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Recent Patents on Inflammation & Allergy Drug Discovery

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https://read.qxmd.com/read/30592257/urinary-tract-infection-in-children
#1
Alexander K C Leung, Alex H C Wong, Amy A M Leung, Kam L Hon
BACKGROUND: Urinary Tract Infection (UTI) is a common infection in children. Prompt diagnosis and appropriate treatment are very important to reduce the morbidity associated with this condition. OBJECTIVE: To provide an update on the evaluation, diagnosis, and treatment of urinary tract infection in children. METHODS: A PubMed search was completed in clinical queries using the key terms "urinary tract infection", "pyelonephritis" and "cystitis"...
December 28, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30539708/the-inhibitory-role-of-m2000-%C3%AE-d-mannuronic-acid-on-expression-of-toll-like-receptor-2-and-4-in-ht29-cell-line
#2
Laleh Sharifi, Mona Moshiri, Mohammad M S Dallal, Mohammad H Asgardoon, Maryam Nourizadeh, Saied Bokaie, Abbas Mirshafiey
BACKGROUND/OBJECTIVES: Anti-inflammatory agents play a crucial role in controlling inflammatory diseases such as Inflammatory Bowel Disease (IBD) but their use is restricted due to their vast side effects. M2000 (β-D-mannuronic Acid) is a new immunomodulatory drug. According to the capacity of M2000 in suppressing some molecules involved in Toll Like Receptors (TLRs) signaling and reducing oxidative stress we hypothesize that, this molecule may have a potential role in decreasing inflammatory responses in IBD...
December 11, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30457056/anti-arthritic-effect-of-garcinol-enriched-fraction-against-adjuvant-induced-arthritis
#3
Purnima Warriar, Kalyani Barve, Bala Prabhakar
BACKGROUND: Garcinia indica also known as kokum is used in traditional system of medicine for relieving inflammation and rheumatic pain. Garcinol, a benzophenone obtained from its fruit rind is reported to have anti-inflammatory effect via modulating arachidonic acid metabolism, suppressing iNOS expression, NF-κB activation and COX-2 expression. It has also been studied for antioxidant and anticancer activity. Apart from these, few patents claim that Garcinol also has anti-obesity and hepatoprotective effect and has a potential to be used for treatment of renal disorders, endometriosis and cardiac dysfunction...
November 19, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30318010/inhaled-biologicals-for-the-treatment-of-cystic-fibrosis
#4
Valentina Sala, Alessandra Murabito, Alessandra Ghigo
BACKGROUND: Cystic Fibrosis, one of the most frequent genetic diseases, is characterized by the production of viscous mucus in several organs. In the lungs, mucus clogs the airways and traps bacteria, leading to recurrent/resistant infections and lung damage. For Cystic Fibrosis patients, respiratory failure is still lethal in early adulthood since available treatments display incomplete efficacy. OBJECTIVE: The objective of this review is to extend the current knowledge in the field of available treatments for Cystic Fibrosis...
October 11, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30255762/flare-up-phenomenon-of-intradermal-test-with-anaphylactic-reaction-to-paracetamol-acetaminophen
#5
Ana Rodriguez Fernandez, Marcos Sanchez Dominguez, Blanca Noguerado-Mellado, Patricia Rojas Perez-Ezquerra
BACKGROUND: Paracetamol is a non-steroidal anti-inflammatory drug (NSAID) that can produce hypersensitive reactions mediated by specific immunological mechanisms (IgE or T cell dependent) or by non-immunological mechanism (inhibition of cyclooxygenase COX-1). OBJECTIVE: A 80-year-old man with a history of allergy to pyrazolones, with good tolerance to other NSAIDs was referred to our Allergy Department because he presented a generalized urticaria after the administration of intravenous (IV) paracetamol...
September 26, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29932038/community-acquired-pneumonia-in-children
#6
Alexander Kc Leung, Alex H C Wong, Kam Lun Hon
BACKGROUND: Community-acquired pneumonia is an important cause of morbidity in developed countries and an important cause of morbidity and mortality in developing countries. Prompt diagnosis and appropriate treatment are very important. OBJECTIVE: To provide an update on the evaluation, diagnosis, and treatment of community-acquired pneumonia in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "community-acquired pneumonia"...
June 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29714140/omalizumab-in-the-therapy-of-pediatric-asthma
#7
Dimitri Poddighe, Ilaria Brambilla, Amelia Licari, Gian Luigi Marseglia
BACKGROUND: Eosinophilic asthma is driven by Th2 immune response and is usually characterized by the increase of total serum IgE levels and/or specific IgE that express single or multiple allergen sensitization. In such an immune- pathological background, the anti-IgE therapy, namely omalizumab, found its main clinical utility and recommendation to treat severe asthma. OBJECTIVE: in this mini-review, we summarized the most relevant immuno-pathological and clinical evidences supporting the use of omalizumab in the therapy of pediatric asthma, Furthermore, we provided the main practical points for such a therapeutic management...
April 30, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29473530/allergoids-for-allergy-treatment
#8
Jeronimo Carnes, Maria T Gallego, Raquel Moya, Victor Iraola
Background Chemically modified allergen extracts, known as allergoids, are commonly used for treating allergic patients. In general terms, the concept of allergoids implies allergen extracts with a reduction of their allergenicity maintaining their immunogenicity. Different methods to obtain allergoids have been developed in the past years, opening attractive lines of research. Objective To review the different approaches to allergoid development as well as their characterization, mechanism of action and efficacy and safety issues...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29366431/prednisolone-effects-on-urine-cross-linked-n-telopeptides-of-type-i-collagen-ntx-diurnal-rhythms-in-children
#9
Ole D Wolthers, Carsten Carsten Heuck
Recently, methods for mimicking endogenous cortisol rhythms hereby potentially reducing the risk of systemic adverse effects of exogenous corticosteroids have been patented. Methods for sensitive detection of adverse effects on bone turnover of various doses, administration routes and regimens of exogenous corticosteroids have been patented. Urine cross-linked N-telopeptides of type I collagen (Ntx) have been established as a sensitive bone resorption marker and urine levels of Ntx have been found to exhibit a distinct diurnal rhythm...
January 24, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30152277/advances-in-developing-prophylactics-and-therapeutics-to-counter-inflammatory-allergic-and-infectious-diseases
#10
EDITORIAL
Ashok Munjal, Hafiz M N Iqbal, Kuldeep Dhama
No abstract text is available yet for this article.
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30109827/prevention-of-cardiovascular-diseases-with-anti-inflammatory-and-anti-oxidant-nutraceuticals-and-herbal-products-an-overview-of-pre-clinical-and-clinical-studies
#11
Sajal Jain, Harpal S Buttar, Meena Chintameneni, Ginpreet Kaur
BACKGROUND: Inflammation-induced endothelial abnormalities, dietary habits, and tobacco smoking are considered to be the primary risk factors for causing atherosclerosis and Cardiovascular Diseases (CVDs), including Coronary Heart Disease (CHD), cerebrovascular disorders, peripheral arterial disease, rheumatic heart disease, congenital heart defects, deep vein thrombosis and pulmonary embolism. Prevention of CVDs with anti-inflammatory and anti-oxidant agents has been a challenging task for decades...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30058499/impact-of-ocular-compatible-lipoids-and-castor-oil-in-fabrication-of-brimonidine-tartrate-nanoemulsions-by-3-3-full-factorial-design
#12
Rimple, Maria J Newton
BACKGROUND: Brimonidine Tartrate (BRT) is used in the treatment of glaucoma. Brimonidine tartrate nanoemulsion was fabricated in this research work to enhance the permeability through barriers and faster onset of action and therapeutic effect. OBJECTIVE: To fabricate an ocular compatible nanoemulsion of brimonidine tartrate by using surfactant and co-surfactants. METHODS: The experimental work involved compatibility studies by using FTIR, DSC and crystallinity study by XRD...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/30019654/complications-of-diabetes-an-insight-into-genetic-polymorphism-and-role-of-insulin
#13
Sobia Aleem, Riffat Iqbal, Tanzila Shar, Sadia Noreen, Naila Rafiq, Irum Javed, Sumaira Kosar, Humaira N Majeed, Naila A Sattar, Muhammad K Abid
BACKGROUND: Diabetes Mellitus (DM) is an advanced and chronic endocrine disorder characterized by an insufficiency of insulin secretion from pancreatic β-cells and liver, adipose tissues, and skeletal muscles. OBJECTIVE: The main objective of this study is to understand the mechanism and genes which are responsible for the prevalence of diabetes. The study also covers various types of diabetic complications with special reference to insulin role and defects. METHODS: The scientific literature and patents were reviewed and analyzed based on their suitability and relevance to the theme of the study...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29972106/role-of-curcumin-in-regulation-of-tnf-%C3%AE-mediated-brain-inflammatory-responses
#14
Tirthraj Baj, Rohit Seth
BACKGROUND: Inflammation is a protective response of the body system that protects the body from the various kinds of external and internal insults; however, it has been found that most chronic illnesses are caused by dysregulated and excessive inflammation. Inflammation plays a major role in developing neurological diseases. In the brain cytokines, TNF-α and TNF-β are known to mediate inflammation in many diseases. Functions of these cytokines are regulated by the activation of transcription factor NF-κb...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29932039/effect-of-prolonged-anti-hm1-imss-entamoeba-histolytica-antibody-activity-in-humoral-and-cellular-immunity-of-experimentally-induced-animal-model
#15
Swati Bagde, Vinod Singh
BACKGROUND: The Cellular immunity plays an important role in amoebic infections, whereas humoral immune responses have little influence on the outcome of the disease. Chronic infestation with Entameoba histolytica, a common protozoan parasite, has been associated with autoimmune phenomena, including the appearance of antibodies to colonic epithelial cells. The mechanism whereby the protozoan parasite E. histolytica causes suppression of the immune response to allow it to survive in humans is unclear...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29879894/evaluation-of-the-effect-of-%C3%AE-l-guluronic-acid-g2013-on-cox-1-cox-2-activity-and-gene-expression-for-introducing-this-drug-as-a-novel-nsaid-with-immunomodulatory-property
#16
Abbas Mirshafiey, Seyed S Mortazavi-Jahromi, Mahsa Taeb, Salvatore Cuzzocrea, Emanuela Esposito
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat the pathological pain and inflammation through inhibition of cyclooxygenase (COX) enzyme and disruption of the synthesis of prostaglandins (PGs). The α-L-guluronic acid (G2013) patented (PCT/EP2017/067920), as a novel NSAID with the immunomodulatory property, has been shown its positive effects in experimental models of multiple sclerosis and anti-aging. OBJECTIVE: This study was aimed to investigate the effects of G2013 on the gene expression and activity of COX-1/COX-2 enzymes in order to introduce a novel NSAID for the treatment of inflammatory diseases...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29745347/febrile-infection-related-epilepsy-syndrome-fires-an-overview-of-treatment-and-recent-patents
#17
REVIEW
Kam L Hon, Alexander K C Leung, Alcy R Torres
BACKGROUND: New-Onset Refractory Status Epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile Infection-Related Epilepsy Syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29485014/in-vitro-and-in-vivo-immunomodulating-properties-of-mesenchymal-stem-cells
#18
Divya Chaudhary, Raj N Trivedi, Ashima Kathuria, Tapas K Goswami, Rekha Khandia, Ashok Munjal
BACKGROUND: Mesenchymal Stem Cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into all cell types of mesodermal origin, such as adipocytes, osteocytes and chondrocytes. Mesenchymal Stem Cells (MSCs) are adult stem cells which can be isolated from human and animal sources. OBJECTIVE: Besides the differentiation potential of MSCs, these also regulate the immune response in numerous ailments. The present review expedites the immunomodulating prospective of MSCs...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29473532/the-promising-pharmacological-effects-and-therapeutic-medicinal-applications-of-punica-granatum-l-pomegranate-as-a-functional-food-in-humans-and-animals
#19
Muhammad Saeed, Muhammad Naveed, Jannat BiBi, Asghar A Kamboh, Muhammad A Arain, Qurban A Shah, Mahmoud Alagawany, Mohamed E A El-Hack, Mervat A Abdel-Latif, Mohd I Yatoo, Ruchi Tiwari, Sandip Chakraborty, Kuldeep Dhama
BACKGROUND: Punica granatum L. (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to their promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp, and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://read.qxmd.com/read/29473531/diabetic-complications-and-insight-into-antidiabetic-potentialities-of-ethno-medicinal-plants-a-review
#20
Muhammad Bilal, Muhammad S Iqbal, Syed B Shah, Tahir Rasheed, Hafiz M N Iqbal
BACKGROUND: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world. OBJECTIVE: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications...
2018: Recent Patents on Inflammation & Allergy Drug Discovery
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