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Journals Clinical, Cosmetic and Investi...

Clinical, Cosmetic and Investigational Dermatology

https://read.qxmd.com/read/38779302/examining-constraints-a-critical-appraisal-of-autoimmune-diseases-and-facial-aging-study-letter
#1
JOURNAL ARTICLE
Muhammad Hamza Shuja, Minal Hasan
No abstract text is available yet for this article.
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38779301/congenital-triangular-alopecia-a-case-of-effective-response-with-5-topical-minoxidil-in-a-male-adolescent
#2
Frizam Dwindamuldan Sutisna, Srie Prihianti Gondokaryono, Reiva Farah Dwiyana, Raden Mohamad Rendy Ariezal Effendi, Nisrina Tache, Rafithia Anandita
Congenital triangular alopecia (CTA) is a rare entity of non-cicatricial alopecia characterized by triangular or oval-shaped alopecia patches on the frontotemporal region of the scalp. Few therapeutic options exist, and there is currently no effective treatment except for hair transplantation. We report the case of an adolescent boy with CTA who was treated with 5% topical minoxidil solution. During therapy, the patient showed improvement in the form of the appearance of terminal hairs, which started to show after two months of treatment...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38774812/endoplasmic-reticulum-dysfunction-an-emerging-mechanism-of-vitiligo-pathogenesis
#3
REVIEW
Yongyi Xie, Nanhui Wu, Suwei Tang, Zhiyu Zhou, Jiashe Chen, Jie Li, Fei Wu, Mingyuan Xu, Xiaoxiang Xu, Yeqiang Liu, Xin Ma
The endoplasmic reticulum (ER) is the main site of protein synthesis, transport, and modification. Its abnormal status has now emerged as an established cause of many pathological processes, such as tumors and autoimmune diseases. Recent studies also demonstrated that the defective functions of ER may lead to pigmentary diseases. Vitiligo is a depigmenting ailment skin disorder whose pathogenesis is now found to be associated with ER. However, the detailed mechanism is still unclear. In this review, we try to link the association between ER with its inter- and intra-organellar interactions in vitiligo pathogenesis and focus on the function, mechanism, and clinical potential of ER with vitiligo...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38770090/drug-reaction-with-eosinophilia-and-systemic-symptoms-induced-by-diosmin-and-hesperidin-a-case-report
#4
Pasita Palakornkitti, Teerapong Rattananukrom
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction which exhibits a diverse range of presentations. We described a 48-year-old man diagnosed with acute generalized exanthematous pustulosis (AGEP)-like DRESS following the administration of diosmin and hesperidin. To our knowledge, diosmin and hesperidin-induced DRESS are exceptionally rare. This aims to raise awareness of potential severe cutaneous side effects in patients taking these agents.
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38770089/mutation-p-arg127pro-in-the-1a-domain-of-krt16-causes-pachyonychia-congenita-in-chinese-patient-a-case-report-of-pc-associated-with-acral-melanoma
#5
Wei-Wei Ge, Zai-Ming Chen, Meng-Wei Chou, Ferina Ismail, Guang Chen, Li-Ming Wu, Jian-Qiang Yang
Pachyonychia congenita (PC) is a group of rare hereditary disorders, characterised by hypertrophic nails and palmoplantar keratoderma (PPK), particularly localised to the pressure areas of the feet. At a molecular level, it is caused by mutations in genes encoding KRT6A, KRT6B, KRT6C, KRT16, or KRT17. To identify the underlying gene mutation in a Chinese family with PC presenting with disabling palmoplantar keratoderma and subsequent associated acral melanoma. Genomic DNA was extracted from peripheral blood samples of three available individuals in the Chinese family, which included the patient and his two unaffected sisters...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38765196/effect-of-chloroquine-on-type-2-inflammatory-response-in-mc903-induced-atopic-dermatitis-mice
#6
JOURNAL ARTICLE
Mingjing Wei, Huixue Yang, Zhengchao Shao, Haoyue Wan, Yiheng Wang, Wenqi Chen
INTRODUCTION: Atopic dermatitis (AD) is a chronic, non-infectious inflammatory dermatosis. Chloroquine (CQ) has long been proven to possess anti-inflammatory properties. OBJECTIVE: This paper aims to investigate the impact of CQ on type 2 inflammatory response in MC903-induced AD mice. METHODS: An AD mouse model was established via MC903 induction. After CQ treatment, AD mice were intraperitoneally injected with polyinosinic: polycyclic acid [poly (I:C)] or Nigericin...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38765195/pilomatricoma-located-at-the-identical-position-in-the-right-upper-limb-of-the-twins-a-rare-case-report
#7
Guiyun Zhang, Yufeng Lu, Lin Qi, Chunli Yao
INTRODUCTION: Rare studies have reported pilomatricoma in twins, and extremely rare cases showed lesions in the same part of the body position. We reported a case of monozygotic twins with pilomatricoma in the same location on the skin of the right upper extremity. CASE PRESENTATION: Seven-year-old monozygotic twins presented to our department with a palpable, painless, and solid mass in the subcutaneous tissue of the right upper limb. A 1.5-cm diameter nodule was seen on the anterolateral aspect of the right upper extremity of the twins...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38765194/facial-skin-aging-characteristics-of-the-old-perceived-age-in-a-20-40-years-old-chinese-female-population
#8
JOURNAL ARTICLE
Qianghua Quan, Haihao Pan, Fei Wang, Siyi Wang, Lingli Yang, Mixiang Guan, Quan An
PURPOSE: In the quest for a youthful appearance, women use a variety of anti- aging cosmetics. Defining skin problems is especially important for the selection of anti-aging solutions. However, the skin problems faced by Chinese women at different ages are different. This study aimed at Chinese women aged 20-40 years old and analyzed facial skin aging characteristics of those with old-perceived age. PATIENTS AND METHODS: The total of 400 standard facial photographs from Chinese female volunteers aged 20-40 was assessed by another 126 Chinese women...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38765193/ustekinumab-in-the-treatment-of-generalized-pustular-psoriasis-in-a-pregnant-patient
#9
Hao Wu, Yan Na Shen, Zhongxiao Wu, Feng Mao, You Gang Ren, Li Zhang
Although the use of biologics has led to great improvement in psoriasis patients, the treatment of psoriasis during pregnancy still faces many challenges. We herein report on a 29-year-old pregnant woman treated with ustekinumab for generalized pustular psoriasis. Upon becoming pregnant, the woman underwent continued treatment with ustekinumab in the first trimester. We also considered the need for neonatal vaccination. The patient discontinued ustekinumab therapy in the second trimester, and during the period of drug discontinuation we noted a slight rash recurrence...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38765192/advancements-in-dermatological-applications-of-curcumin-clinical-efficacy-and-mechanistic-insights-in-the-management-of-skin-disorders
#10
REVIEW
Zhiming Mo, Jiayi Yuan, Xuelian Guan, Jianhong Peng
Curcumin, derived from Curcuma longa (turmeric), exhibits significant potential in dermatology, addressing conditions like atopic dermatitis, psoriasis, chronic wounds, skin cancer, and infections through its anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. This review synthesizes evidence on curcumin's mechanisms, including modulation of immune responses and promotion of wound healing, showcasing its efficacy in reducing inflammation, cytokine levels, and enhancing skin barrier functions...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38745872/pityriasis-rosea-and-immunosuppressive-drugs-letter
#11
JOURNAL ARTICLE
Francesco Drago, Cristian Fidanzi, Giulia Ciccarese
No abstract text is available yet for this article.
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38745871/becker-s-nevus-on-face-misdiagnosed-as-whiskers
#12
Huiyi Yao, Wenzhong Xiang
Becker's nevus (BN) is a kind of epidermal cutaneous hamartoma. A noticeable hyperpigmented patch with a big, unilateral, hyperpigmented macule and irregularly shaped borders is the manner in which BN often presents. In this case, a 16-year-old boy has asymptomatic dark brown colored follicular macule on the left side of the cheek shortly after birth. The lesions were initially inconspicuous but gradually became darker as time passed. The macules on some of them grew hair. This case of BN with apparent hypertrichosis on one side of the cheek, which made it challenging to make a differential diagnosis with whiskers...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38742169/anti-interleukin-17a-biologic-therapy-attempts-on-livedoid-vasculopathy-a-report-of-case-series
#13
Fei Qi, Yimeng Gao, Hongzhong Jin
The application of biologics such as anti-tumor necrosis factor (TNF) has shown great efficacy in livedoid vasculopathy (LV). However, new biological options need to be identified for those with a high tuberculosis reactivation risk. In this study, we evaluated the efficacy of anti-17A biologics for LV therapy. Two patients with LV who were irresponsive to traditional anticoagulation therapy were studied at the outpatient dermatology clinic of Peking Union Medical College Hospital. All patients received anti-17A biological therapy for at least two-four weeks...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38742168/single-cell-rna-sequencing-analyses-identify-aplnr-ins-igf2-rgcc-genes-may-be-involved-in-the-pathogenesis-of-systemic-sclerosis-skin
#14
JOURNAL ARTICLE
Peiqiu Zhu, Weiwei Deng
BACKGROUND: Systemic sclerosis represents a persistent autoimmune disorder marked with fibrosis affecting both skin and other organs, which leads to a diminished quality of life and increased mortality. The affected skin provides a valuable opportunity to explore the pathogenesis of systemic sclerosis. Nevertheless, the roles of various cell populations within scleroderma remain intricate. METHODS: We conducted a comprehensive reanalysis of recently published single-cell RNA-sequencing data from skin tissue cells in scleroderma...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38737948/tinea-incognito
#15
REVIEW
Amal Atallah Kokandi
Tinea incognito (TI), or incognita, are superficial fungal dermatophyte infections that are changed in shape, most frequently because of topical, systemic steroids use and other immunosuppressants. There are different clinical presentations depending on host factors and the species of dermatophyte causing the disorder. Diagnosis can be challenging and might need combined methods. Once diagnosed the treatment is the usual antifungals, either topical or systemic or combined depending on the site, extent, and host factors...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38737947/sporotrichosis-mimicking-rosacea-lesions-a-case-report
#16
You-Shu Hong, Lun-Fei Liu, Hong-Hua Hu
Sporotrichosis is a subacute or chronic infectious disease caused by sporothrix. It is mainly caused by Sporothrix inoculation after accidental skin injury during human labor. The clinical manifestations of sporotrichosis are variable, ranging from nodules, plaques, ulcers, verrucous lesions, and subcutaneous masses. Some reports indicate that sporotrichosis can mimic psoriasis-like lesions. We herein report a case of sporotrichosis mimicking rosacea lesions. In addition, the patient had a history of nasal trauma, and we believe that the patient was inoculated with Sporothrix after the nasal skin was damaged during labor activities...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38737946/angiotensin-1-7-inhibits-transforming-growth-factor-%C3%AE-1-induced-epithelial-mesenchymal-transition-of-human-keratinocyte-hacat-cells-in-vitro
#17
JOURNAL ARTICLE
Yueda Jihu, Ruobing Leng, Mengchang Liu, Hongjing Ren, Defu Xie, Chong Yao, Hong Yan
INTRODUCTION: Angiotensin (1-7) (Ang-(1-7)) is an emerging component of the renin-angiotensin system (RAS) with effective anti-fibrosis properties and has been shown to interfere with epithelial-mesenchymal transition (EMT) by numerous studies. In recent years, EMT has been proposed as a new therapeutic target for skin fibrotic diseases such as keloids. However, the effect of Ang-(1-7) on EMT in skin is still unclear. Hence, the purpose of this study was to explore the effect of Ang-(1-7) on Transforming growth factor-β1(TGF-β1)-induced EMT of human immortalized keratinocytes HaCaT in vitro...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38737945/thread-lifting-materials-a-review-of-its-difference-in-terms-of-technical-and-mechanical-perspective
#18
REVIEW
Gi-Woong Hong, Soo-Bin Kim, Soo Yeon Park, Jovian Wan, Kyu-Ho Yi
Thread lifting involves the use of slender materials, reminiscent of threads, for aesthetic procedures. These materials are distinct from traditional sutures and vary in composition, purpose, and performance. The introduction delves into the literal and material significance of threads, establishing the broad concept of thread lifting materials. The article revisits the evolution of thread lifting materials, emphasizing the preexistence of cog threads for tissue manipulation before their widespread adoption in plastic surgery...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38737944/few-shot-classification-with-multiscale-feature-fusion-for-clinical-skin-disease-diagnosis
#19
JOURNAL ARTICLE
Tianle Chen, Qi Liu, Jie Yang
INTRODUCTION: Skin disease is one of the most common diseases and can affect people of all ages and races. However, the diagnosis of skin diseases via observation is a highly challenging task for both doctors and patients, and would benefit from the use of an intelligent system. Building a large benchmark with professional dermatologists is resource-intensive, and we believe that few-shot learning (FSL) methods would be helpful in solving the problem of annotated data scarcity. In this paper, we propose CDD-Net (Context Feature Fusion and Dual Attention Dermatology Net), a plug-in module for FSL clinical skin disease classification...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38737943/effectiveness-and-safety-of-tildrakizumab-in-psoriasis-patients-who-failed-anti-il17-treatment-a-28-week-real-life-study
#20
JOURNAL ARTICLE
Matteo Megna, Angelo Ruggiero, Nello Tommasino, Claudio Brescia, Fabrizio Martora, Sara Cacciapuoti, Luca Potestio
Tildrakizumab is a humanised IgG1/k-type monoclonal antibody that targets the p19 protein subunit of IL23. Despite its effectiveness and safety have been widely reported by clinical trials and real-life experiences, data regarding its use on patients who previously failed anti-IL17 (brodalumab, ixekizumab, bimekizumab and/or secukinumab) are scant. Therefore, further studies on this topic would be beneficial for clinicians in guiding the selection of biologic shifting, considering that anti-IL23, -12/23, and -IL17 partially share their therapeutic targets...
2024: Clinical, Cosmetic and Investigational Dermatology
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