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Journal of Biomedical Materials Research. Part A

Sudipta Senapati, Dinesh K Patel, Biswajit Ray, Pralay Maiti
Fluorescence probe has attracted significant attention for biomedical imaging in recent years due to their high resolution at the cellular level. Organic based fluorescent probes with high quantum yield are widely applied in bioimaging but most of them suffer from a serious obstacle called aggregation-caused quenching in cellular systems. New fluorophore has been designed through functionalization of graphene oxide which emphatically exhibits aggregation-induced emission along with pH-responsive nanoprobe. Significantly higher emission of this material in slightly acidic media helps to detect tumor cell by creating a sharp contrast with the image of normal cells...
April 16, 2019: Journal of Biomedical Materials Research. Part A
Fatemeh Safari, Nesa Fani, David Eglin, Mauro Alini, Martin J Stoddart, Mohamadreza Baghaban Eslaminejad
Since articular cartilage is an avascular tissue, it has limited self-regeneration capacity after damage. Current methods for human bone marrow-derived Mesenchymal Stem Cell (hBM-MSC) differentiation into cartilage result in tissues with a lower quality as compared to native articular cartilage. Decellularized biological scaffolds have the potential to provide appropriate signals, in order to support cellular retention, migration, proliferation and differentiation. Given the high amount of collagen, hyaluronic acid (HA) and glycosaminoglycan (GAG) in umbilical cord, this tissue can be considered as an abundant natural biomaterial for tissue engineering applications...
April 15, 2019: Journal of Biomedical Materials Research. Part A
Parinaz Khadivi, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Polydimethylsiloxane-based polyurethane (PU)/crystalline nanocellulose (CNC) bio-nanocomposites were produced via in-situ pre-polymer approach. Also, Hexamethylene diisocyanate (HDI) as aliphatic diisocyanate monomer and 1,4-butanediol (BDO) as aliphatic chain extender were used. CNC was incorporated into PU matrix to prepare different PU/CNC bio-nanocomposites. Effect of CNC content on the properties of the bio-nanocomposites such as thermal, thermophysical, microstructure and in vitro cytotoxicity was investigated...
April 14, 2019: Journal of Biomedical Materials Research. Part A
Makoto Noiri, Kenta Asawa, Naoya Okada, Tomonobu Kodama, Yuichi Murayama, Yuuki Inoue, Kazuhiko Ishihara, Kristina N Ekdahl, Bo Nilsson, Yuji Teramura
Promising cell therapies using mesenchymal stem cells (MSCs) is proposed for stroke patients. Therefore, we aimed to efficiently accumulate human MSC (hMSC) to damaged brain area to improve the therapeutic effect using poly(ethylene glycol) (PEG)-conjugated phospholipid (PEG-lipid) carrying an oligopeptide as a ligand, specific for E-selectin which is up-regulated on activated endothelial cells under hypoxia like stroke. Here we synthesized E-selectin-binding oligopeptide (ES-bp) conjugated with PEG spacer having different molecular weights from 1 kDa to 40 kDa...
April 14, 2019: Journal of Biomedical Materials Research. Part A
Tara D Sutherland, Aditya V Vashi, Egi Kardia, Alagacone Sriskantha, Trevor D Rapson, Robyn N Hall, Jerome A Werkmeister
If tolerated in biological environments, recombinant structural proteins offer the advantage that biological cues dictating cell attachment and material degradation can be modified as required for clinical application using genetic engineering. In this study, we investigate the biological response to materials generated from the recombinant honeybee silk protein, AmelF3, a structural protein that can be produced at high levels by fermentation in E. coli. The protein can be readily purified from E. coli host cell proteins after transgenic production and fabricated into various material formats...
April 14, 2019: Journal of Biomedical Materials Research. Part A
David S Tilden, Marie E Roy, Leo A Whiteside
The purpose of this study was to evaluate the suitability of a plasma sprayed titanium porous coating on polished magnesia-stabilized zirconia (Mg-PSZ) ceramic surfaces. We hypothesized that diffusion bonding was responsible for the adhesion of the coating to the ceramic substrate. Mg-PSZ tensile test coupons were vibratory polished (roughness Sa = 0.50 μm) or vibratory polished/lapped (Sa = 0.12 μm) before coating and testing. The exposed surfaces after tensile testing were examined by energy dispersive X-ray (EDX) analysis...
April 14, 2019: Journal of Biomedical Materials Research. Part A
Justin R Adams, Sujata Senapati, Shannon L Haughney, Michael J Wannemuehler, Balaji Narasimhan, Surya K Mallapragada
Injectable thermogelling polymers have been recently investigated as novel adjuvants and delivery systems for next generation vaccines. As research into natural and synthetic biocompatible polymers progresses, the safety and biocompatibility of these compounds is of paramount importance. We have developed cationic pentablock copolymer vaccine adjuvants based on Pluronic F127, a thermogelling triblock copolymer that has been approved by the FDA for multiple applications, and methacrylated poly(diethylaminoethyl methacrylate) (PDEAEM) outer blocks...
April 10, 2019: Journal of Biomedical Materials Research. Part A
ZhenZhen Zhang, HongMei Xu, Giuseppe Mazza, MingMan Zhang, Luca Frenguelli, QuanBo Liu, Walid Al-Akkad, JiHua Ren, RuiQiu Zhao, Fang Ren, Xin Chen, AiLong Huang, Juan Chen
Hepatitis B virus (HBV) study is hampered by lacking of idea cell model which support effective HBV infection, and meanwhile recapitulate hepatocyte biology function in vivo. In this study, we developed decellularized human liver scaffolds for cell culture and further applied for HBV infection. As a result, primary human hepatocytes (PHH) engrafted into liver scaffolds and maintained differentiation with stable albumin secretion and liver specific gene expression. Comparing to mono-layer cell culture, scaffold-based 3D culture system significantly augment HBV DNA (including cccDNA), RNA level as well as HBsAg secretion...
April 8, 2019: Journal of Biomedical Materials Research. Part A
Chao Yang, Lilong Gao, Xiyan Liu, Ting Yang, Guangming Yin, Jianyu Chen, Haiyong Guo, Bing Yu, Hailin Cong
A novel voriconazole (VCZ)-loaded injectable hydrogel was in situ synthetized via a Schiff base reaction between poly aldehyde dextran (PAD) and carboxymethyl chitosan (CMCTS) for intraocular drug loading and release. Water-insoluble VCZ, which is an effective agent in clinic treating fungal endophthalmitis, was loaded through the inclusion into the β-cyclodextrin (β-CD) cavity based on host-guest interaction on the linear poly β-CD chain, which was in situ twined in the cross-linked hydrogel structure. The gelation time, degradation and drug release process were investigated by studying three kinds of hydrogels with different volume ratio of PAD to CMCTS resolving in PBS solution (3:7, 6:7, 9:7) respectively...
April 4, 2019: Journal of Biomedical Materials Research. Part A
Akbar Esmaeili, Faranak Bahramimehr
On incidence of kidney failure, the concentration of urea increases and there is need for patients to visit the hospital all through the week for blood purification. However, current hemodialysis has been found to reduce only 66-75% urea in the blood of patients. The main goal of this article is to observe the effect of biocompatible and high mechanical hemodiafiltration in reducing urea and creatinine within the shortest time frame, using two methods of Nano electrospinning fiber (hybrid and coaxial). Hybrid electrospinning was made by zeolite 940-HOA(beta), Fe3 O4 , polyacrylonitrile1 as well as the addition of nettle plant's leaf extract...
April 3, 2019: Journal of Biomedical Materials Research. Part A
Haomin Cui, Yimin Chai, Yaling Yu
The skin is the largest organ in the human body, and skin defects are very common. Skin flap transplantation is the best treatment for serious wound defects, and donor site tissues are always sacrificed during this process. Decellularized biomaterials, derived mainly from various nonautologous organs and tissues, have promising applications in tissue engineering and repair of wound defects. To date, decellularized mesothelium, intestine, amniotic membrane, dermis, and skin flaps have been developed and applied for skin coverage in animal models and clinical practice...
April 3, 2019: Journal of Biomedical Materials Research. Part A
Kulwinder Kaur, K J Singh, Vikas Anand, Gaurav Bhatia, Amrit Pal Singh, Manpreet Kaur
Osteoporosis caused by overdose of steroids is one of the major concerns for the orthopedic surgeons. Current therapeutic strategies offer limited success due to their inability to regenerate damaged bone at osteoporosis site. Therefore, there is an urgent need to develop a material having bone regeneration ability and also, ability to cure osteoporosis simultaneously. In this work, nano and micro sized hydroxyl apatite (HAp) particles doped with Europium (Eu) were prepared for diagnostic and therapeutic applications in biomedical engineering...
March 29, 2019: Journal of Biomedical Materials Research. Part A
D M Valcourt, M N Dang, E S Day
Triple-negative breast cancer (TNBC) accounts for 15-25% of breast cancer cases and lacks expression of the three most common receptors seen on other subtypes of breast cancer. This lack of expression makes TNBC unsusceptible to currently available targeted or hormonal therapies, so new treatment strategies are desperately needed. Photothermal therapy (PTT), which utilizes nanoparticles (NPs) embedded in tumors as exogenous energy absorbers to convert externally applied near-infrared (NIR) light into heat to ablate cancer cells, has shown promise as an alternative strategy...
March 28, 2019: Journal of Biomedical Materials Research. Part A
Shervin Ilanlou, Mehrdad Khakbiz, Ghasem Amoabediny, Javad Mohammadi, Hodjattallah Rabbani
The development of decellularized small diameter vascular grafts is a potential solution for patients requiring vascular reconstructive procedures. However, there is a limitation for acellular scaffolds due to incomplete recellularization and exposure of extracellular matrix (ECM) components to whole blood resulting in platelet adhesion. To address this issue, a perfusion decellularization method was developed using a custom-designed set up which completely removed cell nuclei and preserved three dimensional structure and mechanical properties of native tissue (sheep carotid arteries)...
March 28, 2019: Journal of Biomedical Materials Research. Part A
Dongjian Shi, Jiali Shen, Zhuying Zhang, Chang Shi, Mingqing Chen, Yanglin Gu, Yang Liu
Three-dimensional (3D) homogenous scaffolds composed of natural biopolymers have been reported as superior candidates for bone tissue engineering. There are still remaining challenges in fabricating the functional scaffolds with gradient structures to similar with natural bone tissues, as well as high mechanical properties and excellent affinity to surround tissues. Herein, inspired by the natural bone structure, a gradient-structural scaffold composed of functional biopolymers was designed to provide an optimized 3D environment for promoting cell growth...
March 28, 2019: Journal of Biomedical Materials Research. Part A
Irene Lodoso-Torrecilla, Eline-Claire Grosfeld, Abe Marra, Brandon T Smith, Antonios G Mikos, Dietmar Jo Ulrich, John A Jansen, Jeroen Jjp van den Beucken
Calcium phosphate cements (CPCs) represent excellent bone substitute materials due to their biocompatibility and injectability. However, their poor degradability and lack of macroporosity limits bone regeneration. The addition of poly(D,L-lactic-co-glycolic acid) (PLGA) particles improves macroporosity and therefore late stage material degradation. CPC degradation and hence bone formation at an early stage remains challenging, due to the delayed onset of PLGA degradation (i.e. after 2-3 weeks). Consequently, we here explored multimodal porogen platforms based on sucrose porogens (for early pore formation) and PLGA porogens (for late pore formation) to enhance CPC degradation and analyzed mechanical properties, dynamic in vitro degradation and in vivo performance in a rat femoral bone defect model...
March 28, 2019: Journal of Biomedical Materials Research. Part A
Isabel Pereira, Sónia Fraga, Luís Maltez, João Requicha, Luísa Guardão, Joana Oliveira, Justina Prada, Helena Alves, José Domingos Santos, João Paulo Teixeira, José Eduardo Pereira, Raquel Soares, Francisco Miguel Gama
The worldwide incidence of bone disorders is raising, mainly due to ageing population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels to produce injectable/moldable SBSs. Dextrin, a low-molecular-weight carbohydrate, was used to develop a fully resorbable and injectable hydrogel...
March 28, 2019: Journal of Biomedical Materials Research. Part A
Jing Sun, Kun Sun, Kai Bai, Sun Chen, Fujun Wang, Fan Zhao, Nanchao Hong, Hanbo Hu
BACKGROUND: To evaluate the properties and efficacy of a novel braided biodegradable stent (BBS) consisting of poly (p-dioxanone) (PPDO) and polycaprolactone (PCL) for usage in children with congenital cardiovascular diseases. METHODS: PCL/PPDO composite filaments were fabricated by coating PCL layers onto PPDO filaments, which were fused with PPDO monofilaments to form the BBS. Physical properties of BBSs including elastic recovery rate, deformation rate and mechanical characteristics with adjunctive post-dilation were evaluated by radial force-tests...
March 27, 2019: Journal of Biomedical Materials Research. Part A
Yidi Zhang, Tianqi Guo, Qiushi Li, Jie Qin, Xinxin Ding, Shan Ye, Jinghui Zhao, Yanmin Zhou
Titanium alloys are widely accepted as orthopedic or dental implant materials in the medical field. It is important to evaluate the biocompatibility of an implant material prior to use. A new β-type ultrafine-grained Ti-28Nb-2Zr-8Sn (TNZS) alloy with low Young's modulus of 31.6 GPa was fabricated. This study aims to evaluate the biocompatibility of TNZS alloy. In this study, we examined the microstructure, chemical composition and surface wettability of the TNZS alloy. The mouse embryonic osteoblast MC3T3-E1 cells and human umbilical vein endothelial cells (HUVECs) were cultured to study the cytocompatibility of TNZS alloy...
March 27, 2019: Journal of Biomedical Materials Research. Part A
Marie Schneider, Sandra Rother, Stephanie Möller, Matthias Schnabelrauch, Dieter Scharnweber, Jan-Christoph Simon, Vera Hintze, Vuk Savkovic
The aim of this work was to establish improved cultivation conditions for human keratinocytes (HUKORS) and melanocytes (HUMORS) from the outer root sheath (ORS) of human hair follicles for purposes of generating an epidermal graft. To this end, the cells were cultivated on artificial extracellular matrix coatings composed of collagen (COLL) and hyaluronan (HA) with varying sulfation degrees. HUKORS and HUMORS were characterized based on their morphology and proliferation, marker gene expression, protein expression and melanin content in melanocytes...
March 27, 2019: Journal of Biomedical Materials Research. Part A
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