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BMJ Open Diabetes Research & Care

Erin S LeBlanc, Ning X Smith, Gregory A Nichols, Michael J Allison, Gregory N Clarke
Objective: To determine the possible association between insomnia and risk of type 2 diabetes mellitus (T2DM) in the naturalistic clinical setting. Research design and methods: We conducted a retrospective cohort study to examine the risk of developing T2DM among patients with pre-diabetes with and without insomnia. Participants with pre-diabetes (identified by a physician or via two laboratory tests) between January 1, 2007 and December 31, 2015 and without sleep apnea were followed until December 31, 2016...
2018: BMJ Open Diabetes Research & Care
Fang Liz Zhou, Jason Yeaw, Swapna U Karkare, Mitch DeKoven, Paulos Berhanu, Timothy Reid
Objective: Treatment adherence and persistence are essential to achieving therapeutic goals in diabetes and may be improved by patient support programs (PSPs). The COACH Program was launched in 2015 with the goal of supporting patients with diabetes who are prescribed insulin glargine 300 U/mL (Gla-300). The study objective was to assess the program's impact on persistence and adherence with therapy among patients with type 2 diabetes. Research design and methods: A retrospective 12-month analysis was conducted to compare treatment adherence and persistence in patients treated with Gla-300 who actively participated in the COACH PSP versus those who did not enroll using COACH engagement and claims data for the identification period from February 1, 2016 to July 31, 2016...
2018: BMJ Open Diabetes Research & Care
Saumeth Cardona, Patricia C Gomez, Priyathama Vellanki, Isabel Anzola, Clementina Ramos, Maria A Urrutia, Jeehea Sonya Haw, Maya Fayfman, Heqiong Wang, Rodolfo J Galindo, Francisco J Pasquel, Guillermo E Umpierrez
Importance: The frequency and impact of asymptomatic hypoglycemia in hospitalized patients with diabetes is not known. Objective: We determined the clinical characteristics and hospital outcomes of general medicine and surgery patients with symptomatic and asymptomatic hypoglycemia. Research design and methods: Prospective observational study in adult patients with diabetes and blood glucose (BG) <70 mg/dL. Participants were interviewed about signs and symptoms of hypoglycemia using a standardized questionnaire...
2018: BMJ Open Diabetes Research & Care
Abdallah Ahmed Gunaid, Mohammed Mohammed Al-Kebsi, Mahfouth Abdalla Bamashmus, Saleh Ahmed Al-Akily, Ahmed Nasser Al-Radaei
Objective: To identify clinical phenotypes of type 2 diabetes (T2D) among adults presenting with a first diagnosis of diabetes. Research design and methods: A total of 500 consecutive patients were subject to clinical assessment and laboratory investigations. We used data-driven cluster analysis to identify phenotypes of T2D based on clinical variables and Homeostasis Model Assessment (HOMA2) of insulin sensitivity and beta-cell function estimated from paired fasting blood glucose and specific insulin levels...
2018: BMJ Open Diabetes Research & Care
Lars-Petter Jelsness-Jørgensen, Øystein Jensen, Charlotte Gibbs, Ragnar Bekkhus Moe, Dag Hofsø, Tomm Bernklev
Objective: The Diabetes Health Profile-18 (DHP-18) was developed to measure disease-specific health-related quality of life. It has been translated into Norwegian but remains invalidated. The purpose of this paper was to examine the psychometric properties of the Norwegian DHP-18. Research design and methods: Participants with type 1 diabetes were recruited from three outpatient clinics in Norway. Clinical and sociodemographic data were collected, and participants completed the DHP-18 and the Short-Form 36 (SF-36)...
2018: BMJ Open Diabetes Research & Care
Thamra S Alghafri, Saud Mohamed Alharthi, Yahya Al-Farsi, Abdul Hakeem Alrawahi, Elaine Bannerman, Angela M Craigie, Annie S Anderson
Objective: This study examined the impact of a multicomponent intervention to increase physical activity (PA) in adults with type 2 diabetes (T2D) in Oman. Research design and methods: This is a cluster randomized controlled trial in eight primary health centers. Participants were physically inactive, aged ≥18 years, and with no contraindication to PA. Patients attending intervention health centers (n=4) received the 'MOVEdiabetes' intervention, which consisted of personalized, individual face-to-face consultations by dietitians...
2018: BMJ Open Diabetes Research & Care
Sanne M Schreuder, M Nieuwdorp, Marc J W Koelemay, Shandra Bipat, Jim A Reekers
Objective: There is evidence from the literature that dysfunctionality of the sympathetic nervous system of the foot with subsequent loss of local autoregulation could be a predictor of early amputation in patients with diabetes with a neuroischemic ulcer. To confirm this we tested the functionality of the sympathetic nervous system in the foot in a consecutive group of 31 patients with diabetes with critical limb ischemia and non-healing neuroischemic ulcer. Research design and methods: Prospective cohort with retrospective analysis after 12 months of routinely acquired clinical data...
2018: BMJ Open Diabetes Research & Care
Takehiro Kanamori, Yumie Takeshita, Yuki Isobe, Ken-Ichiro Kato, Hirofumi Misu, Shuichi Kaneko, Toshinari Takamura
Objective: Glucose variability induces endothelial dysfunction and cardiac autonomic nerve abnormality. Here we compared the effects of mealtime insulin aspart and bedtime insulin detemir on glucose variability, endothelial function, and cardiac autonomic nerve activity among Japanese patients with type 2 diabetes. Research design and methods: Forty hospitalized patients received either mealtime insulin aspart or bedtime insulin detemir treatment for 2 weeks. We assessed glucose variability indices, including M-value, SD of blood glucose level, and mean blood glucose (MBG) level...
2018: BMJ Open Diabetes Research & Care
Jacqueline M McMillan, Bria S Mele, David B Hogan, Alexander A Leung
Background: The association between diabetes mellitus (DM) treatment and dementia is not well understood. Objective: To investigate the association between treatment of diabetes, hypoglycemia, and dementia risk. Research design and methods: We performed a systematic review and meta-analysis of pharmacological treatment of diabetes and incident or progressive cognitive impairment. We searched Ovid MEDLINE, Embase, Cochrane Central Registry of Controlled Trials, and PsychINFO from inception to 18 October 2017...
2018: BMJ Open Diabetes Research & Care
Ilze Dirnena-Fusini, Marte Kierulf Åm, Anders Lyngvi Fougner, Sven Magnus Carlsen, Sverre Christian Christiansen
Objective: Hypoglycemia is a frequent and potentially dangerous event among patients with diabetes mellitus type 1. Subcutaneous glucagon is an emergency treatment to counteract severe hypoglycemia. The effect of intraperitoneal glucagon delivery is sparsely studied. We performed a direct comparison of the blood glucose response following intraperitoneally, subcutaneously and intravenously administered glucagon. Research design and methods: This is a prospective, randomized, controlled, open-label, crossover trial in 20 octreotide-treated rats...
2018: BMJ Open Diabetes Research & Care
Anastasios Toumpanakis, Triece Turnbull, Isaura Alba-Barba
Diet interventions have suggested an association between plant-based diets and improvements in psychological well-being, quality of life and glycated hemoglobin (HbA1c) control in populations with diabetes. The aims of this review are to systematically analyze the available literature on plant-based diet interventions targeting diabetes in adults and to clearly define the benefits on well-being of such interventions. This is a systematic review of controlled trials. A computerized systematic literature search was conducted in the following electronic databases: Allied and Complementary Medicine, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, E-Journals, Excerpta Medica Database, MEDLINE, Health Management Information Consortium, PsycARTICLES, PsycINFO, PubMed, SocINDEX and Web of Science...
2018: BMJ Open Diabetes Research & Care
Saima Hasan, Sian M Shaw, Leslie H Gelling, Catherine J Kerr, Catherine A Meads
Objective: Type 1 diabetes mellitus rates are rising worldwide. The health benefits of physical exercise in this condition are many, but more than 60% do not participate, mainly from fear of hypoglycemia. This systematic review explores the effects of physical exercise modes on blood glucose levels in adults for hypoglycemia prevention. Research design and methods: Predefined inclusion criteria were randomized or non-randomized cross-over trials of healthy non-obese adults with type 1 diabetes mellitus...
2018: BMJ Open Diabetes Research & Care
Ingrid Heuch, Ivar Heuch, Knut Hagen, Elin Pettersen Sørgjerd, Bjørn Olav Åsvold, John-Anker Zwart
Objective: The purpose of this study was to examine the risk of diabetes associated with the presence or absence of chronic low back pain, considering both cross-sectional and cohort data. Research design and methods: Analyses were based on the Norwegian HUNT2 and HUNT3 surveys of Nord-Trøndelag County. The prevalence of diabetes was compared in groups with and without chronic low back pain among 45 157 participants aged 30-69 years. Associations between low back pain at baseline and risk of diabetes were examined in an 11-year follow-up of 30 380 individuals with no baseline diagnosis of diabetes...
2018: BMJ Open Diabetes Research & Care
Michael Morkos, Bettina Tahsin, Louis Fogg, Leon Fogelfeld
Objective: To characterize the clinical presentation of newly diagnosed type 2 diabetes of ethnic minority adults in Chicago and compare with other populations. Research design and methods: Cross-sectional study examining the data of 2280 patients newly diagnosed with type 2 diabetes treated between 2003 and 2013 in a large Chicago public healthcare system. Results: Mean age of the patients was 49±11.3 years, men 54.4%, African-Americans 48...
2018: BMJ Open Diabetes Research & Care
Catherine E Cioffi, Harish Ranjani, Lisa R Staimez, Ranjit Mohan Anjana, Viswanathan Mohan, Mary Beth Weber
Objective: We evaluated the effects of a diabetes prevention itervention on self-efficacy (SE) and the associations between SE and diabetes-related outcomes among overweight Asian Indian adults with pre-diabetes in a randomized controlled translational trial (the Diabetes Community Lifestyle Improvement Program, D-CLIP). Research design and methods: Data were obtained from 550 adults who were randomized to a diabetes prevention program or standard of care. Dietary and exercise-related SEs were measured at baseline, core intervention completion (4  months), and annually until the end of follow-up (3 years or diabetes diagnosis)...
2018: BMJ Open Diabetes Research & Care
Caroline E Wright, Stephen Yeung, Helen Knowles, Antoinette Woodhouse, Emma Barron, Sian Evans
Objective: Participation in the National Diabetes Audit (NDA) has become a contractual requirement for all general practices in England and is used as part of the assessment framework for sustainability and transformation partnership (STP) footprints. The study aimed to investigate general practice-related factors which may influence participation in the NDA, and the impact that participation in the NDA may have on diabetes management and patient care. Research design: A cross-sectional analysis of routine primary care data from 45 725 646 patients aged 17+ years registered across 7779 general practices in England was performed using logistic regression...
2018: BMJ Open Diabetes Research & Care
Carla Assaf-Balut, Nuria Garcia de la Torre, Alejandra Durán, Manuel Fuentes, Elena Bordiú, Laura Del Valle, Johanna Valerio, Cristina Familiar, Inés Jiménez, Miguel Angel Herraiz, Nuria Izquierdo, Maria José Torrejón, Isabelle Runkle, Maria Paz de Miguel, Inmaculada Moraga, Maria Carmen Montañez, Ana Barabash, Martín Cuesta, Miguel A Rubio, Alfonso Luis Calle-Pascual
Objectives: To assess whether Mediterranean Diet (MedDiet)-based medical nutrition therapy facilitates near-normoglycemia in women with gestational diabetes mellitus (GDMw) and observe the effects on adverse pregnancy outcomes. Research design and methods: This is a secondary analysis of the St Carlos GDM Prevention Study, conducted between January and December 2015 in Hospital Clínico San Carlos (Madrid, Spain). One thousand consecutive women with normoglycemia were included before 12 gestational weeks (GWs), with 874 included in the final analysis...
2018: BMJ Open Diabetes Research & Care
Thomas H Wieringa, Maartje de Wit, Jos Wr Twisk, Frank J Snoek
Objective: Insulin glargine 300 (Gla-300) provides less hypoglycemia risk and more flexibility in injection time. The extent to which these effects translate into improved patient-reported outcomes (PROs) is unknown, and is the subject of this observational study. Research design and methods: Adults with type 2 diabetes treated with basal insulin for at least 6 months initiating Gla-300 were included. Data were collected at baseline (start Gla-300) and at 3-month and 6-month follow-up...
2018: BMJ Open Diabetes Research & Care
Dawn Cameron, Fiona Harris, Josie M M Evans
Objective: To explore how and why self-monitoring of blood glucose (SMBG) is carried out in a real-world context. Research design and methods: We conducted a multicase study among ten people with type 1 and insulin-treated type 2 diabetes mellitus in Scotland, alongside seven nominated support people and four healthcare professionals. All participants were interviewed in depth and six participants provided SMBG diaries. Stones' version of structuration theory informed the analysis...
2018: BMJ Open Diabetes Research & Care
Rachel G Tabak, Renee G Parks, Peg Allen, Rebekah R Jacob, Stephanie Mazzucca, Katherine A Stamatakis, Allison R Poehler, Marshall H Chin, Maureen Dobbins, Debra Dekker, Ross C Brownson
Objective: The nearly 3000 local health departments (LHDs) nationwide are the front line of public health and are positioned to implement evidence-based interventions (EBIs) for diabetes control. Yet little is currently known about use of diabetes-related EBIs among LHDs. This study used a national online survey to determine the patterns and correlates of the Centers for Disease Control and Prevention Community Guide-recommended EBIs for diabetes control in LHDs. Research design and methods: A cross-sectional study was conducted to survey a stratified random sample of LHDs regarding department characteristics, respondent characteristics, evidence-based decision making within the LHD, and delivery of EBIs (directly or in collaboration) within five categories (diabetes-related, nutrition, physical activity, obesity, and tobacco)...
2018: BMJ Open Diabetes Research & Care
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