Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Kazuki Sasaki, Yu Takeda, Yoshiko Tsuji, Yasuko Arao, Ken Ofusa, Toru Kitagawa, Daisaku Yamada, Hidenori Takahashi, Shogo Kobayashi, Daisuke Motooka, Yutaka Suzuki, Sarah Rennie, Shizuka Uchida, Masaki Mori, Kazuhiko Ogawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
N6-methyladenosine (m6A) is an RNA modification involved in RNA processing and widely found in transcripts. In cancer cells, m6A is upregulated, contributing to their malignant transformation. In this study, we analyzed gene expression and m6A modification in cancer tissues, ducts, and acinar cells derived from pancreatic cancer patients using MeRIP-seq. We found that dozens of RNAs highly modified by m6A were detected in cancer tissues compared with ducts and acinar cells. Among them, the m6A-activated mRNA TCEAL8 was observed, for the first time, as a potential marker gene in pancreatic cancer...
April 24, 2024: Cancer Science