Journals Clinical, Cosmetic and Investi...

Clinical, Cosmetic and Investigational Dermatology
Zicheng Guo, Qingli Yu, Wencheng Huang, Fengyu Huang, Xiurong Chen, Chuzhong Wei
BACKGROUND: Keloid is a common condition characterized by abnormal scarring of the skin, affecting a significant number of individuals worldwide. OBJECTIVE: The occurrence of keloids may be related to the reduction of cell death. Recently, a new cell death mode that relies on copper ions has been discovered. This study aimed to identify novel cuproptosis-related genes that are associated with keloid diagnosis. METHODS: We utilized several gene expression datasets, including GSE44270 and GSE145725 as the training group, and GSE7890, GSE92566, and GSE121618 as the testing group...
2024: Clinical, Cosmetic and Investigational Dermatology
Raiwin Suwannamajo, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Chingching Foocharoen
PURPOSE: Anti-neutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) overlap with systemic sclerosis (SSc) is uncommon. We aimed to determine the incidence of AAV and define clinical outcomes relevant to asymptomatic screening positive for ANCA in SSc after 2 years of follow-up. PATIENTS AND METHODS: The study was a cohort study of 185 Thai adult SSc patients testing for ANCA and having a 2-year follow-up at the Scleroderma Clinic, Khon Kaen University, Thailand...
2024: Clinical, Cosmetic and Investigational Dermatology
Xing Wang, Dong Zhang, Qingxia Lin, Changying Niu, Huiping Fan, Mogen Zhang, Xiangfeng Yuan, Weiyuan Ma
Acquired digital fibrokeratoma (ADF) is rare in clinical practice and is easily misdiagnosed. Herein, 5 cases of patients (3 males and 2 females) with ADF are reported. The mean age at onset was 42.6 years, and the mean disease duration was 3 years. Four patients had ADF on the hands, and 1 patient had ADF on the foot. The clinical manifestations were all solitary, skin-colored papules, with a firm texture and smooth surface, protruding from the skin surface. In 3 patients, ADF manifested as columnar protrusions, and in 2 patients, ADF manifested as dome-shaped protrusions...
2024: Clinical, Cosmetic and Investigational Dermatology
Miki Iwai, Koichi Nakaoji, Kazuhiko Hamada, Yutaka Inaba, Kyoko Muraoka, Emi Tohsuji, Masatoshi Jinnin
PURPOSE: In the skin of elderly people with dryness, the production of inflammatory cytokines tends to be induced under the influence of external stimuli. Therefore, there has been a hypothesis that the deterioration of skin conditions due to aging is linked to systemic inflammation. This study aimed to verify the possibility that the use of moisturizer improves skin condition and suppresses systemic inflammation. METHODS: As an open study, the participants (n=75) were randomly assigned to either control group or moisturizer group...
2024: Clinical, Cosmetic and Investigational Dermatology
Sicheng Zhao, Tingyan Wu, Mingjing Fu, Zhe Zhang
BACKGROUND: Psoriasis is a chronic inflammatory skin disease characterized by erythema, papules, and plaques. Adiponectin (ADIPOQ) is an important protein hormone secreted by adipose tissue. Here, we aimed to explore the expression of ADIPOQ in psoriasis patients and the moderation effect of histone lactylation on ADIPOQ. METHODS: The GSE78097 data set was downloaded from GEO database to analyze the differentially expressed genes (DEGs) in psoriasis. A total of 36 psoriasis patients were recruited to obtain the skin samples...
2024: Clinical, Cosmetic and Investigational Dermatology
Carmen Bobeica, Elena Niculet, Carmina Liana Musat, Lina Iancu, Mihaela Craescu, Andreea Mioara Luca, Bogdan Ioan Stefanescu, Emma Gheorghe, Mihaela Debita, Claudiu-Ionut Vasile, Gabriela Balan, Camelia Busila, Alin Laurentiu Tatu
PURPOSE: Systemic sclerosis (SSc) is a relatively rare collagenosis manifested as microvasculopathy, excessive cutaneous and visceral fibrosis in a background of autoimmune alteration. Autoimmune vasculopathy in SSc occurs early and begins with endothelial cell activation followed by blood vessel intimal proliferation in a context of defective angiogenesis. The alteration of peripheral micro and macrocirculation in SSc is evident through vascular lesions, such as Raynaud's phenomenon, telangiectasias, acrocyanosis, digital ulcers, gangrene, peripheral pulse deficiency...
2024: Clinical, Cosmetic and Investigational Dermatology
Tao Huang, Yongling Lv, Wei Wang, Yunyao Chen, Lixin Fan, Zhaowei Teng, Xianfeng Zhou, Hexiao Shen, Guang Fu
Adverse skin reactions caused by the COVID-19 vaccine have attracted considerable attention. As we all know, the development mechanism of some skin diseases is related to the gut and skin microbiome. A 78-year-old male patient who received the COVID-19 vaccine developed generalized eczema with multiple dense black patches over the body, a widespread rash, erosion, and scabs on his limbs, as well as facial edema. The patient experienced recurrent flare-ups after conventional treatment, but then recovered well without recurrence after undergoing three fecal microbial transplantation (FMT) treatments...
2024: Clinical, Cosmetic and Investigational Dermatology
Fabrizio Martora, Claudio Marasca, Sara Cacciapuoti, Federica Fariello, Luca Potestio, Teresa Battista, Massimiliano Scalvenzi, Matteo Megna
BACKGROUND: The treatment of hidradenitis suppurativa (HS) has always been a real challenge for dermatologists; to date, adalimumab the only biologic drug approved for HS is adalimumab, an anti-tumor necrosis factor (TNF)-α drug, the approval of this drug dates to 2015, data provided by real life show an effectiveness rate of about 60% percent. Recently (31 October 2023) FDA approves secukinumab for moderate-severe HS. The treatment and management of HS is very challenging as available treatments are very limited and show very variable outcomes...
2024: Clinical, Cosmetic and Investigational Dermatology
Yanhua Fu, Yuanyuan Xiao, Tianji Gao, Junxiu Zhang, Tianjiao Wang
Toxic epidermal necrolysis (TEN) is a type of drug eruption in dermatology emergencies that is rare in clinical practice but has a high mortality rate. The main causes are drug and viral infections. Unfortunately, no expert consensus on treating this disease exists, and a standard therapy is absent. Up to now, glucocorticoids combined with gamma globulin are commonly used in clinical practice, but their efficacy is highly controversial. This study reports on a 7-year-old girl with TEN who did not respond to traditional therapy, such as methylprednisolone combined with gamma globulin, but was finally cured with an additional low-dose etanercept...
2024: Clinical, Cosmetic and Investigational Dermatology
Nan Tang, Xiao-Ting Liu, Xiao-Li Lin, Wen-Xiu Yang, Qi-Lin Li, Guo-En Wang, Yan-Hua Wu
PURPOSE: Vitiligo is an autoimmune disease that results in the loss of epidermal melanocytes. The treatments for patients with vitiligo remain lacking. Erzhiwan (EZW), a traditional Chinese Medicine composed of Ligustri Lucidi Fructus and Ecliptae Herba , was used to ameliorate depigmentation since ancient China. This study aims to investigate the effect of EZW on vitiligo-related depigmentation. METHODS: A vitiligo-related depigmentation mouse model was induced by monobenzone and restraint stress...
2024: Clinical, Cosmetic and Investigational Dermatology
Xiuping Wang, Xiaoliang Ouyang, Deng Zhang, Yunxia Zhu, Liang Wu, Zhen Xiao, Simin Yu, Wei Li, Chunming Li
PURPOSE: Porokeratosis (PK) is a chronic autosomal-dominant cutaneous keratinization disorder exhibiting clinical and genetic heterogeneity. Mevalonate decarboxylase ( MVD ), farnesyl diphosphate synthase ( FDPS ), phosphomevalonate kinase( PMVK ), and mevalonate kinase genes( MVK ), which encode the mevalonate pathway, are disease-causing genes in PK. PATIENTS AND METHODS: Data and blood samples were collected from two Chinese families and five sporadic patients with porokeratosis...
2024: Clinical, Cosmetic and Investigational Dermatology
Cassidy Nguyen, Guilherme Kuceki, Michael Birdsall, Dev Ram Sahni, Vikram Nath Sahni, Christopher M Hull
Rosacea is a common chronic dermatosis. Clinically, rosacea can present with flushing, erythema, papules, pustules, telangiectasias, phymatous changes, pruritus, burning, and stinging. In 2017, the National Rosacea Society Expert Committee recommended a phenotype-based classification for therapy. In this review, we identify monotherapies and multimodal treatment approaches for the clinical management of rosacea including topical, systemic, laser and light, alternative, and combination therapies.
2024: Clinical, Cosmetic and Investigational Dermatology
Liuli Xu, Yujuan Wang, Yunzhu Mu, Qing Huang, Wenlong Shuai, Hao Yang
We described a 58-year-old female diagnosed with zosteriform cutaneous metastases from breast carcinoma. She was initially diagnosed with herpes zoster. Correct diagnosis was obtained after pathological biopsy. Various forms of cutaneous metastases have various forms, which require careful discrimination by dermatologists to reduce the rate of misdiagnosis.
2024: Clinical, Cosmetic and Investigational Dermatology
Yuan Li, Xianxu Yang, Jiejie Lu, Kai Chen, Weiwei Wu, Ming Zhang, Wanni Li
Eosinophilic pustular folliculitis (EPF) is a rare skin disease. The typical skin lesions of classic EPF are localized on the upper limbs' face, trunk, and extensor surfaces. However, when the skin lesions initially appear on the palms and soles, it is not easy to diagnose as EPF. Here, we report a case of a male patient who presented with erythematous plaques, pustules, and crusted erosions on the hands and feet, which were misdiagnosed as eczema ten years ago. Over ten years, the patient experienced recurrent erythematous patches with bumps and itching on the face, trunk, and extremities after improving the hand and foot lesions...
2024: Clinical, Cosmetic and Investigational Dermatology
Anon Paichitrojjana, Thep Chalermchai
BACKGROUND: Demodex mites can lead to various skin disorders, from non-specific dermatitis to conditions that mimic other diseases, making it challenging to diagnose accurately. Additionally, it has been reported that Demodex mites can cause skin conditions such as perioral dermatitis, pustular folliculitis, pityriasis folliculorum, blepharitis, and rosacea. Due to conflicting studies, there is a debate regarding the link between Demodex mites and acne vulgaris. This study aims to determine the prevalence of Demodex mites on the faces of individuals with acne vulgaris, acne with nonspecific facial dermatitis, and healthy facial skin to clarify the association...
2024: Clinical, Cosmetic and Investigational Dermatology
(no author information available yet)
[This corrects the article DOI: 10.2147/CCID.S446429.].
2024: Clinical, Cosmetic and Investigational Dermatology
Sung Bin Cho, Yea-Jin Lee, Sun Young Kang, Min Choi, Bora Kim, Jin-Chul Ahn
BACKGROUND: Skin cooling during laser or radiofrequency (RF) treatments is a method to minimize thermal damage to the epidermis, reduce pain, and decrease post-treatment downtime. We evaluated the effect of parallel contact cooling (PCC) on RF-induced thermal reactions in minipig skin in vivo after bipolar microneedling RF treatment. METHODS: RF treatments were administered at frequencies of 0.5, 1, and 2 MHz with single (500 ms), six (1000 ms), and ten (5000 ms) sub-pulse packs to minipig skin with or without PCC...
2024: Clinical, Cosmetic and Investigational Dermatology
Qingan Huang, Yuan Li, Mu Niu, Gaihe Chen
Superficial Acral fibroma (SAF), also known as osteofibroma, is a rare fibromatous tumor primarily involving superficial soft tissues. Clinically, SAF typically manifests as a slow-growing, solitary, well-defined nodule or mass. Although these lesions are generally asymptomatic, some cases may present with associated pain, often linked to a history of trauma. SAF lesions commonly exhibit hemispherical, polypoid, or warty growths, with occasional occurrences of ulceration and bleeding.The majority of SAFs express CD34 and CD99, but in the two cases we report, there was diffuse expression of CD34 and focal positive expression of CD68...
2024: Clinical, Cosmetic and Investigational Dermatology
Qiaochu Zhou
OBJECTIVE: It is challenging to reconstruct defects resulting from surgical procedures in areas with high tension. We present modified kite flaps that allowed us to reconstruct the defect with high mechanical tension. METHODS: With the combination of advancement and rotation, the defect using bilateral modified kite flaps closes with significantly reduced tension. The double flap not only advances but also rotates the flap. This technique retained and exploited the limbs of the flaps, which were often removed with the traditional V-Y flaps...
2024: Clinical, Cosmetic and Investigational Dermatology
Miao Wan, Xiangrong Xu, Xiaojiao Zhao, Xia You, Guiying Zhang, Hai Long, Ping He, Jian Long, Jianjian Zhu
Necrotizing fasciitis is a rare, severe, rapidly progressing disease with a high mortality rate. We report a case of a 72-year female with erythematous pemphigus who developed erythema, swelling and ulceration on right vulva, groin, and thigh. The early clinical manifestations of the patient were nonspecific and easily misdiagnosed as cellulitis. However, upon the occurrence of ulceration and necrosis, deep fungal infection, pyoderma gangrenosum or lymphoproliferative disorders were considered. The pathology suggested IgG4-related diseases, plasmacytoma et al...
2024: Clinical, Cosmetic and Investigational Dermatology
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