Jared Radbel, Debra L Laskin, Jeffrey D Laskin, Howard M Kipen
Acute respiratory distress syndrome (ARDS) is a highly morbid lung pathology induced by exposure to chemical warfare agents, including vesicants, phosgene, chlorine, and ricin. In this review, we describe the pathology associated with the development of ARDS in humans and experimental models of acute lung injury following animal exposure to these high-priority threat agents. Potential future approaches to disease-modifying treatment used in preclinical animal studies, including antioxidants, anti-inflammatories, biologics, and mesenchymal stem cells, are also described...
July 29, 2020: Annals of the New York Academy of Sciences
Qing Nie, Aiwu Ye, Shixiong WeiW
Acute respiratory distress syndrome (ARDS) is a serious lung injury in patients with severe coronavirus disease 2019 (COVID-19). This process often is difficult to reverse, eventually leading to the death of patients. Extracorporeal membrane oxygenation (ECMO) treatment can provide patients with cardiopulmonary function support and buy time for clinicians' treatment. However, some patients still suffer from poor oxygenation after ECMO treatment. At this time, nurses can change the patient's position to prone position to improve oxygenation level and promote sputum excretion...
June 15, 2020: Heart Surgery Forum
Melanie A Hundt, Yanhong Deng, Maria M Ciarleglio, Michael H Nathanson, Joseph K Lim
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is associated with significant morbidity and mortality due to pneumonia, acute respiratory distress syndrome (ARDS) and multiorgan failure. Liver injury has been reported as a non-pulmonary manifestation of COVID-19 but characterization of liver test abnormalities and their association with clinical outcomes is incomplete. We conducted a retrospective cohort study of 1827 patients with confirmed COVID-19 who were hospitalized within the Yale-New Haven Health System (YNHHS) between March 14, 2020 and April 23, 2020...
July 29, 2020: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Mohammad A Uddin, Mohammad S Akhter, Khadeja-Tul Kubra, Nektarios Barabutis
Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) represent a significant cause of morbidity and mortality in critically ill hospitalized patients. Emerging evidence suggest that the expression levels of P53 in the lungs are associated with the supportive effects of heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists in the endothelium. In the current study, we employed an in vivo model of intratracheal administration of lipopolysaccharides (LPS)-induced ALI to investigate the role of P53 in counteracting LPS-induced lung inflammatory responses...
December 2020: Current research in physiology
Sadaf Sheikh, Muhammad Akbar Baig
Hypoxemia is the most common cause for hospitalization in COVID-19 patients. Acute hypoxemic respiratory failure or acute respiratory distress syndrome (ARDS) is the most common complication in COVID-19 patients. Close monitoring of respiratory decompensation is essential. Supplemental oxygen, high flow nasal canula, non-invasive ventilation and endotracheal intubation are the most commonly suggested methods to improve oxygenation. Early intubation with pre-oxygenation, modified rapid sequence intubation and intubation using a video laryngoscope has been advised as a strategy including lung protective ventilation, prone position ventilation, adequate sedation and extracorporeal membrane oxygenation...
June 2020: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Saad Khan, Zeeshan Ahmad, Fahad Khan, Hamza Asif, Asma Zia-Ur-Rahman
Coronavirus disease 19 (COVID-19) is a viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease started as an epidemic in China in December 2019 that later achieved a pandemic potential spreading to over 210 countries with more than 3.5 million confirmed cases and close to 250,000 deaths till date. Its symptoms most commonly include, dry cough, fever, myalgia, and fatigue. As the number of new cases keeps on rising, many patients have been documented with gastrointestinal manifestations such as diarrhoea, vomiting and abdominal pain...
June 2020: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Masoumeh Asgharpour, Elham Zare, Muhammed Mubarak, Amirhesam Alirezaei
Acute kidney injury (AKI) is relatively common in critically ill coronavirus disease 2019 (COVID-19) patients and it increases mortality and prolongs hospital stay. This article aimed to investigate the history, virology, epidemiology, clinical manifestations, pathophysiology and management of COVID-19 disease, in general, and the pathogenetic mechanisms of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV2)-induced kidney damage, in particular. Keywords like SARS-CoV2, COVID-19, renal impairment, sepsis, viremia, etc...
June 2020: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Jiong Zhang, Fang Cao, Shu-Kun Wu, Lu Xiang-Heng, Wei Li, Gui-Sen Li, Jia Wang
AIM: Novel coronavirus pneumonia (COVID-19) has become pandemic. It brings serious threat to hemodialysis (HD) patients. Therefore, we carried out a study on the clinical characteristics of HD patients with COVID-19. METHODS: We retrospectively analyzed the data of 31 HD patients with COVID-19. The clinical features of patients include epidemiology, clinical symptoms, laboratory and imaging test, treatment and prognosis. RESULTS: 61.3% were severe, and 38...
November 2020: Renal Failure
A Manfredi, F Luppi, G Cassone, C Vacchi, C Salvarani, M Sebastiani
INTRODUCTION: Main clinical manifestations of SARS-CoV-2 infection are characterized by fever, cough, dyspnoea and interstitial pneumonia frequently evolving in an acute respiratory distress syndrome (ARDS). AREAS COVERED: Features of coronavirus disease 2019 (COVID-19) pneumonia presents some common points with interstitial lung disease (ILD) both idiopathic and related to rheumatoid arthritis (RA), typically characterized by a chronic progression over some years and possibly complicated by acute exacerbation...
July 28, 2020: Expert Review of Clinical Immunology
Jia Song, Weihang Hu, Yihua Yu, Xin Shen, Yueben Wang, Jin Yan, Xianghong Yang, Shijin Gong, Minjia Wang
BACKGROUND The aim of this study was to describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and compare these parameters in an elderly group with those in a younger group. MATERIAL AND METHODS This retrospective, single-center observational study included 69 hospitalized patients with laboratory-confirmed COVID-19 from a tertiary hospital in Wuhan, China, between January 14, 2020, and February 26, 2020. Epidemiological, demographic, clinical, and laboratory data, as well as treatments, complications, and outcomes were extracted from electronic medical records and compared between elderly patients (aged ≥60 years) and younger patients (aged <60 years)...
July 28, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Zhou-Feng Wang, Yu-Min Yang, Heng Fan
OBJECTIVE: We aimed to investigate the diagnostic value of microRNA-155 (miR-155) for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in patients with sepsis. METHODS: In this prospective study, we used Spearman correlation analysis to investigate relationships between miR-155 expression and inflammatory factors, oxygenation ratio (PaO2 /FiO2 ), and ALI/ARDS score, and used area under the receiver operating characteristic curve (AU-ROC) to evaluate miR-155's diagnostic accuracy for ALI/ARDS in patients with sepsis...
July 2020: Journal of International Medical Research
Barbara Seeliger, Guillaume Philouze, Zineb Cherkaoui, Emanuele Felli, Didier Mutter, Patrick Pessaux
PURPOSE: Patients with an acute abdomen require emergency surgery. SARS-CoV-2 infection can affect multiple organ systems, including the digestive tract. Little is known about the consequences of COVID-19 infection in emergency surgical patients. METHODS: Perioperative data for COVID-19 patients undergoing emergency surgery from March 1, 2020, to May 23, 2020 were collected prospectively (NCT04323644). RESULTS: During this period, 215 patients underwent surgery, including 127 patients in an emergency setting, of whom 13 (10...
July 27, 2020: Langenbeck's Archives of Surgery
M K Taneja
The Coronavirus (2019-Cov-2) infection Covid-19 is highly contagious caused by single stranded RNA virus (+ssRNA) with nucleocapsid and spreading widely all across the world and responsible for more than 3.6 million morbidity and 0.25 million mortality No specific treatment is available till date. The clinical symptoms are mainly upper respiratory leading to diffuse viral pneumonia and multiple organ failure involving. Kidney, Liver and Heart along with coagulopathies. During 2004 (SARS-CoV) pandemic role of nitric oxide in its management is well demonstrated...
September 2020: Indian Journal of Otolaryngology and Head and Neck Surgery
Chengcong Yin, Long Cheng, Jiajia Pan, Lili Chen, Qi Xue, Juliang Qin, Shaoying Wang, Bing Du, Mingyao Liu, Ying Zhang, Wenzheng Jiang, Min Qian, Hua Ren
Acute respiratory distress syndrome (ARDS) is a kind of comprehensive disease with excessive inflammation and high clinical mortality. Multiple immune cells are involved in the ARDS process. Amongst these populations, lung-resident alveolar macrophages (AMs) are known to participate in the regulation of ARDS. GPR84, a metabolite-sensing GPCR sensing medium-chain fatty acids (MCFAs), is highly expressed in LPS-challenged macrophages and considered as a pro-inflammatory receptor. In this study, it was hypothesized that Gpr84 may be involved in pulmonary homeostasis via its regulatory effect on the switch of AM status...
July 27, 2020: Mucosal Immunology
Wei-Chih Chen, Kuo-Chin Kao, Chau-Chyun Sheu, Ming-Cheng Chan, Yu-Mu Chen, Ying-Chun Chien, Chung-Kan Peng, Shinn-Jye Liang, Han-Chung Hu, Ming-Ju Tsai, Wen-Feng Fang, Wann-Cherng Perng, Hao-Chien Wang, Chieh-Liang Wu, Kuang-Yao Yang
BACKGROUND: Patients with severe influenza-related acute respiratory distress syndrome (ARDS) have high morbidity and mortality. Moreover, nosocomial lower respiratory tract infection (NLRTI) complicates their clinical management and possibly worsens their outcomes. This study aimed to explore the clinical features and impact of NLRTI in patients with severe influenza-related ARDS. METHODS: This was an institutional review board approved, retrospective, observational study conducted in eight medical centers in Taiwan...
January 2020: Therapeutic Advances in Respiratory Disease
Christopher Kabrhel
As COVID-19 swept across the globe, emergency physicians stood on the front lines of a pandemic unlike any seen in our lifetimes. In areas where cases surged, we rapidly assessed and stabilized large numbers of critically ill patients using the limited data available to us, for that is, fundamentally, what we do. In the beginning, we relied on first principles. Vital signs are vital. Isolate the infected. Intubate ARDS early.
July 27, 2020: Academic Emergency Medicine
Shubhi Kaushik, Sindy Villacres, Ruth Eisenberg, Shivanand S Medar
OBJECTIVES: To describe the incidence of and risk factors for acute kidney injury (AKI) in children with acute respiratory distress syndrome (ARDS) and study the effect of AKI on patient outcomes. DESIGN: A single-center retrospective study. SETTING: A tertiary care children's hospital. PATIENTS: All patients less than 18 years of age who received invasive mechanical ventilation (MV) and developed ARDS between July 2010 and July 2013 were included...
July 27, 2020: Journal of Intensive Care Medicine
Zahra Soleimani, Azam Soleimani
BACKGROUND: Management of acute respiratory distress syndrome (ARDS) in pregnant women infected with new severe acute respiratory syndrome Corona virus 2 (SARS-CoV2 ) is a challenging clinical task. CASE: A 30- year-old woman (gravid 3, parity 2) presented at her 21 and 2/7 weeks gestation (pre pregnancy BMI: 36.1 kg/m2 ), with ARDS caused by SARS-CoV2 infection. She received lopinavir/ritonavir and azithromycin as well as early methyl prednisolone therapy. Given the persistent hypoxemia despite oxygen therapy via non rebreather face mask (FiO2 :80%), convalescent plasma transfusion was administered that led to a mild clinical improvement as well as decrease in inflammatory markers...
July 26, 2020: Journal of Maternal-fetal & Neonatal Medicine
Tatsuki Abe, Takehiro Izumo, Akihiro Ueda, Munehiro Hayashi, Yoshitaka Ishibashi
Novel coronavirus disease 2019 (COVID-19) is a highly infectious and deadly disease, spreading worldwide. There are limited data about the clinical course of end-stage renal disease (ESRD) patients infected with COVID-19. However, previous cohort studies showed a high mortality rate of ESRD patients infected with COVID-19. We report here two Japanese ESRD patients confirmed with severe COVID-19 pneumonia. Case 1 was a 60-year-old man with ESRD due to diabetic nephropathy who were infected with COVID-19 and exhibited acute respiratory distress syndrome (ARDS) requiring mechanical ventilation and intensive care unit (ICU) admission...
July 26, 2020: CEN Case Reports
Saya Ikegami, Kei Jitsuiki, Hiroki Nagasawa, Ryota Nishio, Youichi Yanagawa
A 44-year-old man who had been feeling general fatigue was found in an unconscious state on the same day. He had no remarkable medical history. On arrival at the hospital, his Glasgow Coma Scale was E1V2M3; he had tachycardia and hypertension, was afebrile, and in a severe hypoxic state. His PaO2 /FiO2 (P/F) was under 100, even with tracheal intubation with 100% oxygen. Chest X-ray and CT revealed a bilateral ground-glass appearance with consolidation. Cardiac echo initially showed hyper-dynamic wall motion...
June 22, 2020: Curēus
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"