Mitali Bhattacharjee, Rajesh Raju, Aneesha Radhakrishnan, Vishalakshi Nanjappa, Babylakshmi Muthusamy, Kamlendra Singh, Dheebika Kuppusamy, Bhavya Teja Lingala, Archana Pan, Premendu Prakash Mathur, H C Harsha, T S Keshava Prasad, Gerald J Atkins, Akhilesh Pandey, Aditi Chatterjee
TNF-related weak inducer of apoptosis (TWEAK) is a new member of the TNF superfamily. It signals through TNFRSF12A, commonly known as Fn14. The TWEAK-Fn14 interaction regulates cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, tissue remodeling and inflammation. Although TWEAK has been reported to be associated with autoimmune diseases, cancers, stroke, and kidney-related disorders, the downstream molecular events of TWEAK-Fn14 signaling are yet not available in any signaling pathway repository...
2012: Journal of Signal Transduction