Tom P Pielhop, Carolin Popp, Sebastian Fricke, Dennis Knierim, Paolo Margaria, Edgar Maiß
Since the first report in 2009, at least ten additional viruses have been identified and assigned to the proposed virus family Alternaviridae. Here we report two new mycoviruses tentatively assigned to this family, both identified as members of the fungal family Nectriaceae, which were isolated from surface-disinfected apple roots (Malus x domestica, Borkh.) affected by apple replant disease (ARD). ARD is a highly complex, worldwide-occurring disease resulting from plant reactions to a disturbed (micro)-biome and leads to high economic losses every year...
March 22, 2023: Archives of Microbiology
John W Devlin, Sarah E Train, Karen E A Burns, Anthony Massaro, Ting Ting Wu, Timothy Castor, John Vassaur, Kavitha Selvan, John P Kress, Brian L Erstad
BACKGROUND: Current critical care pharmacist (CCP) practices and perceptions related to neuromuscular infusion (NMBI) use for acute respiratory distress syndrome (ARDS) maybe different with the COVID-19 pandemic and the publication of 2020 NMBI practice guidelines. OBJECTIVE: To evaluate CCP practices and perceptions regarding NMBI use for patients with moderate-severe ARDS. METHODS: We developed, tested, and electronically administered a questionnaire (7 parent-, 42 sub-questions) to 409 American College of Clinical Pharmacy (ACCP) Critical Care Practice and Research Network members in 12 geographically diverse states...
March 22, 2023: Annals of Pharmacotherapy
Michelle Gates, Jennifer Pillay, Megan Nuspl, Aireen Wingert, Ben Vandermeer, Lisa Hartling
BACKGROUND: To inform recommendations by the Canadian Task Force on Preventive Health Care, we reviewed evidence on the benefits, harms, and acceptability of screening and treatment, and on the accuracy of risk prediction tools for the primary prevention of fragility fractures among adults aged 40 years and older in primary care. METHODS: For screening effectiveness, accuracy of risk prediction tools, and treatment benefits, our search methods involved integrating studies published up to 2016 from an existing systematic review...
March 21, 2023: Systematic Reviews
Mônica Rodrigues da Cruz, Luciana Moisés Camilo, Tiago Batista da Costa Xavier, Gabriel Casulari da Motta Ribeiro, Denise Machado Medeiros, Luís Felipe da Fonseca Reis, Bruno Leonardo da Silva Guimarães, André Miguel Japiassú, Alysson Roncally Silva Carvalho
BACKGROUND: The profile of changes in airway driving pressure (dPaw ) induced by positive-end expiratory pressure (PEEP) might aid for individualized protective ventilation. Our aim was to describe the dPaw versus PEEP curves behavior in ARDS from COVID-19 patients. METHODS: Patients admitted in three hospitals were ventilated with fraction of inspired oxygen (FiO2 ) and PEEP initially adjusted by oxygenation-based table. Thereafter, PEEP was reduced from 20 until 6 cmH2 O while dPaw was stepwise recorded and the lowest PEEP that minimized dPaw (PEEPmin_dPaw ) was assessed...
March 21, 2023: Critical Care: the Official Journal of the Critical Care Forum
Qingbo Liao, Yufan Pu, Xiaoer Jin, Zhiwei Zhuang, Xiaowen Xu, Xiaoqiang Ren, Gaoqing Liu, Qi Ding
OBJECTIVE: We aimed to identify new classes in acute respiratory distress syndrome (ARDS) using physiological and clinical variables and to explore heterogeneity in the effects of glucocorticoid therapy between classes. METHODS: Using the Medical Information Mart for Intensive Care-IV database, we identified patients with ARDS. Potential profile analysis was used to identify classes with physiological and clinical data as delineating variables. Baseline characteristics and clinical outcomes were compared between classes...
March 21, 2023: BMC Pulmonary Medicine
Kevin W Gibbs, Jonathan L Forbes, Kelsey Harrison, Jennifer T W Krall, Aubrae Isenhart, Stephanie P Taylor, R Shayn Martin, Nathaniel S O'Connell, Rita N Bakhru, Jessica A Palakshappa, D Clark Files
BACKGROUND: Patient triggered Adaptive Pressure Control (APC-CMV) has been widely adopted as an alternative ventilator mode to patient-triggered Volume control (VC-CMV). However, the comparative effectiveness of the two ventilator modes remain uncertain. RESEARCH QUESTION: We sought to explore clinical and implementation factors pertinent to a future definitive RCT assessing APC-CMV vs VC-CMV as an initial ventilator mode strategy. The research objectives in our pilot trial test clinician adherence and explore clinical outcomes...
March 21, 2023: Respiratory Care
Lorraine B Ware
No abstract text is available yet for this article.
March 21, 2023: American Journal of Respiratory and Critical Care Medicine
Ravindranath Tiruvoipati, Bindu Akkanti, Kha Dinh, Nicholas Barrett, Alexandra May, Jeremy Kimmel, Steven A Conrad
OBJECTIVES: Extracorporeal carbon dioxide removal (ECCO2R) devices are effective in reducing hypercapnia and mechanical ventilation support but have not been shown to reduce mortality. This may be due to case selection, device performance, familiarity, or the management. The objective of this study is to investigate the effectiveness and safety of a single ECCO2R device (Hemolung) in patients with acute respiratory failure and identify variables associated with survival that could help case selection in clinical practice as well as future research...
March 21, 2023: Critical Care Medicine
Berkan Armağan, Hatice Ecem Konak, Bahar Özdemir, Hakan Apaydın, Ebru Atalar, Pınar Akyüz Dağlı, Serdar Can Güven, Abdulsamet Erden, Orhan Küçükşahin, Ahmet Omma, Şükran Erten
INTRODUCTION: Rituximab, which is used in autoimmune rheumatic diseases (ARD), can cause both an increased risk of development of COVID-19 disease and re-infection due to its potent and long-acting immunosuppression. So, we aimed to evaluate the frequency, risk factors and re-infection rates of COVID-19 in ARD patients receiving rituximab. METHODS: A single-center retrospective study was performed with patients receiving rituximab for ARD in 12 months before the onset of COVID-19 in Turkey...
March 21, 2023: International Journal of Rheumatic Diseases
Christopher Lai, Xavier Monnet, Jean-Louis Teboul
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from .
March 21, 2023: Critical Care: the Official Journal of the Critical Care Forum
Lieuwe Durk Jacobus Bos, Harm Jan de Grooth, Pieter Roel Tuinman
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from .
March 21, 2023: Critical Care: the Official Journal of the Critical Care Forum
Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G Hansbro, Philip M Hansbro, Trevor T Hansel, Ian M Adcock, Antonio David, Paul Kirkham, Gaetano Caramori, Carlo Alberto Volta, Savino Spadaro
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS...
March 20, 2023: Journal of Inflammation
Nerea Alonso, Omar M E Albagha, Asim Azfer, Beatriz Larraz-Prieto, Kathryn Berg, Philip L Riches, Barbara Ostanek, Tomaz Kocjan, Janja Marc, Bente L Langdahl, Stuart H Ralston
OBJECTIVES: Teriparatide (TPTD) is an effective treatment for osteoporosis but the individual response to therapy is variable for reasons that are unclear. This study aimed to determine whether the response to TPTD might be influenced by genetic factors. METHODS: We searched for predictors of the response of bone mineral density (BMD) to TPTD using a two-stage genome-wide association study in 437 patients with osteoporosis from three referral centres. Demographic and clinical data including the response of BMD to treatment at the lumbar spine and hip were extracted from the medical records of each participant...
March 20, 2023: Annals of the Rheumatic Diseases
Celeste G Dixon, Sameer Thadani, Julie C Fitzgerald, Ayse Akcan-Arikan, Nadir Yehya
OBJECTIVES: Given the complex interrelatedness of fluid overload (FO), creatinine, acute kidney injury (AKI), and clinical outcomes, the association of AKI with poor outcomes in critically ill children may be underestimated due to definitions used. We aimed to disentangle these temporal relationships in a large cohort of children with acute respiratory distress syndrome (ARDS). DESIGN: Retrospective cohort study. SETTING: Quaternary care PICU...
March 20, 2023: Critical Care Medicine
Ruchita Kabra, Sunil Kumar, Sourya Acharya, Pratik J Bhansali, Varun Daiya
Acute respiratory distress syndrome (ARDS)-like symptoms and rapid progression characterize the interstitial lung disease known as acute interstitial pneumonitis, also known as Hamman-Rich syndrome. It has a bad prognosis and a high incidence of mortality. We describe the case of a 25-year-old male patient with acute-onset type I respiratory failure with detrimental X-ray abnormalities who presented to the emergency room without any history of pulmonary disease or smoking. The provisional diagnosis of Hamman-Rich syndrome was reached after other clinical entities were ruled out based on CT findings...
February 2023: Curēus
Jingfei Li, Haotian Lin, Tinghui Fan, Linfei Huang, Xinyong Zhang, Yanhong Tai, Yi Fang, Qihong Li, Ruzhou Zhao, Penghao Wang, Li Zhou, Luming Wan, Yuhua Wu, Hui Zhong, Congwen Wei, Xiaopan Yang
INTRODUCTION: Inflammation play important roles in the initiation and progression of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), septic shock, clotting dysfunction, or even death associated with SARS-CoV-2 infection. However, the pathogenic mechanisms underlying SARS-CoV-2-induced hyperinflammation are still largely unknown. METHODS: The animal model of septic shock and ALI was established after LPS intraperitoneal injection or intratracheal instillation...
2023: Frontiers in Cellular and Infection Microbiology
Giuseppe Accurso, Luigi Vetrugno, Paola Pierucci
No abstract text is available yet for this article.
2023: Frontiers in Medicine
Safwat A M Eldaboosy, Amgad Awad, Abdullah Farouk, Waheed Mahdy, Eman Abdelsalam, Sameh O Nour, Ahmed Kabil, Ahmad Taha, Sameh Makled, Ahmed Lotfi, Usama Nabway, Hatem Kanany
BACKGROUND: Acute kidney injury (AKI) poses a significant morbidity and mortality risk to critically ill COVID-19 patients. The aim of this study was to investigate the incidence, predictors, and outcomes of AKI in patients admitted to the intensive care unit (ICU) with critically ill COVID-19 pneumonia. METHODS: A multicenter retrospective study in Saudi Arabia of adult patients aged at least 18 years diagnosed with COVID-19 pneumonia and admitted to the intensive care unit between May 2020 and May 2021 was conducted...
January 17, 2023: Multidisciplinary Respiratory Medicine
Armin-Kai Schoeberl, Stefan Schwarz, Alberto Benazzo, Thomas Schweiger, György Lang, Peter Jaksch, Konrad Hoetzenecker
BACKGROUND: The main causes of early respiratory failure after lung transplantation include primary graft dysfunction (PGD), acute rejection, and infection. This report describes a case of unclear early respiratory failure after bilateral lung transplantation for extensive COVID-19-induced acute respiratory distress syndrome (ARDS). METHODS: We reviewed the patient file to investigate the course of the functional decline and evaluate reasons for early graft failure...
February 23, 2023: Transplantation Proceedings
Thomas C Rollinson, Joleen Rose, Luke A McDonald, Cara Green, Michelle Topple, Stephen Warrillow, Lucy Modra, Rahul Costa-Pinto, Sue Berney
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic resulted in a surge of patients with refractory hypoxaemic respiratory failure being admitted to the intensive care unit (ICU). Prone positioning can improve oxygenation but requires a team of skilled personnel to complete safely. Critical care physiotherapists (PTs) are ideally suited to lead proning teams, due to their expertise in moving critically unwell, invasively ventilated patients. OBJECTIVES: The aim of this study was to describe the feasibility of implementing a physiotherapy-led intensive proning (PhLIP) team to support the critical care team during surges...
February 13, 2023: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
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