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World Journal of Methodology

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https://read.qxmd.com/read/30705871/importance-of-the-telemedicine-network-for-neurosurgery-in-slovenia
#1
REVIEW
Tomaz Velnar, Tilen Zele, Roman Bosnjak
The number of invasive procedures in medicine is increasing, as is the employment of new technological achievements. In the era of information-communication technology, one such achievement is also the telemedicine network. In Slovenia, it is known as the Telekap (TeleStroke) network, which was primarily designed for fast and efficient management of stroke patients. In the neurosurgical community, the system is frequently used also for conveying vital information regarding subarachnoid haemorrhage and trauma...
January 18, 2019: World Journal of Methodology
https://read.qxmd.com/read/30705870/risk-stratification-for-coronary-artery-disease-in-multi-ethnic-populations-are-there-broader-considerations-for-cost-efficiency
#2
REVIEW
Pupalan Iyngkaran, William Chan, Danny Liew, Jalal Zamani, John D Horowitz, Michael Jelinek, David L Hare, James A Shaw
Coronary artery disease (CAD) screening and diagnosis are core cardiac specialty services. From symptoms, autopsy correlations supported reductions in coronary blood flow and dynamic epicardial and microcirculatory coronaries artery disease as etiologies. While angina remains a clinical diagnosis, most cases require correlation with a diagnostic modality. At the onset of the evidence building process much research, now factored into guidelines were conducted among population and demographics that were homogenous and often prior to newer technologies being available...
January 18, 2019: World Journal of Methodology
https://read.qxmd.com/read/30596035/radiosurgical-techniques-for-the-treatment-of-brain-neoplasms-a-short-review
#3
REVIEW
Tomaz Velnar, Roman Bosnjak
Radiotherapy has long been used as an adjunct to neurosurgery for the treatment of malignant and benign intracranial tumors and other intracranial lesions. Intracranial tumors can be irradiated in three different ways: I) fractional radiotherapy, II) stereotactic radiotherapy and III) stereotactic radiosurgery. The third is most often by means of a gamma knife or a specially designed linear accelerator. Additionally, radiosurgery is increasingly used in combination with systemic therapy to treat metastases.
December 14, 2018: World Journal of Methodology
https://read.qxmd.com/read/30519539/assessment-of-quality-control-system-by-sigma-metrics-and-quality-goal-index-ratio-a-roadmap-towards-preparation-for-nabl
#4
Monica Verma, Kiran Dahiya, Veena Singh Ghalaut, Vasudha Dhupper
AIM: To study sigma metrics and quality goal index ratio (QGI). METHODS: The retrospective study was conducted at the Clinical Biochemistry Laboratory, PGIMS, Rohtak, which recently became a National Accreditation Board for Testing and Calibration of Laboratories accredited lab as per the International Organization for Standardization 15189:2012 and provides service to a > 1700-bed tertiary care hospital. Data of 16 analytes was extracted over a period of one year from January 2017 to December 2017 for calculation of precision, accuracy, sigma metrics, total error, and QGI...
November 29, 2018: World Journal of Methodology
https://read.qxmd.com/read/30519538/microembolic-signal-detection-by-transcranial-doppler-old-method-with-a-new-indication
#5
EDITORIAL
Sombat Muengtaweepongsa, Charturong Tantibundhit
Transcranial Doppler (TCD) is useful for investigation of intracranial arterial blood flow and can be used to detect a real-time embolic signal. Unfortunately, artefacts can mimic the embolic signal, complicating interpretation and necessitating expert-level opinion to distinguish the two. Resolving this situation is critical to achieve improved accuracy and utility of TCD for patients with disrupted intracranial arterial blood flow, such as stroke victims. A common type of stroke encountered in the clinic is cryptogenic stroke (or stroke with undetermined etiology), and patent foramen ovale (PFO) has been associated with the condition...
November 29, 2018: World Journal of Methodology
https://read.qxmd.com/read/30519537/can-extracorporeal-shock-wave-therapy-be-used-for-the-management-of-lateral-elbow-tendinopathy
#6
EDITORIAL
Dimitrios Stasinopoulos
Lateral elbow tendinopathy (LET) is one of the two most common tendinopathies of the upper limb. The most effective treatment in the management of LET is the exercise program. Clinicians combine exercise program with other physiotherapy, electrotherapeutic and no, techniques. Extracorporeal shock wave therapy (ESWT) is one of the most common recommended electrotherapeutic modalities for the management of LET. Further research is needed to find out the optimal treatment protocol of ESWT in the management of LET...
November 29, 2018: World Journal of Methodology
https://read.qxmd.com/read/30519536/precision-medicine-allergy-immunoassay-methods-for-assessing-immunoglobulin-e-sensitization-to-aeroallergen-molecules
#7
EDITORIAL
Florin-Dan Popescu, Mariana Vieru
Molecular-based allergy diagnosis for the in vitro assessment of a patient immunoglobulin E (IgE) sensitization profile at the molecular level uses allergen molecules (also referred to as allergen components), which may be well-defined, highly purified, natural allergen components or recombinant allergens. Modern immunoassay methods used for the detection of specific IgE against aeroallergen components are either singleplex (such as the fluorescence enzyme immunoassay with capsulated cellulose polymer solid-phase coupled allergens, the enzyme-enhanced chemiluminescence immunoassay and the reversed enzyme allergosorbent test, with liquid-phase allergens), multiparameter (such as the line blot immunoassay for defined partial allergen diagnostics with allergen components coating membrane strips) or multiplex (such as the microarray-based immunoassay on immuno solid-phase allergen chip, and the two new multiplex nanotechnology-based immunoassays: the patient-friendly allergen nano-bead array, and the macroarray nanotechnology-based immunoassay used as a molecular allergy explorer)...
November 29, 2018: World Journal of Methodology
https://read.qxmd.com/read/30345225/towards-a-better-understanding-of-anesthesia-emergence-mechanisms-research-and-clinical-implications
#8
REVIEW
Marco Cascella, Sabrina Bimonte, Maria Rosaria Muzio
Emergence from anesthesia (AE) is the ending stage of anesthesia featuring the transition from unconsciousness to complete wakefulness and recovery of consciousness (RoC). A wide range of undesirable complications, including coughing, respiratory/cardiovascular events, and mental status changes such as emergence delirium, and delayed RoC, may occur during this critical phase. In general anesthesia processes, induction and AE represent a neurobiological example of "hysteresis". Indeed, AE mechanisms should not be simply considered as reverse events of those occurring in the induction phase...
October 12, 2018: World Journal of Methodology
https://read.qxmd.com/read/29988909/noninvasive-hemodynamic-monitoring-of-septic-shock-in-children
#9
REVIEW
Emad Mohamed Fathi, Hassib Narchi, Fares Chedid
Septic shock in children is associated with high mortality and morbidity. Its management is time-sensitive and must be aggressive and target oriented. The use of clinical assessment alone to differentiate between cold and warm shock and to select the appropriate inotropic and vasoactive medications is fraught with errors. Semi-quantitative and quantitative assessment of the preload, contractility and afterload using non-invasive tools has been suggested, in conjunction with clinical and laboratory assessment, to direct shock management and select between vasopressors, vasodilators and inotropes or a combination of these drugs...
June 28, 2018: World Journal of Methodology
https://read.qxmd.com/read/29354487/laparoscopic-extracorporeal-surgery-performed-with-a-fixation-device-for-adnexal-masses-complicating-pregnancy-report-of-two-cases
#10
Hanako Kasahara, Iwaho Kikuchi, Aya Otsuka, Yoko Tsuzuki, Michio Nojima, Koyo Yoshida
The potential complications associated with an adnexal mass discovered during early pregnancy call for surgical treatment. Ideally, surgery is performed after gestational week 12, but uterine expansion after the first trimester makes surgery difficult. We report two pregnancies complicated by adnexal masses for which we used an organ fixation device for safe performance of single-site umbilical laparoscopic surgery. Pelvic magnetic resonance imaging depicted a dichorionic, diamniotic twin pregnancy and 60-mm right adnexal mass in the first patient and bilateral adnexae in the second...
December 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29354486/quantitative-comparison-of-cranial-approaches-in-the-anatomy-laboratory-a-neuronavigation-based-research-method
#11
Francesco Doglietto, Jimmy Qiu, Mayoorendra Ravichandiran, Ivan Radovanovic, Francesco Belotti, Anne Agur, Gelareh Zadeh, Marco Maria Fontanella, Walter Kucharczyk, Fred Gentili
AIM: To describe the development and validation of a novel neuronavigation-based method, which allows the quantification of the anatomical features that define an approach, as well as real-time visualization of the surgical pyramid. METHODS: The method was initially developed with commercially-available hardware for coordinate collection (a digitizer and a frameless navigation system) and software for volume rendering; dedicated neuronavigation software (ApproachViewer, part of GTx-UHN) was then developed...
December 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29354485/is-forced-oscillation-technique-the-next-respiratory-function-test-of-choice-in-childhood-asthma
#12
REVIEW
Afaf Alblooshi, Alia Alkalbani, Ghaya Albadi, Hassib Narchi, Graham Hall
Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to perform forced expiratory manoeuvre. The development of novel diagnostic methods which require minimal effort, such as forced oscillation technique (FOT) is, therefore, a welcome and promising addition. FOT involves applying external, small amplitude oscillations to the respiratory system during tidal breathing...
December 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29354484/shortness-of-breath-in-clinical-practice-a-case-for-left-atrial-function-and-exercise-stress-testing-for-a-comprehensive-diastolic-heart-failure-workup
#13
REVIEW
Pupalan Iyngkaran, Nagesh S Anavekar, Christopher Neil, Liza Thomas, David L Hare
The symptom cluster of shortness of breath (SOB) contributes significantly to the outpatient workload of cardiology services. The workup of these patients includes blood chemistry and biomarkers, imaging and functional testing of the heart and lungs. A diagnosis of diastolic heart failure is inferred through the exclusion of systolic abnormalities, a normal pulmonary function test and normal hemoglobin, coupled with diastolic abnormalities on echocardiography. Differentiating confounders such as obesity or deconditioning in a patient with diastolic abnormalities is difficult...
December 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29354483/predictive-power-of-statistical-significance
#14
EDITORIAL
Thomas F Heston, Jackson M King
A statistically significant research finding should not be defined as a P -value of 0.05 or less, because this definition does not take into account study power. Statistical significance was originally defined by Fisher RA as a P -value of 0.05 or less. According to Fisher, any finding that is likely to occur by random variation no more than 1 in 20 times is considered significant. Neyman J and Pearson ES subsequently argued that Fisher's definition was incomplete. They proposed that statistical significance could only be determined by analyzing the chance of incorrectly considering a study finding was significant (a Type I error) or incorrectly considering a study finding was insignificant (a Type II error)...
December 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29026691/accuracy-of-crescent-sign-on-ocular-ultrasound-in-diagnosing-papilledema
#15
Ananth Bhosale, Virna M Shah, Parag K Shah
AIM: To study the usefulness of orbital ultrasonography in the diagnosis of papilledema. METHODS: Fifty patients who were referred to the neurophthalmology clinic and clinically suspected to have papilledema were selected. Thorough, clinical examination with slitlamp biomicroscopy and visual acuity assessment was done. These patients underwent ultrasonography to demonstrate the crescent sign. The patients were further evaluated with the neurologist and magnetic resonance imaging (MRI) thus confirming the diagnosis of papilledema...
September 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29026690/pancreatic-imaging-current-status-of-clinical-practices-and-small-animal-studies
#16
REVIEW
Ting Yin, Yewei Liu, Ronald Peeters, Yuanbo Feng, Yicheng Ni
Different causative factors acting on the pancreas can result in diseases such as pancreatitis, diabetes and pancreatic tumors. The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice. In this mini-review article different pancreatic imaging techniques are discussed, from the standard clinical imaging modalities and state of the art clinical magnetic resonance imaging techniques to current situations in pre-clinical pancreatic imaging studies...
September 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29026689/accurate-diagnosis-of-prenatal-cleft-lip-palate-by-understanding-the-embryology
#17
REVIEW
Bram Smarius, Charlotte Loozen, Wendy Manten, Mireille Bekker, Lou Pistorius, Corstiaan Breugem
Cleft lip with or without cleft palate (CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and palate develop in a very characteristic way. For ultrasonographers involved in screening these patients it is crucial to have a thorough understanding of the embryology of the face. This could help them to make a more accurate diagnosis and save time during the ultrasound. Subsequently, the current postnatal classification will be discussed to facilitate the communication with the CP teams...
September 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/29026688/establishing-the-presence-or-absence-of-chronic-kidney-disease-uses-and-limitations-of-formulas-estimating-the-glomerular-filtration-rate
#18
REVIEW
Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas
The development of formulas estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease (CKD), which is based on eGFR values and albuminuria. This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course...
September 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/28706861/nutech-functional-score-a-novel-scoring-system-to-assess-spinal-cord-injury-patients
#19
Geeta Shroff, Jitendra Kumar Barthakur
AIM: To develop a new scoring system, nutech functional scores (NFS) for assessing the patients with spinal cord injury (SCI). METHODS: The conventional scale, American Spinal Injury Association's (ASIA) impairment scale is a measure which precisely describes the severity of the SCI. However, it has various limitations which lead to incomplete assessment of SCI patients. We have developed a 63 point scoring system, i.e., NFS for patients suffering with SCI. A list of symptoms either common or rare that were found to be associated with SCI was recorded for each patient...
June 26, 2017: World Journal of Methodology
https://read.qxmd.com/read/28706860/targeted-temperature-management-in-neurological-intensive-care-unit
#20
REVIEW
Sombat Muengtaweepongsa, Winchana Srivilaithon
Targeted temperature management (TTM) shows the most promising neuroprotective therapy against hypoxic/ischemic encephalopathy (HIE). In addition, TTM is also useful for treatment of elevated intracranial pressure (ICP). HIE and elevated ICP are common catastrophic conditions in patients admitted in Neurologic intensive care unit (ICU). The most common cause of HIE is cardiac arrest. Randomized control trials demonstrate clinical benefits of TTM in patients with post-cardiac arrest. Although clinical benefit of ICP control by TTM in some specific critical condition, for an example in traumatic brain injury, is still controversial, efficacy of ICP control by TTM is confirmed by both in vivo and in vitro studies...
June 26, 2017: World Journal of Methodology
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