journal
https://read.qxmd.com/read/38475962/orosomucoid-2-upregulation-mediates-liver-injury-induced-colorectal-cancer-liver-metastasis-by-promoting-emt-and-cell-migration
#21
JOURNAL ARTICLE
Xundong Wei, Lei Wang, Bing Yang, Yuanyuan Ma, Wei Yuan, Jie Ma
The relationship between drug-induced liver injury and liver metastasis of colorectal cancer and the underlying mechanisms are not well understood. In this study, we used carbon tetrachloride to construct a classic mouse liver injury model and injected CT26 colorectal cancer cells into the mouse spleen to simulate the natural route of colorectal cancer liver metastasis. Liver injury significantly increased the number of colorectal cancer liver metastases. Transcriptome sequencing and data-independent acquisition protein quantification identified proteins that were significantly differentially expressed in injured livers, and orosomucoid (ORM) 2 was identified as a target protein for tumor liver metastasis...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38475938/trim21-is-critical-in-regulating-hepatocellular-carcinoma-growth-and-response-to-therapy-by-altering-the-mst1-yap-pathway
#22
JOURNAL ARTICLE
Bo Shu, Yingxia Zhou, Guoqiong Lei, Yu Peng, Cong Ding, Zhuan Li, Chao He
Liver cancer is the sixth most common cancer and the third leading cause of cancer-related death globally. Despite efforts being made in last two decades in cancer diagnosis and treatment, the 5-year survival rate of liver cancer remains extremely low. TRIM21 participates in cancer metabolism, glycolysis, immunity, chemosensitivity and metastasis by targeting various substrates for ubiquitination. TRIM21 serves as a prognosis marker for human hepatocellular carcinoma (HCC), but the mechanism by which TRIM21 regulates HCC tumorigenesis and progression remains elusive...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38475675/serum-itih5-as-a-novel-diagnostic-biomarker-in-cholangiocarcinoma
#23
JOURNAL ARTICLE
Meiru Chen, Jinghan Ma, Xiaoli Xie, Miao Su, Dongqiang Zhao
Cholangiocarcinoma often remains undetected until advanced stages due to the lack of reliable diagnostic markers. Our goal was to identify a unique secretory protein for cholangiocarcinoma diagnosis and differentiation from other malignancies, benign hepatobiliary diseases, and chronic liver conditions. We conducted bulk RNA-seq analysis to identify genes specifically upregulated in cholangiocarcinoma but not in most other cancers, benign hepatobiliary diseases, and chronic liver diseases focusing on exocrine protein-encoding genes...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38475666/klk10-derived-from-tumor-endothelial-cells-accelerates-colon-cancer-cell-proliferation-and-hematogenous-liver-metastasis-formation
#24
JOURNAL ARTICLE
Kazuya Kato, Takehiro Noda, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hidenori Takahashi, Mamoru Uemura, Tadafumi Asaoka, Junzo Shimizu, Yuichiro Doki, Hidetoshi Eguchi
Tumor endothelial cells (TECs), which are thought to be structurally and functionally different from normal endothelial cells (NECs), are increasingly attracting attention as a therapeutic target in hypervascular malignancies. Although colorectal liver metastasis (CRLM) tumors are hypovascular, inhibitors of angiogenesis are a key drug in multidisciplinary therapy, and TECs might be involved in the development and progression of cancer. Here, we analyzed the function of TEC in the CRLM tumor microenvironment...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38475661/ctdna-predicts-clinical-t1a-to-pathological-t3a-upstaging-after-partial-nephrectomy
#25
JOURNAL ARTICLE
Jee Soo Park, Hongkyung Kim, Won Sik Jang, Jongchan Kim, Won Sik Ham, Seung-Tae Lee
Most patients diagnosed with clear cell renal cell carcinoma (ccRCC) are also detected with small and organ-confined tumors, and the majority of these are classified as clinical tumor stage 1a (cT1a). A considerable proportion of patients with cT1 RCC shows tumor upstaging to pathological stage 3a (pT3a), and these patients have worse oncological outcomes. The role of circulating tumor DNA (ctDNA) in RCC has been limited to monitoring treatment response and resistance. Therefore, the present study aimed to evaluate the potential of ctDNA in predicting pT3a upstaging in cT1a ccRCC...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38468443/rb1-loss-induces-quiescent-state-through-downregulation-of-ras-signaling-in-mammary-epithelial-cells
#26
JOURNAL ARTICLE
Linxiang Gong, Dominic Chih-Cheng Voon, Joji Nakayama, Chiaki Takahashi, Susumu Kohno
While loss of function (LOF) of retinoblastoma 1 (RB1) tumor suppressor is known to drive initiation of small-cell lung cancer and retinoblastoma, RB1 mutation is rarely observed in breast cancers at their initiation. In this study, we investigated the impact on untransformed mammary epithelial cells given by RB1 LOF. Depletion of RB1 in anon-tumorigenic MCF10A cells induced reversible growth arrest (quiescence) featured by downregulation of multiple cyclins and MYC, upregulation of p27KIP1 , and lack of expression of markers which indicate cellular senescence or epithelial-mesenchymal transition (EMT)...
March 11, 2024: Cancer Science
https://read.qxmd.com/read/38450844/nationwide-data-from-comprehensive-genomic-profiling-assays-for-detecting-driver-oncogenes-in-non-small-cell-lung-cancer
#27
JOURNAL ARTICLE
Masaki Ishida, Masahiro Iwasaku, Toshifumi Doi, Takeshi Ishikawa, Yusuke Tachibana, Ryo Sawada, Yuri Ogura, Hayato Kawachi, Yuki Katayama, Naoya Nishioka, Kenji Morimoto, Shinsaku Tokuda, Tadaaki Yamada, Koichi Takayama
Driver oncogenes are investigated upfront at diagnosis using multi-CDx systems with next-generation sequencing techniques or multiplex reverse-transcriptase polymerase chain reaction assays. Additionally, from 2019, comprehensive genomic profiling (CGP) assays have been available in Japan for patients with advanced solid tumors who had completed or were expected to complete standard chemotherapy. These assays are expected to comprehensively detect the driver oncogenes, especially for patients with non-small cell lung cancer (NSCLC)...
March 7, 2024: Cancer Science
https://read.qxmd.com/read/38438251/smyd4-monomethylates-prmt5-and-forms-a-positive-feedback-loop-to-promote-hepatocellular-carcinoma-progression
#28
JOURNAL ARTICLE
Zhenyu Zhou, Zheng Chen, Qianlei Zhou, Shiyu Meng, Juanyi Shi, Sintim Mui, Hai Jiang, Jianhong Lin, Gui He, Wenbin Li, Jianlong Zhang, Jie Wang, Chuanchao He, Yongcong Yan, Zhiyu Xiao
Both lysine and arginine methyltransferases are thought to be promising therapeutic targets for malignant tumors, yet how these methyltransferases function in malignant tumors, especially hepatocellular carcinoma (HCC), has not been fully elucidated. Here, we reported that SMYD4, a lysine methyltransferase, acts as an oncogene in HCC. SMYD4 was highly upregulated in HCC and promoted HCC cell proliferation and metastasis. Mechanistically, PRMT5, a well-known arginine methyltransferase, was identified as a SMYD4-binding protein...
March 4, 2024: Cancer Science
https://read.qxmd.com/read/38438247/serum-and-tissue-metallome-of-pancreatic-ductal-adenocarcinoma
#29
JOURNAL ARTICLE
Sooin Byeon, Taymin du Toit-Thompson, Luke Hipperson, Sarah Maloney, Ross Wenzel, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal, Sumit Sahni
Pancreatic ductal adenocarcinoma (PDAC) patients have late presentation at the time of diagnosis and a poor prognosis. Metal dyshomeostasis is known to play a role in cancer progression. However, the blood and tissue metallome of PDAC patients has not been assessed. This study aimed to determine the levels of essential and toxic metals in the serum and pancreatic tissue from PDAC patients. Serum samples were obtained from PDAC patients before surgical resection. Tissue (tumor and adjacent normal pancreas) were obtained from the surgically resected specimen...
March 4, 2024: Cancer Science
https://read.qxmd.com/read/38433527/region-specific-dna-hydroxymethylation-along-the-malignant-progression-of-idh-mutant-gliomas
#30
JOURNAL ARTICLE
Taijun Hana, Akitake Mukasa, Masashi Nomura, Genta Nagae, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Shiro Fukuda, Takayoshi Umeda, Shota Tanaka, Takahide Nejo, Yosuke Kitagawa, Erika Yamazawa, Satoshi Takahashi, Tsukasa Koike, Yoshihiro Kushihara, Hirokazu Takami, Shunsaku Takayanagi, Hiroyuki Aburatani, Nobuhito Saito
The majority of low-grade isocitrate dehydrogenase-mutant (IDHmt ) gliomas undergo malignant progression (MP), but their underlying mechanism remains unclear. IDHmt gliomas exhibit global DNA methylation, and our previous report suggested that MP could be partly attributed to passive demethylation caused by accelerated cell cycles. However, during MP, there is also active demethylation mediated by ten-eleven translocation, such as DNA hydroxymethylation. Hydroxymethylation is reported to potentially contribute to gene expression regulation, but its role in MP remains under investigation...
March 3, 2024: Cancer Science
https://read.qxmd.com/read/38433526/ilt4-facilitates-angiogenesis-in-non-small-cell-lung-cancer
#31
JOURNAL ARTICLE
Shuyun Wang, Jing Wang, Wenjing Gong, Fang Zhang, Xiaozheng Chen, Huijun Xu, Yali Han, Xuebing Fu, Leirong Wang, Juan Li, Aiqin Gao, Yuping Sun
Antiangiogenic therapy targeting VEGF-A has become the standard of first-line therapy for non-small cell lung cancer (NSCLC). However, its clinical response rate is still less than 50%, and most patients eventually develop resistance, even when using combination therapy with chemotherapy. The major cause of resistance is the activation of complex bypass signals that induce angiogenesis and tumor progression. Therefore, exploring novel proangiogenic mechanisms and developing promising targets for combination therapy are crucial for improving the efficacy of antiangiogenic therapy...
March 3, 2024: Cancer Science
https://read.qxmd.com/read/38433331/clinical-features-and-impact-of-p53-status-on-sporadic-mismatch-repair-deficiency-and-lynch-syndrome-in-uterine-cancer
#32
JOURNAL ARTICLE
Mayumi Kobayashi Kato, Erisa Fujii, Yuka Asami, Yukihide Momozawa, Kengo Hiranuma, Masaaki Komatsu, Ryuji Hamamoto, Takahiro Ebata, Koji Matsumoto, Mitsuya Ishikawa, Takashi Kohno, Tomoyasu Kato, Hiroshi Yoshida, Kouya Shiraishi
The clinical features of sporadic mismatch repair deficiency (MMRd) and Lynch syndrome (LS) in Japanese patients with endometrial cancer (EC) were examined by evaluating the prevalence and prognostic factors of LS and sporadic MMRd in patients with EC. Targeted sequencing of five LS susceptibility genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) was carried out in 443 patients with EC who were pathologically diagnosed with EC at the National Cancer Center Hospital between 2011 and 2018. Pathogenic variants in these genes were detected in 16 patients (3...
March 3, 2024: Cancer Science
https://read.qxmd.com/read/38433313/mitochondrial-fission-enhances-il-6-induced-metastatic-potential-in-ovarian-cancer-via-erk1-2-activation
#33
JOURNAL ARTICLE
Juwon Lee, Youngjin Han, Soochi Kim, HyunA Jo, Wenyu Wang, Untack Cho, Se Ik Kim, Boyun Kim, Yong Sang Song
Ovarian cancer is a lethal gynecologic cancer mostly diagnosed in an advanced stage with an accumulation of ascites. Interleukin-6 (IL-6), a pro-inflammatory cytokine is highly elevated in malignant ascites and plays a pleiotropic role in cancer progression. Mitochondria are dynamic organelles that undergo fission and fusion in response to external stimuli and dysregulation in their dynamics has been implicated in cancer progression and metastasis. Here, we investigate the effect of IL-6 on mitochondrial dynamics in ovarian cancer cells (OVCs) and its impact on metastatic potential...
March 3, 2024: Cancer Science
https://read.qxmd.com/read/38429886/whole-transcriptome-sequencing-in-advanced-gastric-or-gastroesophageal-cancer-a-deep-dive-into-its-clinical-potential
#34
JOURNAL ARTICLE
Tadayoshi Hashimoto, Yoshiaki Nakamura, Saori Mishima, Izuma Nakayama, Daisuke Kotani, Akihito Kawazoe, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Naoko Iida, Taro Shibuki, Mitsuho Imai, Takao Fujisawa, Michiko Nagamine, Naoya Sakamoto, Takeshi Kuwata, Takayuki Yoshino, Kohei Shitara
Advanced gastric and gastroesophageal junction cancers (GC/GEJCs) harbor diverse molecular signatures, highlighting the need for intricate evaluations to identify potential therapeutic targets. Although whole-transcriptome sequencing (WTS) has emerged as a useful tool for understanding these molecular intricacies, its clinical implications have yet to be fully elucidated. This study evaluated the correlation between immunohistochemistry (IHC) and WTS, compared their clinical significance, and identified potential therapeutic targets undetectable through IHC alone...
March 1, 2024: Cancer Science
https://read.qxmd.com/read/38422408/development-and-experimental-validation-of-an-m2-macrophage-and-platelet-associated-gene-signature-to-predict-prognosis-and-immunotherapy-sensitivity-in-bladder-cancer
#35
JOURNAL ARTICLE
Bahaerguli Muhuitijiang, Jiawei Zhou, Ranran Zhou, Zhiyong Zhang, Guang Yan, Zaosong Zheng, Xiangbo Zeng, Yuanchao Zhu, Haowei Wu, Ruxi Gao, Tianhang Zhu, Xiaojun Shi, Wanlong Tan
Platelets and M2 macrophages both play crucial roles in tumorigenesis, but their relationship and the prognosis value of the relative genes in bladder cancer (BLCA) remain obscure. In the present study, we found that platelets stimulated by BLCA cell lines could promote M2 macrophage polarization, and platelets were significantly associated with the infiltration of M2 macrophages in BLCA samples. Through the bioinformatic analyses, A2M, TGFB3, and MYLK, which were associated with platelets and M2 macrophages, were identified and verified in vitro and then included in the predictive model...
February 29, 2024: Cancer Science
https://read.qxmd.com/read/38417449/salivary-metabolomic-biomarkers-for-non-invasive-lung-cancer-detection
#36
JOURNAL ARTICLE
Naohiro Kajiwara, Masatoshi Kakihana, Junichi Maeda, Miku Kaneko, Sana Ota, Ayame Enomoto, Norihiko Ikeda, Masahiro Sugimoto
Identifying novel biomarkers for early detection of lung cancer is crucial. Non-invasively available saliva is an ideal biofluid for biomarker exploration; however, the rationale underlying biomarker detection from organs distal to the oral cavity in saliva requires clarification. Therefore, we analyzed metabolomic profiles of cancer tissues compared with those of adjacent non-cancerous tissues, as well as plasma and saliva samples collected from patients with lung cancer (n = 109 pairs). Additionally, we analyzed plasma and saliva samples collected from control participants (n = 83 and 71, respectively)...
February 28, 2024: Cancer Science
https://read.qxmd.com/read/38413370/cell-cycle-heterogeneity-and-plasticity-of-colorectal-cancer-stem-cells
#37
REVIEW
Tsunaki Higa, Keiichi I Nakayama
Cancer stem cells (CSCs) are a long-lived and self-renewing cancer cell population that drives tumor propagation and maintains cancer heterogeneity. They are also implicated in the therapeutic resistance of various types of cancer. Recent studies of CSCs in colorectal cancer (CRC) have uncovered fundamental paradigms that have increased understanding of CSC systems in solid tumors. Colorectal CSCs share multiple biological properties with normal intestinal stem cells (ISCs), including expression of the stem cell marker Lgr5...
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38413363/hypoxia-related-carbonic-anhydrase-9-induces-serpinb9-expression-in-cancer-cells-and-apoptosis-in-t-cells-via-acidosis
#38
JOURNAL ARTICLE
Mamoru Harada, Hitoshi Kotani, Yuichi Iida, Ryosuke Tanino, Takafumi Minami, Yoshihiro Komohara, Kazuhiro Yoshikawa, Hirotsugu Uemura
Hypoxia is a common feature of solid tumors. However, the impact of hypoxia on immune cells within tumor environments remains underexplored. Carbonic anhydrase 9 (CA9) is a hypoxia-responsive tumor-associated enzyme. We previously noted that regardless of human CA9 (hCA9) expression, hCA9-expressing mouse renal cell carcinoma RENCA (RENCA/hCA9) presented as a "cold" tumor in syngeneic aged mice. This study delves into the mechanisms behind this observation. Gene microarray analyses showed that RENCA/hCA9 cells exhibited elevated mouse serpinB9, an inhibitor of granzyme B, relative to RENCA cells...
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38411349/correction-to-hdac5-negatively-regulated-by-mir-148a-3p-promotes-colon-cancer-cell-migration
#39
(no author information available yet)
No abstract text is available yet for this article.
February 27, 2024: Cancer Science
https://read.qxmd.com/read/38411285/scoring-system-for-diagnosis-and-pretreatment-risk-assessment-of-neuroblastoma-using-urinary-biomarker-combinations
#40
JOURNAL ARTICLE
Hizuru Amano, Hiroo Uchida, Kazuharu Harada, Atsushi Narita, Shigehisa Fumino, Yuji Yamada, Shun Kumano, Mayumi Abe, Takashi Ishigaki, Minoru Sakairi, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Shuhei Karakawa, Yuichi Mitani, Shojiro Matsumoto, Yutaka Tomioka, Hideki Muramatsu, Nobuhiro Nishio, Tsuyoshi Osawa, Masataka Taguri, Katsuyoshi Koh, Tatsuro Tajiri, Motohiro Kato, Kimikazu Matsumoto, Yoshiyuki Takahashi, Akinari Hinoki
The urinary catecholamine metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA), are used for the adjunctive diagnosis of neuroblastomas. We aimed to develop a scoring system for the diagnosis and pretreatment risk assessment of neuroblastoma, incorporating age and other urinary catecholamine metabolite combinations. Urine samples from 227 controls (227 samples) and 68 patients with neuroblastoma (228 samples) were evaluated. First, the catecholamine metabolites vanillactic acid (VLA) and 3-methoxytyramine sulfate (MTS) were identified as urinary marker candidates through comprehensive analysis using liquid chromatography-mass spectrometry...
February 27, 2024: Cancer Science
journal
journal
40398
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.