Recent Patents on Inflammation & Allergy Drug Discovery

BACKGROUND: Infectious encephalitis is a serious and challenging condition to manage. This overview summarizes the current literature regarding the etiology, clinical manifestations, diagnosis, management and recent patents of acute childhood infectious encephalitis. METHODS: We used PubMed Clinical Queries and keywords of "encephalitis" AND "childhood" as a search engine, and patents were searched using the key term "encephalitis" in google...

BACKGROUND: Conventional treatments of arthritis use toxic and poorly tolerated drugs; Therefore, natural products are an alternative because they are important sources of bioactive substances with therapeutic potential. OBJECTIVE: To perform synthesis of patent applications associated with the use of natural products in the technological development of the invention for use in treating arthritis. METHODS: The search for patents was conducted using the databases World Intellectual Property Organization (WIPO), European Patent Office (EPO, Espacenet), United States Patents and Trademark Office (USPTO) and National Institute of Intellectual Property (INPI) using as keywords - arthritis, treatment and the International Patent Classification (IPC) A61K36 / 00...

AIM: To discuss and present current status of MSCs immuno-modulatory properties. BACKGROUND: Mesenchymal stem cells (MSCs) are present in almost all the tissues of the body and act as backbone of the internal tissue homeostasis. Among their various characteristic features, immuno-modulatory and/ anti-inflammatory properties play an important role in therapeutics. OBJECTIVE: The current topic focuses on characterization and immuno-modulatory and/ anti-inflammatory properties of MSCs...

BACKGROUND: Chitinases are the evolutionary conserved glycosidic enzymes that are characterized by their ability to cleave the naturally abundant polysaccharide chitin. The potential role of chitinases has been identified in the manifestation of various allergies and inflammatory diseases. In recent years, chitinases inhibitors are emerging as alluring area of interests for the researchers and scientists and there is a dire need for the development of potential and safe chitinase antagonists for the prophylaxis and treatment of several diseases...

BACKGROUND: Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad. OBJECTIVE: This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema. METHODS: A PubMed search was performed in using the key terms "nummular eczema", "discoid eczema", OR "nummular dermatitis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews...

BACKGROUND: Alopecia Areata (AA) is a systemic autoimmune condition that usually starts in childhood. OBJECTIVE: This article aims to review genetics, therapy, prognosis, and recent patents for AA. METHODS: We used clinical queries and keywords "alopecia areata" AND "childhood" as a search engine. Patents were searched using the key term "alopecia areata" in Patents.google.com and freepatentsonline. com. RESULTS: Due to an immune-mediated damage to the hair follicles, hair is lost from the scalp and other areas of the body temporarily or even permanently...

BACKGROUND: Ascaris lumbricoides is the most common helminthic infection. More than 1.2 billion people have ascariasis worldwide. OBJECTIVE: This article aimed to provide an update on the evaluation, diagnosis, and treatment of ascariasis. METHODS: A PubMed search was conducted in February 2020 in Clinical Queries using the key terms "ascariasis" OR "Ascaris lumbricoides". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews published within the past 10 years...

BACKGROUND: Pediatric myocarditis is rare but challenging. This overview summarized the current knowledge and recent patents on childhood myocarditis. METHODS: Clinical queries and keywords of "myocarditis" and "childhood" were used as search engine. RESULTS: Viral infections are the most common causes of acute myocarditis. Affected children often have a prodrome of fever, malaise, and myalgia. Clinical manifestations of acute myocarditis in children can be nonspecific...

BACKGROUND: Leukotrienes are powerful mediators of inflammation and interact with specific receptors in target cell membrane to initiate an inflammatory response. Thus, Leukotrienes (LTs) are considered to be potent mediators of inflammatory diseases including allergic rhinitis, inflammatory bowel disease and asthma. Leukotriene B4 and the series of cysteinyl leukotrienes (C4, D4, and E4) are metabolites of arachidonic acid metabolism that cause inflammation. The cysteinyl LTs are known to increase vascular permeability, bronco-constriction and mucus secretion...

BACKGROUND: Aspirin is a nonsteroidal anti-inflammatory drug that is very effective in the treatment of inflammation and other health conditions, however, it causes gastric irritation. Recently, researchers have developed patents (US9757529, 2019) of inhalable aspirin for rapid absorption and circumvention of gastric irritation. OBJECTIVE: The aim of this work was to formulate aspirin-loaded lipid based formulation in order to enhance oral bioavailability and inhibit gastric irritation...

BACKGROUND: Tinea capitis is a common and, at times, difficult to treat, fungal infection of the scalp. OBJECTIVE: This article aimed to provide an update on the evaluation, diagnosis, and treatment of tinea capitis. METHODS: A PubMed search was performed in Clinical Queries using the key term "tinea capitis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews...

BACKGROUND: Regarding the leukocytes infiltration into the synovium of rheumatoid arthritis (RA) patients is mostly mediated by chemokine ligands and receptors, and following the efficient and motivating results of international Phase III clinical trial of β-D-Mannuronic acid (M2000) patented EP067919 (2017), as a novel anti-inflammatory drug, in patients with RA, the present research was designed. OBJECTIVES: This study aimed to assess the oral administration effects of this new drug on gene expression of some chemokine receptors and ligands including CXCR4, CXCR3, CCR2, CCR5 and CCL2/MCP-1 in PBMCs of patients with active form of RA...

BACKGROUND: Onychomycosis is a common fungal infection of the nail. OBJECTIVE: The study aimed to provide an update on the evaluation, diagnosis, and treatment of onychomycosis. METHODS: A PubMed search was completed in Clinical Queries using the key term "onychomycosis". The search was conducted in May 2019. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews published within the past 20 years...

BACKGROUND: Natural products represent a therapeutic charm for the treatment of inflammation-associated diseases. Flavonoids which are one of the special categories of such natural products, have previously shown promising therapeutic potential. OBJECTIVES: The current review discusses about the synthetic preview and anti-inflammatory potential of apigenin along with the underlying molecular mechanism in chronic human diseases especially cancer. In addition, the relevant patents on therapeutic potential of apigenin have also been mentioned...

BACKGROUND: Among the various phenolics metabolites, ferulic acid is considered as the promising mitigating, restorative and antioxidant agent. The ferulic acid is for the mostly found in natural products, vegetables, for example, tomatoes, sweet corn, and rice grain. Phytochemicals are utilized in the treatment of human ailments and these are derived from the dietary compounds. OBJECTIVE: The present review widely argued the calming restorative capability of ferulic acid alongside the scientific evidences and its proposed mechanism for activity...

BACKGROUND: Giardiasis is an important cause of waterborne and foodborne diarrhea, day-care center outbreaks, and traveler's diarrhea. OBJECTIVE: To provide an update on the evaluation, diagnosis, and treatment of giardiasis. METHODS: A PubMed search was completed in Clinical Queries using the key terms "giardiasis", "Giardia lamblia", "Giardia duodenalis" and "Giardia intestinalis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews...

BACKGROUND: Several compositions for determination of specific molecular components in allergens have recently been patented. The role of molecular allergy (MA) diagnostics in suspected IgE mediated allergic conditions is currently debated. Guideline reports have concluded that population-based studies involving evaluation of the usefulness of MA diagnostics are needed. OBJECTIVE: To evaluate the usefulness of MA diagnostics in a secondary pediatric referral center...

BACKGROUND: Inflammation has become pathology in the majority of the prevalent diseases such as diabetes, atherosclerosis, epilepsy and neurodegenerative disorders. Anti-inflammatory drugs work wonder in all these conditions, where the patient has become refractory to standard treatment. However, available anti-inflammatory agents have side effects associated with chronic use, thus if we could develop safe and efficacious molecules, quality of health care provided will improve. Since plant sources have been extensively explored, the focus needs to be shifted on the alternative natural sources of anti-inflammatory agents...

BACKGROUND: Various pieces of evidence have shown that people who consume foods rich in polyphenolic and flavonoids compounds have a lower incidence of inflammatory, autoimmune diseases and cancer. OBJECTIVE: The study aimed to review the most potent compounds that affect the immune response and diseases associated with it. METHODS: Publications in PubMed and EmBase, from 1974-2018, and patents form Free patents online, Scifinder, Espacenet and Mendeley in which flavonoids, their semi-synthetic and synthetic derivatives are involved in immunosuppressive or immunostimulatory responses in vitro and in vivo...

No abstract text is available yet for this article.