journal
https://read.qxmd.com/read/38413370/cell-cycle-heterogeneity-and-plasticity-of-colorectal-cancer-stem-cells
#1
REVIEW
Tsunaki Higa, Keiichi I Nakayama
Cancer stem cells (CSCs) are a long-lived and self-renewing cancer cell population that drives tumor propagation and maintains cancer heterogeneity. They are also implicated in the therapeutic resistance of various types of cancer. Recent studies of CSCs in colorectal cancer (CRC) have uncovered fundamental paradigms that have increased understanding of CSC systems in solid tumors. Colorectal CSCs share multiple biological properties with normal intestinal stem cells (ISCs), including expression of the stem cell marker Lgr5...
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38413363/hypoxia-related-carbonic-anhydrase-9-induces-serpinb9-expression-in-cancer-cells-and-apoptosis-in-t-cells-via-acidosis
#2
JOURNAL ARTICLE
Mamoru Harada, Hitoshi Kotani, Yuichi Iida, Ryosuke Tanino, Takafumi Minami, Yoshihiro Komohara, Kazuhiro Yoshikawa, Hirotsugu Uemura
Hypoxia is a common feature of solid tumors. However, the impact of hypoxia on immune cells within tumor environments remains underexplored. Carbonic anhydrase 9 (CA9) is a hypoxia-responsive tumor-associated enzyme. We previously noted that regardless of human CA9 (hCA9) expression, hCA9-expressing mouse renal cell carcinoma RENCA (RENCA/hCA9) presented as a "cold" tumor in syngeneic aged mice. This study delves into the mechanisms behind this observation. Gene microarray analyses showed that RENCA/hCA9 cells exhibited elevated mouse serpinB9, an inhibitor of granzyme B, relative to RENCA cells...
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38411349/correction-to-hdac5-negatively-regulated-by-mir-148a-3p-promotes-colon-cancer-cell-migration
#3
(no author information available yet)
No abstract text is available yet for this article.
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38411285/scoring-system-for-diagnosis-and-pretreatment-risk-assessment-of-neuroblastoma-using-urinary-biomarker-combinations
#4
JOURNAL ARTICLE
Hizuru Amano, Hiroo Uchida, Kazuharu Harada, Atsushi Narita, Shigehisa Fumino, Yuji Yamada, Shun Kumano, Mayumi Abe, Takashi Ishigaki, Minoru Sakairi, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Shuhei Karakawa, Yuichi Mitani, Shojiro Matsumoto, Yutaka Tomioka, Hideki Muramatsu, Nobuhiro Nishio, Tsuyoshi Osawa, Masataka Taguri, Katsuyoshi Koh, Tatsuro Tajiri, Motohiro Kato, Kimikazu Matsumoto, Yoshiyuki Takahashi, Akinari Hinoki
The urinary catecholamine metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA), are used for the adjunctive diagnosis of neuroblastomas. We aimed to develop a scoring system for the diagnosis and pretreatment risk assessment of neuroblastoma, incorporating age and other urinary catecholamine metabolite combinations. Urine samples from 227 controls (227 samples) and 68 patients with neuroblastoma (228 samples) were evaluated. First, the catecholamine metabolites vanillactic acid (VLA) and 3-methoxytyramine sulfate (MTS) were identified as urinary marker candidates through comprehensive analysis using liquid chromatography-mass spectrometry...
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38410865/acid-sensing-receptor-gpr4-plays-a-crucial-role-in-lymphatic-cancer-metastasis
#5
JOURNAL ARTICLE
Masako Nakanishi, Akiya Ibe, Kiyoto Morishita, Kazutaka Shinagawa, Yushi Yamamoto, Hibiki Takahashi, Kyoka Ikemori, Yasuteru Muragaki, Shogo Ehata
Cancer tissues exhibit an acidic microenvironment owing to the accumulation of protons and lactic acid produced by cancer and inflammatory cells. To examine the role of an acidic microenvironment in lymphatic cancer metastasis, gene expression profiling was conducted using human dermal lymphatic endothelial cells (HDLECs) treated with a low pH medium. Microarray and gene set enrichment analysis revealed that acid treatment induced the expression of inflammation-related genes in HDLECs, including genes encoding chemokines and adhesion molecules...
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38409909/harnessing-the-potential-of-reverse-phase-protein-array-technology-advancing-precision-oncology-strategies
#6
REVIEW
Mari Masuda, Riko Nakagawa, Tadashi Kondo
The last few decades have seen remarkable strides in the field of cancer therapy. Precision oncology coupled with comprehensive genomic profiling has become routine clinical practice for solid tumors, the advent of immune checkpoint inhibitors has transformed the landscape of oncology treatment, and the number of cancer drug approvals has continued to increase. Nevertheless, the application of genomics-driven precision oncology has thus far benefited only 10%-20% of cancer patients, leaving the majority without matched treatment options...
February 26, 2024: Cancer Science
https://read.qxmd.com/read/38403332/foxo1-promotes-ovarian-cancer-by-increasing-transcription-and-mettl14-mediated-m-6-a-modification-of-smc4
#7
JOURNAL ARTICLE
Liping Tan, Shuangan Wang, Shijia Huang, Yujuan Tie, Na Sai, Yichen Mao, Shuli Zhao, Yayi Hou, Huan Dou
The transcription factor forkhead box protein O1 (FoxO1) is closely related to the occurrence and development of ovarian cancer (OC), however its role and molecular mechanisms remain unclear. Herein, we found that FoxO1 was highly expressed in clinical samples of OC patients and was significantly correlated with poor prognosis. FoxO1 knockdown inhibited the proliferation of OC cells in vitro and in vivo. ChIP-seq combined with GEPIA2 and Kaplan-Meier database analysis showed that structural maintenance of chromosome 4 (SMC4) is a downstream target of FoxO1, and FoxO1 promotes SMC4 transcription by binding to its -1400/-1390 bp promoter...
February 25, 2024: Cancer Science
https://read.qxmd.com/read/38402853/long-term-experience-with-tepotinib-in-japanese-patients-with-met-exon-14-skipping-nsclc-from-the-phase-ii-vision-study
#8
JOURNAL ARTICLE
Masahiro Morise, Terufumi Kato, Shingo Matsumoto, Takako Inoue, Tomohiro Sakamoto, Takaaki Tokito, Shinji Atagi, Toshiyuki Kozuki, Hiroaki Takeoka, Kenichi Chikamori, Naofumi Shinagawa, Hiroshi Tanaka, Eisuke Horii, Svenja Adrian, Rolf Bruns, Andreas Johne, Paul K Paik, Hiroshi Sakai
Tepotinib is a highly selective MET tyrosine kinase inhibitor (TKI) that has demonstrated robust and durable clinical activity in patients with MET exon 14 (METex14) skipping non-small-cell lung cancer (NSCLC). In the Phase II VISION study, patients received oral tepotinib 500 mg once daily. The primary endpoint was an objective response by an independent review committee (IRC) according to RECIST v1.1 criteria. The secondary endpoints included duration of response (DOR), progression-free survival (PFS), overall survival (OS), and safety...
February 25, 2024: Cancer Science
https://read.qxmd.com/read/38402640/integration-of-cd4-t-cells-and-molecular-subtype-predicts-benefit-from-pd-l1-blockade-in-muscle-invasive-bladder-cancer
#9
JOURNAL ARTICLE
Ge Liu, Kaifeng Jin, Zhaopei Liu, Xiaohe Su, Ziyue Xu, Bingyu Li, Jingtong Xu, Hailong Liu, Yuan Chang, Yu Zhu, Le Xu, Zewei Wang, Yiwei Wang, Weijuan Zhang
Muscle-invasive bladder cancer (MIBC) is a disease characterized by molecular and clinical heterogeneity, posing challenges in selecting the most appropriate treatment in clinical settings. Considering the significant role of CD4+ T cells, there is an emerging need to integrate CD4+ T cells with molecular subtypes to refine classification. We conducted a comprehensive study involving 895 MIBC patients from four independent cohorts. The Zhongshan Hospital (ZSHS) and The Cancer Genome Atlas (TCGA) cohorts were included to investigate chemotherapeutic response...
February 25, 2024: Cancer Science
https://read.qxmd.com/read/38382459/emerging-potential-of-immunopeptidomics-by-mass-spectrometry-in-cancer-immunotherapy
#10
REVIEW
Yuriko Minegishi, Yoshimi Haga, Koji Ueda
With significant advances in analytical technologies, research in the field of cancer immunotherapy, such as adoptive T cell therapy, cancer vaccine, and immune checkpoint blockade (ICB), is currently gaining tremendous momentum. Since the efficacy of cancer immunotherapy is recognized only by a minority of patients, more potent tumor-specific antigens (TSAs, also known as neoantigens) and predictive markers for treatment response are of great interest. In cancer immunity, immunopeptides, presented by human leukocyte antigen (HLA) class I, play a role as initiating mediators of immunogenicity...
February 21, 2024: Cancer Science
https://read.qxmd.com/read/38369705/cross-individual-cancer-transmission-to-children-during-the-gestational-and-perinatal-periods
#11
REVIEW
Ayumu Arakawa, Kayoko Tao, Takashi Kohno, Chitose Ogawa
Cancer transmission may rarely occur between individuals. Besides through allogenic transplantation, cancer transmission via the hemochorial placenta, which is permissive for cell traffic, has been described in a few reports. Three etiologies of transplacental cancer transmission include (1) maternofetal transmission of maternal cancer cells, (2) transmission of gestational choriocarcinoma to the fetus, and (3) transfer of preleukemic cells from one monozygotic twin to the other. Additionally, we recently reported two pediatric cases of lung tumors in which the lung-only distribution of tumors and genomic profiling of both the child's and mother's tumor samples suggested the airway/transbronchial transmission of maternal cervical cancer cells to the child by aspiration at birth...
February 18, 2024: Cancer Science
https://read.qxmd.com/read/38356184/dietary-melatonin-and-liver-cancer-incidence-in-japan-from-the-takayama-study
#12
JOURNAL ARTICLE
Keiko Wada, Atsuhiko Hattori, Yusuke Maruyama, Tomoka Mori, Masaaki Sugino, Yuma Nakashima, Michiyo Yamakawa, Masayuki Yamamoto, Akihiro Hori, Mitsuru Seishima, Shinobu Tanabashi, Shogen Matsushita, Chisato Nagata
There is some biological plausibility that exogenous melatonin plays a role in preventing liver carcinogenesis. There has been little research on the association between melatonin intake in a normal diet and health outcomes. We evaluated the association between dietary melatonin intake and the incidence of liver cancer in a population-based prospective study in Japan. This study included 30,824 residents of Takayama city who were 35 years of age or older in 1992 and had participated in the Takayama study, Japan...
February 14, 2024: Cancer Science
https://read.qxmd.com/read/38354746/phase-i-trial-of-apatinib-and-paclitaxel-oxaliplatin-5-fu-levoleucovorin-for-treatment-na%C3%A3-ve-advanced-gastric-cancer
#13
JOURNAL ARTICLE
Shen Zhao, LiYu Su, Feng Huang, Changhua Zhuo, Zaisheng Ye, Hui Li, Yi Yin, Pengqiang Gao, Yong Zhu, Rongbo Lin
Chinese guidelines recommend POF (paclitaxel, oxaliplatin, and 5-FU/levoleucovorin) as first-line treatment for advanced gastric cancer (AGC). Apatinib can augment the antitumor effect of paclitaxel, oxaliplatin, or fluorouracil in preclinical studies of AGC. A phase I clinical trial was conducted to evaluate the anticancer activity and maximum tolerated dose (MTD) of apatinib plus POF in treatment-naïve patients with AGC and to establish a recommended phase II dose. Participants received escalating doses of daily oral apatinib (250, 375, 500, 625, 750, and 850 mg) plus POF every 2 weeks using a conventional "3 + 3" study design...
February 14, 2024: Cancer Science
https://read.qxmd.com/read/38351514/transient-inhibition-of-neutrophil-functions-enhances-the-antitumor-effect-of-intravenously-delivered-oncolytic-vaccinia-virus
#14
JOURNAL ARTICLE
Danya Zhou, Wei Xu, Xuping Ding, Haoran Guo, Jianyao Wang, Guanghao Zhao, Chenglin Zhang, Zhongxian Zhang, Zhimin Wang, Pengju Wang, Liming Lu, Ming Yuan
Oncolytic viruses (OVs) possess the unique ability to selectively replicate within tumor cells, leading to their destruction, while also reversing the immunosuppression within the tumor microenvironment and triggering an antitumor immune response. As a result, OVs have emerged as one of the most promising approaches in cancer therapy. However, the effective delivery of intravenously administered OVs faces significant challenges imposed by various immune cells within the peripheral blood, hindering their access to tumor sites...
February 13, 2024: Cancer Science
https://read.qxmd.com/read/38348576/application-of-plasma-circulating-kras-mutations-as-a-predictive-biomarker-for-targeted-treatment-of-pancreatic-cancer
#15
JOURNAL ARTICLE
Mi Rim Lee, Sang Myung Woo, Min Kyeong Kim, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee, Dong-Eun Lee, Sun Il Choi, Wonyoung Choi, Kyong-Ah Yoon, Jung Won Chun, Yun-Hee Kim, Sun-Young Kong
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in circulating tumor deoxyribonucleic acid (ctDNA) have been reported as representative noninvasive prognostic markers for pancreatic ductal adenocarcinoma (PDAC). Here, we aimed to evaluate single KRAS mutations as prognostic and predictive biomarkers, with an emphasis on potential therapeutic approaches to PDAC. A total of 128 patients were analyzed for multiple or single KRAS mutations (G12A, G12C, G12D, G12R, G12S, G12V, and G13D) in their tumors and plasma using droplet digital polymerase chain reaction (ddPCR)...
February 13, 2024: Cancer Science
https://read.qxmd.com/read/38342762/retraction
#16
(no author information available yet)
Retraction: Tongyi Lu, Binhua Wu, Yunfei Yu, Wenhui Zhu, Simin Zhang, Yinmei Zhang, Jiaying Guo, Ning Deng. Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis. Cancer Sci. 2018; 109: 2221-2234. https://doi.org/10.1111/cas.13633 The above article published online on 08 May 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama, the Japanese Cancer Association and John Wiley and Sons Ltd...
February 11, 2024: Cancer Science
https://read.qxmd.com/read/38342100/gap-junction-beta-4-accelerates-cell-cycle-progression-and-metastasis-through-met-akt-activation-in-pancreatic-cancer
#17
JOURNAL ARTICLE
Joji Muramatsu, Yohei Arihara, Makoto Yoshida, Tomohiro Kubo, Hajime Nakamura, Kazuma Ishikawa, Hiromi Fujita, Shintaro Sugita, Takumi Konno, Takashi Kojima, Yutaka Kawano, Masayoshi Kobune, Kohichi Takada
Despite continuing advances in the development of effective new therapies, including immunotherapies, the prognosis of pancreatic cancer remains extremely poor. Gap junction proteins have become attractive targets for potential cancer therapy. However, the role of gap junction beta-4 (GJB4) protein remains unexplored in pancreatic cancer. Through bioinformatic analyses we discovered pancreatic cancer tissues showed higher levels of GJB4 transcripts compared to normal pancreatic tissues and this had a negative effect on overall survival in patients that had pancreatic cancer...
February 11, 2024: Cancer Science
https://read.qxmd.com/read/38332689/potent-ctls-can-be-induced-against-tumor-cells-in-an-environment-of-lower-levels-of-systemic-mfg-e8
#18
JOURNAL ARTICLE
Yu Mizote, Takako Inoue, Takashi Akazawa, Kei Kunimasa, Motohiro Tamiya, Yachiyo Kumamoto, Arisa Tsuda, Satomi Yoshida, Kumiko Tatsumi, Tomoya Ekawa, Keiichiro Honma, Kazumi Nishino, Hideaki Tahara
The direction and magnitude of immune responses are critically affected when dead cells are disposed of. Milk fat globule-epidermal growth factor-factor 8 (MFG-E8) promotes the engulfment of apoptotic normal and cancerous cells without inducing inflammation. We have previously reported that a certain proportion of the cancer cells express abundant MFG-E8, and that such expression is associated with the shorter survival of patients with esophageal cancer who had received chemotherapy before surgery. However, the influence of tumor-derived and systemically existing MFG-E8 on antitumor immune responses has not yet been fully investigated...
February 8, 2024: Cancer Science
https://read.qxmd.com/read/38327103/glasdegib-with-intensive-nonintensive-chemotherapy-in-japanese-patients-with-untreated-acute-myeloid-leukemia-or-high-risk-myelodysplastic-syndromes
#19
JOURNAL ARTICLE
Koji Izutsu, Kumi Ubukawa, Takanobu Morishita, Yasushi Onishi, Kenichi Ishizawa, Yosuke Fujii, Nobuyuki Kimura, Miyuu Yokochi, Tomoki Naoe
Glasdegib is a potent, selective, oral inhibitor of the hedgehog signaling pathway. In this phase I study, previously untreated Japanese patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes were treated with glasdegib (100 mg once daily) combinations: low-dose cytarabine (20 mg twice daily; cohort 1, n = 6; expansion cohort, n = 15); daunorubicin and cytarabine (60 mg/m2 i.v.; cohort 2, n = 6); or azacitidine (100 mg/m2 i...
February 7, 2024: Cancer Science
https://read.qxmd.com/read/38321872/potential-of-mac-2-binding-protein-glycan-isomer-as-a-new-therapeutic-target-in-pancreatic-cancer
#20
JOURNAL ARTICLE
Takahiro Yamanaka, Kenichiro Araki, Takehiko Yokobori, Ryo Muranushi, Kouki Hoshino, Kei Hagiwara, Dolgormaa Gantumur, Norihiro Ishii, Mariko Tsukagoshi, Akira Watanabe, Norifumi Harimoto, Atsushi Masamune, Haruki Uojima, Masashi Mizokami, Kiyoaki Ito, Ken Shirabe
Pancreatic cancer (PC) is a challenging malignancy to treat. Mac-2-binding protein glycan isomer (M2BPGi) is a novel serum marker of liver fibrosis and hepatocellular carcinoma and is secreted by hepatic stellate and stroma cells. Serum M2BPGi levels are upregulated in PC patients. We measured the expression of M2BPGi in the serum of 27 PC patients and determined whether M2BPGi affects the malignant potential of PC cells in vitro. We also examined the effect of M2BP on PC tumor growth and gemcitabine sensitivity in vivo...
February 6, 2024: Cancer Science
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