Marcos Adriano Garcia Campos, Ézio Arthur Monteiro Cutrim, Érico Murilo Monteiro Cutrim, João Victor Pimentel de Oliveira, Eduardo José Silva Gomes de Oliveira, Daniel de Brito Pontes, José Albuquerque de Figueiredo Neto, Gyl Eanes Barros Silva
The Verbal Autopsy (VA) is a questionnaire about the circumstances surrounding a death. It was widely used in Brazil to assist in postmortem diagnoses and investigate excess mortality during the Coronavirus Disease 2019 (COVID-19) pandemic. This study aimed to determine the accuracy of investigating acute respiratory distress syndrome (ARDS) using VA. This is a cross-sectional study with prospective data collected from January 2020 to August 2021 at the Death Verification Service of Sao Luis city, Brazil. VA was performed for suspected COVID-19 deaths, and one day of the week was randomly chosen to collect samples from patients without suspected COVID-19...
2024: Revista do Instituto de Medicina Tropical de São Paulo
Ashley A Zurawel, Bria M Coates
Pediatric acute respiratory distress syndrome (ARDS) is severe, noncardiac hypoxemic respiratory failure that carries a substantial risk of death. Given the complexity of this clinically defined syndrome and the repeated failure of therapeutic trials, there has been an effort to identify subphenotypes of ARDS that may share targetable mechanisms of disease. In this issue of the JCI, Yehya and colleagues measured 19 plasma biomarkers in 279 children over the first seven days of ARDS. Increases in select tissue injury makers and inflammatory cytokines in peripheral blood were associated with multiple organ dysfunction syndrome and death, but not persistent ARDS...
May 15, 2024: Journal of Clinical Investigation
Zhi-Ying Kang, Qian-Yu Huang, Ning-Xin Zhen, Nan-Xia Xuan, Qi-Chao Zhou, Jie Zhao, Wei Cui, Zhao-Cai Zhang, Bao-Ping Tian
BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) or its earlier stage Acute lung injury (ALI), is a worldwide health concern that jeopardizes human well-being. Currently, the treatment strategies to mitigate the incidence and mortality of ARDS are severely restricted. This limitation can be attributed, at least in part, to the substantial variations in immunity observed in individuals with this syndrome. METHODS: Bulk and single cell RNA sequencing from ALI mice and single cell RNA sequencing from ARDS patients were analyzed...
2024: Frontiers in Immunology
Andréanne Côté, Chel Hee Lee, Sayed M Metwaly, Christopher J Doig, Graciela Andonegui, Bryan G Yipp, Ken Kuljit S Parhar, Brent W Winston
BACKGROUND: The Berlin definition of acute respiratory distress syndrome (ARDS) includes only clinical characteristics. Understanding unique patient pathobiology may allow personalized treatment. We aimed to define and describe ARDS phenotypes/endotypes combining clinical and pathophysiologic parameters from a Canadian ARDS cohort. METHODS: A cohort of adult ARDS patients from multiple sites in Calgary, Canada, had plasma cytokine levels and clinical parameters measured in the first 24 h of ICU admission...
May 14, 2024: European Journal of Medical Research
Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M Hendrickson, Kirsten N Kangelaris, Kathleen D Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V Eric Kerchberger, Ann Zalucky, Michael A Matthay, Lorraine B Ware, Carolyn S Calfee
BACKGROUND: Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be determined. We aimed to estimate the population attributable fraction of death from ARDS (PAFARDS ) in hypoinflammatory and hyperinflammatory sepsis, and to determine the primary cause of death within each phenotype. METHODS: We studied 1737 patients with sepsis from two prospective cohorts...
May 14, 2024: Critical Care: the Official Journal of the Critical Care Forum
Jeyanthan Jayakumaran, Gerald C Smaldone, Ann D Cuccia
BACKGROUND: During invasive ventilation, external flow jet nebulization results in increases in displayed exhaled tidal volumes (VT ). We hypothesized that the magnitude of the increase is inaccurate. An ASL 5000 simulator measured ventilatory parameters over a wide range of adult settings: actual VT , peak inspiratory pressure (PIP), and time to minimum pressure. METHODS: Ventilators with internal and external flow sensors were tested by using a variety of volume and pressure control modes (the target VT was 420 mL)...
May 14, 2024: Respiratory Care
Jamy D Ard, Kristina H Lewis, Justin B Moore
No abstract text is available yet for this article.
May 14, 2024: JAMA
Xiao Bo Li, Jia Li Liu, Shuang Zhao, Jing Li, Guang-Yan Zhang, Qing Tang, Wei Yong Chen
BACKGROUND: Inflammation-induced apoptosis of alveolar type II epithelial cells is a primary contributor to sepsis-induced acute respiratory distress syndrome (ARDS). Klotho is a single-pass transmembrane protein with anti-inflammatory and anti-apoptotic effects. However, the role and mechanism of Klotho in the development of ARDS remains unknown. OBJECTIVES: This study aimed to investigate the effect of Klotho on sepsis-induced apoptosis in human pulmonary alveolar epithelial cells (HPAEpiCs) together with the potential mechanism...
May 14, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Zixin Luo, Xinyue Song, Duoqin Huang, Li Xiao, Kang Zou
Endothelial and epithelial barrier dysfunction due to increased permeability and heightened inflammatory reactions influences the emergence of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Nevertheless, bibliometric research comparing endothelial and epithelial barriers is limited. Therefore, this bibliometric study analyzed the Web of Science Core Collection (WoSCC) of the Science Citation Index Expanded literature to explore present research priorities and development tendencies within this field...
May 15, 2024: Heliyon
Donald Dennis, Sagar Kumar, Huma Akta, Brian Fouty, Kane Schaphorst
Group A Streptococcal (GAS) infections can potentially progress into streptococcal toxic shock syndrome (STSS) with multiorgan failure. Even with a benign presentation, GAS can rapidly lead to fatal necrotizing infections. While myositis and cutaneous infections are the typical initial presentation of STSS, genitourinary infections are a less common source. This report presents a case of a previously healthy woman with the chief complaint of ankle pain who subsequently developed streptococcal toxic shock syndrome and multiorgan failure from a Group A streptococcus infection of the genitourinary tract...
April 2024: Curēus
Yang Liu, Milan Ončák, Jennifer Meyer, Shaun G Ard, Nicholas S Shuman, Albert A Viggiano, Hua Guo
The activation of carbon dioxide (CO2 ) by a transition-metal cation in the gas phase is a unique model system for understanding single-atom catalysis. The mechanism of such reactions is often attributed to a "two-state reactivity" model in which the high-energy barrier of a spin state correlating with ground-state reactants is avoided by intersystem crossing (ISC) to a different spin state with a lower barrier. However, such a "spin-forbidden" mechanism, along with the corresponding dynamics, has seldom been rigorously examined theoretically, due to the lack of global potential energy surfaces (PESs)...
May 13, 2024: Journal of the American Chemical Society
Lucy Marie Carter, Md Yuzaiful Md Yusof, Zoe Wigston, Darren Plant, Stephanie Wenlock, Adewonuola Alase, Antonios Psarras, Edward M Vital
OBJECTIVE: Mechanisms underpinning clinical evolution to systemic lupus erythematosus (SLE) from preceding antinuclear antibodies (ANA) positivity are poorly understood. This study aimed to understand blood immune cell transcriptional signatures associated with subclinical ANA positivity, and progression or non-progression to SLE. METHODS: Bulk RNA-sequencing of peripheral blood mononuclear cells isolated at baseline from 35 ANA positive (ANA+) subjects with non-diagnostic symptoms was analysed using differential gene expression, weighted gene co-expression network analysis, deconvolution of cell subsets and functional enrichment analyses...
May 13, 2024: Annals of the Rheumatic Diseases
Janis Timsans, Raine Tiihonen, Markku Kauppi
No abstract text is available yet for this article.
May 13, 2024: Annals of the Rheumatic Diseases
Megan E Campany, Britton B Donato, Pedro Reck Dos Santos, Cory M Alwardt, Kristin Sell-Dottin, Stephanie Blakeman, Penny Hung, Ayan Sen, Patrick DeValeria, Lara Schaheen, Jonathan D'Cunha
BACKGROUND AND OBJECTIVE: Extracorporeal membrane oxygenation (ECMO) has historically been utilized as a temporary life support option for patients with severe cardiac and pulmonary dysfunction. Recent advancements have enabled the safe application of ECMO in a wider variety of patients; we present a review of its use in patients undergoing general thoracic procedures supported by a case series at our institution. METHODS: We review current literature focusing on ECMO applications in thoracic surgery outside of the traditional use...
April 30, 2024: Journal of Thoracic Disease
Faryal Altaf, Vedangkumar Bhatt, Mohit Sekhon, Shitij Shrivastava, Naqash Mazhar, Sarah Moore
Acute respiratory distress syndrome (ARDS) presents a formidable challenge in critical care, often resulting in high mortality rates, particularly in severe cases or those compounded by preexisting conditions. Despite substantial advancements in critical care, the heterogeneous nature of ARDS necessitates nuanced clinical approaches. ARDS is generally diagnosed through clinical evaluation, radiographic imaging, and laboratory tests, as well as acute onset, bilateral lung infiltrates on imaging, and a partial pressure of oxygen in arterial blood (PaO2)/fraction of inspiratory oxygen concentration (FiO2) ratio of less than 300 mmHg...
April 2024: Curēus
Lu Lv, Xinyue Shao, Enhai Cui
BACKGROUND: Community-acquired pneumonia (CAP) is a global health concern due to its high rates of morbidity and mortality. Bacterial pathogens are common causes of CAP. It is one of the most common causes of acute respiratory distress syndrome (ARDS), a common severe respiratory system manifestation threatening human health. This study aimed to establish a predictive model for ARDS in patients with bacterial pneumonia, which was conducive to early identification of the occurrence and effective prevention of ARDS...
2024: Journal of Inflammation Research
Cheng Su, Cai Li, Xinyi Hu, Jing Wang, Linlin Liu, Xianfeng Zhang, Yeqing Tong
Angiotensin-converting enzyme 2 (ACE2) is an important regulator of the Renin-Angiotensin System (RAS). Additionally, it has been identified as a functional receptor for the Coronavirus. Research indicates that ACE2 plays a role in the regulation of cardiovascular systems by modulating blood pressure and electrolyte balance. Its role in pulmonary diseases has also garnered significant attention due to the widespread prevalence of Coronavirus. There is solid evidence linking ACE2 to other pulmonary diseases, including chronic obstructive pulmonary disease, acute respiratory distress syndrome, allergic asthma, among others...
2024: Infection and Drug Resistance
Na-Na Li, Kai Kang, Yang Zhou, Yan-Qi Liu, Qian-Qian Zhang, Pei-Yao Luo, Lei Wang, Ming-Yin Man, Jia-Feng Lv, Xi-Bo Wang, Ya-Hui Peng, Fei-Yu Luan, Yue Li, Jian-Nan Zhang, Yang Chong, Yi-Qi Wang, Chang-Song Wang, Ming-Yan Zhao, Kai-Jiang Yu
OBJECTIVES: The translocation of intestinal flora has been linked to the colonization of diverse and heavy lower respiratory flora in patients with septic ARDS, and is considered a critical prognostic factor for patients. METHODS: On the first and third days of ICU admission, BALF, throat swab, and anal swab were collected, resulting in a total of 288 samples. These samples were analyzed using 16S rRNA analysis and the traceability analysis of new generation technology...
December 2024: Virulence
Xuemeng Li, Qianqian Xiong, Qingqing Yang, Jing Shi, Yuhong Han, Yishu Dong, Jun Qian, Zhongqing Qian, Hongtao Wang, Ting Wang, Fengjiao Wu
Acute lung injury (ALI) and its severe manifestation, acute respiratory distress syndrome (ARDS), represent critical clinical syndromes with multifactorial origins, notably stemming from sepsis within intensive care units (ICUs). Despite their high mortality rates, no selective cure is available beside ventilation support. Apoptosis plays a complex and pivotal role in the pathophysiology of acute lung injury. Excessive apoptosis of alveolar epithelial and microvascular endothelial cells can lead to disruption of lung epithelial barrier integrity, impairing the body's ability to exchange blood and gas...
May 8, 2024: Biochemical and Biophysical Research Communications
Chun Yang, Yuanyuan Tan, Zihao Li, Lei Hu, Yuanyuan Chen, Shouliang Zhu, Jiawei Hu, Tingting Huai, Mingqing Li, Guobin Zhang, Dewang Rao, Guanghe Fei, Min Shao, Zhenxing Ding
BACKGROUND: COVID-19-associated pulmonary fibrosis remains frequent. This study aimed to investigate pulmonary redox balance in COVID-19 ARDS patients and possible relationship with pulmonary fibrosis and long-term lung abnormalities. METHODS: Baseline data, chest CT fibrosis scores, N-terminal peptide of alveolar collagen III (NT-PCP-III), transforming growth factor (TGF)-β1, superoxide dismutase (SOD), reduced glutathione (GSH), oxidized glutathione (GSSG) and malondialdehyde (MDA) in bronchoalveolar lavage fluid (BALF) were first collected and compared between SARS-CoV-2 RNA positive patients with moderate to severe ARDS (n = 65, COVID-19 ARDS) and SARS-CoV-2 RNA negative non-ARDS patients requiring mechanical ventilation (n = 63, non-ARDS)...
May 12, 2024: Annals of Intensive Care
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