ICB efficacy. We report that protein kinase C delta (PKCδ), a serine/threonine kinase, is abundantly expressed by MPs in human and mouse tumors. PKCδ-/- mice displayed reduced tumor progression compared to wild types, with increased response to anti-PD-1. Tumors from PKCδ-/- mice demonstrated TH 1-skewed immune response including increased antigen presentation and T cell activation...
December 22, 2023: Science Advances
#16
JOURNAL ARTICLE
Dominik Awad, Pham Hong Anh Cao, Thomas L Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V Tellman, Caroline F Ribeiro, Riccardo Muzzioli, Brittany E Jewell, Hubert Pakula, Jeffrey J Ackroyd, Mollianne M Murray, Jenny J Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, Jingjing Liu, Xingzhi Song, Jianhua Zhang, Albert R Klekers, Justin M Drake, Michael M Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C Farach-Carson, Massimo Loda, Livia S Eberlin, Daniel E Frigo
UNLABELLED: Lipid metabolism plays a central role in prostate cancer. To date, the major focus has centered on de novo lipogenesis and lipid uptake in prostate cancer, but inhibitors of these processes have not benefited patients. A better understanding of how cancer cells access lipids once they are created or taken up and stored could uncover more effective strategies to perturb lipid metabolism and treat patients. Here, we identified that expression of adipose triglyceride lipase (ATGL), an enzyme that controls lipid droplet homeostasis and a previously suspected tumor suppressor, correlates with worse overall survival in men with advanced, castration-resistant prostate cancer (CRPC)...
March 4, 2024: Cancer Research
#17
RANDOMIZED CONTROLLED TRIAL
Jeffrey L Carson, Maria Mori Brooks, Paul C Hébert, Shaun G Goodman, Marnie Bertolet, Simone A Glynn, Bernard R Chaitman, Tabassome Simon, Renato D Lopes, Andrew M Goldsweig, Andrew P DeFilippis, J Dawn Abbott, Brian J Potter, Francois Martin Carrier, Sunil V Rao, Howard A Cooper, Shahab Ghafghazi, Dean A Fergusson, William J Kostis, Helaine Noveck, Sarang Kim, Meechai Tessalee, Gregory Ducrocq, Pedro Gabriel Melo de Barros E Silva, Darrell J Triulzi, Caroline Alsweiler, Mark A Menegus, John D Neary, Lynn Uhl, Jordan B Strom, Christopher B Fordyce, Emile Ferrari, Johanne Silvain, Frances O Wood, Benoit Daneault, Tamar S Polonsky, Manohara Senaratne, Etienne Puymirat, Claire Bouleti, Benoit Lattuca, Harvey D White, Sheryl F Kelsey, P Gabriel Steg, John H Alexander
BACKGROUND: A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level. METHODS: In this phase 3, interventional trial, we randomly assigned patients with myocardial infarction and a hemoglobin level of less than 10 g per deciliter to a restrictive transfusion strategy (hemoglobin cutoff for transfusion, 7 or 8 g per deciliter) or a liberal transfusion strategy (hemoglobin cutoff, <10 g per deciliter)...
December 28, 2023: New England Journal of Medicine
#18
Melissa J Mann, Chris Melendez-Suchi, Maria Sukhoplyasova, Ashley R Flory, Mary Carson Irvine, Anuradha R Iyer, Hannah Vorndran, Christopher J Guerriero, Jeffrey L Brodsky, Linda M Hendershot, Teresa M Buck
GRP170, a product of the Hyou1 gene, is required for mouse embryonic development, and its ablation in kidney nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its chaperone family in the ER lumen. However, the cellular requirement for GRP170, which both binds non-native proteins and acts as nucleotide exchange factor for BiP, is poorly understood. Here, we report on the isolation of embryonic fibroblasts from mice in which LoxP sites were engineered in the Hyou1 loci ( Hyou1 LoxP/LoxP )...
October 20, 2023: bioRxiv
#19
JOURNAL ARTICLE
Carson C Cole, Le Tracy Yu, Mikita Misiura, Joseph Williams, Thi H Bui, Jeffrey D Hartgerink
Collagen mimetic peptides are composed of triple helices. Triple helical formation frequently utilizes charge pair interactions to direct protein assembly. The design of synthetic triple helices is challenging due to the large number of competing species and the overall fragile nature of collagen mimetics. A successfully designed triple helix incorporates both positive and negative criteria to achieve maximum specificity of the supramolecular assembly. Intrahelical charge pair interactions, particularly those involved in lysine-aspartate and lysine-glutamate pairs, have been especially successful both in driving helix specificity and for subsequent stabilization by covalent capture...
October 23, 2023: Biomacromolecules
#20
JOURNAL ARTICLE
Lawrence C M Yip, Elina Rascevska, Parsa Omidi, Jeffrey J L Carson
Currently, there are no non-invasive experimental methods available for measuring optical fluence distributions in tissue. We present photoacoustic tomography (PAT) as a method to approximate the relative optical fluence distribution in a homogeneous optically scattering medium. Three-dimensional photoacoustic images were captured with a near-full view PAT scanner in phantoms with known optical absorption and scatter properties. Resultant 3D PAT images were compared to the expected optical fluence distributions from Monte Carlo simulations and diffusion theory using volumetric and shape analysis...
October 1, 2023: Biomedical Optics Express
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