Anwar I Joudeh, Abdu Qaid Lutf, Salah Mahdi, Gui Tran
BACKGROUND: Patients with autoimmune rheumatic diseases (ARD) are at a potentially higher risk for COVID-19 infection complications. Given their inherent altered immune system and the use of immunomodulatory medications, vaccine immunogenicity could be unpredictable with a suboptimal or even an exaggerated immunological response. The aim of this study is to provide real-time data on the emerging evidence of COVID-19 vaccines' efficacy and safety in patients with ARDs. METHODS: We performed a literature search of the PubMed, EMBASE, and OVID databases up to 11-13 April 2022 on the efficacy and safety of both types of the mRNA-vaccines and the AstraZeneca COVID-19 vaccines in patients with ARD...
May 22, 2023: Vaccine
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which is closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying enzyme which could affect chromatin structure and transcriptional regulation. Here, we explored the effects of HDAC3 in type II alveolar epithelial cells (AT2) on lipopolysaccharide (LPS)-induced ALI and shed light on potential molecular mechanisms. We generated ALI mouse model with HDAC3 conditional knockout mice (Sftpc-cre; Hdac3f/f ) in AT2 and the roles of HDAC3 in ALI and epithelial barrier integrity were investigated in LPS-treated AT2...
May 20, 2023: Redox Biology
Wei Li, Yuehong Chen, Ye Feng, Jing Li, Xiaoping Kang, Sen Zhang, Yuchang Li, Zhiyan Zhao, Wenguang Yang, Lu Zhao, Huiyao Wang, Tao Jiang
Human adenovirus 55 (HAdV-55) has recently caused outbreaks of acute respiratory disease (ARD), posing a significant public threat to civilians and military trainees. Efforts to develop antiviral inhibitors and quantify neutralizing antibodies require an experimental system to rapidly monitor viral infections, which can be achieved through the use of a plasmid that can produce an infectious virus. Here, we used a bacteria-mediated recombination approach to construct a full-length infectious cDNA clone, pAd55-FL, containing the whole genome of HadV-55...
May 18, 2023: Viruses
Gabriela Droc, Maria Camelia Stancioaica, Corina Gabriela Soare, Mihai-Gabriel Stefan, Daiana Ingustu, Cristina Martac, Daniel Coriu, Sebastian Isac, Nicolae Suciu, Stefan Andrei
Acute promyelocytic leukemia (APL) is generated by the PML-RARA fusion gene. In patients suffering from APL, the early diagnosis and treatment are essential in the successful management. We reported a case of a 27-year-old 17th-week pregnant patient diagnosed with APL. After an extensive hematological diagnostic panel, the acute promyelocytic leukemia was confirmed, and the patient received all- trans retinoic acid (ATRA), idarubicin (IDA), and dexamethasone, following national guidelines. Due to ATRA-related differentiation syndrome, the therapy was adjusted, and hydroxycarbamide was added with a good outcome...
May 8, 2023: Life
George Karlis, Despina Markantonaki, Sotirios Kakavas, Dimitra Bakali, Georgia Katsagani, Theodora Katsarou, Christos Kyritsis, Vasiliki Karaouli, Paraskevi Athanasiou, Mary Daganou
Ventilation in a prone position (PP) for 12 to 16 h per day improves survival in ARDS. However, the optimal duration of the intervention is unknown. We performed a prospective observational study to compare the efficacy and safety of a prolonged PP protocol with conventional prone ventilation in COVID-19-associated ARDS. Prone position was undertaken if P/F < 150 with FiO2 > 0.6 and PEEP > 10 cm H2 O. Oxygenation parameters and respiratory mechanics were recorded before the first PP cycle, at the end of the PP cycle and 4 h after supination...
May 17, 2023: Journal of Clinical Medicine
Maria Paparoupa, Marlene Fischer, Hans O Pinnschmidt, Jörn Grensemann, Kevin Roedl, Stefan Kluge, Dominik Jarczak
COVID-19-associated ARDS (C-ARDS) is mentioned to express higher analgosedation needs, in comparison to ARDS of other etiologies. The objective of this monocentric retrospective cohort study was to compare the analgosedation needs between C-ARDS and non-COVID-19 ARDS (non-C-ARDS) on veno-venous extracorporeal membrane oxygenation (VV-ECMO). Data were collected from the electronic medical records of all adult patients treated with C-ARDS in our Department of Intensive Care Medicine between March 2020 and April 2022...
May 17, 2023: Journal of Clinical Medicine
Beatrice Ragnoli, Beatrice Da Re, Alessandra Galantino, Stefano Kette, Andrea Salotti, Mario Malerba
Since the first description of COVID-19 infection, among clinical manifestations of the disease, including fever, dyspnea, cough, and fatigue, it was observed a high incidence of thromboembolic events potentially evolving towards acute respiratory distress syndrome (ARDS) and COVID-19-associated-coagulopathy (CAC). The hypercoagulation state is based on an interaction between thrombosis and inflammation. The so-called CAC represents a key aspect in the genesis of organ damage from SARS-CoV-2. The prothrombotic status of COVID-19 can be explained by the increase in coagulation levels of D-dimer, lymphocytes, fibrinogen, interleukin 6 (IL-6), and prothrombin time...
May 18, 2023: International Journal of Molecular Sciences
Evgeniia V Fot, Natalia O Khromacheva, Aleksei A Ushakov, Aleksei A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov
We compared two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Sixty patients with sepsis and ARDS were randomized to receive de-escalation fluid therapy, guided either by the extravascular lung water index (EVLWI, n = 30) or the global end-diastolic volume index (GEDVI, n = 30). In cases of GEDVI > 650 mL/m2 or EVLWI > 10 mL/kg, diuretics and/or controlled ultrafiltration were administered to achieve the cumulative 48-h fluid balance in the range of 0 to -3000 mL...
May 15, 2023: International Journal of Molecular Sciences
Alexander Rombauts, Marta Bódalo Torruella, Gabriela Abelenda-Alonso, Júlia Perera-Bel, Anna Ferrer-Salvador, Ariadna Acedo-Terrades, Maria Gabarrós-Subirà, Isabel Oriol, Carlota Gudiol, Lara Nonell, Jordi Carratalà
The clinical manifestations of SARS-CoV-2 infection vary widely, from asymptomatic infection to the development of acute respiratory distress syndrome (ARDS) and death. The host response elicited by SARS-CoV-2 plays a key role in determining the clinical outcome. We hypothesized that determining the dynamic whole blood transcriptomic profile of hospitalized adult COVID-19 patients and characterizing the subgroup that develops severe disease and ARDS would broaden our understanding of the heterogeneity in clinical outcomes...
May 3, 2023: Biomedicines
Sara Hey, Dayjah Whyte, Minh-Chau Hoang, Nick Le, Joseph Natvig, Claire Wingfield, Charles Onyeama, Judie Howrylak, Inimary T Toby
Acute Respiratory Distress Syndrome (ARDS) is an illness that typically develops in people who are significantly ill or have serious injuries. ARDS is characterized by fluid build-up that occurs in the alveoli. T-cells are implicated as playing a role in the modulation of the aberrant response leading to excessive tissue damage and, eventually, ARDS. Complementarity Determining Region 3 (CDR3) sequences derived from T-cells are key players in the adaptive immune response. This response is governed by an elaborate specificity for distinct molecules and the ability to recognize and vigorously respond to repeated exposures to the same molecules...
May 12, 2023: Biomolecules
Huimin Shan, Wenhui Liu, Yangyang Li, Kunpeng Pang
Dry eye disease is a chronic disease of the ocular surface characterized by abnormal tear film composition, tear film instability, and ocular surface inflammation, affecting 5% to 50% of the population worldwide. Autoimmune rheumatic diseases (ARDs) are systemic disorders with multi-organ involvement, including the eye, and play a significant role in dry eye. To date, most studies have focused on Sjögren's syndrome (one of the ARDs) since it manifests as two of the most common symptoms-dry eyes and a dry mouth-and attracts physicians to explore the relationship between dry eye and ARDs...
April 23, 2023: Biomolecules
Carlo Dani, Martina Ciarcià, Vittoria Barone, Mariarosaria Di Tommaso, Federico Mecacci, Lucia Pasquini, Simone Pratesi
Background Meconium-stained amniotic fluid (MSAF) is considered an alarming sign of possible fetal compromise and it has recently been reported that neonatal outcome correlates with the degree of meconium thickness. Methods We retrospectively studied 400 term infants allocated in clear amniotic fluid and grade 1, 2, and 3 MSAF groups on the basis of color and thickness of AF. Multivariable logistic regression analysis was performed to evaluate the potential independent effect of delivery with MSAF of different severity on the risk of a composite adverse neonatal outcome...
April 26, 2023: Children
Bairbre A McNicholas, Emanuele Rezoagli, Andrew J Simpkin, Sankalp Khanna, Jacky Y Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F Fraser, John Laffey
No abstract text is available yet for this article.
May 26, 2023: Critical Care: the Official Journal of the Critical Care Forum
Olga A Aleshina, Kristina Zakurdaeva, Anastasia N Vasileva, Sergey K Dubov, Vitaly S Dubov, Vladimir I Vorobyev, Lev S Butaev, Alena M Sukhareva, Lubov V Gavrilova, Inessa Yu Toropova, Marina O Popova, Aleksandr A Siniaev, Aleksandr D Kulagin, Kamil D Kaplanov, Andrei A Petrenko, Oksana I Ochirova, Alina Karpova, Ekaterina Yu Chelysheva, Anna G Turkina, Margarita A Gurianova, Liubov S Al-Radi, Elena A Gilyazitdinova, Elena K Egorova, Yulia A Chabaeva, Sergey M Kulikov, Yulia V Sveshnikova, Mikhail A Kunst, Vasily Shuvaev, Anzhelika F Rakhmani, Olga L Panteleeva, Maria E Grishunina, Olga S Samoylova, Ekaterina Vorontsova, Daria V Baryshnikova, Elena N Parovichnikova
BACKGROUND: Patients with hematologic diseases are at higher risk of the SARS-CoV-2 infection and more severe clinical outcomes of the coronavirus disease. CHRONOS19 is an observational prospective cohort study with the aim to determine the short and longer-term clinical outcomes, risk factors for disease severity and mortality, and rates of postinfectious immunity in patients with malignant and nonmalignant hematologic diseases and COVID-19. PATIENTS AND METHODS: Overall, 666 patients were enrolled in the study, of which 626 were included in the final data analysis...
April 14, 2023: Clinical Lymphoma, Myeloma & Leukemia
Blake Miller, Maxwell Phillips, Laura Krech, Bryce Biberstein, Jessica Parker, Steffen Pounders, Chelsea Fisk, Alistair J Chapman, Gable Moffitt
INTRODUCTION: Repair of multiple lower extremity long bone fractures with intramedullary nail (IMN) fixation is associated with significant cardiopulmonary burden and may result in mortality. These patients are at an increased risk for fat embolism syndrome, pulmonary embolism, Acute Respiratory Distress Syndrome (ARDS), and pneumonia. No standardized guidelines exist to guide treatment of these patients. Further, there is a paucity of data regarding the risk of simultaneous versus staged fixation of multiple long bone fractures that includes both tibial and femoral injuries, as patients with multiple concomitant fractures are often excluded from relevant analyses...
May 21, 2023: Injury
Vasiliki Tsolaki, George E Zakynthinos, John Papanikolaou, Nikitas Karavidas, Vasileios Vazgiourakis, Maria Eirini Papadonta, Paris Zygoulis, Ioannis Pantazopoulos, Demosthenes Makris, Epaminondas Zakynthinos
No abstract text is available yet for this article.
May 26, 2023: American Journal of Respiratory and Critical Care Medicine
Shaurya Taran, Doulia M Hamad, Stephan von Düring, Armaan K Malhotra, Areti Angeliki Veroniki, Victoria A McCredie, Jeffrey M Singh, Bettina Hansen, Marina Englesakis, Neill K J Adhikari
PURPOSE: Acute respiratory distress syndrome (ARDS) is common in patients with acute brain injury admitted to the ICU. We aimed to identify factors associated with ARDS in this population. METHODS: We searched MEDLINE, Embase, Cochrane Central, Scopus, and Web of Science from inception to January 14, 2022. Three reviewers independently screened articles and selected English-language studies reporting risk factors for ARDS in brain-injured adult patients. Data were extracted on ARDS incidence, adjusted and unadjusted risk factors, and clinical outcomes...
May 24, 2023: Journal of Critical Care
(no author information available yet)
An erratum was issued for: Eyestalk Ablation to Increase Ovarian Maturation in Mud Crabs. The Introduction, Protocol, Discussion and References were updated. The forth sentence in the third paragraph of the Introduction has been updated from: The eyestalk ablation protocol in this work minimizes stress by using fully sedated crabs and minimizes physical injury to personnel from crab bites.  to: The eyestalk ablation protocol in this work minimizes stress by using fully anesthetized crabs and minimizes physical injury to personnel from crab bites...
May 26, 2023: Journal of Visualized Experiments: JoVE
Carlos Cacciuttolo, Deyvis Cano, María Custodio
There is a need to define mine tailings in a clear, precise, multidisciplinary, transdisciplinary, and holistic manner, considering not only geotechnical and hydraulic concepts but also integrating environmental and geochemical aspects with implications for the sustainability of mining. This article corresponds to an independent study that answers questions concerning the definition of mine tailings and the socio-environmental risks linked with mine tailings chemical composition by examining the practical experience of industrial-scale copper and gold mining projects in Chile and Peru...
May 16, 2023: Toxics
Jule Cecilia Artzenroth, Joseph Tintelnot, Georg Martin Haag, Eray Gökkurt, Johann Steffens, Alexander Stein
Introduction Esophagogastric adenocarcinoma (EGA) is one of the leading causes of cancer- related mortality worldwide. Therapeutic options are limited for patients with recurrent or metastatic disease. Targeted therapy may be a suitable treatment for selected patients, but its efficacy remains elusive. Case Presentation Here, a 52-year-old male patient with advanced EGA Siewert Type II shows a significant response to combination therapy with olaparib and pembrolizumab. After progression following first- and second-line therapy, including a programmed cell death ligand 1 (PD-L1) inhibitor, next-generation sequencing of a tumor sample was performed to identify possible molecular targets...
May 9, 2023: Oncology Research and Treatment
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