Silvia Coppola, Davide Chiumello
No abstract text is available yet for this article.
January 18, 2021: Anesthesia and Analgesia
Pierrick Le Borgne, Morgane Solis, François Severac, Hamid Merdji, Yvon Ruch, Karine Alamé, Eric Bayle, Yves Hansmann, Pascal Bilbault, Samira Fafi-Kremer, Ferhat Meziani
INTRODUCTION: The ongoing COVID-19 pandemic has led to devastating repercussions on healthcare systems worldwide. This viral infection has a broad clinical spectrum broad (ranging from influenza-like disease, viral pneumonia, hypoxemia to ARDS requiring prolonged ICU stays). The prognostic impact of measuring viral load on nasopharyngeal swab specimens (by RT-PCR) is yet to be elucidated. METHODS: Between March 3rd and April 5th , 2020, we conducted a retrospective study on a cohort of COVID-19 patients (mild or severe disease) who were hospitalized after presenting to the emergency department (ED) and had at least one positive nasopharyngeal swab during their hospital stay...
January 22, 2021: Academic Emergency Medicine
Yuan Zhan, Chunjian Yang, Qunhui Zhang, Li Yao
Silent information regulator type-1 (SIRT1) is crucial during the development of acute respiratory distress syndrome (ARDS). We aimed to explore whether SIRT1 activation could protect against ARDS. SIRT1 was activated by its agonist SRT1720. ARDS was induced by intraperitoneal injection of 5 mg/kg lipopolysaccharide (LPS). Lung injuries were determined by the lung wet/dry ratio, inflammatory cells in the broncho-alveolar lavage fluid (BALF) and histological analysis. Inflammatory cytokine release was detected by enzyme-linked immunosorbent assay...
January 22, 2021: Journal of Biochemistry
Pirouz Piran, Robert D Stevens
PURPOSE OF REVIEW: The coexistence of neurological injury and respiratory failure is common in intensive care. This article provides a contemporary overview of the safety and efficacy of different strategies for mechanical ventilation and adjunctive respiratory approaches in patients with acute brain injury. RECENT FINDINGS: Available evidence indicates that lung-protective ventilation (LPV) can be implemented safely in a range of patients with concurrent respiratory failure and brain injury of different etiologies; however, the clinical efficacy of LPV in this setting needs to be established...
January 18, 2021: Current Opinion in Critical Care
Liangkai Chen, Wenwu Sun, Yanli Liu, Lijuan Zhang, Yanling Lv, Qiang Wang, Ding Long, Yujun Wang, Su Zhao, Shuang Rong, Li Yu, Liegang Liu
OBJECTIVE: To investigate the association of in-hospital early-phase glycemic control with adverse outcomes among inpatients with coronavirus disease 2019 (COVID-19) in Wuhan, China. RESEARCH DESIGN AND METHODS: The study is a large case series, and data were obtained regarding consecutive patients hospitalized with COVID-19 in the Central Hospital of Wuhan between 2 January and 15 February 2020. All patients with definite outcomes (death or discharge) were included...
January 21, 2021: Diabetes Care
Xiaoyi Liu, Hui Liu, Qing Lan, Xiangde Zheng, Jun Duan, Fanwei Zeng
OBJECTIVE: In December 2019, Wuhan, China, experienced an outbreak of coronavirus disease 2019 (COVID-19). Some patients admitted to our hospital were treated with early prone positioning (PP). Here, we analyzed its clinical significance. METHODS: This was a retrospective observational study. We defined the early PP group as mild COVID-19 patients who were placed into a prone position within 24h of admission; others served as the control group. We recorded basic data and outcomes of early PP and compared the results to those of controls...
December 26, 2020: Medicina Clínica
Peter Stachon, Klaus Kaier, Timo Heidt, Dennis Wolf, Daniel Duerschmied, Dawid Staudacher, Manfred Zehender, Christoph Bode, Constantin von Zur Mühlen
OBJECTIVES: This study hypothesized that cerebral protection prevents strokes in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR) in clinical practice. BACKGROUND: Preventing strokes is an important aim in TAVR procedures. Embolic protection devices may protect against cardiac embolism during TAVR, but their use and outcomes in clinical practice remain controversial. METHODS: Isolated transfemoral TAVR procedures performed in Germany with or without cerebral protection devices were extracted from a comprehensive nationwide billing dataset...
January 25, 2021: JACC. Cardiovascular Interventions
Karin Wildi, Samantha Livingstone, Chiara Palmieri, Gianluigi LiBassi, Jacky Suen, John Fraser
The acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing pharmacological agents to treat ARDS, its mortality rate remains unaltered high and treatment is still only supportive. Over the years, there have been many attempts to identify meaningful subgroups likely to react differently to treatment among the heterogenous ARDS population, most of them unsuccessful...
January 21, 2021: Journal of Intensive Care
Katarzyna Kotfis, Kacper Lechowicz, Sylwester Drożdżal, Paulina Niedźwiedzka-Rystwej, Tomasz K Wojdacz, Ewelina Grywalska, Jowita Biernawska, Magda Wiśniewska, Miłosz Parczewski
In March 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was declared a global pandemic by the World Health Organization (WHO). The clinical course of the disease is unpredictable but may lead to severe acute respiratory infection (SARI) and pneumonia leading to acute respiratory distress syndrome (ARDS). It has been shown that pulmonary fibrosis may be one of the major long-term complications of COVID-19. In animal models, the use of spironolactone was proven to be an important drug in the prevention of pulmonary fibrosis...
January 17, 2021: Pharmaceuticals
Morteza Izadi, Luca Cegolon, Mohammad Javanbakht, Ali Sarafzadeh, Hassan Abolghasemi, Gholamhossein Alishiri, Shi Zhao, Behzad Einollahi, Mandana Kashaki, Nematollah Jonaidi-Jafari, Mosa Asadi, Ramezan Jafari, Saeid Fathi, Hassan Nikoueinejad, Mehrdad Ebrahimi, Sina Imanizadeh, Amir Hosein Ghazale
Severe forms of COVID-19 can evolve into pneumonia, featured by acute respiratory failure due to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In viral diseases, the replication of viruses is seemingly stimulated by an imbalance between pro-oxidant and antioxidant activity as well as by the deprivation of antioxidant mechanisms. In COVID-19 pneumonia, oxidative stress also appears to be highly detrimental to lung tissues. Although inhaling ozone (O3) gas has been shown to be toxic to the lungs, recent evidence suggests that its administration via appropriate routes and at small doses can paradoxically induce an adaptive reaction capable of decreasing the endogenous oxidative stress...
December 21, 2020: International Immunopharmacology
Aslihan Avanoglu Guler, Nezrin Tombul, Pınar Aysert Yıldız, Hasan Selçuk Özger, Kenan Hızel, Ozlem Gulbahar, Abdurrahman Tufan, Gonca Erbaş, Gülbin Aygencel, Ozlem Guzel Tunçcan, Murat Dizbay, Mehmet Akif Öztürk
Angiotensin-converting enzyme (ACE)/Angiotensin (Ang) II pathway has crucial regulatory effects on circulatory hemostasis and immune responses. This pathway has a major role in the development of acute lung injury and acute respiratory distress syndrome (ARDS), which is a devastating complication of SARS-CoV-2 infection. The aim of this study is to investigate the serum ACE activity and its correlation with clinical features and the disease severity in patients with COVID-19. Patients with confirmed COVID-19 by detecting SARS-CoV-2 nucleic acid RT-PCR were included in the study...
January 21, 2021: Scandinavian Journal of Clinical and Laboratory Investigation
Gábor Speer, Péter Somogyi
We have reviewed the available literature on thyroid diseases and coronavirus disease 2019 (COVID-19), and data from the previous coronavirus pandemic, the severe acute respiratory syndrome (SARS) epidemic. We learned that both SARS and COVID-19 patients had thyroid abnormalities. In the limited number of SARS cases, where it was examined, decreased serum T3, T4 and TSH levels were detected. In a study of survivors of SARS approximately 7% of the patients had hypothyroidism. In the previous evaluation evidence was found that pituitary function was also affected in SARS...
January 19, 2021: Endocrine Journal
Imad R Khan, Yang Gu, Benjamin P George, Laura Malone, Kyle S Conway, Fabienne Francois, Jack Donlon, Nadim Quazi, Ashwin Reddi, Cheng-Ying Ho, Daniel L Herr, Mahlon D Johnson, Gunjan Y Parikh
OBJECTIVE: To test the hypothesis that brain injury is more common and varied in ECMO patients than radiographically observed, we described neuropathology findings of ECMO decedents and associated clinical factors from three institutions. METHODS: We conducted a retrospective multi-center observational study of brain autopsies from adult ECMO recipients. Pathology findings were examined for correlation with demographics, clinical data, ECMO characteristics, and outcomes...
January 20, 2021: Neurology
Jijia Hu, Yingang Zhang, Wei Wang, Zhihe Tao, Juan Tian, Ning Shao, Nian Liu, Hui Wei, Hao Huang
BACKGROUND: The treatment of critically ill patients with COVID-19 who were hospitalized in Wuhan has been reported. However, the clinical characteristics of patients who died of COVID-19 in regions with relatively scarce healthcare resources remain unknown. METHODS: In this retrospective study, a total of 14 patients who were admitted from January 18 to February 11, 2020 and died of COVID-19 were evaluated. The epidemiological, symptomatic, laboratory, radiological and treatment records were reviewed and analyzed...
January 20, 2021: BMC Infectious Diseases
Mònica Girona-Alarcon, Sara Bobillo-Perez, Anna Sole-Ribalta, Lluisa Hernandez, Carmina Guitart, Ricardo Suarez, Mònica Balaguer, Francisco-Jose Cambra, Iolanda Jordan
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has collapsed health systems worldwide. In adults, the virus causes severe acute respiratory distress syndrome (ARDS), while in children the disease seems to be milder, although a severe multisystem inflammatory syndrome (MIS-C) has been described. The aim was to describe and compare the characteristics of the severe COVID-19 disease in adults and children. METHODS: This prospective observational cohort study included the young adults and children infected with SARS-CoV-2 between March-June 2020 and admitted to the paediatric intensive care unit...
January 20, 2021: BMC Infectious Diseases
Wenjing Chen, Jing Ye Pan
The spread of the coronavirus (SARS-CoV-2, COVID-19 for short) has caused a large number of deaths around the world. We summarized the data reported in the past few months and emphasized that the main causes of death of COVID-19 patients are DAD (Diffuse Alveolar Damage) and DIC (Disseminated intravascular coagulation). Microthrombosis is a prominent clinical feature of COVID-19, and 91.3% of dead patients had microthrombosis.Endothelial damage caused by SARS-CoV-2 cell invasion and subsequent host response disorders involving inflammation and coagulation pathways play a key role in the progression of severe COVID-19...
January 20, 2021: Biological Procedures Online
Maria Gianniki, Tania Siahanidou, Evanthia Botsa, Athanasios Michos
BACKGROUND AND AIM: A measles outbreak occurred in Greece during 2017-2018 affecting mainly pediatric population. The aim of the study was to describe the epidemiological and clinical characteristics of the cases diagnosed in the major pediatric tertiary hospital of Athens, where 26.5% of national pediatric measles cases were diagnosed and treated. METHODS: This is a retrospective study of children 0-16 years old, who presented at the emergency department and/or were hospitalized with clinical presentation compatible with measles and diagnosis was confirmed with molecular detection of the measles RNA in pharyngeal swabs...
2021: PloS One
Kevin C J Yuen, Lewis S Blevins, James W Findling
OBJECTIVE: In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19) that resulted in a global pandemic with substantial morbidity and mortality. Currently, there is no specific treatment or approved vaccine against COVID-19. The underlying associated comorbidity and diminished immune function of some pituitary patients (whether caused by the disease and its sequelae or treatment with excess glucocorticoids) increases their risk of contracting and developing complications from COVID-19 infection...
August 2020: Endocrine Practice
P Mikolka, P Kosutova, S Balentova, D Cierny, J Kopincova, M Kolomaznik, M Adamkov, A Calkovska, D Mokra
Acute respiratory distress syndrome (ARDS) is characterized by diffuse lung damage, inflammation, oedema formation, and surfactant dysfunction leading to hypoxemia. Severe ARDS can accelerate the injury of other organs, worsening the patient´s status. There is an evidence that the lung tissue injury affects the right heart function causing cor pulmonale. However, heart tissue changes associated with ARDS are still poorly known. Therefore, this study evaluated oxidative and inflammatory modifications of the heart tissue in two experimental models of ARDS induced in New Zealand rabbits by intratracheal instillation of neonatal meconium (100 mg/kg) or by repetitive lung lavages with saline (30 ml/kg)...
January 20, 2021: Physiological Research
Saurabh Mittal, Sryma Pb, Karan Madan, Anant Mohan, Pawan Tiwari, Janamejey Gaur, Vijay Hadda
No abstract text is available yet for this article.
January 20, 2021: Advances in Respiratory Medicine
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