Hui-Ching Hsu, Yu-Sheng Chang, Tsung-Yun Hou, Lung-Fang Chen, Li-Fang Hu, Tzu-Min Lin, Chi-Sheng Chiou, Kai-Len Tsai, Sheng-Hong Lin, Pei-I Kuo, Wei-Sheng Chen, Yi-Chun Lin, Jin-Hua Chen, Chi-Ching Chang
OBJECTIVE: To compare Pneumocystis jirovecii pneumonia (PJP) risk between patients with autoimmune rheumatic diseases (ARD) and the general population METHODS: We identified patients with ARD recorded in the National Health Insurance Research Database of Taiwan from 2002 to 2015 and randomly selected a comparison cohort from the general population matched for age and sex. We analyzed PJP risk stratified by sex, age, comorbidities, and medications using Cox proportional hazard model. RESULTS: We enrolled 103,117 patients with ARD...
March 1, 2021: Clinical Rheumatology
Francesca Simioli, Anna Annunziata, Gerardo Langella, Maria Martino, Salvatore Musella, Giuseppe Fiorentino
OBJECTIVE: Prone positioning (PP) has demonstrated to be a safe adjunctive therapy for severe acute respiratory distress syndrome (ARDS). There is limited evidence of PP effects on awake patients. This study aimed to investigate the effects and feasibility of PP on coronavirus disease 2019 (COVID-19)-associated awake patients with ARDS in a subintensive setting of care. MATERIAL AND METHODS: This is a single-center case-control study involving patients with severe COVID-19 infection...
January 2021: Turkish Thoracic Journal
Yi-Shan Tang, Xiao-Jun Zhang, Wan-Neng Wang, Ting Wang, Wu-Long Cao, Qiu-Han Zhang, Fu Chen
BACKGROUND: Pulmonary surfactant dysfunction is an important pathological factor in acute respiratory distress syndrome (ARDS) and pulmonary fibrosis (PF). OBJECTIVE: In this study, the characteristics of recombinant mature surfactant protein B (SP-B) and reteplase (rPA) fusion protein maintaining good pulmonary surface activity and rPA fibrinolytic activity in acute lung injury cell model were studied. METHODS: We studied the characteristics of SP-B fusion expression, cloned rPA gene and N-terminal rPA/C-terminal SP-B co-expression gene, and constructed them into eukaryotic expression vector pEZ-M03 to obtain recombinant plasmids pEZ-rPA and pEZ-rPA/SP-B...
March 1, 2021: Protein and Peptide Letters
Lauren Morata, Mary Lou Sole, Frank Guido-Sanz, Carrie Ogilvie, Rebecca Rich
BACKGROUND: Prone positioning is a standard treatment for moderate to severe acute respiratory distress syndrome (ARDS), but the outcomes associated with manual versus automatic prone positioning have not been evaluated. OBJECTIVE: To retrospectively evaluate outcomes associated with manual versus automatic prone positioning as part of a pronation quality improvement project implemented by a multidisciplinary team. METHODS: A retrospective, descriptive-comparative approach was used to analyze data from 24 months of a prone positioning protocol for ARDS...
March 1, 2021: American Journal of Critical Care
Jagdish C Joshi, Bhagwati Joshi, Ian Rochford, Dolly Mehta
Acute respiratory distress syndrome (ARDS) is the major cause of mortality among hospitalized acute lung injury (ALI) patients. Lung macrophages play an important role in maintaining the tissue-fluid homeostasis following injury. We recently showed that circulating monocytes recruited into the alveolar space suppressed the stimulator of type 1 interferon genes (STING) signaling in alveolar macrophages through sphingosine-1-phosphate (S1P). We used CD11b-DTR mice to deplete CD11b+ monocytes following LPS or Pseudomonas aeruginosa infection...
2021: Journal of cellular signaling
Michael F Harrison, Dolores Villar, Siva Naga S Yarrarapu, Pramod Guru, Jorge Mallea, Klaus Torp, Perry Bechtle, Augustine Lee, Pablo Moreno Franco, Devang K Sanghavi
COVID-19 has placed a significant strain upon healthcare resources at a global level and refractory hypoxemia is the leading cause of death among COVID-19 patients. The management of limited resources such as mechanical ventilators has remained a contentious issue both at an individual and institutional level since the beginning of the pandemic. As a result, the COVID-19 pandemic has presented challenges to critical care practitioners to find innovative ways to provide supplemental oxygen therapy to their patients...
2021: Respiratory Medicine Case Reports
Caroline Sampson, Jennifer Taylor, Luke Dyson, Mostafa Hassanein
Veno-venous extra-corporeal membrane oxygenation (VV ECMO) provides support in severe acute respiratory failure (SARF) refractory to maximal conventional ventilatory support. ECMO does not treat the lungs per se, but allows time for the underlying condition to reverse or resolve. Common indications include acute respiratory distress syndrome (ARDS) and life-threatening asthma. On occasion, rarer conditions causing respiratory failure are diagnosed during ECMO support. The anti-synthetase syndrome (ASS) comprises of a group of conditions characterised by the presence of anti-aminoacyl-tRNA-synthetase antibodies with one or more of interstitial lung disease, inflammatory myositis and/or arthritis...
February 2021: Journal of the Intensive Care Society
Raymond Dominic Savio, Rajalakshmi Parasuraman, Daphnee Lovesly, Bhuvaneshwari Shankar, Lakshmi Ranganathan, Nagarajan Ramakrishnan, Ramesh Venkataraman
Aim: To assess the feasibility, tolerance and effectiveness of enteral nutrition in critically ill patients receiving invasive mechanical ventilation in the prone position for severe Acute Respiratory Distress Syndrome (ARDS). Methods: Prospective observational study conducted in a multidisciplinary critical care unit of a tertiary care hospital from January 2013 until July 2015. All patients with ARDS who received invasive mechanical ventilation in prone position during the study period were included...
February 2021: Journal of the Intensive Care Society
S Mleyhi, J Ziadi, Y Ben Hmida, F Ghédira, M Ben Mrad, R Denguir
INTRODUCTION: In Tunisia, as elsewhere in the world, severe forms of acute respiratory distress syndrome (ARDS) related to SARS-Covid19 have been observed. When the usual means of resuscitation were no longer sufficient, the implementation of the Extracorporeal membrane oxygenation or ECMO was needed. AIM: The whole problem of the management of these patients in this pandemic period has been to manage the operation of the ECMO machine, usually reserved for expert and specialized centers in the field...
January 5, 2021: Annales de Cardiologie et D'angéiologie
Aakriti Gupta, Mahesh V Madhavan, Timothy J Poterucha, Ersilia M DeFilippis, Jessica A Hennessey, Bjorn Redfors, Christina Eckhardt, Behnood Bikdeli, Jonathan Platt, Ani Nalbandian, Pierre Elias, Matthew J Cummings, Shayan N Nouri, Matthew Lawlor, Lauren S Ranard, Jianhua Li, Claudia Boyle, Raymond Givens, Daniel Brodie, Harlan M Krumholz, Gregg W Stone, Sanjum S Sethi, Daniel Burkhoff, Nir Uriel, Allan Schwartz, Martin B Leon, Ajay J Kirtane, Elaine Y Wan, Sahil A Parikh
The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections, but their benefit has not been assessed in COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1st through May 12th , 2020 with study period ending on June 11th , 2020...
February 26, 2021: Nature Communications
Sara Chiappalupi, Laura Salvadori, Aleksandra Vukasinovic, Rosario Donato, Guglielmo Sorci, Francesca Riuzzi
A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global pandemic by the World Health. Approximately 15% of patients with COVID-19 progress to severe pneumonia and eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure with high morbidity and mortality. Evidence points towards a determinant pathogenic role of members of the renin-angiotensin system (RAS) in mediating the susceptibility, infection, inflammatory response and parenchymal injury in lungs and other organs of COVID-19 patients...
February 23, 2021: Life Sciences
Ashwin Kumar Shukla, Monisha Banerjee
Ever since its outbreak, Corona Virus Disease 2019(COVID-19) caused by SARS-CoV-2 has affected more than 26 million individuals in more than 200 countries. Although the mortality rate of COVID-19 is low, but several clinical studies showed, patients with diabetes mellitus (DM) or other major complication at high risk of COVID-19 and reported more severe disease and increased fatality. The angiotensin-converting-enzyme 2 (ACE2), a component of renin-angiotensin-system (RAS); acts on ACE/Ang-II/AT1recptor axis, and regulates pathological processes like hypertension, cardiac dysfunction, Acute Respiratory Distress Syndrome (ARDS) etc...
February 26, 2021: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
Diddier Prada, Daniel Belsky, Andrea Baccarelli
Aging is characterized by a gradual and progressive decline in system integrity that occurs with advancing chronological age. Although it is a physiological process, aging is associated with a myriad of age-related diseases (ARDs), including frailty, sarcopenia, chronic obstructive pulmonary disease, cardiovascular disease, cancer, and neurodegenerative diseases. While not exclusively ARDs, many of these diseases lead to death, a lesser quality of life, and increased healthcare costs for individuals and systems...
February 23, 2021: La Medicina del Lavoro
Genoveva Uzunova, Stefano Pallanti, Eric Hollander
COVID-19 is associated with neuropsychiatric complications, the most frequent one being anxiety. Multiple biological and psychosocial factors contribute to anxiety in COVID-19. Among the biological factors, stress, genetics, gender, immune system, resilience, anosmia, hypogeusia, and central nervous system infection with SARS-CoV-2 are key. Anxiety is a complication of COVID-19 that may exacerbate the infection course, and the infection may exacerbate anxiety. We present the mechanisms of anxiety in symptomatic or asymptomatic COVID-19...
February 26, 2021: International Journal of Psychiatry in Clinical Practice
F Fiaschè, B Adriani, I Mancinelli, A Taranto
INTRODUCTION: Catatonia is a psychomotor syndrome that presents with severe symptoms which can lead to dangerous and lethal conditions if not diagnosed and treated properly. SARS-CoV-2 is a positive-sense single-stranded RNA virus that can occur in severe cases with acute pneumonia, ARDS, sepsis and septic shock. In these cases, ICU admission is necessary. CASE SUMMARY: A 59-year-old Caucasian man with septic shock and bilateral interstitial pneumonia from SARS-CoV-2 and schizotypal personality disorder presented with catatonic behaviour manifested by soporous state, response to intense painful stimuli with opening of the eyes, execution of simple verbal commands, maintenance of the same position, catalepsy, immobility, rigidity and mutism...
February 25, 2021: CNS & Neurological Disorders Drug Targets
Colleen J Bergin, Sophia Wilton, Matthew Hg Taylor, Michelle Locke
INTRODUCTION: Thoracic imaging of people who have survived exposure to a volcanic pyroclastic flow has not been described. In December 2019, an active volcano in New Zealand erupted with loss of life and severe burns to groups of people who were within one kilometre of a new fissure. Our aim was to describe the range of pulmonary abnormality in patients admitted to the Burns unit at Middlemore Hospital. METHODS: We describe the initial radiographic and computed tomography (CT) appearance of lung injuries in 14 people close to this fissure who were transported to our national burns centre in Middlemore hospital...
February 26, 2021: Journal of Medical Imaging and Radiation Oncology
Yanting Zhang, Wei Sun, Chun Wu, Yiwei Zhang, Li Cui, Yuji Xie, Bin Wang, Lin He, Hongliang Yuan, Yongxing Zhang, Yu Cai, Meng Li, Yu Zhang, Yun Yang, Yuman Li, Jing Wang, Yali Yang, Qing Lv, Li Zhang, Mingxing Xie
Background: RVEF (right ventricular ejection fraction) measured by three-dimensional echocardiography (3DE) has been used in evaluating right ventricular (RV) function and can provide useful prognostic information in other various cardiovascular diseases. However, the prognostic value of 3D-RVEF in coronavirus disease 2019 (COVID-19) remains unknown. We aimed to investigate whether 3D-RVEF can predict the mortality of COVID-19 patients. Methods: A cohort of 128 COVID-19-confirmed patients who had undergone echocardiography were studied...
2021: Frontiers in Cardiovascular Medicine
Yichen Li, Jie Li, Jia Ke, Na Jiao, Lixin Zhu, Lihan Shen, Lei Chen, Zhiqiang Jiang, Sijing Cheng, Yibo Huang, Yifeng Zou, Ruixin Zhu, Guangjun Yan
Corticosteroid is commonly used to reduce damage from inflammatory reactions in coronavirus disease 2019 (COVID-19). We aim to determine the outcomes of corticosteroid use in critically ill COVID-19 patients. Ninety six critically ill patients, hospitalized in 14 hospitals outside Wuhan from January 16 to March 30, 2020 were enrolled in this study. Among 96 critical patients, 68 were treated with corticosteroid (CS group), while 28 were not treated with corticosteroids (non-CS group). Multivariable logistic regression were performed to determine the possible correlation between corticosteroid use and the treatment outcomes...
2021: Frontiers in Medicine
Georgios Zagkotsis, Maria Markou, Panagiota Papanikolaou, Nikolaos Sabanis
Hypercalcemic crisis associated with the development of acute respiratory distress syndrome (ARDS) has been rarely documented in the literature. Most cases have been described in patients suffering from malignancies or renal failure with the presence of metastatic calcifications being a prominent feature. Only three cases of ARDS have been reported to date in patients with hypercalcemic crisis due to primary hyperparathyroidism (PHPT). Herein, we report a 72-year-old patient with PHPT that presented with severe hypercalcemic crisis and developed ARDS...
January 24, 2021: Curēus
Ansam Barakat, Matthijs Blankers, Jurgen E Cornelis, Louk van der Post, Nick M Lommerse, Aartjan T F Beekman, Jack J M Dekker
Objective: This study aims to determine factors associated with psychiatric hospitalisation of patients treated for an acute psychiatric crisis who had access to intensive home treatment (IHT). Methods: This study was performed using data from a randomised controlled trial. Interviews, digital health records and eight internationally validated questionnaires were used to collect data from patients on the verge of an acute psychiatric crisis enrolled from two mental health organisations. Thirty-eight factors were assigned to seven risk domains...
2021: Frontiers in Psychiatry
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"