Smitha Sammith Shetty, Mohit Sharma, Kanaka Sai Ram Padam, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan
BACKGROUND: Oral submucous fibrosis (OSF) is a persistent oral mucosal condition that carries an elevated risk of undergoing malignant transformation. Our objective was to elucidate the involvement of epithelial-to-mesenchymal transition (EMT) in OSF and its progression to malignancy by studying a panel of EMT markers, thereby understanding the molecular mechanisms. METHODS: An immunohistochemical analysis was done to detect the presence of E-cadherin, N-cadherin, pan-cytokeratin (PanCK), vimentin, α-SMA (alpha-smooth muscle actin), and CD44 in a total of 100 tissue samples...
2024: Journal of Oral Biology and Craniofacial Research