Tarek Abdel Latif Ghonimi, Mohamad Mahmood Alkad, Essa Abdulla Abuhelaiqa, Muftah M Othman, Musab Ahmed Elgaali, Rania Abdelaziz M Ibrahim, Shajahan M Joseph, Hassan Ali Al-Malki, Abdullah Ibrahim Hamad
CONTEXT: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated risks of COVID-19 infection in dialysis patients in the state of Qatar. METHODS: This was an observational, analytical, retrospective, nationwide study. We included all adult patients on maintenance dialysis therapy who tested positive for COVID-19 (PCR assay of the nasopharyngeal swab) during the period from February 1, 2020, to July 19, 2020...
2021: PloS One
A N Aripov, U K Kayumov, F Kh Inoyatova, M R Khidoyatova
The lung tissue contains various hemostatic system elements, which can be released from the lungs, both under physiological and pathological conditions. The COVID-19 pandemic has led to an increase in the number of patients with acute respiratory distress syndrome (ARDS) in intensive care units worldwide. When the lungs are damaged, coagulation disorders are mediated by tissue factor (TF) - factor VIIa (F VIIa), and inhibition of this pathway completely eliminates intrapulmonary fibrin deposition. A tissue factor pathway inhibitor TFPI also contributes to pulmonary coagulationdisturbance in ARDS...
July 16, 2021: Klinicheskaia Laboratornaia Diagnostika
Jayakumar Sreenivasan, Sagar Ranka, Shubham Lahan, Ahmed Abu-Haniyeh, Heyi Li, Risheek Kaul, Aaqib Malik, Wilbert S Aronow, William H Frishman, Steven Lansman
Coronavirus disease 2019 (COVID-19) is characterized by a clinical spectrum of diseases ranging from asymptomatic or mild cases to severe pneumonia with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) has been used as rescue therapy in appropriate patients with COVID-19 complicated by ARDS refractory to mechanical ventilation. In this study, we review the indications, challenges, complications and clinical outcomes of ECMO utilization in critically ill patients with COVID-19 related ARDS...
July 20, 2021: Cardiology in Review
V S Santana, L Salvi, F Cavalcante, F Campos, E Algranti
BACKGROUND: Brazil has a long history of heavy asbestos consumption. However, the number of asbestos-related diseases (ARDs) falls far below the one expected compared with other asbestos consumer countries. AIMS: To examine underreporting of ARDs, that is mesothelioma, asbestosis and pleural plaques, in Brazil's Mortality Information System (SIM). METHODS: Health information systems (HIS) were mapped, datasets retrieved and records of ARD deaths extracted...
July 22, 2021: Occupational Medicine
Youssif M Ali, Matteo Ferrari, Nicholas J Lynch, Sadam Yaseen, Thomas Dudler, Sasha Gragerov, Gregory Demopulos, Jonathan L Heeney, Wilhelm J Schwaeble
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe inflammatory response to SARS-CoV-2 by recruiting cells of the cellular immune system to the sites of infection and shifting their state of activation towards an inflammatory phenotype. It precedes pathophysiological milestone events like the cytokine storm, progressive endothelial injury triggering microangiopathy, and further complement activation, and causes an acute respiratory distress syndrome (ARDS)...
2021: Frontiers in Immunology
Samuel M Brown, Ithan D Peltan, Christina Barkauskas, Angela J Rogers, Virginia Kan, Annetine Gelijns, B Taylor Thompson
No abstract text is available yet for this article.
July 21, 2021: Annals of the American Thoracic Society
Weiwei Shu, Shuliang Guo, Fuxun Yang, Bicui Liu, Zhongxing Zhang, Xiaoyi Liu, Baixu Chen, Tao Huang, Liucun Li, Ke Wang, Dehua He, Qimin Chen, Bilin Wei, Lijuan Chen, Manyun Tang, Guodan Yuan, Min Mao, ZhiJun Tang, Fei Ding, Wenpin Ge, Xiaoli Han, Rui Zhang, Lei Jiang, Linfu Bai, Jun Duan
RATIONALE: The etiology of acute respiratory distress syndrome (ARDS) may play an important role in the failure of noninvasive ventilation (NIV). OBJECTIVES: To explore the association between ARDS etiology and risk of noninvasive ventilation failure. METHODS: A multicenter prospective observational study was performed in 17 ICUs in China from September 2017 to December 2019. Patients with ARDS who used NIV as a first-line therapy were enrolled...
July 21, 2021: Annals of the American Thoracic Society
Max A Laansma, Joanna K Bright, Sarah Al-Bachari, Tim J Anderson, Tyler Ard, Francesca Assogna, Katherine A Baquero, Henk W Berendse, Jamie Blair, Fernando Cendes, John C Dalrymple-Alford, Rob M A de Bie, Ines Debove, Michiel F Dirkx, Jason Druzgal, Hedley C A Emsley, Gäetan Garraux, Rachel P Guimarães, Boris A Gutman, Rick C Helmich, Johannes C Klein, Clare E Mackay, Corey T McMillan, Tracy R Melzer, Laura M Parkes, Fabrizio Piras, Toni L Pitcher, Kathleen L Poston, Mario Rango, Letícia F Ribeiro, Cristiane S Rocha, Christian Rummel, Lucas S R Santos, Reinhold Schmidt, Petra Schwingenschuh, Gianfranco Spalletta, Letizia Squarcina, Odile A van den Heuvel, Chris Vriend, Jiun-Jie Wang, Daniel Weintraub, Roland Wiest, Clarissa L Yasuda, Neda Jahanshad, Paul M Thompson, Ysbrand D van der Werf
BACKGROUND: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. OBJECTIVE: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. METHODS: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources...
July 20, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
Angelo Silverio, Marco Di Maio, Fernando Scudiero, Vincenzo Russo, Luca Esposito, Emilio Attena, Salvatore Pezzullo, Guido Parodi, Antonello D'Andrea, Antonio Damato, Antonio Silvestro, Patrizia Iannece, Michele Bellino, Davide Di Vece, Anna Borrelli, Rodolfo Citro, Carmine Vecchione, Gennaro Galasso
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a recently recognized viral infective disease which can be complicated by acute respiratory stress syndrome (ARDS) and cardiovascular complications including severe arrhythmias, acute coronary syndromes, myocarditis and pulmonary embolism. The aim of the present study was to identify the clinical conditions and echocardiographic parameters associated with in-hospital mortality in COVID-19. METHODS: This is a multicentre retrospective observational study including seven Italian centres...
July 20, 2021: European Journal of Clinical Investigation
C Gerosa, D Fanni, F Cau, A Ravarino, G Senes, R Demontis, P Coni, M Piras, G Orrù, F Coghe, T Congiu, G La Nasa, E D'Aloja, L Saba, G Faa
OBJECTIVE: Acute respiratory distress syndrome (ARDS) is characterized by quantitative and qualitative changes in surfactant composition, leading to surfactant dysregulation with alveolar collapse and acute respiratory hypoxic failure. Recently, surfactant has been hypothesized to play a relevant role in COVID-19, representing a strong defender against SARS-CoV-2 infection. The aim of our work was the study of immunohistochemical surfactant expression in the lungs of patients died following SARS-CoV-2 ARDS, in order to shed light on a possible therapeutic surfactant administration...
July 2021: European Review for Medical and Pharmacological Sciences
Tania Ahmed Shakoori, Muhammad Mansoor Hafeez, Arif Malik
The world is struggling to deal with the corona pandemic. Effective therapies are still awaited due to the lack of understanding of the pathophysiological mechanism of the disease. Bearing recent research and clinical observations in mind, the authors propose a novel physiological mechanism of COVID-19 and explain development of COVID-19 related acute respiratory distress syndrome (ARDS) secondary to COVID-19 related hemoglobinopathy. It is a consistent observation that the radiological picture of COVID-19 related ARDS bears more resemblance to high altitude pulmonary edema (HAPE) than typical ARDS...
December 2020: Acta Clinica Croatica
John Kyle Bohman, Scott D Nei, Laurie N Mellon, Robert Spencer Ashmun, Pramod K Guru
OBJECTIVES: This study aimed to determine whether patients on extracorporeal membrane oxygenation (ECMO) with coronavirus disease 2019 (COVID-19) achieved lower rates of physical therapy participation and required more sedation than those on ECMO without COVID-19. DESIGN: Retrospective, observational, matched-cohort study. SETTING: Bicenter academic quaternary medical centers. PARTICIPANTS: All adults on ECMO for severe COVID-19-associated acute respiratory distress syndrome (ARDS) during 2020 and matched (matched 1:1 based on age ± 15 years and medical center) adults on ECMO for ARDS not associated with COVID-19...
June 29, 2021: Journal of Cardiothoracic and Vascular Anesthesia
Azza Sarfraz, Saman Hasan Siddiqui, Junaid Iqbal, Syed Asad Ali, Zahra Hasan, Zouina Sarfraz, Najeeha Talat Iqbal
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to acute respiratory distress syndrome (ARDS). Understanding the evolution of the virus, and immune-pathogenic processes are critical for designing future therapeutic interventions. In this review, we collate information on the structure, genome, viral life cycle, and adult and pediatric host immune responses in response to SARS-CoV-2. The immunological responses are a prototype of the developmental origins of health and disease (DOHaD) hypothesis to explain the socio-geographic differences impacting the severity and mortality rates in SARS-CoV-2 infections...
July 21, 2021: Journal of Developmental Origins of Health and Disease
Cristiano Van Zeller, Asad Anwar, Nordita Ramos-Bascon, Natalie Barnes, Brendan Madden
COVID-19 ARDS has a high mortality and few therapeutic options. We present a preliminary report on our experience using high-dose pulsed methylprednisolone in COVID-19 ARDS and three-month outcomes. We performed a retrospective analysis of all patients treated with high-dose methylprednisolone for COVID-19 ARDS and three-month lung function, 6MWT, and CT findings. 15 patients were treated of which 10 survived to discharge. Reduced DLCO was the commonest abnormality in lung function tests and had the lowest mean value...
July 19, 2021: Monaldi Archives for Chest Disease
Guanghui Xu, Huiqi Wan, Litao Yi, Wei Chen, Youhua Luo, Yiqi Huang, Xiaojuan Liu
Accumulating evidence showed that berberine possessed the anti-inflammatory action in various diseases caused by inflammation. However, it was still unclear whether both inhalation and injection with berberine produced pulmonary protective role in acute respiratory distress syndrome (ARDS). This study was aimed to evaluate the effects of both administration routes including inhalation and injection with berberine in ARDS induced by lipopolysaccharide (LPS) inhalation. Histopathological examination and weight of lung were evaluated...
July 17, 2021: European Journal of Pharmacology
Christian Karagiannidis, Stephan Strassmann, Michaela Merten, Thomas Bein, Wolfram Windisch, Patrick Meybohm, Steffen Weber-Carstens
No abstract text is available yet for this article.
July 20, 2021: American Journal of Respiratory and Critical Care Medicine
Álvaro Jesús Gómez-Ruiz, Alida González-Gil, José Gil, Felipe Alconchel, Álvaro Navarro-Barrios, Elena Gil-Gómez, Jerónimo Martínez, Aníbal Nieto, Carlos García-Palenciano, Pedro Antonio Cascales-Campos
BACKGROUND: The main objective of this study was to evaluate the differences between cisplatin and paclitaxel in the development of postoperative renal toxicity, using as a reference the RIFLE (Risk, Injury, Insufficiency, Loss, and End-stage renal function) and AKIN (Acute Kidney Injury Network) criteria in patients with primary or recurrent ovarian cancer with peritoneal dissemination treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: One hundred fifty-two patients who were treated between December 2007 and June 2017 were analyzed...
July 20, 2021: Langenbeck's Archives of Surgery
Kari Ann Shirey, Jorge C G Blanco, Stefanie N Vogel
Respiratory viral infections have been a long-standing global burden ranging from seasonal recurrences to the unexpected pandemics. The yearly hospitalizations from seasonal viruses such as influenza can fluctuate greatly depending on the circulating strain(s) and the congruency with the predicted strains used for the yearly vaccine formulation, which often are not predicted accurately. While antiviral agents are available against influenza, efficacy is limited due to a temporal disconnect between the time of infection and symptom development and viral resistance...
2021: Frontiers in Immunology
Rufaida, Tarique Mahmood, Ismail Kedwai, Farogh Ahsan, Arshiya Shamim, Mohammad Shariq, Saba Parveen
The dissemination of the 2019 novel coronavirus (2019-nCoV) is presenting the planet with a new health emergency response or threat to health. The virus emerged in bats and was disseminated to humans in December 2019 via still unknown intermediate species in Wuhan, China. It is disseminated by inhalation or breaks out with infected droplets and the incubation period is between 2 and 14 days. The symptoms usually include high body temperature, cough, sore throat, dyspnea, low energy or tiredness, and weakness...
July 19, 2021: Journal of Basic and Clinical Physiology and Pharmacology
Kate C Tatham, Niall D Ferguson, Qi Zhou, Lori Hand, Peggy Austin, Ravi Taneja, Alejandro C Arroliga, Juan F Sanchez, Edgar J Jimenez, Brandon P Staub, Michelle E Kho, J Guillermo Domínguez-Cherit, Adam Mullaly, Yaseen M Arabi, Maureen O Meade
PURPOSE: We sought to examine changes in acute respiratory distress syndrome (ARDS) management over a 12-year period of two successive randomized trials. METHODS: Analyses included baseline data, from eligible patients, prior to influence of trial protocols, and daily study data, from randomized patients, of variables not determined by trial protocols. Mixed linear regressions examined changes in practice year-on-year. RESULTS: A total of 2376 patients met the inclusion criteria...
July 5, 2021: Journal of Critical Care
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