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Clinical, Cosmetic and Investigational Dermatology

Federica Dall'Oglio, Francesco Lacarrubba, Maria Luca, Simona Boscaglia, Corinne Granger, Giuseppe Micali
Purpose: Topical agents play a key role in the management of facial seborrheic dermatitis (SD) by reducing inflammation and scale production. The aim of this open-label trial was to assess the efficacy and tolerability of a new non-corticosteroid, antifungal/anti-inflammatory/antiseborrheic cream containing piroctone olamine, stearyl glycyrrhetinate, and zinc PCA in the treatment of facial SD using clinical and instrumental evaluation. Patients and methods: Twenty adult subjects affected by mild-to-moderate inflamed facial SD were enrolled and instructed to apply the study cream twice daily for 60 days...
2019: Clinical, Cosmetic and Investigational Dermatology
Azza Gaber Antar Farag, Eman Ae Badr, Abdel Monem A Eltorgoman, Mohamed Fa Assar, Eman N Elshafey, Nermin Reda Tayel, Hossam Ea Aboutaleb
Background: 11β HSD1 generates cortisol from cortisone. 11β HSD1 single-nucleotide polymorphism (SNP) was associated with metabolic syndrome (MeTS). Although the relation of acne vulgaris (AV) and skin tags (STs) with MeTS has been reported, the relationship between 11β HSD 1 SNP and cortisol activity in those patients has not studied till now. Aims: To investigate, two 11β-HSD1 SNPs (rs846910 and rs12086634), serum lipid profile and cortisol levels in patients with AV and STs in an Egyptian population...
2019: Clinical, Cosmetic and Investigational Dermatology
Adele Sparavigna, Beatrice Tenconi, Andrea Maria Giori, Gilberto Bellia, Laura La Penna
Purpose: Aim of the study was to determine both clinically and by noninvasive instrumental evaluations the efficacy, tolerability and the duration of the effects of a new hyaluronic acid (HA) gel in human volunteers with moderate aging/photoaging. Patients and methods: Eighteen volunteers (35-55 years) were enrolled in this single-center study. The subjects underwent five visits. The first visit was at baseline to determine the adherence to the inclusion criteria, followed by the first injection of the HA-based study product, and the second visit was at 48 hours after the injection...
2019: Clinical, Cosmetic and Investigational Dermatology
Martina Kerscher, Arti Tania Nurrisyanti, Christine Eiben-Nielson, Susanne Hartmann, Judith Lambert-Baumann
Purpose: The efficacy of microfocused ultrasound with visualization (MFU-V; Ultherapy® ) has been demonstrated in clinical studies and daily practice. However, data addressing skin physiology after MFU-V treatment are lacking. This observational evaluation was aimed to assess skin physiology before and after MFU-V treatment using noninvasive biophysical measurements. Patients and methods: Twenty-two female patients with moderate-to-severe skin sagging at the jawline and submental region on the Merz Aesthetics Scale obtained a single MFU-V treatment according to protocol...
2019: Clinical, Cosmetic and Investigational Dermatology
Katsuyuki Yuki, Sawako Kawano, Shinobu Mori, Takatoshi Murase
Purpose: The transdermal application of carbon dioxide (CO2 ) gas dissolved in a solution and bathing in carbonated springs have been known to improve circulatory disorders. We aimed to elucidate and profile the effects of CO2 application on local skin function. Patients and methods: A liquid formulation that included high-concentration CO2 or a control formulation was applied to the face of healthy men for 8 weeks. Quantitative analysis was performed during the dry winter months...
2019: Clinical, Cosmetic and Investigational Dermatology
Xia Dai, Li Li, Ward Peterson, Renate R Baumgartner, Jinmei Huang, Alexandra Baer-Zwick, Sonja Hoeller, Zrinka Ivezic-Schoenfeld, Martin Prinz
Background: Modified sodium hyaluronate gel for injection, Princess® VOLUME (PV), has been on the European market since 2009 to correct deeper wrinkles and folds, increasing or restoring volume of the face, and remodeling facial contours. Objective: To evaluate the safety and effectiveness of PV in correction of moderate-to-severe nasolabial folds (NLF) in Chinese subjects. Methods: In this prospective, split-face, randomized, evaluator and subject-blinded, multicenter, noninferiority trial, 120 subjects were randomized to bilateral NLF treatment with PV administered in one NLF and Restylane® (RL) administered in the other NLF...
2019: Clinical, Cosmetic and Investigational Dermatology
María Rosario Alonso, Silvia Pérez Damonte, Claudia Anesini
Purpose: A combination of extracts, from two plant species, ie, Coffea arabica and Larrea divaricata (Jarilla) (ECOHAIR® ) , is being successfully used in Argentina as a cosmetic for hair recovery in androgenic and areata alopecia, and for eyelash and eyebrow growth. The objectives of this prospective study were to evaluate the capacity of Jarilla-Coffea extract gel of improving hair growth in relation to thickness, appearance of new hair, and hair length in comparison with a placebo in premenopausal and postmenopausal volunteers and to identify possible signs of ocular adverse local reactions related to the application of the gel...
2019: Clinical, Cosmetic and Investigational Dermatology
Marilyn S Kwolek, Jon E Block
Background: Although freehand injection of botulinum toxin remains the status quo, it is an inaccurate technique for delivering precise amounts of neurotoxin at multiple injection sites with expediency. We developed an inexpensive, ergonomic, single-use, disposable exostructure device that rapidly converts a standard syringe into a highly accurate injection instrument. Materials and methods: Based on the results of two independent injectors, we determined the comparative delivery dose accuracy, precision, and amount of product waste associated with a standard syringe using the freehand injection technique vs a prototype injection assist device...
2019: Clinical, Cosmetic and Investigational Dermatology
Shady M Ibrahim, Wael M Saudi, Mohamed F Abozeid, Mohamed L Elsaie
Background: Fractional CO2 laser is one of the most effective treatment options used to resurface scars. Objective: To evaluate the efficacy and safety of early treatment of postsurgical scar by fractional ablative CO2 laser. Methods: A total of 27 Egyptian patients with recent postoperative scars were enrolled in this study. Three sessions of fractional CO2 laser with a 1-month interval were started 4 weeks after surgery. Vancouver Scar Scale (VSS) was used as an assessment tool at 1 and 3 months after the final treatment...
2019: Clinical, Cosmetic and Investigational Dermatology
Hugo Guimarães Scotelaro-Alves, Nurimar Conceição Fernandes, Marcia Ramos-E-Silva
Background: Previously known as dyshidrosis, recurrent vesicular palmoplantar dermatitis (RVPD) is presented as severe eruption of nonerythematous, symmetrical vesicles or bullae located along the lateral sides of fingers, on the palmar or plantar areas, and developing into a chronic and recurrent condition. Although very frequently observed on the hands, there are no specific studies about such eczema in children and adolescents. Objectives: To report on the RVPD clinical profile in children and adolescents, and monitor the association of RVPD with seasonal variations, hyperhidrosis, atopy and nickel sulfate...
2019: Clinical, Cosmetic and Investigational Dermatology
Laith N Al-Eitan, Hanan A Aljamal, Rami Q Alkhatib
Background: Sunscreens are one of the most widely used products among cosmetics and personal care products. Recent studies have shown that some of sunscreen formulations may contain toxic, carcinogenic, or even nonallowed chemicals that may affect skin, cells, and hormones. Materials and methods: This study aimed to develop and validate a method that allows the determination of sunscreen ingredients by gas chromatography-mass spectrometry (GC-MS). Analysis of original sunscreen products (n=5) from a licensed pharmacy and counterfeit sunscreen products (n=5) from local markets in Jordan was performed using GC-MS...
2019: Clinical, Cosmetic and Investigational Dermatology
P Micheels, S Besse, J Vandeputte
Background: Concentrated hyaluronic acid (HA) gels with a high degree of cross-linking such as Cohesive Polydensified Matrix® (CPM) HA have been designed for long-term facial volume restoration. Objective: To determine the behavior and longevity of CPM HA gel, a case series of subjects underwent magnetic resonance imaging (MRI) or computed tomography (CT) scans several years after their initial treatment. Methods: Six subjects, three from the initial CPM HA Conformité Européenne registration study and three from private practice who had received prior injection of CPM HA for facial volumizing indications agreed to undergo an MRI or CT scan at intervals ranging from 1 to 4 years after the initial treatment...
2019: Clinical, Cosmetic and Investigational Dermatology
(no author information available yet)
[This corrects the article on p. 273 in vol. 11.].
2018: Clinical, Cosmetic and Investigational Dermatology
Daisy Kopera, Zrinka Ivezic-Schoenfeld, Ira G Federspiel, Doris Grablowitz, Benjamin Gehl, Martin Prinz
Purpose: The aim of this study was to evaluate the effectiveness and safety of hyaluronic acid (HA) dermal filler when used in the face for medical reconstructive purposes. Patients and methods: Adult patients with moderately severe facial lipoatrophy (FLA), morphological asymmetry (MA) of the face, or debilitating scars (DS) on the face were included in a prospective, noncomparative, multicenter, postmarket clinical follow-up study. All patients were treated with an HA filler (Princess® FILLER), which was injected intradermally on study Day 1, with optional touch-up 2 weeks later...
2018: Clinical, Cosmetic and Investigational Dermatology
Sahar Dalvand, Abbas Ebadi, Reza Ghanei Gheshlagh
Introduction: Inadequate knowledge on pressure injury (PI) can have a detrimental effect on preventive care strategies. The aim of this study was to assess the overall knowledge of nurses on PI prevention based on their scores on the Pressure Ulcer Knowledge Assessment Tool (PUKAT) and its subscales in different settings. Methods: In this systematic review and meta-analysis, databases including Web of Science, Science Direct, Google Scholar, PubMed, and Scopus were searched, using the following keywords: Pressure Ulcer, Pressure injury, Bedsore, Pressure Sore, Decubitus Ulcer, knowledge, and their possible combinations...
2018: Clinical, Cosmetic and Investigational Dermatology
Izolda Heydenrych, Krishan M Kapoor, Koenraad De Boulle, Greg Goodman, Arthur Swift, Narendra Kumar, Eqram Rahman
The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures...
2018: Clinical, Cosmetic and Investigational Dermatology
Ana Kilic, Anastasia Harder, Hubert Reich, Ulrich Knie, Clarissa Masur, Christoph Abels
Background: Pruritus reduces quality of life and may occur at different sites of the body. To alleviate pruritus, lipid replenishing and rehydration of the skin is often unsatisfactory. Thus, products with additional antipruritic effects are needed. Objectives: Antipruritic effects and cosmetic properties of two different emulsions, water-in-oil (w/o) or oil-in-water (o/w), and a shampoo containing a lipophilic Echinacea purpurea root extract (Ec.-extract) were assessed in adults suffering from pruritus...
2018: Clinical, Cosmetic and Investigational Dermatology
M Saint Aroman, P Guillot, S Dahan, D Coustou, K Mortazawi, O Zourabichvili, T Aardewijn
Background: The frequency of dermatological acts is increasing. These procedures often cause injuries and traumatic alterations in specific skin layers, slowing down wound healing. Patients and methods: An open observational study lasting 1 month was conducted on 2,363 patients who had undergone various dermatological procedures. This study was conducted in eight European countries and an Asian country during which the tolerance and efficacy of a cosmetic cream based on Rhealba oat plantlets' extract, l-ALA-l-GLU dipeptide, and hyaluronic acid were assessed on patients' wounds...
2018: Clinical, Cosmetic and Investigational Dermatology
Mridvika Narda, Gabriel Bauza, Palmira Valderas, Corinne Granger
Background: The effects of pollution on health have received increasing attention in recent years. Extrinsic skin aging occurs via multiple processes, and pollution is now recognized as a major component, causing increased pigmentation and wrinkles via oxidative mechanisms. We tested the antipollution efficacy of a cosmetic facial cream (FC) by assessing its effects on carbon particle adhesion to skin and on oxidative and inflammatory pathways in the skin. Methods: In an in vivo study, FC was applied once to the forearms of healthy subjects...
2018: Clinical, Cosmetic and Investigational Dermatology
Marianne J Middelveen, Iris Du Cruz, Melissa C Fesler, Raphael B Stricker, Jyotsna S Shah
Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of Borrelia and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. We sought to explore this association further in a cohort of MD patients. Patients and methods: Sera from 30 patients with MD were tested for antibody reactivity to antigens from the Borrelia burgdorferi (Bb) group and the relapsing fever Borrelia (RFB) group of spirochetes...
2018: Clinical, Cosmetic and Investigational Dermatology
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