journal
https://read.qxmd.com/read/38350671/racial-differences-in-measures-of-glycemia-in-the-vitamin-d-and-type-2-diabetes-d2d-study-a-secondary-analysis-of-a-randomized-trial
#21
RANDOMIZED CONTROLLED TRIAL
Erin S LeBlanc, Anastassios G Pittas, Jason Nelson, Ranee Chatterjee, Neda Rasouli, Mary K Rhee, Richard E Pratley, Cyrus V Desouza, Lisa M Neff, Anne M Peters, Samuel Dagogo-Jack, Daniel S Hsia
INTRODUCTION: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race. RESEARCH DESIGN AND METHODS: From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT and observational longitudinal follow-up of the subset with high-risk pre-diabetes...
February 12, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38336383/association-between-lower-extremity-arterial-calcification-and-coronary-arterial-calcification-in-a-population-at-increased-risk-of-cardiovascular-disease
#22
JOURNAL ARTICLE
Romain Meer, Anna G Hoek, Emma J Bouman, Teddo Doesburg, Petra J M Elders, Pim A de Jong, Joline Beulens, Ucc-Smart Study Group
INTRODUCTION: There is conflicting evidence whether lower extremity arterial calcification coincides with coronary arterial calcification (CAC). The aims of this study were to investigate the associations between (1) femoral and crural calcification with CAC, and (2) femoral and crural calcification pattern with CAC. RESEARCH DESIGN AND METHODS: This cross-sectional study included 405 individuals (74% men, 62.6±10.9 years) from the ARTEMIS cohort study at high risk of cardiovascular disease (CVD) who underwent a CT scan of the femoral, crural and coronary arteries...
February 8, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38302432/burden-of-impaired-awareness-of-hypoglycemia-in-people-with-diabetes-undergoing-hemodialysis
#23
JOURNAL ARTICLE
Hellena Hailu Habte-Asres, Yutong Jiang, Miranda Rosenthal, David Collins Wheeler
INTRODUCTION: Impaired awareness of hypoglycemia (IAH) refers to a diminished capacity to detect hypoglycemia. IAH can result in severe and even life-threatening outcomes for individuals with diabetes, especially those in advanced stages of the disease. This study aimed to assess the prevalence of IAH in people with diabetes on hemodialysis. RESEARCH DESIGN AND METHODS: We conducted a single-center audit to assess the prevalence of IAH using the Clarke questionnaire...
February 1, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38290988/unfavorable-social-determinants-of-health-and-risk-of-mortality-in-adults-with-diabetes-findings-from-the-national-health-interview-survey
#24
JOURNAL ARTICLE
Ryan Chang, Jerrin Philip, Umair Javed, Anoop Titus, Syed Karam Gardezi, Harun Kundi, Raman Yousefzai, Adnan A Hyder, Elias Mossialos, Khurram Nasir, Zulqarnain Javed
INTRODUCTION: Understanding the role of social determinants of health as predictors of mortality in adults with diabetes may help improve health outcomes in this high-risk population. Using population-based, nationally representative data, this study investigated the cumulative effect of unfavorable social determinants on all-cause mortality in adults with diabetes. RESEARCH DESIGN AND METHODS: We used data from the 2013-2018 National Health Interview Survey, linked to the National Death Index through 2019, for mortality ascertainment...
January 30, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38272538/adverse-perinatal-outcomes-in-gestational-diabetes-mellitus-with-and-without-sars-cov-2-infection-during-pregnancy-results-from-two-nationwide-registries-in-germany
#25
MULTICENTER STUDY
Tatjana P Liedtke, Katharina S Weber, Heinke Adamczewski, Dietmar Weber, Babett Ramsauer, Ute M Schaefer-Graf, Tanja Groten, Eike A Strathmann, Wolfgang Lieb, Mario Rüdiger, Ulrich Pecks, Helmut J Kleinwechter
INTRODUCTION: Pregnancy is a known independent risk factor for a severe course of COVID-19. The relationship of SARS-CoV-2 infection and gestational diabetes mellitus (GDM) on neonatal outcomes is unclear. Our aim was to determine if SARS-CoV-2 infection represents an independent risk factor for adverse perinatal outcomes in pregnancy with GDM. RESEARCH DESIGN AND METHODS: We compared data from two German registries including pregnant women with GDM, established during the SARS-CoV-2 pandemic (COVID-19-Related Obstetric and Neonatal Outcome Study (CRONOS), a multicenter prospective observational study) and already existing before the pandemic (German registry of pregnant women with GDM; GestDiab)...
January 25, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38272537/incident-dementia-risk-among-patients-with-type-2-diabetes-receiving-metformin-versus-alternative-oral-glucose-lowering-therapy-an-observational-cohort-study-using-uk-primary-healthcare-records
#26
JOURNAL ARTICLE
William Doran, Louis Tunnicliffe, Rutendo Muzambi, Christopher T Rentsch, Krishnan Bhaskaran, Liam Smeeth, Carol Brayne, Dylan M Williams, Nish Chaturvedi, Sophie V Eastwood, Susanna J Dunachie, Rohini Mathur, Charlotte Warren-Gash
INTRODUCTION: 4.2 million individuals in the UK have type 2 diabetes, a known risk factor for dementia and mild cognitive impairment (MCI). Diabetes treatment may modify this association, but existing evidence is conflicting. We therefore aimed to assess the association between metformin therapy and risk of incident all-cause dementia or MCI compared with other oral glucose-lowering therapies (GLTs). RESEARCH DESIGN AND METHODS: We conducted an observational cohort study using the Clinical Practice Research Datalink among UK adults diagnosed with diabetes at ≥40 years between 1990 and 2019...
January 25, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38267205/correction-normative-data-on-cardiovascular-autonomic-function-in-greenlandic-inuit
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 24, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38267204/effectiveness-of-sars-cov-2-primary-vaccines-and-boosters-in-patients-with-type-2-diabetes-mellitus-in-hungary-hun-ve-4-study
#28
JOURNAL ARTICLE
Gergő A Molnár, Zoltán Vokó, Gábor Sütő, György Rokszin, Dávid Nagy, György Surján, Orsolya Surján, Péter Nagy, István Kenessey, András Wéber, Mihály Pálosi, Cecília Müller, Miklós Kásler, István Wittmann, Zoltan Kiss
INTRODUCTION: Type 2 diabetes mellitus is a risk factor for severe COVID-19 infection and is associated with increased risk of complications. The present study aimed to investigate effectiveness and persistence of different COVID vaccines in persons with or without diabetes during the Delta wave in Hungary. RESEARCH DESIGN AND METHODS: Data sources were the national COVID-19 registry data from the National Public Health Center and the National Health Insurance Fund on the total Hungarian population...
January 24, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38267203/diabetes-and-chronic-kidney-disease-in-chinese-adults-a-population-based-cohort-study
#29
JOURNAL ARTICLE
Xue Wang, Lu Chen, Kexiang Shi, Jun Lv, Dianjianyi Sun, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Jiaqiu Liu, Xiaoming Yang, Maxim Barnard, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu
INTRODUCTION: Cohort evidence of the association of diabetes mellitus (DM) with chronic kidney disease (CKD) is limited. Previous studies often describe patients with kidney disease and diabetes as diabetic kidney disease (DKD) or CKD, ignoring other subtypes. The present study aimed to assess the prospective association of diabetes status (no diabetes, pre-diabetes, screened diabetes, previously diagnosed controlled/uncontrolled diabetes with/without antidiabetic treatment) and random plasma glucose (RPG) with CKD risk (including CKD subtypes) among Chinese adults...
January 24, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38267202/impact-of-sodium-glucose-cotransporter-2-inhibitors-on-cardiovascular-outcomes-in-patients-with-chronic-kidney-disease-propensity-score-matched-analysis
#30
LETTER
Wen Sun, Bryan P Yan
No abstract text is available yet for this article.
January 24, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38238025/effects-of-sodium-glucose-cotransporter-2-sglt-2-inhibitors-on-serum-uric-acid-levels-in-patients-with-chronic-kidney-disease-a-systematic-review-and-network-meta-analysis
#31
JOURNAL ARTICLE
Linli Zhang, Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong, Xianwen Zhang
Elevated serum uric acid levels are an independent predictor of occurrence and development of chronic kidney disease (CKD) and are strongly associated with prognosis. Several clinical trials have demonstrated the benefits of sodium-glucose cotransporter-2 (SGLT-2) inhibitors. To evaluate and rank the effects and safety of various SGLT-2 for serum uric acid levels in patients with CKD. We performed a systematic PubMed, Embase, Scopus, and Web of Science search, including studies published before July 1, 2023...
January 18, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38233078/association-between-brain-imaging-biomarkers-and-continuous-glucose-monitoring-derived-glycemic-control-indices-in-japanese-patients-with-type-2-diabetes-mellitus
#32
JOURNAL ARTICLE
Chikako Inoue, Yoshiki Kusunoki, Mana Ohigashi, Keiko Osugi, Kazuhiro Kitajima, Ayako Takagi, Maki Inoue, Chisako Yagi, Taku Tsunoda, Miki Kakutani, Manabu Kadoya, Kosuke Konishi, Tomoyuki Katsuno, Hidenori Koyama
INTRODUCTION: Although type 2 diabetes mellitus (T2DM) is associated with alterations in brain structure, the relationship between glycemic control indices and brain imaging markers remains unclear. This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic control indices and brain imaging biomarkers assessed by MRI. RESEARCH DESIGN AND METHODS: This cross-sectional study included 150 patients with T2DM. The severity of cerebral white matter lesions (WMLs) was assessed using MRI for deep and subcortical white matter and periventricular hyperintensities...
January 17, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38233077/increased-glycemic-variability-in-pregnant-women-with-roux-en-y-gastric-bypass-compared-with-sleeve-gastrectomy
#33
JOURNAL ARTICLE
Kleopatra Alexiadou, Saleem Ansari, Bryony Jones, Christina Yu, Anne Dornhorst, Nick Oliver, Christos Tsironis, Sanjay Purkayastha, Ahmed Ahmed, Rochan Agha-Jaffar, Bernard Khoo, Tricia M-M Tan
INTRODUCTION: Bariatric surgery is associated with adverse pregnancy outcomes such as reduced birth weight and premature birth. One possible mechanism for this is increased glycemic variability (GV) which occurs after bariatric surgery. The objective of this study was to compare the effect of Roux-en-Y gastric bypass (RYGB) versus vertical sleeve gastrectomy (SG) on GV during pregnancy and to investigate the relationships of GV, type of bariatric surgery and maternal and neonatal outcomes...
January 17, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38233076/association-of-urinary-albumin-to-creatinine-ratio-with-cardiometabolic-risk-markers-and-pre-diabetes-in-adults-with-normoglycemia-normoalbuminuria-and-normotension-with-parental-type-2-diabetes
#34
JOURNAL ARTICLE
Matthew Everett, Natasha Rushing, Peace Asuzu, Jim Wan, Samuel Dagogo-Jack
INTRODUCTION: This is a post hoc analysis of urinary albumin-to-creatinine ratio (uACR) within the normoalbuminuric range in relation to cardiometabolic risk factors among initially normoglycemic, normotensive participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) Study. RESEARCH DESIGN AND METHODS: 308 healthy African American (AA) and European American (EA) participants in the POP-ABC Study underwent baseline assessments, including oral glucose tolerance test, anthropometry, urinary albumin-to-creatinine ratio (uACR), lipids, adipocytokines, insulin sensitivity and secretion...
January 17, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38216296/continuous-intrafemoral-artery-infusion-of-urokinase-improves-diabetic-foot-ulcers-healing-and-decreases-cardiovascular-events-in-a-long-term-follow-up-study
#35
JOURNAL ARTICLE
Jiayue Tong, Junxia Zhang, Lin Xiang, Shuguang Li, Jinling Xu, Guangping Zhu, Jing Dong, Yangyang Cheng, Hujun Ren, Min Liu, Ling Yue, Guangda Xiang
INTRODUCTION: Diabetic foot ulcer (DFU) is a disabling complication of diabetes mellitus. Here, we attempted to assess whether long-term intrafemoral artery infusion of low-dose urokinase therapy improved DFUs and decreased cardiovascular events in patients with DFUs. RESEARCH DESIGN AND METHODS: This trial was a single-center, randomized, parallel study. A total of 195 patients with DFU were randomized to continuous intrafemoral thrombolysis or conventional therapy groups...
January 12, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38199777/association-of-glp-1-secretion-with-parameters-of-glycemic-control-in-women-after-gestational-diabetes-mellitus
#36
JOURNAL ARTICLE
Eleni Pappa, Kristina Busygina, Saori Harada, Hana Hermann, Cornelia Then, Andreas Lechner, Uta Ferrari, Jochen Seissler
INTRODUCTION: Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes, while the exact mechanisms underlying its pathophysiology are still unclear. We investigated the association of glucagon-like peptide-1 (GLP-1) response to oral glucose with parameters of glycemic control in women with previous GDM in the prospective PPSDiab (Prediction, Prevention, and Subclassification of Type 2 Diabetes) study. RESEARCH DESIGN AND METHODS: Glucose metabolism parameters and GLP-1 secretion were analyzed during oral glucose tolerance test (OGTT) in women with previous GDM (n=129) and women with a history of normal glucose tolerance (n=67) during pregnancy (controls)...
January 10, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38191206/should-insulin-resistance-homa-ir-insulin-secretion-homa-%C3%AE-and-visceral-fat-area-be-considered-for-improving-the-performance-of-diabetes-risk-prediction-models
#37
JOURNAL ARTICLE
Huan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Tetsuya Mizoue
INTRODUCTION: Insulin resistance and defects in pancreatic beta cells are the two major pathophysiologic abnormalities that underlie type 2 diabetes. In addition, visceral fat area (VFA) is reported to be a stronger predictor for diabetes than body mass index (BMI). Here, we tested whether the performance of diabetes prediction models could be improved by adding HOMA-IR and HOMA-β and replacing BMI with VFA. RESEARCH DESIGN AND METHODS: We developed five prediction models using data from a cohort study (5578 individuals, of whom 94...
January 8, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38167607/young-onset-type-2-diabetes-and-retinopathy-evidence-of-an-adverse-phenotype
#38
EDITORIAL
Soon H Song
No abstract text is available yet for this article.
January 2, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38167606/ocular-microvascular-complications-in-diabetic-retinopathy-insights-from-machine-learning
#39
JOURNAL ARTICLE
Thiara S Ahmed, Janika Shah, Yvonne N B Zhen, Jacqueline Chua, Damon W K Wong, Simon Nusinovici, Rose Tan, Gavin Tan, Leopold Schmetterer, Bingyao Tan
INTRODUCTION: Diabetic retinopathy (DR) is a leading cause of preventable blindness among working-age adults, primarily driven by ocular microvascular complications from chronic hyperglycemia. Comprehending the complex relationship between microvascular changes in the eye and disease progression poses challenges, traditional methods assuming linear or logistical relationships may not adequately capture the intricate interactions between these changes and disease advances. Hence, the aim of this study was to evaluate the microvascular involvement of diabetes mellitus (DM) and non-proliferative DR with the implementation of non-parametric machine learning methods...
January 2, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38167605/high-prevalence-of-retinopathy-in-young-onset-type-2-diabetes-and-possible-sex-differences-insights-from-norwegian-general-practice
#40
JOURNAL ARTICLE
Katrina Tibballs, Anne Karen Jenum, Lars Kirkebøen, Tore Julsrud Berg, Tor Claudi, John Graham Cooper, Kjersti Nøkleby, Sverre Sandberg, Jørund Straand, Esben Selmer Buhl
INTRODUCTION: People with young-onset type 2 diabetes (YOD), defined as diabetes diagnosis before age 40, have a high lifetime risk of vascular complications. We aimed to estimate the prevalence of YOD among adults with type 2 diabetes (T2D) in Norwegian general practice and explore associations between age at diabetes diagnosis and retinopathy overall and in men and women. RESEARCH DESIGN AND METHODS: We collected cross-sectional data from general practice electronic medical records of 10 241 adults with T2D in 2014, and repeated measurements of hemoglobin A1c (HbA1c ) from 2012 to 2014...
January 2, 2024: BMJ Open Diabetes Research & Care
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